CN104984037A - Traditional Chinese medicine preparation for treatment of dilated cardiomyopathy and preparing method thereof - Google Patents
Traditional Chinese medicine preparation for treatment of dilated cardiomyopathy and preparing method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine preparation for treatment of dilated cardiomyopathy and a preparing method thereof. The traditional Chinese medicine preparation is prepared from the following pharmaceutical raw materials: radix astragali, codonopsis pilosula, herba epimedii, cassia twig, cortex moutan, salvia miltiorrhiza, white mulberry root-bark, semen lepidii, lily, and radix asparagi. The traditional Chinese medicine preparation has significant efficacies of warming yang and replenishing qi, promoting blood circulation to remove blood stasis, purging the lung of pathogenic fire and relieving asthma, inducing diuresis to alleviate edema, and nourishing heart and yin, has quite good treatment effects in treatment of dilated cardiomyopathy, especially treatment of qi-yin deficiency type dilated cardiomyopathy, is low in drug side effects, allows the disease to be difficult to relapse, and has significant clinical promotional value.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy and preparation method thereof.
Background technology
Cardiomyopathy (DDM) is a kind of due to the structural change of heart lower part chamber (i.e. ventricle) and the pathological changes of myocardial wall function impaired caused cardiac function Progressive symmetric erythrokeratodermia obstacle.Dilated cardiomyopathy, hypertrophic cardiomyopathy and restrictive cardiomyopathy can be divided into by pathology, wherein common with dilated cardiomyopathy, account for myocardiac 70% ~ 80%.Be characterized in there is obvious expansion with left ventricle (majority) or right ventricle, and all with myocardial hypertrophy in various degree, ventricular systolic function goes down, with cardiac dilatation, heart failure, arrhythmia, thromboembolism is basic feature, is once called as congestive cardiomyopathy.Without the name of disease of " dilated cardiomyopathy " in TCM Document, the category such as Chinese medicine " cardiopalmus ", " thoracic obstruction ", " edema ", " the syndrome of dyspnea " is belonged to by its symptom and sign dilated cardiomyopathy, its total pathogenesis is heart kidney yang gas virtual loss is this, and general, the upper icepro cardiopulmonary of blood stasis water, excessive skin are target Primary Asthenia-Secondary Sthenia Syndrome.
Modern medicine is thought, dilated cardiomyopathy morbidity is relevant with viral infection, autoimmune response, heredity, drug intoxication and Developmental and Metabolic Disorder etc.This sick onset is slow, and just diagnosed even generally have during the congestive heart failure sudden deaths such as out of breath, edema, orthopnea, case fatality rate is higher.Universal along with ultrasonic technique, its recall rate is in ascendant trend gradually.
Primary disease doctor trained in Western medicine there is no specific short except heart transplantation, but there is this fundamental contradiction of donor wretched insufficiency.Treatment by Chinese herbs has multiple target effect, multipath onset, relapse rate is low, adverse reaction rate is low, late result is good feature, can play and improve patient survival and the object of quality of life.In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect and relapse rate, through carrying out to Chinese medicine the Chinese medicine preparation that screening is extracted and/or compatibility is obtained, the inclined Sheng utilizing the natural quality of Chinese medicine to correct body negative and positive declines partially, recover to improve disease-resistant, the more condition of disease power of body, have the advantage that chemical synthetic drug can not be compared, the Chinese medicine preparation therefore developing the more definite treatment dilated cardiomyopathy of curative effect is necessary.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy and preparation method thereof.
An object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of dilated cardiomyopathy.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of dilated cardiomyopathy.
Chinese medicine preparation of the present invention is obtained by following crude drug: the Radix Astragali, Radix Codonopsis, Herba Epimedii, Ramulus Cinnamomi, Cortex Moutan, Radix Salviae Miltiorrhizae, Cortex Mori, Semen Lepidii (Semen Descurainiae), Bulbus Lilii, Radix Asparagi.
Preferably, its active ingredient is made up of the crude drug of following weight portion: Radix Astragali 16-18 part, Radix Codonopsis 8-10 part, Herba Epimedii 4-6 part, Ramulus Cinnamomi 10-12 part, Cortex Moutan 7-9 part, Radix Salviae Miltiorrhizae 14-16 part, Cortex Mori 12-14 part, Semen Lepidii (Semen Descurainiae) 6-8 part, Bulbus Lilii 3-5 part, Radix Asparagi 8-10 part.
