CN104995210A - 类风湿关节炎的治疗 - Google Patents

类风湿关节炎的治疗 Download PDF

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Publication number
CN104995210A
CN104995210A CN201380049042.8A CN201380049042A CN104995210A CN 104995210 A CN104995210 A CN 104995210A CN 201380049042 A CN201380049042 A CN 201380049042A CN 104995210 A CN104995210 A CN 104995210A
Authority
CN
China
Prior art keywords
antibody
administered
dose
csf
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380049042.8A
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English (en)
Chinese (zh)
Inventor
S.赫尔特勒
S.勒克莱尔
A.舍布尔
S.斯泰德尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphosys GmbH
Original Assignee
Morphosys GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys GmbH filed Critical Morphosys GmbH
Priority to CN201811553113.9A priority Critical patent/CN109999195A/zh
Publication of CN104995210A publication Critical patent/CN104995210A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380049042.8A 2012-09-20 2013-09-19 类风湿关节炎的治疗 Pending CN104995210A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811553113.9A CN109999195A (zh) 2012-09-20 2013-09-19 类风湿关节炎的治疗

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12185235 2012-09-20
EP12185235.4 2012-09-20
US201261703871P 2012-09-21 2012-09-21
US61/703871 2012-09-21
PCT/EP2013/069501 WO2014044768A1 (en) 2012-09-20 2013-09-19 Treatment for rheumatoid arthritis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811553113.9A Division CN109999195A (zh) 2012-09-20 2013-09-19 类风湿关节炎的治疗

Publications (1)

Publication Number Publication Date
CN104995210A true CN104995210A (zh) 2015-10-21

Family

ID=46963526

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380049042.8A Pending CN104995210A (zh) 2012-09-20 2013-09-19 类风湿关节炎的治疗
CN201811553113.9A Pending CN109999195A (zh) 2012-09-20 2013-09-19 类风湿关节炎的治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811553113.9A Pending CN109999195A (zh) 2012-09-20 2013-09-19 类风湿关节炎的治疗

Country Status (22)

Country Link
US (4) US20150246969A1 (enExample)
EP (3) EP3916013A1 (enExample)
JP (4) JP2015533806A (enExample)
KR (4) KR20230041086A (enExample)
CN (2) CN104995210A (enExample)
AU (2) AU2013320261A1 (enExample)
BR (1) BR112015006189B1 (enExample)
CL (2) CL2015000696A1 (enExample)
CR (1) CR20150153A (enExample)
DO (1) DOP2015000070A (enExample)
EA (1) EA031489B1 (enExample)
HK (1) HK1208231A1 (enExample)
IL (1) IL237554B (enExample)
IN (1) IN2015KN00657A (enExample)
MA (1) MA37946B1 (enExample)
MX (2) MX382937B (enExample)
MY (1) MY175388A (enExample)
PE (1) PE20151079A1 (enExample)
PH (1) PH12015500591A1 (enExample)
SG (2) SG11201501595YA (enExample)
UA (1) UA117228C2 (enExample)
WO (1) WO2014044768A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025218746A1 (en) * 2024-04-17 2025-10-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis

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* Cited by examiner, † Cited by third party
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CN104995210A (zh) * 2012-09-20 2015-10-21 莫弗系统股份公司 类风湿关节炎的治疗
AR093297A1 (es) * 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
US9833410B2 (en) 2012-10-31 2017-12-05 Takeda Gmbh Lyophilized formulation comprising GM-CSF neutralizing compound
RU2714919C2 (ru) * 2013-08-30 2020-02-21 Такеда Гмбх Антитела, нейтрализующие gm-csf, для применения в лечении ревматоидного артрита или в качестве анальгетиков
WO2015138638A1 (en) * 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
US11173208B2 (en) * 2014-05-07 2021-11-16 Takeda Gmbh Liquid formulation comprising GM-CSF neutralizing compound
GB201519331D0 (en) * 2015-11-02 2015-12-16 Glaxosmithkline Ip Dev Ltd Treatment paradigm
US11007251B2 (en) 2015-12-17 2021-05-18 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
CN109195620B (zh) 2016-04-07 2022-06-28 约翰霍普金斯大学 用死亡受体激动剂治疗胰腺炎和疼痛的组合物和方法
DK3328887T3 (da) 2016-09-19 2021-09-20 I Mab Biopharma Hangzhou Co Ltd Anti-GM-CSF antistoffer og anvendelser deraf
US11655293B2 (en) 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
EP3623382A1 (en) 2018-09-14 2020-03-18 Universität Zürich Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct
WO2021204649A1 (en) 2020-04-06 2021-10-14 Glaxosmithkline Intellectual Property Development Limited Gm-csf antagonists for use in the treatment of severe pulmonary covid-19, cytokine release syndrome and/or acute respiratory distress syndrome

