CN104984241A

CN104984241A - Menstrual period external application medicine bag for women and preparation method of menstrual period external application medicine bag

Info

Publication number: CN104984241A
Application number: CN201510395876.5A
Authority: CN
Inventors: 宁飞鹏; 谢波
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-05
Filing date: 2015-07-05
Publication date: 2015-10-21

Abstract

The invention discloses a menstrual period external application medicine bag for women and a preparation method of the menstrual period external application medicine bag. The menstrual period external application medicine bag is composed of, by weight, 1.0 part to 30 parts of folium artemisiae argyi, 1.0 part to 30 parts of cassia twig, 1.0 part to 30 parts of galangal, 1.0 part to 30 parts of agastache rugosus, 1.0 part to 30 parts of lignum dalbergiae odoriferae, 1.0 part to 30 parts of rhizoma cyperi, 1.0 part to 30 parts of radix angelicae, 1.0 part to 30 parts of fructus evodiae, 1.0 part to 30 parts of salviae miltiorrhizae, 1.0 part to 30 parts of crude Sichuan aconite roots, 1.0 part to 30 parts of rhizoma chuanxiong, 1.0 part to 30 parts of curcuma aromatica, 1.0 part to 30 parts of cowherb seeds and 1.0 part to 30 parts of sinapis alba. The external application medicine bag is composed of the fourteen medicines according to the proportion. Folium artemisiae argyi, cassia twig and rhizoma chuanxiong have the warning, upbearing and effusion effects so that vigor of wood can be cultivated; curcuma aromatica has the effects of soothing the liver and relieving depression so that wood nourishing and wind calming can be achieved; crude Sichuan aconite roots, cowherb seeds and semen brassicae expel evil outwards; lignum dalbergiae odoriferae calms the adverse-rising energy; agastache rugosus, radix angelicae and rhizoma cyperi remove dampness by means of aromatics; galangal and fructus evodiae conduct warming and smoothing so that cold stagnation can be eliminated; salviae miltiorrhizae removes extravagated blood, all the components act together, and therefore the whole medicine bag has the effects of warming and activating meridian, regulating menstruation, removing blood stasis, relieving pains and the like, and the medicine bag has an obvious treatment effect on the premenstrual syndrome (PMS).

Description

A kind of feminine menstrual phase outer charging and preparation method thereof

Technical field

The present invention relates to a kind of outer charging, specifically, relate to a kind of feminine menstrual phase outer charging and preparation method thereof.

Background technology

Menstrual period syndrome PMS is the modal disease of women, refer at menstrual period or the lower abdominal pain that occurs around menstrual period, often be attended by nausea,vomiting,diarrhea etc., serious occurred pale complexion, trick be ice-cold, the symptom such as dripping cold sweat, and with menstrual cycle recurrent exerbation.Relevant PMS symptom reaches more than 150 and plants, but each patient also not all possesses all symptoms, and each one has respective outstanding symptom, the order of severity also because of people because of time and different, not immobilize, but the appearance of symptom is then substantially fixing with the relation of same menstruation of disappearing, and is primary disease feature.Fertility and final recognition and PMS onrelevant.Stadium continues different in size, and serious symptom needs therapist stadium longer, about has 40% patient's stadium to continue 1 ~ 5 year.10% sustainable more than 10 years.Classical symptom is everlasting beginning in premenstrual 1 week, increases the weight of gradually, the most serious to premenstrual last 2 ~ 3 days of the moon, through after suddenly disappear.Some patient symptom regression time is longer, gradually alleviates, continue up to menstruation start after 3 ~ 4 talentes disappear completely.Separately there is a kind of uncommon type, i.e. biphasic or bipolar type, there is the serious symptoms stage that two are not linked, one before and after the onset of ovulation, then through one section of asymptomatic stage, there is classical symptom again in premenstrual 1 week of the moon, be referred to as intermenstruum anxiety in the past, due to its clinical symptoms and pathogeny consistent with primary disease, reality is the specific type of PMS.

