CL2018000933A1 - Una composición farmacéutica que comprende un anticuerpo anti-factor estimulante de colonias de granulocitos-macrógagos (anti-gm-csf) y vehículos, excipientes o estabilizadores farmacéuticamente aceptables, útil para tratar artritis reumatoide (divisional de la solicitud 696-2015). - Google Patents
Una composición farmacéutica que comprende un anticuerpo anti-factor estimulante de colonias de granulocitos-macrógagos (anti-gm-csf) y vehículos, excipientes o estabilizadores farmacéuticamente aceptables, útil para tratar artritis reumatoide (divisional de la solicitud 696-2015).Info
- Publication number
- CL2018000933A1 CL2018000933A1 CL2018000933A CL2018000933A CL2018000933A1 CL 2018000933 A1 CL2018000933 A1 CL 2018000933A1 CL 2018000933 A CL2018000933 A CL 2018000933A CL 2018000933 A CL2018000933 A CL 2018000933A CL 2018000933 A1 CL2018000933 A1 CL 2018000933A1
- Authority
- CL
- Chile
- Prior art keywords
- strong
- excipients
- stabilizers
- pharmaceutically acceptable
- csf
- Prior art date
Links
- 239000003937 drug carrier Substances 0.000 title abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 title abstract 3
- 239000003381 stabilizer Substances 0.000 title abstract 3
- 230000002281 colonystimulating effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010039073 rheumatoid arthritis Diseases 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
<p>Una Composición farmacéutica que comprende un anticuerpo anti-factor estimulante de colonias de granulocitos-macrófagos (anti-GM-CSF) y vehículos, excipientes o estabilizadores farmacéuticamente aceptables, donde los vehículos, excipientes o estabilizadores farmacéuticamente aceptables son un regulador que es histidina; un azúcar que es sorbitol; y un tensoactivo no iónico que es TWEEN-80, donde dicho anticuerpo anti-GM-CSF comprende un péptido de cadena pesada variable (donde las CDRs están en negrillas y subrayadas): QVQLVESGGGLVQPGGSLRLSCAAS<u><strong>GFTFSSYWMN</strong></u>WVRQAPGKGLEWVS<strong><u>GIENKYAGGATYYA ASVKG</u></strong>RFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR<u><strong>GFGTDF</strong></u>WGQGTLVTVSS; y un péptido de cadena liviana variable ( donde las CDRs estan en negrillas y subrayadas): DlELTQPPSVSVAPGQTARISC<strong><u>SGDSIGKKYAY</u></strong>WYQQKPGQAPVLVIY<strong><u>KKRPS</u></strong>GIPERFSGSNSGN TATLTISGTQAEDEADYYC<strong><u>SAWGDKGM</u></strong>VFGGGTKLTVLGQ. </p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12185235 | 2012-09-20 | ||
| US201261703871P | 2012-09-21 | 2012-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018000933A1 true CL2018000933A1 (es) | 2018-07-20 |
Family
ID=46963526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015000696A CL2015000696A1 (es) | 2012-09-20 | 2015-03-19 | Tratamiento para artritis reumatoide |
| CL2018000933A CL2018000933A1 (es) | 2012-09-20 | 2018-04-12 | Una composición farmacéutica que comprende un anticuerpo anti-factor estimulante de colonias de granulocitos-macrógagos (anti-gm-csf) y vehículos, excipientes o estabilizadores farmacéuticamente aceptables, útil para tratar artritis reumatoide (divisional de la solicitud 696-2015). |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015000696A CL2015000696A1 (es) | 2012-09-20 | 2015-03-19 | Tratamiento para artritis reumatoide |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20150246969A1 (es) |
| EP (3) | EP3345923A1 (es) |
| JP (3) | JP2015533806A (es) |
| KR (4) | KR20220028177A (es) |
| CN (2) | CN109999195A (es) |
| AU (2) | AU2013320261A1 (es) |
| BR (1) | BR112015006189B1 (es) |
| CA (1) | CA2884124A1 (es) |
| CL (2) | CL2015000696A1 (es) |
