CN105028864B - A kind of black tea extract buccal tablet and preparation method thereof - Google Patents
A kind of black tea extract buccal tablet and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of black tea extract buccal tablets and preparation method thereof.The black tea extract buccal tablet raw material mass mixture ratio is：1~15 part of black tea extract, 0.1~5 part of heavy metal absorbent, 5~20 parts of ascorbic acid, 0.5~3 part of pulullan, 50~80 parts of filler, 0.1~1 part of acidity regulator, 0.1~1 part of sweetener, 0.1~1 part of natural perfume material, 0.5~2 part of lubricant.The buccal tablet of the present invention after being mixed in a certain ratio with auxiliary material, is granulated using fluidized drying comminutor using black tea extract, heavy metal absorbent as functional component, tabletted.The present invention uses a step prilling process, and production efficiency is high, and the buccal tablet of preparation is clearly fine and smooth, in good taste, slightly black tea is fragrant, convenient, not only can fresh breath, replenishing vitamins C, but also the content of human body nitrite and heavy metal ion can be reduced, play the purpose of anti-curing cancers.
Description
Technical field
The present invention relates to food deep processing pressed candy field, specifically a kind of black tea extract buccal tablet and its preparation side
Method.
Background technology
The influence of the factors such as increase, environmental pollution and the facility technology application due to nitrogen application, is present in meat products, vegetable
The content of nitrate, nitrite in the foods such as dish be in increase trend, become influence food security an important factor for, have
It is the important content for ensureing food security that effect, which reduces content of nitrite,.Meanwhile with the rapid development of modern industry, increasingly
More heavy metals are widely applied in the life and production of the mankind, and the heavy metal in environment mainly passes through empty gas and water, soil
Etc. approach enter animal and plant body, and enter human body via food chain amplification, enrichment, extremely low concentration can destroy human normal physiology
Activity damages health；The mankind also can absorb heavy metal classes pollutant by approach such as respiratory tract, skin contacts.Heavy metal
Pollution is mainly based on the heavy metal elements such as lead, mercury, chromium, copper, cadmium.In recent years, multiple countries of the world have been reported that in biological sample
Heavy metal substance is detected in (human blood, fat and milk), and content is in ascendant trend year by year.Nitrite and heavy metal from
Son has become an important factor for threatening human health now.So far, in addition to far from pollution sources, being done there are no practicable
Method eliminates the harm of nitrite and heavy metal ion to human body.
Sodium nitrite can react in the cooking or digestion process with the amine in food, generate strong carcinogen nitrosamines
Close object.Studies have shown that many Natural Antioxidants have the function of removing nitrite.With to conventional synthesis antioxidant
The it is proposed of the toxicity problems such as 2,6-di-tert-butyl p-cresol (BHT), butylated hydroxy anisole (BHA), U.S. FDA is in nineteen eighty-two root
According to results of animal, by BHT from Generally Recognized as Safe (GRAS, it is considered that safety) substance table
It deletes.Therefore natural is increasingly favored by industries such as food, especially plant source antioxidant, because it has
Inoxidizability is strong, derives from a wealth of sources, the advantages that recovery rate is high, strong, safe with body affinity, becomes the heat studied both at home and abroad
Point.
Black tea belongs to post-fermented tea, natural nuisance-free, be processing technology is most complicated in all black tea products, the period most
The most unique a kind of product of long, technique, rich in fungi polysaccharide, tea polysaccharide, tea polyphenols (including catechin, phenolic acid class, flavonoids
Close object) etc. nutritional ingredients.Its fungi polysaccharide is generated by " golden flower " during floating, has various health care functions.Black tea
Hypoglycemic, reducing blood lipid, blood pressure lowering, weight-reducing, coordinating intestines and stomach and other effects generally approved by the common people, but black tea goes nitrite to act on
Document report is yet there are no, the present invention is found by experiment that, the buccal tablet provided, which has, significantly goes nitrite effect, this work
With dependent on the polysaccharide and tea polyphenols contained by it.