Due to the menstrual period syndrome PMS cause of disease and pathogeny not clear, also lack Therapeutic Method that is special, specification at present, mainly symptomatic treatment.Thus, the main aspect of first clear and definite symptom, vary with each individual, treat to the ill, comprise 2 aspects: be 1. the mental pathology factor for patient, pass through health mission, patient is understood occur the physiological knowledge of symptom, to assist patient to improve reaction to symptom, then by adjustment daily life rhythm, strengthen physical training, improve nutrition, reduce methods such as the stress of environment with mitigation symptoms; 2. be Drug therapy, application adjustment central nervous system nerve medium active medicine, with the psychology that disappears, dysthymic disorder, or application hormone ovulation inhibition is to eliminate the serious PMS symptoms such as distending pain of the breast.Also Chinese patent medicine or prescription treatment can be selected under Chinese medical discrimination instructs.

Summary of the invention

The object of the invention is to overcome the deficiencies in the prior art, outer charging of a kind of therapeutic effect significant feminine menstrual phase and preparation method thereof is provided.

To achieve these goals, the present invention adopts following technical scheme:

A kind of feminine menstrual phase outer charging, is made up of the component of following parts by weight: Folium Artemisiae Argyi 1.0-30, Ramulus Cinnamomi 1.0-30, Rhizoma Alpiniae Officinarum 1.0-30, Herba Pogostemonis 1.0-30, Lignum Dalbergiae Odoriferae 1.0-30, Rhizoma Cyperi 1.0-30, Radix Angelicae Dahuricae 1.0-30, Fructus Evodiae 1.0-30, Radix Salviae Miltiorrhizae 1.0-30, Radix Aconiti 1.0-30, Rhizoma Chuanxiong 1.0-30, Radix Curcumae 1.0-30, Semen Vaccariae 1.0-30, Semen Sinapis Albae 1.0-30.

In side, Folium Artemisiae Argyi has warming the meridian for stopping bleeding, cold expelling regulating menstruation, the effect such as antiabortive; In side, Ramulus Cinnamomi has diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effects such as dispersing cold for relieving pain; In side, Rhizoma Alpiniae Officinarum has warming stomach for dispelling cold, and help digestion the effects such as pain relieving; In side, Herba Pogostemonis has eliminating turbid pathogen with aromatics, and appetizing preventing or arresting vomiting, delivers the effects such as expelling summer-heat; The effects such as in side, Lignum Dalbergiae Odoriferae has promoting flow of QI and blood, pain relieving, hemostasis; The effects such as in side, Rhizoma Cyperi has resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving, antiabortive; In side, the Radix Angelicae Dahuricae has expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, the effects such as dampness leukorrhagia stopping; In side, Fructus Evodiae has warming middle-JIAO, pain relieving, regulates the flow of vital energy, the effects such as dampness; In side, Radix Salviae Miltiorrhizae has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and relieving restlessness such as to be calmed the nerves at the effect; The effects such as in side, Radix Aconiti has expelling wind and removing dampness, antalgic; In side, Rhizoma Chuanxiong has blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the effects such as wind-expelling pain-stopping; In side, Radix Curcumae has promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, and clear away heart-fire the effects such as removing heat from blood, promoting the function of the gallbladder to alleviate jaundice; The effects such as in side, Semen Vaccariae has promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, and lactogenesis of invigorating blood circulation, expedites the emergence of stimulating milk secretion, thymus dredging in puerperal; In side, Semen Sinapis Albae has warming the lung eliminating phlegm promoting the circulation of QI, the effects such as resolving mass and removing the obstruction of the collateral pain relieving.This ten four Chinese medicine coordinates in limited ratio, can play its synergism to the full extent, and tool has clear improvement the effect of menstrual period syndrome PMS.

Compared with prior art, the present invention has following beneficial effect: female menstrual period outer charging of the present invention is for raw material with the leaf of pure natural medicinal plants, flower, fruit, rhizome etc., the assorted product be processed into by a certain percentage, and by highly-breathable, close Cutaneous cloth bag packaging.Outer charging of the present invention is made up of in proportion ten four Chinese medicines, and side is sent out with Folium Artemisiae Argyi, Ramulus Cinnamomi, the warm liter of Rhizoma Chuanxiong, to train the anger of wood; Radix Curcumae dispersing the stagnated live-QI to relieve the stagnation of QI, supports wooden endogenous wind stopping; Radix Aconiti, Semen Vaccariae, Semen Sinapis Albae expelling pathogenic factors from the exterior are gone out; Lignum Dalbergiae Odoriferae sending down the abnormal ascending QI; Herba Pogostemonis, the Radix Angelicae Dahuricae, Rhizoma Cyperi removing dampness by means of aromatics; Rhizoma Alpiniae Officinarum, Fructus Evodiae Wen Tonghan are stagnant, and Radix Salviae Miltiorrhizae is to remove congestion, and each component synergism, makes the effects such as whole medicated bag has promoting the flow of QI in the collateral by warming the meridian, regulating menstruation is regulated the flow of vital energy, stasis-dispelling and pain-killing, have obvious therapeutical effect to menstrual period syndrome PMS.

