CN105007917A - 由小分子靶向人癌症中的gli蛋白 - Google Patents

由小分子靶向人癌症中的gli蛋白 Download PDF

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Publication number
CN105007917A
CN105007917A CN201480012588.0A CN201480012588A CN105007917A CN 105007917 A CN105007917 A CN 105007917A CN 201480012588 A CN201480012588 A CN 201480012588A CN 105007917 A CN105007917 A CN 105007917A
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CN
China
Prior art keywords
compound
gli
compounds
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480012588.0A
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English (en)
Chinese (zh)
Inventor
何飚
M·曼
D·M·贾伯朗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California, San Diego
Original Assignee
University of California, San Diego
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Filing date
Publication date
Application filed by University of California, San Diego filed Critical University of California, San Diego
Priority to CN201910535271.XA priority Critical patent/CN110143953B/zh
Publication of CN105007917A publication Critical patent/CN105007917A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201480012588.0A 2013-01-23 2014-01-22 由小分子靶向人癌症中的gli蛋白 Pending CN105007917A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910535271.XA CN110143953B (zh) 2013-01-23 2014-01-22 由小分子靶向人癌症中的gli蛋白

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361755878P 2013-01-23 2013-01-23
US61/755,878 2013-01-23
PCT/US2014/012466 WO2014116651A1 (en) 2013-01-23 2014-01-22 Targeting gli proteins in human cancer by small molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910535271.XA Division CN110143953B (zh) 2013-01-23 2014-01-22 由小分子靶向人癌症中的gli蛋白

Publications (1)

Publication Number Publication Date
CN105007917A true CN105007917A (zh) 2015-10-28

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CN201480012588.0A Pending CN105007917A (zh) 2013-01-23 2014-01-22 由小分子靶向人癌症中的gli蛋白
CN201910535271.XA Active CN110143953B (zh) 2013-01-23 2014-01-22 由小分子靶向人癌症中的gli蛋白

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Country Status (10)

Country Link
US (1) US9840470B2 (cg-RX-API-DMAC7.html)
EP (1) EP2948144B1 (cg-RX-API-DMAC7.html)
JP (2) JP2016505049A (cg-RX-API-DMAC7.html)
CN (2) CN105007917A (cg-RX-API-DMAC7.html)
AU (1) AU2014209559B2 (cg-RX-API-DMAC7.html)
CA (1) CA2898614C (cg-RX-API-DMAC7.html)
ES (1) ES3007293T3 (cg-RX-API-DMAC7.html)
HU (1) HUE069988T2 (cg-RX-API-DMAC7.html)
PL (1) PL2948144T3 (cg-RX-API-DMAC7.html)
WO (1) WO2014116651A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017290705B2 (en) * 2016-06-29 2021-08-26 Rascal Therapeutics, Inc. Compounds and compositions for the treatment of cancer
WO2018005697A1 (en) 2016-06-29 2018-01-04 The Regents Of The University Of California Antibodies specific to sonic hedgehog and method of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0741459A (ja) 1993-07-29 1995-02-10 Sumitomo Pharmaceut Co Ltd 新規エラスターゼ阻害剤
CN101370498A (zh) * 2005-12-09 2009-02-18 加利福尼亚大学董事会 由小分子靶向人癌中的gli蛋白
KR20110044304A (ko) 2008-09-18 2011-04-28 화이자 리미티드 치료에 유용한 아마이드 화합물
JP2010070514A (ja) 2008-09-19 2010-04-02 Toray Ind Inc ピラゾール誘導体及びその医薬用途
WO2010094009A2 (en) 2009-02-13 2010-08-19 Children's Hospital Medical Center Methods and compositions for the treatment of ras associated disorders
EP2734042B1 (en) 2011-07-21 2017-02-01 The Regents Of The University Of California Targeting gli proteins in human cancer by small molecules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714014B2 (en) * 2005-12-09 2010-05-11 The Regents Of The University Of California Targeting GLI proteins in human cancer by small molecules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NEERAJ MAHINDROO ET AL: "Structure-Activity Relationships and Cancer-Cell selective Toxicity of Novel Inhibition of Glioma-Associated Oncogene Homologue 1(Gli1) Mediated Transcription", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
PIRKLE ET AL: "A Widely Useful Chiral Stationary Phase for the High-Performance Liquid Chromatography Separation of Enantiomers", 《J.AM.CHEM.SOC.》 *

Also Published As

Publication number Publication date
CA2898614A1 (en) 2014-07-31
ES3007293T3 (en) 2025-03-19
EP2948144C0 (en) 2024-12-04
US9840470B2 (en) 2017-12-12
JP2019006816A (ja) 2019-01-17
PL2948144T3 (pl) 2025-03-31
HUE069988T2 (hu) 2025-04-28
US20150361048A1 (en) 2015-12-17
AU2014209559B2 (en) 2018-11-15
CN110143953A (zh) 2019-08-20
CA2898614C (en) 2021-10-26
JP2016505049A (ja) 2016-02-18
WO2014116651A1 (en) 2014-07-31
AU2014209559A1 (en) 2015-08-06
CN110143953B (zh) 2022-08-26
EP2948144A4 (en) 2017-01-25
EP2948144A1 (en) 2015-12-02
EP2948144B1 (en) 2024-12-04

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Application publication date: 20151028