CN105026431B - 单接头FabFv抗体和制备其的方法 - Google Patents

单接头FabFv抗体和制备其的方法 Download PDF

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Publication number
CN105026431B
CN105026431B CN201380072293.8A CN201380072293A CN105026431B CN 105026431 B CN105026431 B CN 105026431B CN 201380072293 A CN201380072293 A CN 201380072293A CN 105026431 B CN105026431 B CN 105026431B
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variable domain
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domain
sequence
formula
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CN105026431A (zh
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E·达弗
S·P·海伍德
D·P·汉弗莱斯
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UCB Biopharma SRL
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CN201380072293.8A 2012-12-21 2013-12-20 单接头FabFv抗体和制备其的方法 Expired - Fee Related CN105026431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1223276.5A GB201223276D0 (en) 2012-12-21 2012-12-21 Antibodies and methods of producing same
GB1223276.5 2012-12-21
PCT/EP2013/077758 WO2014096390A1 (en) 2012-12-21 2013-12-20 Single linker fabfv antibodies and methods of producing same

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CN105026431A CN105026431A (zh) 2015-11-04
CN105026431B true CN105026431B (zh) 2021-06-25

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US (2) US10457748B2 (https=)
EP (1) EP2935336B1 (https=)
JP (1) JP6411362B2 (https=)
CN (1) CN105026431B (https=)
BR (1) BR112015014872B1 (https=)
CA (1) CA2895608C (https=)
ES (1) ES2689470T3 (https=)
GB (1) GB201223276D0 (https=)
RU (1) RU2714159C2 (https=)
WO (1) WO2014096390A1 (https=)

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US20150203591A1 (en) * 2012-08-02 2015-07-23 Regeneron Pharmaceuticals, Inc. Mutivalent antigen-binding proteins
GB201223276D0 (en) * 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201506869D0 (en) * 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506868D0 (en) * 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method for protein purification
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
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GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
CN109071643B (zh) * 2016-05-01 2024-03-19 Ucb生物制药有限责任公司 亲和力改造的血清蛋白载体结合结构域
GB201621591D0 (en) * 2016-12-19 2017-02-01 Ucb Biopharma Sprl Antibody molecules and method
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
CA3067835A1 (en) * 2017-06-22 2018-12-27 Apexigen, Inc. Anti-vista antibodies and methods of use
DK3728328T5 (da) 2017-12-22 2025-02-17 Argenx Bvba Bispecifik antigenbindende konstruktion
GB201802487D0 (en) 2018-02-15 2018-04-04 Argenx Bvba Cytokine combination therapy
IL279399B1 (en) 2018-06-14 2026-04-01 Bioatla Llc Multispecific antibody templates
KR20210108421A (ko) 2018-12-24 2021-09-02 사노피 돌연변이 Fab 도메인을 포함하는 다중특이성 결합 단백질
CN113710229B (zh) 2019-02-25 2026-01-06 芝加哥大学 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物
GB201919058D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibodies
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GB202001447D0 (en) 2020-02-03 2020-03-18 Ucb Biopharma Sprl Antibodies
WO2021160265A1 (en) * 2020-02-13 2021-08-19 UCB Biopharma SRL Bispecific antibodies against cd9 and cd137
BR112022019047A2 (pt) 2020-03-27 2022-11-01 UCB Biopharma SRL Peptídeos de domínio knob autônomos
JP2023547795A (ja) 2020-10-15 2023-11-14 ユーシービー バイオファルマ エスアールエル Ｃｄ４５を多量体化する結合分子
WO2022122654A1 (en) 2020-12-07 2022-06-16 UCB Biopharma SRL Multi-specific antibodies and antibody combinations
GB202111905D0 (en) 2021-08-19 2021-10-06 UCB Biopharma SRL Antibodies

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