The present invention most preferably its active ingredient is made up of the crude drug of following weight portion: the Radix Astragali 17 parts, Radix Codonopsis 9 parts, Herba Epimedii 5 parts, Ramulus Cinnamomi 11 parts, Cortex Moutan 8 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Mori 13 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Bulbus Lilii 4 parts, Radix Asparagi 9 parts.
The Chinese medicine preparation that the present invention treats dilated cardiomyopathy can also contain pharmaceutically acceptable carrier, is prepared into conventional formulation, as capsule, tablet and powder agent, is preferably granule.
The preparation method of Chinese medicine preparation of the present invention comprises the steps: that the crude drug of above-mentioned weight portion pulverized 80 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, adding ethanol to alcohol content is again 60%v/v, limit edged stirs, and leaves standstill 24 hours, gets supernatant, reclaim ethanol, when being concentrated into 75 DEG C, its relative density is the clear paste of 1.11-1.18, then to add on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.
Chinese medicine preparation of the present invention, has the following advantages and effect:
(1) mainly the foundation dilated cardiomyopathy motive, the heart-yin virtual loss are that originally expectorant heresy, diseases caused by retention of fluid, blood stasis are that target pathogenic characteristic develops to Chinese medicine preparation prescription of the present invention.Syndrome analysis for dilated cardiomyopathy particularly type of deficiency of both QI and YIN dilated cardiomyopathy: QIYINLIANGXU, deficiency of heart-QI, drum arteries and veins is unable, and stagnation of heart-blood is sensation of oppression over the chest with shortness of breath then; Blood is slow, then spiritlessness and weakness; Dynamic then consume gas, therefore the aggravation of outstanding sense disease feelings; Foretelling the moon declines few, and god loses hiding, then little severe palpitation; Empty people disturbs god, then few dreaminess of sleeping; Yin deficiency and blood stasis, then xerostomia is drunk less; Liver and kidney damage of essence, clear key loses and fills survey vertigo and tinnitus; Tongue is dim red, thin fur or HONGGUANG no fur, and thready and hesitant pulse, is deficiency of both QI and YIN, stagnant the levying of the heart arteries and veins stasis of blood; Thready and rapid pulse is levying of yin asthenia generating intrinsic heat.The Radix Astragali in side, Radix Codonopsis, invigorating QI to consolidate the body surface resistance; Herba Epimedii, Ramulus Cinnamomi, warming and recuperating the kidney-YANG; Cortex Moutan, Radix Salviae Miltiorrhizae, blood circulation promoting and blood stasis dispelling; Cortex Mori, Semen Lepidii (Semen Descurainiae), eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema; Bulbus Lilii, Radix Asparagi, YIN nourishing and the production of body fluid promoting.Full side plays warming YANG and invigorating QI altogether, blood circulation promoting and blood stasis dispelling, eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, nourishes the merit of the heart-yin, to dilated cardiomyopathy particularly type of deficiency of both QI and YIN dilated cardiomyopathy have extremely strong specific aim curative effect, onset is rapid, treating both the principal and secondary aspects of a disease.
(2) Chinese medicine preparation of the present invention adds use on the basis of conventional therapy dilated cardiomyopathy, and drug effect is remarkable.
(3) Chinese medicine preparation of the present invention treat dilated cardiomyopathy time for chemical drugs, untoward reaction and few side effects.
(4) through clinical practice checking, use invention formulation treatment type of deficiency of both QI and YIN type dilated cardiomyopathy, the routine patient for the treatment of group 40, recovery from illness 15 example, obviously progressive 21 examples, total effective rate 90%, clinical effectiveness is remarkable.
The functional effect of Chinese medicine preparation of the present invention each Chinese medicine component is as follows:
The Radix Astragali, warm in nature, sweet in the mouth.Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.
Radix Codonopsis, sweet, flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Herba Epimedii, acrid, sweet, warm.Return liver, kidney channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Ramulus Cinnamomi, acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Cortex Moutan, bitter, pungent, be slightly cold.GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
Radix Salviae Miltiorrhizae, bitter, be slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Cortex Mori, sweet, cold.Return lung meridian.Eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Semen Lepidii (Semen Descurainiae), pungent, bitter, Great Cold.Return lung, urinary bladder channel.Eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung for sputum, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium, must not put down sleeping, and ascites pleural fluid swells, dysuria; Pulmonary heart disease edema.