| CR (1) | CR20150153A (es) |
| DO (1) | DOP2015000070A (es) |
| EA (1) | EA031489B1 (es) |
| HK (1) | HK1208231A1 (es) |
| IL (1) | IL237554B (es) |
| IN (1) | IN2015KN00657A (es) |
| MA (1) | MA37946B1 (es) |
| MX (2) | MX2015003644A (es) |
| MY (1) | MY175388A (es) |
| PE (1) | PE20151079A1 (es) |
| PH (1) | PH12015500591A1 (es) |
| SG (2) | SG10201803778PA (es) |
| UA (1) | UA117228C2 (es) |
| WO (1) | WO2014044768A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015533806A (ja) * | 2012-09-20 | 2015-11-26 | モルフォシス・アー・ゲー | 関節リウマチの治療 |
| JP6339578B2 (ja) * | 2012-10-31 | 2018-06-06 | タケダ・ゲー・エム・ベー・ハーＴａｋｅｄａ ＧｍｂＨ | Ｇｍ−ｃｓｆ中和化合物を含む凍結乾燥製剤 |
| AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res (Munich) Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| AU2014314053C1 (en) | 2013-08-30 | 2023-11-02 | Takeda Pharmaceutical Company Limited | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
| US11299528B2 (en) * | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
| CN106659785B (zh) * | 2014-05-07 | 2021-04-30 | 武田有限公司 | 包含gm-csf中和化合物的液体制剂 |
| GB201519331D0 (en) * | 2015-11-02 | 2015-12-16 | Glaxosmithkline Ip Dev Ltd | Treatment paradigm |
| EA038551B1 (ru) | 2015-12-17 | 2021-09-14 | Дзе Джонс Хопкинс Юниверсити | Способ лечения или профилактики системного склероза |
| KR102508650B1 (ko) | 2016-04-07 | 2023-03-13 | 더 존스 홉킨스 유니버시티 | 사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법 |
| CN109219616B (zh) | 2016-09-19 | 2022-10-21 | 天境生物科技(杭州)有限公司 | Gm-csf抗体及其用途 |
| US11655293B2 (en) * | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| EP3623382A1 (en) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct |
| WO2021204649A1 (en) | 2020-04-06 | 2021-10-14 | Glaxosmithkline Intellectual Property Development Limited | Gm-csf antagonists for use in the treatment of severe pulmonary covid-19, cytokine release syndrome and/or acute respiratory distress syndrome |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| CN1142940C (zh) | 1996-10-04 | 2004-03-24 | 安姆根有限公司 | 含有mpl配体的药物组合物 |
| US7455836B2 (en) | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| HUE058876T2 (hu) * | 2005-05-18 | 2022-09-28 | Morphosys Ag | Anti-GM-CSF antitestek és felhasználásuk |
| US7790679B2 (en) | 2005-08-05 | 2010-09-07 | Amgen Inc. | Pharmaceutical formulations |
| US9399061B2 (en) * | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
| WO2008042261A2 (en) * | 2006-09-28 | 2008-04-10 | Elusys Therapeutics, Inc. | Anti-anthrax antibody, formulations thereof, and methods of use |
| SG176503A1 (en) * | 2006-11-21 | 2011-12-29 | Kalobios Pharmaceuticals Inc | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| MX2009010389A (es) * | 2007-03-30 | 2010-01-20 | Medimmune Llc | Formulacion de anticuerpos. |
| TW200902725A (en) * | 2007-04-02 | 2009-01-16 | Genentech Inc | Biological markers predictive of rheumatoid arthritis response to B-cell antagonists |
| AU2008235044B2 (en) | 2007-04-05 | 2011-08-25 | Sandoz Ag | Stable aqueous G-CSF formulations |
| US20090004189A1 (en) * | 2007-06-18 | 2009-01-01 | Genentech, Inc. | Biological markers predictive of rheumatoid arthritis response to b-cell antagonists |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| PT2215119E (pt) * | 2007-11-13 | 2013-02-11 | Boehringer Ingelheim Int | Anticorpos monoclonais que se ligam a hgm-csf e composições médicas que os compreendem |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| ES2685895T3 (es) * | 2008-12-22 | 2018-10-15 | The University Of Melbourne | Tratamiento del dolor |
| SI2376121T1 (sl) | 2008-12-22 | 2016-07-29 | The University Of Melbourne | Zdravljenje osteoartritisa |