Polysaccharide anti-oxidative function is confirmed by more experiment, and polysaccharide adverse reaction is small, in widespread attention.Just according to Cai
Army reports (Cai Zheng armies Radix Caulophyllis chemical composition and anti-oxidant research, 2009), and the Radix Caulophylli polysaccharide of 4.0mg/mL is to NO2 -It is clear
Except rate is up to 85.1%；The analysis of experiments of Zhang Tingyan (the antioxidant activity research of tri- kinds of plant polyoses of the such as Zhang Tingting, 2002) is sent out
It is existing, 1mL 0.5mg/mL Tea Polysaccharides, polysaccharides, 20 μ g NaNO of Fructus Rosae Laevigatae polysaccharides pair2Scavenging effect up to 88.92%~
99.72%.
Except having polysaccharide component in black tea, also contain larger amount of tea polyphenols.Before and after 1970, it has been found that Vitamin C
Sour (vitamin C) effectively can inhibit nitrosamine compound to generate, this makes the U.S. require to contain at least in meat products
550ppm ascorbic acid.Manufacturer use cost lower sometimes but the comparable arabo-ascorbic acid of effect as substitute.Tea polyphenols have
There are stronger antioxidation, especially ester catechin EGCG, reproducibility to be even up to 100 times of L- arabo-ascorbic acids.
Gamma-polyglutamic acid (γ-PGA) is a kind of multifunctional natural substance, at " natto " --- it is sent out for the first time in fermentation beans
It is existing, there is excellent bioaffinity, non-toxic to humans, edible.Natto is from the appearance point of view, be with the big of very thin bloom
Beans graininess fermentation product, surface is wire drawing shape mucous substance, and the main component of these ropes is γ-PGA, general natto
More more glutinous, better.Contain other multiple nutritional components in natto, can be individually added into inventive formulation, or combines with γ-PGA and make
With.Since γ-PGA have splendid moisture retention, film forming, caking property, plasticity, oxygen barrier, fibre forming property, biodegradable
Etc. many physics and chemistry and biological characteristics, in current patent document, study it is more be using PGA as cosmetic humectant, hand over
Join hydrogel injection, fresh-ness preserving agent for vegetable, capsule shells, soil and adjusts water-retaining agent, fertilizer synergist, heavy metal in water adsorbent etc.
It uses, does not have also directly to eat PGA and report also there is not the proposition of oral concept with the research for adsorbing heavy metal.
In related tea art solutions, CN103141621B " a kind of oolong tea sugar-free buccal tablet and preparation method thereof "
And CN101053352B " a kind of buccal tablet and preparation method thereof ", prilling process are made using certain density alcohol
For wetting agent, drying is also needed after granulation, complex steps are time-consuming and laborious, and the use of alcohol is to the workshop in industrial big production
It is designed with higher requirement.
In view of the above problems, in conjunction with modern food processing technology, the present invention is developed containing black tea extract and γ-
The buccal tablet of PGA or natto powder, the buccal tablet is simply eaten, after containing, can quickly reduce the nitrous in human oral cavity saliva
Hydrochlorate, reduce human body in heavy metal ion content.The present invention uses fluidized drying comminutor, and a step is granulated, from being dosed into
Discharging only needs the short period, and alcohol is not necessarily in production, and using pulullan as adhesive, solves into that graininess is poor, was granulated
The problems such as Cheng Rongyi lumps, makes grain diameter suitable size, is conducive to tabletting, and the tablet being pressed into is in tea brown, and color is uniformly beautiful.
Invention content
The purpose of the present invention is to provide a kind of black tea extract buccal tablets, and provide a kind of black tea extract buccal tablet
Preparation method, the main function of the buccal tablet are the nitrite and heavy metal ion removed in human body.
The present invention is realized by following technical proposals：
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：Black tea extract 1~15
Part, 0.1~5 part of heavy metal absorbent, 5~20 parts of ascorbic acid, 0.5~3 part of pulullan, 50~80 parts of filler, acidity
0.1~1 part of conditioning agent, 0.1~1 part of sweetener, 0.1~1 part of natural perfume material, 0.5~2 part of lubricant.