The manufacture method of above-mentioned female menstrual period outer charging, comprise the steps: by each component through picking pick, smash or grind, drying process, then each component of drying is carried out weight ratio according to recipe requirements assorted, and take breathability, close Cutaneous cloth bag packaging; Production environment requirement is the dust proof workshop of 100,000 grades.

The using method of above-mentioned menstrual phase outer charging comprises: kitchen microwave ovens put into by bag of getting it filled before use, with in high fire heating can use after 1-2 minute.

This employing pure natural of the present invention medicinal plants is as the female menstrual period outer charging of effective ingredient, more meet health care theory and the living habit of modern female, have simultaneously be simple and easy to use, non-evident effect, can the feature of repeated multiple times use, be used for the treatment of the menstrual period syndrome PMS disease of women, there is more wide market prospect.In addition, the preparation technology of female menstrual period outer charging of the present invention is simple, easy to operate, repeatability good, is suitable for suitability for industrialized production.

Detailed description of the invention

Embodiment 1

Formula: Folium Artemisiae Argyi 1g, Ramulus Cinnamomi 5g, Rhizoma Alpiniae Officinarum 25g, Herba Pogostemonis 30g, Lignum Dalbergiae Odoriferae 8g, Rhizoma Cyperi 21g, Radix Angelicae Dahuricae 27g, Fructus Evodiae 7g, Radix Salviae Miltiorrhizae 12g, Radix Aconiti 15g, Rhizoma Chuanxiong 18g, Radix Curcumae 30g, Semen Vaccariae 30g, Semen Sinapis Albae 9g.

Manufacture method: (1) takes Folium Artemisiae Argyi, Ramulus Cinnamomi, Rhizoma Alpiniae Officinarum, Herba Pogostemonis, Lignum Dalbergiae Odoriferae, Rhizoma Cyperi, the Radix Angelicae Dahuricae, Fructus Evodiae, Radix Salviae Miltiorrhizae, Radix Aconiti, Rhizoma Chuanxiong, Radix Curcumae, Semen Vaccariae and Semen Sinapis Albae by weight.(2) load according to formulation ratio in the cloth bag made by highly-breathable, close Cutaneous cloth.Kitchen microwave ovens put into by bag of getting it filled before using, with in high fire heating can use after 1-2 minute.

Embodiment 2

Formula: Folium Artemisiae Argyi 30g, Ramulus Cinnamomi 22g, Rhizoma Alpiniae Officinarum 7g, Herba Pogostemonis 9g, Lignum Dalbergiae Odoriferae 12g, Rhizoma Cyperi 19g, Radix Angelicae Dahuricae 30g, Fructus Evodiae 30g, Radix Salviae Miltiorrhizae 23g, Radix Aconiti 2g, Rhizoma Chuanxiong 5g, Radix Curcumae 9g, Semen Vaccariae 15g, Semen Sinapis Albae 25g.

Manufacture method: (1) takes Folium Artemisiae Argyi, Ramulus Cinnamomi, Rhizoma Alpiniae Officinarum, Herba Pogostemonis, Lignum Dalbergiae Odoriferae, Rhizoma Cyperi, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Radix Salviae Miltiorrhizae, Radix Aconiti, Rhizoma Chuanxiong, Radix Curcumae, Semen Vaccariae and Radix seu Folium Gaultheriae Forrestii by weight.(2) load according to formulation ratio in the cloth bag made by highly-breathable, close Cutaneous cloth.Kitchen microwave ovens put into by bag of getting it filled before using, with in high fire heating can use after 1-2 minute.

Embodiment 3

Formula: Folium Artemisiae Argyi 15g, Ramulus Cinnamomi 15g, Rhizoma Alpiniae Officinarum 9g, Herba Pogostemonis 21g, Lignum Dalbergiae Odoriferae 24g, Rhizoma Cyperi 1g, Radix Angelicae Dahuricae 20g, Fructus Evodiae 10g, Radix Salviae Miltiorrhizae 3g, Radix Aconiti 21g, Rhizoma Chuanxiong 15g, Radix Curcumae 19g, Semen Vaccariae 5g, Semen Sinapis Albae 5g.

