CN107226262A - Integrate the papery food drug packing box of paper substrate micro-fluidic chip - Google Patents

Integrate the papery food drug packing box of paper substrate micro-fluidic chip Download PDF

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Publication number
CN107226262A
CN107226262A CN201710368093.7A CN201710368093A CN107226262A CN 107226262 A CN107226262 A CN 107226262A CN 201710368093 A CN201710368093 A CN 201710368093A CN 107226262 A CN107226262 A CN 107226262A
Authority
CN
China
Prior art keywords
packing box
fluidic chip
paper
paper substrate
micro
Prior art date
Application number
CN201710368093.7A
Other languages
Chinese (zh)
Inventor
范强
范一强
刘士成
张亚军
Original Assignee
北京化工大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京化工大学 filed Critical 北京化工大学
Priority to CN201710368093.7A priority Critical patent/CN107226262A/en
Publication of CN107226262A publication Critical patent/CN107226262A/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02Internal fittings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor

Abstract

Drug packing box is eaten the invention discloses the papery for integrating paper substrate micro-fluidic chip, belongs to the crossing domain of microflow control technique and Package engineering technology.To integrate the papery food drug packing box of paper substrate micro-fluidic chip, microflow control technique is combined with packing technique, after cell type is processed, fluid channel is processed on carton body plate, and pack content or the detection demand of content derivative products are completed using micro-fluidic detection technology.This invents the purposes for being remarkably improved packing box, can be applied in food, pharmaceutical industry, and manufacturing cost is low, easy to use, the great potential with large-scale commercial.

Description

Integrate the papery food drug packing box of paper substrate micro-fluidic chip

Technical field

The present invention belongs to microflow control technique and Packaging Engineering skill to integrate the papery food drug packing box of paper substrate micro-fluidic chip The crossing domain of art.Concretely, it is to process fluid channel in packing box inwall, available for vital sign detection, food security inspection Survey, environment measuring field.

Background technology

Microflow control technique refers to the technology that fluid is controlled in micro-meter scale, and a variety of detected can be completed on one chip Journey, and its detection speed, precision and cost of manufacture are significantly less than conventional method, are widely used in analytical chemistry, life science With the field such as medical diagnosis.

Paper substrate micro-fluidic chip is further development on its basis, using filterability paper as base material, with photoetching, spray The technologies such as wax printing process runner, and colorimetric analysis, chemical analysis etc. are can be used for after processing.The main of fluid is controlled on paper Method is to change runner and the hydrophilic and hydrophobic in other regions, and capillarity of the fluid in paper fiber spreads to hydrophilic region.Example Runner is surrounded with wax (hydrophobic) such as on filter paper, then fluid can only be spread in runner without oozing out the region beyond wax. Paper substrate micro-fluidic chip processing cost is cheaper, and easy to carry, simple to operate, analyze speed is fast, can meet experiment need Will, it can also be used to which family analyzes.

It is to protect a product from extraneous invasion and attack that packing technique, which particularly eats drug package main purpose, now, prevents from volatilizing, oozes The loss such as leak, dissolve, colliding, beautifying commodity, guiding consumption.The development of novel package material also primarily focuses on packaging material Recycle, such as utilize the recyclable material of PET, PP.Generally speaking, the effect of packing box still more limitation, single, example Such as, for food drug package, wrapping paper is only capable of extending shelf life of products with itself barrier, and the measure of shelf life of products is sampling Experiment is measured afterwards, with certain error, if using micro-fluidic detection technology, micro-fluidic chip being processed on the inside of packing box, then can Product quality is detected in real time.In addition, the combination of microflow control technique and packing technique can also be used for the inspection of other many indexes Survey.

The content of the invention

For more efficient utilization packing box, more various, easily consumption experience is provided for consumer, the present invention will be micro- Fluidics is combined with packing technique, after the cell type of packing carton is processed, and miniflow is gone out in the Surface Machining of packing carton Chip is controlled, this process uses different micro-fluidic chips to design according to detection target difference, and to the runner of micro-fluidic chip Corresponding biological, chemical treatment is carried out, for the detection of different target composition, this invention is applied to most of existing food medicines Paper wrapper application.

The papery food drug packing box of paper substrate micro-fluidic chip is integrated, the packing box is divided into paper pack matrix and paper substrate miniflow Two parts of chip are controlled, integrating one or more on any surface of paper pack matrix has the paper substrate micro-fluidic of specific function Chip.

Paper pack matrix is that universaling packing paper, extra package paper, food wrapper and packing board etc. have threadiness The plant of internal structure and synthetic fibers paper.