Another object of the present invention is to provide a kind of black tea extract buccal tablet preparation method, processing step
For：
(1) preparation of black tea extract：Black tea is crushed to 40~60 mesh；It is put into extractor, with flooding, controls liquid
Gu than being 5~10: 1,0.5~1.5h is boiled；Plate-frame filtering after cooling, continuous extraction 3 times, merges leaching liquor；70~80 DEG C true
Sky concentration obtains black tea extract in 60~90 DEG C of 120~160 DEG C of inlet air temperature, leaving air temp spray drying；
(2) pretreatment of material：Black tea extract, heavy metal absorbent are crossed into 80~100 mesh sieve, anti-caking is spare；It will
After ascorbic acid, filler, acidity regulator crush respectively, 80~100 mesh sieve is crossed, it is spare；By pulullan wiring solution-forming, make
For adhesive；
(3) it is granulated：By black tea extract, heavy metal absorbent, ascorbic acid, filler, acidity regulator, sweetener,
Natural perfume material is put into fluidized drying comminutor, sprays pulullan solution, and a step is granulated, and during granulation, is periodically sampled,
With 70~85 DEG C of fast tester for water content, granule moisture level is measured, makes aqueous to be maintained at 1.5%~2.5% eventually；
The parameters of the fluidized drying comminutor granulation process are：50~70 DEG C of set temperature；Temperature of charge 20
~33 DEG C；7~17m of air quantity3/h；3~8rpm of feed flow revolution speed；0.5~2kg/cm of atomizing pressure2；
(4) tabletting：Lubricant is added in particle, always mixed machine mixes 20~60min, tabletting, every 1 ± 0.05g of weight.
The heavy metal absorbent is the mixture of one or both of γ-PGA, natto powder.
The filler is in mannitol, D-sorbite, maltodextrin, xylitol, hydroxyl isomaltulose, Icing Sugar, lactose
One or two or more mixture.
The acidity regulator be one or both of malic acid, tartaric acid, lactic acid, citric acid and its sodium salt and with
On mixture.
The sweetener is the mixed of one or both of Aspartame, Sucralose, honey element, acesulfame potassium or more
Close object.
The natural perfume material is pure plant extraction.
The natural perfume material is one or both of menthol, lemon extract, orange flavor, berry essence or more
Mixture.
The lubricant be magnesium stearate, talcum powder, polyethylene glycols, one or both of magnesium laurylsulfate and
Above mixture.
Beneficial effects of the present invention：
1. black tea extract buccal tablet provided by the present invention, smooth consolidation, appearance are in tea brown, cool taste, exquisiteness
Palatable, the slightly black tea of thin product is fragrant, and fresh breath is convenient.
2. buccal tablet provided by the present invention can supplement the ascorbic acid of needed by human body.
3. buccal tablet provided by the present invention contains all prebiotic components in black tea, it is most important that in black tea extract
Tea polyphenols, fungi polysaccharide, tea polysaccharide and other functional ingredient can reduce the content of nitrite in human oral cavity saliva, play resistance
The effect of disconnected nitrosamine synthesis, to the generation of pre- anti-cancer.
4. γ-the PGA contained in black tea extract buccal tablet provided by the present invention can chelate Cr3+、Cu2+、Pb2+Deng weight
Metal ion plays the role of removing heavy metal ion in human body.
5. the pulullan in buccal tablet prepared by the present invention have stickiness, soluble easily in water, colorless and odorless, it is nontoxic, can
It is edible, play the role of adhesive in buccal tablet, in granulation process, increases granularity and the uniformity, be easy to tabletting.
6. the preparation method of black tea extract buccal tablet provided by the invention is granulated using fluidized drying comminutor, is not necessarily to
Alcohol, one step of entire granulation process are completed, and production efficiency is high, and province's work(is laborsaving, energy conservation and environmental protection.
Specific implementation mode
A kind of black tea extract buccal tablet and preparation method thereof specifically explains the present invention below by embodiment
It states, further illustrates the present invention, but do not limit the embodiments.
