CN104998292A - Use of N-acetylneuraminic acid monomer, hydrate or salt in hygienic products - Google Patents
Use of N-acetylneuraminic acid monomer, hydrate or salt in hygienic products Download PDFInfo
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- CN104998292A CN104998292A CN201510403887.3A CN201510403887A CN104998292A CN 104998292 A CN104998292 A CN 104998292A CN 201510403887 A CN201510403887 A CN 201510403887A CN 104998292 A CN104998292 A CN 104998292A
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Abstract
The invention relates to a use of an N-acetylneuraminic acid monomer, N-acetylneuraminic acid hydrate or N-acetylneuraminic acid salt in hygienic products. The N-acetylneuraminic acid monomer, N-acetylneuraminic acid hydrate or N-acetylneuraminic acid salt is safe and nontoxic and has functions of diminishing inflammation and whitening skin.
Description
Technical field
The present invention relates to biochemical field and hygiene article sector, be specifically related to a kind of compound N for hygienic article-n acetylneuraminic acid n monomer, N-acetyl-neuraminate hydrate or N-acetyl-neuraminate salt.The invention still further relates to the formula combination comprising N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate or N-acetyl-neuraminate salt.
Technical background
Though hygienic article such as the products such as the sanitary towel in mother and baby's articles for use, diaper, diaper, wet paper towel do not belong to cosmetics classification, be with owing to often need contact with skin surface also and serve puzzlement, as baby buttocks causes eczema because being wrapped up by diaper for a long time, female friend also may cause scytitis etc. because using sanitary towel for a long time.
N-acetyl-neuraminate is naturally occurring amino acid glucide, has effect of antiinflammatory whitening, is applied in mother and baby's articles for use and hygienic article, effectively can reduce the risk of skin infection disease.
The present invention is based on the research to N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate or N-acetyl-neuraminate salt and corresponding Study on Fermentation, be applied in hygienic article, as the effective ingredient of antiinflammatory whitening, have and suppress skin infection, Bearberry Extract.
Summary of the invention
The object of the present invention is to provide a kind of N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate or the application of N-acetyl-neuraminate salt in hygienic article, there is antiinflammatory Bearberry Extract.
Therefore one object of the present invention, namely to add the application in hygienic article by lysate or corresponding process means with N-acetyl-neuraminate monomeric form, N-acetyl-neuraminate hydrate forms or N-acetyl-neuraminate salt form.
According to a preferred embodiment of the present invention, described hygienic article, comprises mother and baby's articles for use, makes solid-state or liquid form.
According in the preferred embodiment of the present invention, the use content of described N-acetyl-neuraminate monomer is any content of mass percent 0.01% ~ 20%.
Find according to the present invention, N-acetyl-neuraminate monomer, hydrate or salt derivative are used for hygienic article as effective antiinflammatory whitening composition, therefore, another object of the present invention provides a kind of component composition of hygienic article, described compositions contains N-acetyl-neuraminate monomer, hydrate or salt derivative, and the receptible adjuvant of hygiene article sector composite formula.
The receptible adjuvant of described hygiene article sector composite formula is: textile structure adjuvant, solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence are or/and pigment.
According to a preferred embodiment of the present invention, described hygienic article is sanitary towel, diaper, diaper, puerperium pad, wet paper towel or wet paper towel leachate.These forms are prepared by method well known to those skilled in the art.
According to of the present invention one preferred embodiment, described N-acetyl-neuraminate monomer accounts for 0.001% ~ 3% of above-mentioned composition gross weight.In a preferred embodiment, described N-acetyl-neuraminate monomer accounts for 0.01% ~ 1% of described composition total weight, and more preferably 0.05% ~ 0.5%, most preferably 0.05% ~ 0.1%.
The method that N-acetyl-neuraminate monomer of the present invention is known by biotechnology personnel obtains, as with microbe fermentation method, extraction method, enzymolysis (or hydrolysis) the poly-means such as saliva method, enzymatic conversion (synthesis) method prepare N-acetyl-neuraminate monomer, finally obtain highly purified monomer dry powder or hydrate crystal by crystallization, be obtained by reacting corresponding salt derivative by acid-base neutralization.