Embodiment 4

Formula: Folium Artemisiae Argyi 5g, Ramulus Cinnamomi 25g, Rhizoma Alpiniae Officinarum 19g, Herba Pogostemonis 12g, Lignum Dalbergiae Odoriferae 3g, Rhizoma Cyperi 12g, Radix Angelicae Dahuricae 25g, Fructus Evodiae 20g, Radix Salviae Miltiorrhizae 30g, Radix Aconiti 8g, Rhizoma Chuanxiong 7g, Radix Curcumae 23g, Semen Vaccariae 25g, Semen Sinapis Albae 1g.

Embodiment 5

Formula: Folium Artemisiae Argyi 25g, Ramulus Cinnamomi 5g, Rhizoma Alpiniae Officinarum 1g, Herba Pogostemonis 22g, Lignum Dalbergiae Odoriferae 30g, Rhizoma Cyperi 2g, Radix Angelicae Dahuricae 15g, Fructus Evodiae 10g, Radix Salviae Miltiorrhizae 10g, Radix Aconiti 18g, Rhizoma Chuanxiong 17g, Radix Curcumae 13g, Semen Vaccariae 15g, Semen Sinapis Albae 11g.

Clinical data:

Case selection:

To seek medical advice in outpatient service from July, 2014 ~ 2015 year January the patient of menstrual period syndrome PMS disease, filters out and meet following diagnostic criteria person, be divided into treatment group and matched group at random by consultation time.

Diagnostic criteria:

Draft with reference to relevant criterion in " new Chinese medicine guideline of clinical investigations " (trying) and " Gynecology of Chinese Medicine ".

The normal person of menstrual cycle is about 28 days, but also belongs to normal range at 21-35 days; In menstrual period, normal person is about 3-7 days; Through amount, total amount of generally passing through is 50-80ml.Two below, meet wherein 1 or 2, can diagnose.

(1) menostaxis: menstrual cycle 21-35 days, more than more than 7 days, even 2 weeks just clean persons, there are 2 cycles or more in menstrual period continuously.

(2) menorrhagia: menstrual cycle 21-35 days, the amount of passing through is many at every turn, is greater than 80ml, occurs 2 cycles or more continuously.

Therapeutic Method:

Treatment group: the formula of embodiment 1 is loaded in the cloth bag made by highly-breathable, close Cutaneous cloth.Kitchen microwave ovens put into by bag of getting it filled before using, with in high fire heating can use after 1-2 minute.Beginning application in 3rd day after ovulation or after the rising of basal body temperature curve, 2 times on the 1st, connects to apply and stops using after 10 days, wait menstrual onset.

Matched group: start for the 3rd day to take dydrogesterone sheet lOmg, 2 times on the 1st, drug withdrawal after serveing on 10 days after ovulation or after the rising of basal body temperature curve, wait for menstrual onset.

Efficacy determination:

With reference to curative effect of disease criterion in " new Chinese medicine guideline of clinical investigations " (trying) it " guideline of clinical investigations of new Chinese medicine treatment menoxenia ", associative multiplication proportion by subtraction method is evaluated curative effect.

Integration × 100% before therapeutic index=(before treatment the rear integration of integration-treatment)/treatment

(1) fully recover menstruation menstrual period, recover normal through amount, other transference cures, integration reduces >=95%;

(2) effective menorrhagia person, through amount comparatively before reduce 1/3 or be less than 100ml, menstrual period recovered within 7 days, other transference cures or alleviate, integration minimizing >=70%;

(3) effectively menstruation menstrual period, improve before amount comparatively treatment, other symptoms alleviate before comparatively treating, integration minimizing >=30%;

(4) invalid menstruation menstrual period, through amount without improving, integration reduces < 30%.

Results and analysis

A table 1 liang group ordinary circumstance compares

Compared by the age to two groups, the course of disease, treatment foreset ordinary circumstance of grading, find that without obvious significant difference (#p > 0.05) there is comparability through t inspection.