Paper substrate micro-fluidic chip is integrated in paper pack matrix, the paper substrate micro-fluidic core processed on food drug packing box Piece is for vital sign detection, food safety detection, environment measuring.

The manufacturing process of paper substrate micro-fluidic chip changes including wax printing, inkjet printing, 3D printing, laser/ultraviolet optical surface The methods such as property.

The medical packaging box of detectable pH value is made using microflow control technique, as the preferred embodiments of the present invention, including Following steps:

Step one:Selected packing box cell type, draws two-dimentional packing box structure figure, designs packing box outer pattern.

Step 2:Fluid channel is designed on the inside of packaging structure body plate.

Step 3:High machine-glazed paper is chosen for base material, the outer pattern of printing packing box outside the bloom of base material, inner side is with wax printer Print runner.

Step 4:Heat the runner after printing.

Step 5:Phenolphthalein indicator is added dropwise in four end reservoirs of runner of printing, dries.

Step 6:Cutting, folding packaging box.

By taking saturated sodium carbonate solution as an example, the microfluidic channel integrated by body plate in packing box detects its pH value.

Paper hydrophilic and hydrophobic is changed with wax printing technique in step 3, example, other a variety of change paper hydrophobes is only done Method can also reach this example effect.

This example only simply describes a kind of application for the papery food drug packing box for integrating paper substrate micro-fluidic chip, except this it Outside, other detection applications are not repeated one by one.Compared with the developing direction that tradition improves packing box sole mass, the present invention to learn more Based on section intersects, it is intended to strengthen multipurpose, the facilitation of packing box, strengthened with low cost, a variety of advantages such as be swift in response Product cost.

Brief description of the drawings

Fig. 1 is the two-dimension plane structure figure of packing box example of the present invention.

Fig. 2 is paper substrate micro-fluidic chip structure chart on the inside of packing box example body plate of the present invention.

In figure:1st, paper pack matrix, 2, paper substrate micro-fluidic chip.

Embodiment

Illustrate embodiments of the invention below.But the following example is only limitted to explain the present invention, protection scope of the present invention The full content of claim should be included, and be that can realize the present invention to person skilled in art by following examples The content of claim.

Embodiment 1

1) packing box two-dimensional structure figure, frontal design pattern are drawn, reverse side body plate draws two-dimentional runner structure chart.

2) packing box front pattern is printed with normal printer, and prints with wax printer interior body plate fluid channel.

3) heater plate fluid channel is used, wax is melted to paper internal penetration, processes hydrophilic microchannels.

4) after after paper cooling, micro phenolphthalein indicator is added dropwise in the reservoir on fluid channel corner respectively, dries.

5) cutting, lock carton.

6) this sample test pH value process approach:Micro saturated sodium carbonate solution is drawn with syringe, is dropped in fluid channel The heart, when sodium carbonate liquor infiltrates into corner due to the capillarity between paper fibre, makes phenolphthalein redden with phenolphthalein effect.

Claims (5)

1. integrate the papery food drug packing box of paper substrate micro-fluidic chip, it is characterised in that:The packing box is divided into paper pack matrix With two parts of paper substrate micro-fluidic chip, integrating one or more on any surface of paper pack matrix has specific function Paper substrate micro-fluidic chip.
2. the papery food drug packing box according to claim 1 for integrating paper substrate micro-fluidic chip, it is characterised in that:Paper wrapper Box matrix is the plant that universaling packing paper, extra package paper, food wrapper and packing board etc. have fibrous internal structure With synthetic fibers paper.
3. the papery food drug packing box according to claim 1 for integrating paper substrate micro-fluidic chip, it is characterised in that:By paper substrate Micro-fluidic chip is integrated in paper pack matrix, and the paper substrate micro-fluidic chip processed on food drug packing box is for life entity Levy detection, food safety detection, environment measuring.
4. the papery food drug packing box according to claim 1 for integrating paper substrate micro-fluidic chip, it is characterised in that:Paper substrate is micro- The manufacturing process of fluidic chip includes wax printing, inkjet printing, 3D printing, laser/ultraviolet light surface modifying method.
5. the papery food drug packing box according to claim 1 for integrating paper substrate micro-fluidic chip, it is characterised in that:Using micro- Fluidics makes the medical packaging box of detectable pH value, comprises the following steps:
Step one:Selected packing box cell type, draws two-dimentional packing box structure figure, designs packing box outer pattern;
Step 2:Fluid channel is designed on the inside of packaging structure body plate;
Step 3:High machine-glazed paper is chosen for base material, the outer pattern of printing packing box outside the bloom of base material, inner side is printed with wax printer Runner;
Step 4:Heat the runner after printing;
Step 5:Phenolphthalein indicator is added dropwise in four end reservoirs of runner of printing, dries;
Step 6:Cutting, folding packaging box.
CN201710368093.7A 2017-05-23 2017-05-23 Integrate the papery food drug packing box of paper substrate micro-fluidic chip CN107226262A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710368093.7A CN107226262A (en) 2017-05-23 2017-05-23 Integrate the papery food drug packing box of paper substrate micro-fluidic chip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710368093.7A CN107226262A (en) 2017-05-23 2017-05-23 Integrate the papery food drug packing box of paper substrate micro-fluidic chip