Embodiment 1
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The preparation method of black tea extract buccal tablet, processing step are：
(1) preparation of black tea extract：Black tea is crushed to 40 mesh；It is put into extractor, with flooding, controls liquid-solid ratio
It is 5: 1, boils 0.5h；Plate-frame filtering after cooling, continuous extraction 3 times, merges leaching liquor；80 DEG C of vacuum concentrations, in inlet air temperature
120 DEG C, be spray-dried under the conditions of 60 DEG C of leaving air temp, obtain black tea extract.
(2) pretreatment of material：By black tea extract, heavy metal absorbent crosses 80 mesh sieve, and anti-caking is spare；It will be anti-bad
After hematic acid, filler, acidity regulator crush respectively, 80 mesh sieve is crossed, it is spare；By pulullan wiring solution-forming, as adhesive.
(3) it is granulated：Raw material is put into fluidized drying comminutor, using pulullan solution as adhesive, is granulated.It is making
It during grain, periodically samples, observes graininess, and under the conditions of 85 DEG C, containing for particle is measured with fast tester for water content
Water makes aqueous to 2.5% eventually；
The parameters of the fluidized drying comminutor granulation process are：70 DEG C of set temperature；33 DEG C of temperature of charge；Wind
Measure 15m3/h；Feed flow revolution speed 6rpm；Atomizing pressure 1.5kg/cm2。
(4) tabletting is packed：Lubricant is added in particle prepared by step (3), puts into and always mix machine mixing 40min, tabletting,
Every 1 ± 0.05g of weight obtains finished product after packing.
Embodiment 2
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The preparation method of black tea extract buccal tablet, processing step are：
(1) preparation of black tea extract：Black tea is crushed to 60 mesh；It is put into extractor, with flooding, controls liquid-solid ratio
It is 10: 1, boils 0.8h；Plate-frame filtering after cooling, continuous extraction 3 times, merges leaching liquor；80 DEG C of vacuum concentrations, in inlet air temperature
140 DEG C, be spray-dried under the conditions of 70 DEG C of leaving air temp, obtain black tea extract.
(2) pretreatment of material：By black tea extract, heavy metal absorbent sieves with 100 mesh sieve, and anti-caking is spare；It will be anti-bad
After hematic acid, filler, acidity regulator crush respectively, sieve with 100 mesh sieve, it is spare；By pulullan wiring solution-forming, as bonding
Agent.
(3) it is granulated：Raw material is put into fluidized drying comminutor, using pulullan solution as adhesive, is granulated.It is making
It during grain, periodically samples, detects graininess, and under the conditions of 80 DEG C, containing for particle is measured with fast tester for water content
Water makes aqueous to 2% eventually；
The parameters of the fluidized drying comminutor granulation process are：65 DEG C of set temperature；29 DEG C of temperature of charge；Wind
Measure 12m3/h；Feed flow revolution speed 5rpm；Atomizing pressure 2kg/cm2。
(4) tabletting is packed：Lubricant is added in particle prepared by step (3), puts into and always mix machine mixing 30min, tabletting,
Every 1 ± 0.05g of weight obtains finished product after packing.
Embodiment 3
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The preparation method of black tea extract buccal tablet, processing step are：
(1) preparation of black tea extract：Black tea is crushed to 60 mesh；It is put into extractor, with flooding, controls liquid-solid ratio
It is 10: 1, boils 1h；Plate-frame filtering after cooling, continuous extraction 3 times, merges leaching liquor；80 DEG C of vacuum concentrations, in inlet air temperature
160 DEG C, be spray-dried under the conditions of 70 DEG C of leaving air temp, obtain black tea extract.
(2) pretreatment of material：By black tea extract, heavy metal absorbent sieves with 100 mesh sieve, and anti-caking is spare；It will be anti-bad
After hematic acid, filler, acidity regulator crush respectively, sieve with 100 mesh sieve, it is spare；By pulullan wiring solution-forming, as bonding
Agent.
(3) it is granulated：Raw material is put into fluidized drying comminutor, using pulullan solution as adhesive, is granulated.It is making
It during grain, periodically samples, detects graininess, and under the conditions of 80 DEG C, containing for particle is measured with fast tester for water content
Water makes aqueous to 1.8% eventually；
The parameters of the fluidized drying comminutor granulation process are：60 DEG C of set temperature；29 DEG C of temperature of charge；Wind
Measure 10m3/h；Feed flow revolution speed 5rpm；Atomizing pressure 1.5kg/cm2。
(4) tabletting is packed：Lubricant is added in particle prepared by step (3), puts into and always mix machine mixing 30min, tabletting,
Every 1 ± 0.05g of weight obtains finished product after packing.