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CN101218255A (zh) * 2005-05-18 2008-07-09 莫菲西斯公司 抗gm-csf抗体和其用途
CN101605547A (zh) * 2006-11-21 2009-12-16 卡罗拜奥斯制药公司 使用gm-csf拮抗剂治疗慢性炎症疾病的方法
CN101678103A (zh) * 2007-03-30 2010-03-24 米迪缪尼股份有限公司 抗体制剂
CN101861336A (zh) * 2007-09-18 2010-10-13 安姆根有限公司 人gm-csf抗原结合蛋白质
CN102439039A (zh) * 2009-05-05 2012-05-02 莫佛塞斯公司 多发性硬化的治疗

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US9399061B2 (en) * 2006-04-10 2016-07-26 Abbvie Biotechnology Ltd Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis
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WO2008122415A1 (en) 2007-04-05 2008-10-16 Sandoz Ag Stable aqueous g-csf formulations
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US8679502B2 (en) 2007-11-13 2014-03-25 Evec Inc. Monoclonal antibodies that bind to HGM-CSF and medical compositions comprising same
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
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CN101218255A (zh) * 2005-05-18 2008-07-09 莫菲西斯公司 抗gm-csf抗体和其用途
CN101605547A (zh) * 2006-11-21 2009-12-16 卡罗拜奥斯制药公司 使用gm-csf拮抗剂治疗慢性炎症疾病的方法
CN101678103A (zh) * 2007-03-30 2010-03-24 米迪缪尼股份有限公司 抗体制剂
CN101861336A (zh) * 2007-09-18 2010-10-13 安姆根有限公司 人gm-csf抗原结合蛋白质
CN102439039A (zh) * 2009-05-05 2012-05-02 莫佛塞斯公司 多发性硬化的治疗

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025218746A1 (en) * 2024-04-17 2025-10-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis

Also Published As

Publication number Publication date
US20180230208A1 (en) 2018-08-16
AU2013320261A1 (en) 2015-04-09
UA117228C2 (uk) 2018-07-10
IL237554B (en) 2019-12-31
JP2022169709A (ja) 2022-11-09
KR20230041086A (ko) 2023-03-23
WO2014044768A1 (en) 2014-03-27
PH12015500591B1 (en) 2015-05-11
US10913792B2 (en) 2021-02-09
EP3345923A1 (en) 2018-07-11
CN109999195A (zh) 2019-07-12
IL237554A0 (en) 2015-04-30
MX2021006111A (es) 2021-07-07
EA201590359A1 (ru) 2015-08-31
IN2015KN00657A (enExample) 2015-07-17
BR112015006189B1 (pt) 2022-04-05
AU2016250388B2 (en) 2018-07-19
PE20151079A1 (es) 2015-08-07
EP3916013A1 (en) 2021-12-01
AU2016250388A1 (en) 2016-11-17
EA031489B1 (ru) 2019-01-31
EP2897977A1 (en) 2015-07-29
US20150246969A1 (en) 2015-09-03
US20240417455A1 (en) 2024-12-19
SG10201803778PA (en) 2018-06-28
PH12015500591A1 (en) 2015-05-11
MX382937B (es) 2025-03-13
CA2884124A1 (en) 2014-03-27
MY175388A (en) 2020-06-23
SG11201501595YA (en) 2015-05-28
CL2015000696A1 (es) 2015-10-23
KR20150056846A (ko) 2015-05-27
HK1208231A1 (en) 2016-02-26
KR20220028177A (ko) 2022-03-08
US20210130451A1 (en) 2021-05-06
JP2018138551A (ja) 2018-09-06
KR20240091288A (ko) 2024-06-21
MX2015003644A (es) 2015-09-25
JP2015533806A (ja) 2015-11-26
MA37946B1 (fr) 2018-09-28
BR112015006189A2 (pt) 2019-11-26
DOP2015000070A (es) 2015-08-16
JP2024156992A (ja) 2024-11-06
MA37946A1 (fr) 2018-01-31
CR20150153A (es) 2015-09-14
CL2018000933A1 (es) 2018-07-20

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Application publication date: 20151021

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