CN105013545A - Preparation method of paper-based micro fluidic chip - Google Patents
Preparation method of paper-based micro fluidic chip Download PDFInfo
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- CN105013545A CN105013545A CN201510372123.2A CN201510372123A CN105013545A CN 105013545 A CN105013545 A CN 105013545A CN 201510372123 A CN201510372123 A CN 201510372123A CN 105013545 A CN105013545 A CN 105013545A
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Abstract
The invention discloses a preparation method of a paper-based micro fluidic chip. The preparation method comprises following steps: a substrate is selected, and is washed with deionized water, gasoline, ethanol, and deionized water successively, and is dried in the air; epoxy resin, methylbenzene, polyurethane, and polydimethylsiloxane are mixed and stirred, and are subjected to ultrasonic treatment for 2 to 5min so as to obtain a mixed solution; the mixed solution is delivered into an ink box of an ink-jet printer, and the substrate is printed with a designed chip pattern so as to obtain a semi-finished product; and the semi-finished product is subjected to drying for 3 to 4h at 50 to 60 DEG C under vacuum conditions, and is cooled to room temperature at a constant speed so as to obtain the paper-based micro fluidic chip. The preparation method is simple and convenient; the obtained paper-based micro fluidic chip is high in resolution ratio, excellent in weatherability, and wide in application range.
Description
Technical field
the present invention relates to chip field, be specifically related to a kind of preparation method of papery micro-fluidic chip.
Background technology
micro-fluidic (Microfluidics) or micro-total analysis system (MicroTAS), or the laboratory (Lab On a Chip) on chip is a kind of with accurate manipulation and control minute yardstick fluid, and especially submicrometer structure is the science and technology of principal character." laboratory on chip " refers to utilize microflow control technique by multiple system (as sample preparation, mixing, compartment analysis and detection) integrated concept on one chip.Microflow control technique is proposed in early 1990s first by Manz etc., microminiaturized by analytical instrument, drastically increases efficiency and the speed of compartment analysis.Nowadays, it has developed into the brand-new research field that multidisciplinary (engineering, physics, chemistry, micro Process and bioengineering) intersects, and for many analytical systems bring microminiaturized benefit.Micro-fluidic chip has following characteristics: less sample volume consumption, less energy ezpenditure, less device etc.
the method of current making papery micro-fluidic chip comprises: photoetching process, ink-jet etching method, plasma processing, wax seal method, silk screen print method etc.Wherein, photolithography steps is loaded down with trivial details, and the optical cement reagent used is expensive, is unfavorable for batch production; In plasma processing method, plasma atmosphere easily penetrates into the area of coverage from vacancy section; The papery micro-fluidic chip that wax seal method makes has the shortcomings such as resolution ratio is low.
Summary of the invention
for the deficiencies in the prior art, the object of the present invention is to provide a kind of preparation method of durable in use, the indeformable papery micro-fluidic chip of high temperature.
For solving prior art problem, the technical scheme that the present invention takes is:
A preparation method for papery micro-fluidic chip, comprises the following steps:
Step 1, chooses substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, ultrasonic process 2-5min obtains mixed liquor;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, is printed in substrate and obtains semi-finished product;
Step 4, by 3-4h dry under semi-finished product vacuum environment 50-60 DEG C, then constant speed is down to room temperature, obtains micro-fluidic chip.
as preferably, substrate described in step 1 is porous membrane.
As porous membrane preferably, described porous membrane is cellulose acetate film.
As preferably, epoxy resin described in step 2: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1.
As preferably, the frequency of ultrasonic process in step 2 is 80-120MHz.
As preferably, in step 3, the nozzle temperature of printer and the temperature of substrate are 20 DEG C, and printing voltage is 25-28V, and dot spacing is 100-120 μm, and printing the number of plies is 2-5 layer.
As preferably, in step 4, the speed of temperature-reduction at constant speed is 2-4 DEG C/s.
beneficial effect
The present invention's industry is simple, with low cost, and without the need to preparing mould in advance before preparation, the quantity of raceway groove can be determined because needing, and is independent of each other, so be applicable to large-scale production.In addition, the material of micro-fluidic chip is high temperature resistant, not yielding, and cementability is good, durable in use, reduces the cost of detection.