After two groups of treatments, general curative effect compares

Before and after table 2 liang group treatment, quantizating index scoring is compared

Note: 1. compare employing paired-sample t test before and after self in group;

2. " * " represents p < 0.05, and " * " represents p < 0.01, lower same.

Quantizating index comprises menstrual cycle, menstrual period, through 9 indexs such as amount, premenstrual hemorrhage (luteal phase is hemorrhage), simultaneous phenomenon, BBT high-temperature-phase, migratory stage, the temperature difference, high temperature fluctuations, can reflect the general curative effect of disease.Can find out by observing upper table, two groups all can make quantizating index mark to reduce, and it is 12.63 that treatment group reduces amplitude, and matched group to reduce amplitude be 8.57, illustrates treatment group before the treatment rear entire change be significantly greater than matched group; Compare before and after treatment group self, p=0.027, significant difference.

After table 3 liang group treatment, total effective rate compares (n, %)

Note: through X 2 test, comparitive study after two groups of treatments, p < 0.05, there were significant differences.

Can find out by observing upper table, after treatment group and matched group were treated through 3 months, all without healing; Effective 9 examples (30.0%) for the treatment of group, effective 2 examples (13.3%) of matched group, treatment group is apparently higher than matched group; Two groups of total effective rates compare, treatment group 90%, matched group 73.3%, and treatment group general curative effect is more excellent.

A table 4 liang group treatment front and back natural law in menstrual period compares (my god, x ± s)

Note: after treatment two groups menstrual period natural law have the difference (p < 0.01) of highly significant before all comparatively treating.

A table 5 liang group treatment anteroposterior diameter amount scoring is compared

Note: the difference (p < 0.01) having highly significant before and after treatment group treatment; Before and after treatment of control group, there were significant differences (p < 0.05).

Table 6 liang group treatment front and back bleeding days luteal phase compares (my god, x ± s)

Note: after treatment two groups luteal phase bleeding days have the difference (p < 0.01) of highly significant before all comparatively treating.

Before and after table 7 liang group treatment, cycle scoring is compared

Note: the rear two groups of cycles scoring for the treatment of has the difference (p < 0.01) of highly significant before all comparatively treating.

Can find out by observing above table, before and after treatment group treatment, all value difference is all obviously greater than matched group; Treatment group menstrual cycle, menstrual period, through amount, the premenstrual index such as hemorrhage before the treatment after all have the difference (p < 0.01) of highly significant; Matched group menstrual cycle, menstrual period, the premenstrual index such as hemorrhage have the difference (p < 0.01) of highly significant before the treatment afterwards, and before and after amount treatment, there were significant differences (p < 0.05).

The present invention adopts above-mentioned Chinese medicine composition to make compatibility mutually, can play its collaborative left and right of curing the disease, have drug effect and mutually promote and coordinate usefulness, through clinical verification, have good therapeutic effect to menoxenia between each composition of institute's medication raw material.The applicant's medical practice for many years, all obtains good curative effect, and with low cost, alleviates the burden of patient.The external application of Chinese medicine compositions of the treatment menopathy of the application is with low cost, evident in efficacy, has broad application prospects.

Claims

1. a feminine menstrual phase outer charging, is characterized in that, is made up of the component of following parts by weight:

Folium Artemisiae Argyi 1.0-30, Ramulus Cinnamomi 1.0-30, Rhizoma Alpiniae Officinarum 1.0-30, Herba Pogostemonis 1.0-30, Lignum Dalbergiae Odoriferae 1.0-30, Rhizoma Cyperi 1.0-30, Radix Angelicae Dahuricae 1.0-30, Fructus Evodiae 1.0-30, Radix Salviae Miltiorrhizae 1.0-30, Radix Aconiti 1.0-30, Rhizoma Chuanxiong 1.0-30, Radix Curcumae 1.0-30, Semen Vaccariae 1.0-30, Semen Sinapis Albae 1.0-30.

2. the manufacture method of feminine menstrual phase outer charging described in claim 1, it is characterized in that comprising the steps: each component is picked through picking, smash or grinds, drying process, then each component of drying is carried out weight ratio according to recipe requirements assorted, and take breathability, close Cutaneous cloth bag packaging; Production environment requirement is the dust proof workshop of 100,000 grades.

3. the using method of feminine menstrual phase outer charging described in claim 1, it is characterized in that, kitchen microwave ovens put into by bag of getting it filled before using, with in high fire heating can use after 1-2 minute.