Embodiment 4
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The preparation method of black tea extract buccal tablet, processing step are：
(1) preparation of black tea extract：Black tea is crushed to 40 mesh；It is put into extractor, with flooding, controls liquid-solid ratio
It is 10: 1, boils 1h；Plate-frame filtering after cooling, continuous extraction 3 times, merges leaching liquor；80 DEG C of vacuum concentrations, in inlet air temperature
160 DEG C, be spray-dried under the conditions of 70 DEG C of leaving air temp, obtain black tea extract.
(2) pretreatment of material：By black tea extract, heavy metal absorbent sieves with 100 mesh sieve, and anti-caking is spare；It will be anti-bad
After hematic acid, filler, acidity regulator crush respectively, sieve with 100 mesh sieve, it is spare；By pulullan wiring solution-forming, as bonding
Agent.
(3) it is granulated：Raw material is put into fluidized drying comminutor, using pulullan solution as adhesive, is granulated.It is making
It during grain, periodically samples, detects graininess, and under the conditions of 80 DEG C, containing for particle is measured with fast tester for water content
Water makes aqueous to 1.8% eventually；
The parameters of the fluidized drying comminutor granulation process are：60 DEG C of set temperature；29 DEG C of temperature of charge；Wind
Measure 10m3/h；Feed flow revolution speed 5rpm；Atomizing pressure 1.5kg/cm2。
(4) tabletting is packed：Lubricant is added in particle prepared by step (3), puts into and always mix machine mixing 30min, tabletting,
Every 1 ± 0.05g of weight obtains finished product after packing.
Embodiment 5
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The step of preparation process of black tea extract buccal tablet is the same as embodiment 1.
Embodiment 6
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The step of preparation process of black tea extract buccal tablet is the same as embodiment 2.
Embodiment 7
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The step of preparation process of black tea extract buccal tablet is the same as embodiment 3.
Embodiment 8
A kind of black tea extract buccal tablet, the buccal tablet are made of the raw material of following parts by weight：
The step of preparation process of black tea extract buccal tablet is the same as embodiment 4.
To more fully illustrate product of the present invention in the effect for removing nitrite and heavy metal ions, the above implementation is taken
Buccal tablet in example does compliance test result test.
Influence of 1 buccal tablet of test example to human oral cavity saliva nitrite
Nitrite in human body is other than direct food source, and nitrate in food or drinking-water after entering human body, greatly
Part is absorbed in stomach and enteron aisle epimere, is secreted into saliva automatically after blood circulates in salivary gland enrichment.Through salivary gland point
The nitrate into oral cavity is secreted after the nitrate reductase reduction that oral cavity nitrate reduction bacterium generates, and generates nitrite.It is sub-
It after nitrate enters human body, is reacted with the amine in gastric juice in digestion process, generates Carcinogenic Nitrosamines class compound.This experiment
Purpose is to go nitrite to act on illustrate buccal tablet using the nitrite in buccal tablet removal human oral cavity saliva.
Test process is as follows.(1) subject
20 health adults, 25~40 years old age, random number A~J and A1~J10, wherein A~J is control group, containing change
Buccal tablet be free of black tea extract, other ingredients are same as Example 1；A1~J10For normal assays group, in the embodiment 1 containing change
Buccal tablet.
(2) method
The postprandial fasting 30min of subject, everyone contains naturally changes 1 (1 ± 0.05g/ pieces), takes containing the saliva before and after changing
0.3ml is diluted to 15ml with distilled water, utilizes nitrous nitrification kit (the Hangzhou bio tech ltd Lu Heng) explanation
Testing procedure on book, i.e., colorimetric card colorimetric method for determining is containing the content of nitrite in saliva before and after change.