Publications (1)

Publication Number Publication Date
CN107226262A true CN107226262A (en) 2017-10-03

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CN (1) CN107226262A (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2660530Y (en) * 2003-12-11 2004-12-01 中国科学院大连化学物理研究所 Chip separation analysis kit of glass microflow control
US20060257958A1 (en) * 2005-05-13 2006-11-16 Pronucleotein Biotechnologies, Llc Magnetically-assisted test strip cartridge and method for using same
CN101588868A (en) * 2007-01-17 2009-11-25 安捷伦科技有限公司 Micro-fluid chip with the lateral opening that is used for the fluid introducing
US20100029553A1 (en) * 2006-06-08 2010-02-04 Technische Universitaet Muenchen Microfluidic Device for Controlled Aggregation of Spider Silk
US20110195258A1 (en) * 2010-02-11 2011-08-11 National Chiao Tung University Microencapsulated liquid device and method for making the same
CN104209153A (en) * 2014-09-10 2014-12-17 南京邮电大学 Preparation method of paper micro-fluidic chips
CN104437689A (en) * 2014-11-21 2015-03-25 浙江大学 Manufacturing method for microfluidic paper-based analytical device based on photosensitive seal printing
US20150225151A1 (en) * 2014-02-11 2015-08-13 Christopher L. Osborn Anti-Scalping Transdermal Patch Packaging Film
CN105013545A (en) * 2015-06-30 2015-11-04 苏州东辰林达检测技术有限公司 Preparation method of paper-based micro fluidic chip
CN205067292U (en) * 2015-09-11 2016-03-02 上海交通大学 Circulation tumor cells detect reagent box
WO2016082003A1 (en) * 2014-11-26 2016-06-02 The University Of Melbourne Method and device for determination of aldehydes in biological samples
WO2017019625A1 (en) * 2015-07-24 2017-02-02 Novel Microdevices, Llc (Dba Novel Devices) Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion and methods of use thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2660530Y (en) * 2003-12-11 2004-12-01 中国科学院大连化学物理研究所 Chip separation analysis kit of glass microflow control
US20060257958A1 (en) * 2005-05-13 2006-11-16 Pronucleotein Biotechnologies, Llc Magnetically-assisted test strip cartridge and method for using same
US20100029553A1 (en) * 2006-06-08 2010-02-04 Technische Universitaet Muenchen Microfluidic Device for Controlled Aggregation of Spider Silk
CN101588868A (en) * 2007-01-17 2009-11-25 安捷伦科技有限公司 Micro-fluid chip with the lateral opening that is used for the fluid introducing
US20110195258A1 (en) * 2010-02-11 2011-08-11 National Chiao Tung University Microencapsulated liquid device and method for making the same
US20150225151A1 (en) * 2014-02-11 2015-08-13 Christopher L. Osborn Anti-Scalping Transdermal Patch Packaging Film
CN104209153A (en) * 2014-09-10 2014-12-17 南京邮电大学 Preparation method of paper micro-fluidic chips
CN104437689A (en) * 2014-11-21 2015-03-25 浙江大学 Manufacturing method for microfluidic paper-based analytical device based on photosensitive seal printing
WO2016082003A1 (en) * 2014-11-26 2016-06-02 The University Of Melbourne Method and device for determination of aldehydes in biological samples
CN105013545A (en) * 2015-06-30 2015-11-04 苏州东辰林达检测技术有限公司 Preparation method of paper-based micro fluidic chip
WO2017019625A1 (en) * 2015-07-24 2017-02-02 Novel Microdevices, Llc (Dba Novel Devices) Sample processing device comprising magnetic and mechanical actuating elements using linear or rotational motion and methods of use thereof
CN205067292U (en) * 2015-09-11 2016-03-02 上海交通大学 Circulation tumor cells detect reagent box

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Application publication date: 20171003