According to a preferred embodiment of the present invention, appropriate vehicle is mainly water, comprises distilled water or deionized water etc.
Detailed description of the invention
Unless otherwise defined, all technology used herein and scientific terminology have the identical meanings that one skilled in the art of the present invention understand jointly.Although or any method that be equal to similar with described herein and material can be used for implementing or testing the present invention, described herein is preferred method and material.For object of the present invention, define following term below.
Term " about " used herein refers to and the quantity of reference product, level, numerical value, dimension, size or amount ratio, difference can up to 30%, 20% or 10% quantity, level, numerical value, dimension, size or consumption.
In full section description and claims, Unless Otherwise Requested, following word " comprises " and its variant " contains " and " comprising " is interpreted as meaning to comprise described entirety or step, or one group of overall or step, but does not get rid of other overall or step any.
According to the present invention, term " N-acetyl-neuraminate monomer " refers to by any appropriate ways, as the N-acetyl-neuraminate monomer that microbe fermentation method, extraction method, enzymolysis (hydrolysis) method, enzymatic conversion (synthesis) method are produced or obtained.Term " N-acetyl-neuraminate monomer hydrate " refers to the conjugate of N-acetyl-neuraminate monomer containing any amount water of crystallization and hydrone.Term " N-acetyl-neuraminate salt " refers to the covalent compound compound of N-acetyl-neuraminate monomer and metal ion.
According to the present invention, term " hygienic article " comprises mother and baby's articles for use as daily hygiene articles for use such as sanitary towel, diaper, diaper, puerperium pad, wet paper towel or wet paper towel leachates.
Present invention also offers a kind of hygienic product composition, it is characterized in that, described hygienic product composition contains the receptible adjuvant of N-acetyl-neuraminate monomer and hygiene article sector field.Described " the receptible adjuvant of hygiene article sector " is selected from: textile structure adjuvant, solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence are or/and pigment.
In a preferred embodiment in accordance with the present invention, described hygienic product composition is the hygienic article of mother and baby's articles for use, makes solid-state or liquid form.These forms of hygienic product composition are prepared by method well known to those skilled in the art.
N-acetyl-neuraminate monomer of the present invention can be prepared by bioengineering field method known by the technical staff, such as, and microbe fermentation method, extraction method, enzymatic isolation method, synthetic method etc. obtain N-acetyl-neuraminate monomer or its solution, obtain monomer whose form or hydrate forms by crystallization.Or continue to make salt derivative through chemical method.
According to a preferred embodiment of the present invention, appropriate vehicle is mainly water (comprising distilled water, deionized water).
The present invention is set forth further below in conjunction with specific embodiment.But these embodiments only do not form limitation of the scope of the invention for illustration of invention youngster.The experimental technique of unreceipted actual conditions in the following example, usually conveniently condition, or advise condition according to manufacturer.Except as otherwise noted, all percentage ratio and number are by mass.The 95% purity sample that in all embodiments, N-acetyl-neuraminate monomer sample provides by Wuhan Zhongke Guanggu Green Biological Technology Co., Ltd. below.
Embodiment 1: acute percutaneous toxicological experiment
1.1 experimental technique
According to " cosmetics health specification " 2007 editions, method N-acetyl-neuraminate monomer of once limiting the quantity is adopted to carry out the experiment of Rabbits with Acute percutaneous toxicity, dosage 2000mg/kg.
1.2 experimental results and conclusion
Within 14 day observation period, have no instant toxic reaction and delayed toxicity reaction, rabbit is in good condition, and body weight increases, and all survives.
Embodiment 2: Multiple skin irritation test
2.1 experimental technique
According to " cosmetics health specification " 2007 editions, carry out rabbit Multiple skin irritation test with N-acetyl-neuraminate monomer, stimulus object concentration is 0.5g/ml.
2.2 experimental results and conclusion
In 14 day observation period, show erythema or edematous condition without rabbit.Namely N-acetyl-neuraminate monomer is non-stimulated.
Claims (8)
1.N-n acetylneuraminic acid n monomer, N-acetyl-neuraminate hydrate or the application of N-acetyl-neuraminate salt in hygienic article.
2. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 1, is characterized in that: described hygienic article is mother and baby's articles for use, makes solid-state or liquid form.
3. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 1, is characterized in that: described hygienic article also comprises the receptible adjuvant in this field.
4. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 3, is characterized in that: the receptible adjuvant of described hygiene article sector is: textile structure adjuvant, solvent, solubilizing agent, antiseptic, antioxidant, pH adjusting agent, penetrating agent, liposome, wetting agent, thickening agent, chelating agen, skinfeel regulator, surfactant, emulsifying agent, propelling/propellant, essence are or/and pigment.
5. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 4, is characterized in that: described N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and N-acetyl-neuraminate salt account for 0.001% ~ 3% of above-mentioned composition gross weight in arbitrary hygienic article.
6. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 5, is characterized in that: described N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and N-acetyl-neuraminate salt account for 0.01% ~ 1% of above-mentioned composition gross weight in arbitrary hygienic article.
7. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 6, is characterized in that: described N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and N-acetyl-neuraminate salt account for 0.05% ~ 0.5% of above-mentioned composition gross weight in arbitrary hygienic article.
8. N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and the application of N-acetyl-neuraminate salt in hygienic article as claimed in claim 7, is characterized in that: described N-acetyl-neuraminate monomer, N-acetyl-neuraminate hydrate and N-acetyl-neuraminate salt in arbitrary hygienic article, account for 0.05% ~ 0.1% of above-mentioned composition gross weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510403887.3A CN104998292A (en) | 2015-07-10 | 2015-07-10 | Use of N-acetylneuraminic acid monomer, hydrate or salt in hygienic products |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510403887.3A CN104998292A (en) | 2015-07-10 | 2015-07-10 | Use of N-acetylneuraminic acid monomer, hydrate or salt in hygienic products |
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| CN104998292A true CN104998292A (en) | 2015-10-28 |
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| CN201510403887.3A Pending CN104998292A (en) | 2015-07-10 | 2015-07-10 | Use of N-acetylneuraminic acid monomer, hydrate or salt in hygienic products |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263503A (en) * | 2020-11-04 | 2021-01-26 | 嘉必优生物技术（武汉）股份有限公司 | Application of sialic acid in inhibiting melanin formation and oral whitening products |
| CN112353807A (en) * | 2020-11-04 | 2021-02-12 | 嘉必优生物技术（武汉）股份有限公司 | Application of sialic acid in preparation of melanin pigmentation inhibitor |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015631A (en) * | 1987-06-25 | 1991-05-14 | Mect Corporation | Repairing agent for cells and tissues |
| CN104586862A (en) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer, N-acetylneuraminic acid hydrate or N-acetylneuraminate in external anti-inflammation medicines |
| CN104586642A (en) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | Applications of N-acetvlneuraminic acid monomer, N-acetvlneuraminic acid hydrate or N-acetvlneuraminic acid salt in personal care supplies |
-
2015
- 2015-07-10 CN CN201510403887.3A patent/CN104998292A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015631A (en) * | 1987-06-25 | 1991-05-14 | Mect Corporation | Repairing agent for cells and tissues |
| CN104586862A (en) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | Application of N-acetylneuraminic acid monomer, N-acetylneuraminic acid hydrate or N-acetylneuraminate in external anti-inflammation medicines |
| CN104586642A (en) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | Applications of N-acetvlneuraminic acid monomer, N-acetvlneuraminic acid hydrate or N-acetvlneuraminic acid salt in personal care supplies |
Non-Patent Citations (3)
| Title |
|---|
| 刘志芳等: "《化妆品监管法规》", 30 November 2011, 中国医药科技出版社 * |
| 陈黎敏等: "《日用品包装技术与应用》", 30 September 2002 * |
| 韦安稳等: ""唾液酸在疾病中作用的研究进展"", 《大连医科大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263503A (en) * | 2020-11-04 | 2021-01-26 | 嘉必优生物技术（武汉）股份有限公司 | Application of sialic acid in inhibiting melanin formation and oral whitening products |
| CN112353807A (en) * | 2020-11-04 | 2021-02-12 | 嘉必优生物技术（武汉）股份有限公司 | Application of sialic acid in preparation of melanin pigmentation inhibitor |
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