It is 0.01,0.03,0.05,0.1,0.2,0.3,0.4,0.5mg/L that numerical value is corresponded on colorimetric card, and color adds successively
Deep, from lightpink to peony, reaction solution color is deeper, illustrates that content of nitrite is higher.
(3) result
Content value containing saliva nitrite before and after change is relatively shown in Table 1.
Content value of the table 1 containing saliva nitrite before and after change
By table 1 as it can be seen that the content of subjects saliva's nitrite is in 2.5~20mg/L, it is most of concentrate on 10~
20mg/L.After containing, the content of nitrite in control group saliva is reduced to 0.5~2.5mg/L, and rate of descent is 66.7%~
87.5%；Content of nitrite in normal experimental group saliva is reduced to 0~0.5mg/L, and rate of descent is up to 95%~100%, Asia
Nitrate content significantly reduces, and with obvious effects better than control group.Nitrite is removed for vivider this buccal tablet of explanation
Effect is A with number1Subject for, the reaction solution color containing saliva dilution liquid before change is red gorgeous, the respective value on colorimetric card
For 0.3mg/L, the reaction solution color containing saliva dilution liquid after change is in lightpink, and respective value is 0.01mg/L, face on colorimetric card
Colour response is apparent, and can intuitively find out buccal tablet quickly goes nitrite effect.
Influence of 2 buccal tablet of test example to lead level in rat blood
Heavy metal has very low dose toxicity, longer biological half-life after entering human body, generate larger harm lead (Pb),
In cadmium (Cd), mercury (Hg), chromium (Cr), copper (Cu), Pb is one of the heavy metal that wherein known toxicity is maximum, cumulative bad is extremely strong, can
Accumulate for a long time in human body.
Now by taking Pb lead as an example, use rat blood lead content level as index, buccal tablet removes heavy metal during detection is of the invention
Effect.(1) experimental animal and processing
SPF grades of SD rats, male, 180~200g of weight are provided by medical college of Shandong University animal experimental center.It adapts to
Property feed 1 week after start to test.Whole process is fed with basal feed, free water.SD rats are randomly divided into 6 groups, i.e., normally
The high, medium and low dosage group of control group, model group, blank control group, buccal tablet.Wherein Normal group drinks distilled water, model
The high, medium and low dosage group of group, blank control group, buccal tablet drinks the distilled water containing lead acetate, and wherein Pb contents are 80mg/L,
For 3 weeks, tail vein takes blood, measures Pb-B, every group is selected 10 high blood lead rat as high blood lead model.
Common buccal tablet is free of PGA or natto powder, and other ingredients are same as Example 2.By in embodiment 2 buccal tablet with
Common buccal tablet is configured to gavage solution formulation respectively.Normal group and model group gavage physiological saline；Blank control group
The common buccal tablet of gavage, dosage are respectively 2g/ (kgd)；The high, medium and low dosage group of buccal tablet distinguishes the mouth in gavage embodiment 2
Lozenge, dosage are respectively 2,1,0.5g/ (kgd), one time a day.Remaining time, six groups of rats freely drank distilled water, were filling
When stomach the 2nd, 4,6 week, tail blood is adopted, measures blood lead content.
(2) blood lead measures
Blood sample Triton X-100 make matrix modifier, use nitric acid treatment after haemolysis, utilize sampling Graphite Furnace Atomic Absorption light
Spectrometry measures the lead content in blood.
(3) result
When gavage the 2nd, 4,6 week, the content of lead, is shown in Table 2 in rat blood.
Table 2 treat different time rat blood lead concentration level compare (N=10)
**P < 0.01vs Normal groups；**P < 0.01,*Before P < 0.05vs administrations；P < 0.01,P < 0.05vs
Model group
As can be seen from Table 2, before administration, compared with Normal group, model group blood lead content significantly increases (P < 0.01), respectively
Administration group is substantially close with model group.Compared with before administration, the 4th and 6 week, each group blood lead content decreased (P < 0.05),
To the 6th week, model group about reduced 31.1%, and blank control group reduces 31.6%, this two groups of difference are smaller；But buccal tablet
High, medium and low dosage group reduces 64.7%, 56.2%, 50.5% respectively, and wherein high dose group reduces most apparent, is superior to mould
Type group and blank control group.2nd, 4,6 week, model group and blank control group blood lead content were significantly higher, each dosage group of buccal tablet
It significantly reduces, shows that this buccal tablet has and preferably go lead effect.