| JP2010241718A (ja) | 2009-04-03 | 2010-10-28 | Kyowa Hakko Kirin Co Ltd | 安定な抗体の水溶液製剤 |
| WO2010128035A1 (en) * | 2009-05-05 | 2010-11-11 | Morphosys Ag | Treatment for multiple sclerosis |
| PT2341061E (pt) | 2009-12-31 | 2013-11-05 | Arven Ilac Sanayi Ve Ticaret As | Um processo novo para a preparação de g-csf (fator de estimulação de colónias de granulócitos) |
| NZ602685A (en) * | 2010-03-01 | 2014-10-31 | Cytodyn Inc | Concentrated protein formulations and uses thereof |
| KR20140061379A (ko) | 2011-07-06 | 2014-05-21 | 모르포시스 아게 | 항ｃｄ20 및 항ｇｍｃｓｆ 항체의 치료 조합물 및 이의 용도 |
| JP2015533806A (ja) * | 2012-09-20 | 2015-11-26 | モルフォシス・アー・ゲー | 関節リウマチの治療 |
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2013
- 2013-09-19 JP JP2015532412A patent/JP2015533806A/ja active Pending
- 2013-09-19 CA CA2884124A patent/CA2884124A1/en active Pending
- 2013-09-19 UA UAA201502131A patent/UA117228C2/uk unknown
- 2013-09-19 WO PCT/EP2013/069501 patent/WO2014044768A1/en active Application Filing
- 2013-09-19 MY MYPI2015700862A patent/MY175388A/en unknown
- 2013-09-19 US US14/429,996 patent/US20150246969A1/en not_active Abandoned
- 2013-09-19 EP EP18155371.0A patent/EP3345923A1/en not_active Withdrawn
- 2013-09-19 KR KR1020227006147A patent/KR20220028177A/ko not_active Application Discontinuation
- 2013-09-19 CN CN201811553113.9A patent/CN109999195A/zh active Pending
- 2013-09-19 MX MX2015003644A patent/MX2015003644A/es unknown
- 2013-09-19 SG SG10201803778PA patent/SG10201803778PA/en unknown
- 2013-09-19 BR BR112015006189-3A patent/BR112015006189B1/pt active IP Right Grant
- 2013-09-19 PE PE2015000350A patent/PE20151079A1/es unknown
- 2013-09-19 EP EP21169696.8A patent/EP3916013A1/en active Pending
- 2013-09-19 KR KR1020237008704A patent/KR20230041086A/ko not_active Application Discontinuation
- 2013-09-19 CN CN201380049042.8A patent/CN104995210A/zh active Pending
- 2013-09-19 EA EA201590359A patent/EA031489B1/ru unknown
- 2013-09-19 EP EP13763100.8A patent/EP2897977A1/en not_active Withdrawn
- 2013-09-19 KR KR1020247018370A patent/KR20240091288A/ko active Application Filing
- 2013-09-19 MA MA37946A patent/MA37946B1/fr unknown
- 2013-09-19 IN IN657KON2015 patent/IN2015KN00657A/en unknown
- 2013-09-19 KR KR1020157009911A patent/KR20150056846A/ko active Application Filing
- 2013-09-19 AU AU2013320261A patent/AU2013320261A1/en not_active Abandoned
- 2013-09-19 SG SG11201501595YA patent/SG11201501595YA/en unknown
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2015
- 2015-03-04 IL IL237554A patent/IL237554B/en active IP Right Grant
- 2015-03-18 PH PH12015500591A patent/PH12015500591A1/en unknown
- 2015-03-19 CL CL2015000696A patent/CL2015000696A1/es unknown
- 2015-03-20 DO DO2015000070A patent/DOP2015000070A/es unknown
- 2015-03-20 CR CR20150153A patent/CR20150153A/es unknown
- 2015-03-20 MX MX2021006111A patent/MX2021006111A/es unknown
- 2015-09-09 HK HK15108769.5A patent/HK1208231A1/xx unknown
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2016
- 2016-10-26 AU AU2016250388A patent/AU2016250388B2/en active Active
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2018
- 2018-01-26 US US15/880,726 patent/US10913792B2/en active Active
- 2018-03-28 JP JP2018061614A patent/JP2018138551A/ja active Pending
- 2018-04-12 CL CL2018000933A patent/CL2018000933A1/es unknown
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2021
- 2021-01-08 US US17/144,685 patent/US20210130451A1/en not_active Abandoned
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2022
- 2022-08-25 JP JP2022133957A patent/JP2022169709A/ja active Pending
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