Detailed description of the invention
Below in conjunction with specific embodiment, technical scheme of the present invention is further described, should be appreciated that specific embodiment described herein only in order to explain the present invention, be not construed as limiting the invention.
embodiment 1
A preparation method for papery micro-fluidic chip, comprises the following steps:
Step 1, chooses cellulose acetate film as base substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, obtains mixed liquor with 80MHz ultrasonic process 2min, wherein, and epoxy resin: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, be printed in substrate and obtain semi-finished product, wherein, the nozzle temperature of printer and the temperature of substrate are 20 DEG C, printing voltage is 25V, and dot spacing is 100 μm, and printing the number of plies is 2-5 layer;
Step 4, by dry 3h at lower for semi-finished product vacuum environment 50 DEG C, then is down to room temperature with 2-4 DEG C/s constant speed, obtains micro-fluidic chip.
embodiment 2
A preparation method for papery micro-fluidic chip, comprises the following steps:
Step 1, choosing cellulose acetate film is substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, obtains mixed liquor with 100MHz ultrasonic process 2-5min, wherein, and epoxy resin: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, and be printed in substrate and obtain semi-finished product, wherein the nozzle temperature of printer and the temperature of substrate are 20 DEG C, and printing voltage is 27V, and dot spacing is 120 μm, and printing the number of plies is 4 layers;
Step 4, by dry 3.5h at lower for semi-finished product vacuum environment 55 DEG C, then is down to room temperature with 3 DEG C/s constant speed, obtains micro-fluidic chip.
embodiment 3
A preparation method for papery micro-fluidic chip, comprises the following steps:
Step 1, chooses cellulose acetate film and makes substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, ultrasonic process 2-5min obtains mixed liquor, wherein, epoxy resin: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, and be printed in substrate and obtain semi-finished product, wherein the nozzle temperature of printer and the temperature of substrate are 20 DEG C, and printing voltage is 28V, and dot spacing is 120 μm, and printing the number of plies is 5 layers;
Step 4, by dry 3-4h at lower for semi-finished product vacuum environment 60 DEG C, then is down to room temperature with 4 DEG C/s constant speed, obtains micro-fluidic chip.
comparative example 1
A preparation method for papery micro-fluidic chip, comprises the following steps:
Step 1, choosing cellulose acetate film is substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, obtains mixed liquor with 100MHz ultrasonic process 2-5min, wherein, and epoxy resin: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, and be printed in substrate and obtain semi-finished product, wherein the nozzle temperature of printer and the temperature of substrate are 20 DEG C, and printing voltage is 27V, and dot spacing is 120 μm, and printing the number of plies is 4 layers;
Step 4, by dry 3.5h at lower for semi-finished product vacuum environment 55 DEG C, is down to room temperature, obtains micro-fluidic chip.
performance test
Find embodiment of the present invention 1-3 and the test of comparative example 1-2 gained micro-fluidic chip, chip resolution of the present invention is high, and width is little, and in preparation process, temperature-reduction at constant speed improves the weatherability of material, extends service life.
The foregoing is only the specific embodiment of the present invention; but protection scope of the present invention is not limited thereto; any those of ordinary skill in the art are in the technical scope disclosed by the present invention; the change can expected without creative work or replacement, all should be encompassed within protection scope of the present invention.Therefore, the protection domain that protection scope of the present invention should limit with claims is as the criterion.
Claims (7)
1. a preparation method for papery micro-fluidic chip, is characterized in that, comprises the following steps:
Step 1, chooses substrate, dries for subsequent use successively by deionized water, gasoline, ethanol, washed with de-ionized water;
Step 2, after epoxy resin, toluene, polyurethane and dimethyl silicone polymer mix and blend, ultrasonic process 2-5min obtains mixed liquor;
Step 3, drops into mixed liquor in the print cartridge of ink-jet printer, designs the pattern of chip, is printed in substrate and obtains semi-finished product;
Step 4, by 3-4h dry under semi-finished product vacuum environment 50-60 DEG C, then constant speed is down to room temperature, obtains micro-fluidic chip.
2. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that: substrate described in step 1 is porous membrane.
3. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that: described porous membrane is cellulose acetate film.
4. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that: epoxy resin described in step 2: toluene: polyurethane: the mass ratio of dimethyl silicone polymer is 3:5:2:1.
5. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that: the frequency of ultrasonic process in step 2 is 80-120MHz.
6. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that, in step 3, the nozzle temperature of printer and the temperature of substrate are 20 DEG C, and printing voltage is 25-28V, and dot spacing is 100-120 μm, and printing the number of plies is 2-5 layer.
7. the preparation method of papery micro-fluidic chip according to claim 1, is characterized in that: in step 4, the speed of temperature-reduction at constant speed is 2-4 DEG C/s.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903501A (en) * | 2016-04-18 | 2016-08-31 | 南京大学 | Polydimethylsiloxane-paper composite chip and preparation method and application thereof |
| CN106040326A (en) * | 2016-05-27 | 2016-10-26 | 南京大学 | Macro-porous paper based-polydimethylsiloxane composite microfluidic chip and preparation method and application thereof |
| CN107226262A (en) * | 2017-05-23 | 2017-10-03 | 北京化工大学 | Integrate the papery food drug packing box of paper substrate micro-fluidic chip |
| CN107754961A (en) * | 2017-11-01 | 2018-03-06 | 南通大学 | The preparation method of papery microwell plate based on laser printing |
| CN111111800A (en) * | 2019-12-30 | 2020-05-08 | 清华大学 | Flexible micro-channel preparation method and sensor |
| CN113856779A (en) * | 2021-11-08 | 2021-12-31 | 哈尔滨工业大学 | Method for manufacturing planar microfluidic chip based on ink-jet printing |
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| CN102092669A (en) * | 2009-12-11 | 2011-06-15 | 国家纳米技术与工程研究院 | Microfluidic chip packaging method by combining surface treatment and hot pressing |
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| CN103055981A (en) * | 2012-12-31 | 2013-04-24 | 苏州汶颢芯片科技有限公司 | Polydimethylsiloxane micro-fluidic chip and preparation method thereof |
| CN104209153A (en) * | 2014-09-10 | 2014-12-17 | 南京邮电大学 | Preparation method of paper micro-fluidic chips |
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| CN101530775A (en) * | 2009-03-03 | 2009-09-16 | 南京大学 | Micro-fluidic apparatus integrated with PDMS film, manufacturing method and application thereof |
| CN102092669A (en) * | 2009-12-11 | 2011-06-15 | 国家纳米技术与工程研究院 | Microfluidic chip packaging method by combining surface treatment and hot pressing |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903501A (en) * | 2016-04-18 | 2016-08-31 | 南京大学 | Polydimethylsiloxane-paper composite chip and preparation method and application thereof |
| CN106040326A (en) * | 2016-05-27 | 2016-10-26 | 南京大学 | Macro-porous paper based-polydimethylsiloxane composite microfluidic chip and preparation method and application thereof |
| CN106040326B (en) * | 2016-05-27 | 2018-08-17 | 南京大学 | A kind of macropore paper substrate-compound micro-fluidic chip of dimethyl silicone polymer and its preparation method and purposes |
| CN107226262A (en) * | 2017-05-23 | 2017-10-03 | 北京化工大学 | Integrate the papery food drug packing box of paper substrate micro-fluidic chip |
| CN107754961A (en) * | 2017-11-01 | 2018-03-06 | 南通大学 | The preparation method of papery microwell plate based on laser printing |
| CN111111800A (en) * | 2019-12-30 | 2020-05-08 | 清华大学 | Flexible micro-channel preparation method and sensor |
| CN111111800B (en) * | 2019-12-30 | 2021-12-17 | 清华大学 | Flexible micro-channel preparation method and sensor |
| CN113856779A (en) * | 2021-11-08 | 2021-12-31 | 哈尔滨工业大学 | Method for manufacturing planar microfluidic chip based on ink-jet printing |
| CN113856779B (en) * | 2021-11-08 | 2022-10-14 | 哈尔滨工业大学 | Method for manufacturing planar microfluidic chip based on ink-jet printing |
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