It same or similar remove nitrite in addition, other embodiments have and goes lead effect with testing above.
Claims (3)
1. a kind of black tea extract buccal tablet, step of preparation process are as follows：(1) preparation of black tea extract：Black tea is crushed
To 40~60 mesh；It is put into extractor, with flooding, control liquid-solid ratio is 5: 1, boils 0.5~1.5h；Sheet frame mistake after cooling
Filter, continuous extraction 3 times, merges leaching liquor；70~80 DEG C vacuum concentration, 120~160 DEG C of inlet air temperature, leaving air temp 60~
90 DEG C of spray drying, obtain black tea extract；(2) pretreatment of material：Black tea extract, heavy metal absorbent are crossed 80~100
Mesh sieves, and anti-caking is spare；After ascorbic acid, filler, acidity regulator are crushed respectively, 80~100 mesh sieve is crossed, it is spare；It will
Pulullan wiring solution-forming, as adhesive；(3) it is granulated：By black tea extract, heavy metal absorbent, ascorbic acid, filling
In agent, acidity regulator, sweetener, natural perfume material input fluidized drying comminutor, pulullan solution is sprayed, a step is granulated,
It during granulation, periodically samples, with 70~85 DEG C of fast tester for water content, measures granule moisture level, make aqueous holding eventually
1.5%~2.5%；The parameters of the fluidized drying comminutor granulation process are：50~70 DEG C of set temperature；Material
20~33 DEG C of temperature；7~17m of air quantity3/h；3~8rpm of feed flow revolution speed；0.5~2kg/cm of atomizing pressure2；(4) tabletting：It will profit
Lubrication prescription is added in particle, and always mixed machine mixes 20~60min, tabletting, every 1 ± 0.05g of weight；
It is characterized in that the buccal tablet is mainly made of the raw material of following parts by weight：1~15 part of black tea extract, heavy metal
0.1~5 part of adsorbent, 5~20 parts of ascorbic acid, 0.5~3 part of pulullan, 50~80 parts of filler, acidity regulator 0.1
~1 part, 0.1~1 part of sweetener, 0.1~1 part of natural perfume material, 0.5~2 part of lubricant；
Wherein, the filler is in mannitol, D-sorbite, maltodextrin, xylitol, hydroxyl isomaltulose, Icing Sugar, lactose
One or two kinds of or more mixtures；The acidity regulator is in malic acid, tartaric acid, lactic acid, citric acid and its sodium salt
One or two or more mixture；The sweetener is one in Aspartame, Sucralose, honey element, acesulfame potassium
Kind or two kinds or more of mixture；The natural perfume material is one in menthol, lemon extract, orange flavor, berry essence
Kind or two kinds or more of mixture；The lubricant is magnesium stearate, talcum powder, polyethylene glycols, magnesium laurylsulfate
One or both of or more mixture.
2. a kind of black tea extract buccal tablet described in claim 1, it is characterised in that the heavy metal absorbent is poly- for γ-
The mixture of one or both of glutamic acid (γ-PGA), natto powder.
3. a kind of black tea extract buccal tablet described in claim 1, it is characterized in that the natural perfume material is pure plant extraction.
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| US10029999B2 (en) | 2016-09-21 | 2018-07-24 | Celanese International Corporation | Acesulfame potassium compositions and processes for producing same |
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| CN108740180A (en) * | 2018-05-04 | 2018-11-06 | 任秀江 | A kind of black tea lozenge and preparation method thereof |
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| CN110856513A (en) * | 2018-08-23 | 2020-03-03 | 济南昊雨青田医药技术有限公司 | Sugar-free tea functional food and preparation method thereof |
| CN111588856A (en) * | 2019-02-03 | 2020-08-28 | 安化县茶产业茶文化开发领导小组办公室 | Application of dark tea extract and p38 inhibitor in synergistic inhibition of tumors |
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