Bulbus Lilii, sweet, cold.GUIXIN, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Radix Asparagi, cold in nature, sweet in the mouth, hardship.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Quench one's thirst for dryness of the lung dry cough, cough due to consumptive disease, thirsty, the vexed insomnia of Tianjin wound, interior-heat, dryness of the intestine constipation, diphtheria.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Each raw material is taken: the Radix Astragali 17 parts, Radix Codonopsis 9 parts, Herba Epimedii 5 parts, Ramulus Cinnamomi 11 parts, Cortex Moutan 8 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Mori 13 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Bulbus Lilii 4 parts, Radix Asparagi 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 80 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, then to add ethanol to alcohol content be 60%v/v, limit edged stirs, leave standstill 24 hours, get supernatant, reclaim ethanol, when being concentrated into 75 DEG C, its relative density is the clear paste of 1.11-1.18, and crushed after being dried crosses 80 mesh sieves, then adds pharmaceutically acceptable adjuvant, mix homogeneously, conveniently preparation technology is prepared into capsule.
When using Chinese medicine preparation of the present invention to treat dilated cardiomyopathy, take prepared capsule, every contains crude drug amount 0.15g, every day 3 times, each 3-4 grain.
Embodiment 2 tablet
Each raw material is taken: the Radix Astragali 17 parts, Radix Codonopsis 9 parts, Herba Epimedii 5 parts, Ramulus Cinnamomi 11 parts, Cortex Moutan 8 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Mori 13 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Bulbus Lilii 4 parts, Radix Asparagi 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 80 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, then to add ethanol to alcohol content be 60%v/v, limit edged stirs, leave standstill 24 hours, get supernatant, reclaim ethanol, when being concentrated into 75 DEG C, its relative density is the clear paste of 1.11-1.18, and crushed after being dried crosses 80 mesh sieves, then adds pharmaceutically acceptable adjuvant, mix homogeneously, conveniently preparation technology is prepared into tablet.
When using Chinese medicine preparation of the present invention to treat dilated cardiomyopathy, take prepared tablet, every sheet contains crude drug amount 0.15g, every day 3 times, each 3-4 sheet.
Embodiment 3 granule
Each raw material is taken: the Radix Astragali 17 parts, Radix Codonopsis 9 parts, Herba Epimedii 5 parts, Ramulus Cinnamomi 11 parts, Cortex Moutan 8 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Mori 13 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Bulbus Lilii 4 parts, Radix Asparagi 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 80 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, then to add ethanol to alcohol content be 60%v/v, limit edged stirs, leave standstill 24 hours, get supernatant, reclaim ethanol, when being concentrated into 75 DEG C, its relative density is the clear paste of 1.11-1.18, and crushed after being dried crosses 80 mesh sieves, then adds pharmaceutically acceptable adjuvant, mix homogeneously, conveniently preparation technology is prepared into granule.
When using Chinese medicine preparation of the present invention to treat dilated cardiomyopathy, take prepared granule, every bag contains crude drug amount 0.5g, every day 3 times, each 1 bag.
Embodiment 4 granule
Each raw material is taken: the Radix Astragali 16 parts, Radix Codonopsis 8 parts, Herba Epimedii 4 parts, Ramulus Cinnamomi 10 parts, Cortex Moutan 7 parts, Radix Salviae Miltiorrhizae 14 parts, Cortex Mori 12 parts, Semen Lepidii (Semen Descurainiae) 6 parts, Bulbus Lilii 3 parts, Radix Asparagi 8 parts by following weight portion.
Preparation technology is with embodiment 3.
Embodiment 5 granule
Each raw material is taken: the Radix Astragali 18 parts, Radix Codonopsis 10 parts, Herba Epimedii 6 parts, Ramulus Cinnamomi 12 parts, Cortex Moutan 9 parts, Radix Salviae Miltiorrhizae 16 parts, Cortex Mori 14 parts, Semen Lepidii (Semen Descurainiae) 8 parts, Bulbus Lilii 5 parts, Radix Asparagi 10 parts by following weight portion.
Preparation technology is with embodiment 3.
The clinical observation of embodiment 6 Chinese medicine preparation treatment of the present invention dilated cardiomyopathy
1, physical data:
Outpatient service and ward are diagnosed as patient 80 example of type of deficiency of both QI and YIN DCM (dilated cardiomyopathy), are divided into treatment group, matched group at random.Treatment group 40 example, male 22 example, women 18 example; Age 18-71 year, average 47.8 ± 10.29 years old; The course of disease 6-10 years month in and month out, average 22.5 ± 9.8 months; Cardiac function N Y H A classification, II grade of 12 example, III grade of 23 example, IV grade of 5 example.Matched group 40 example, male 23 example, women 17 example; Age 20-72 year, average 49.3 ± 10.8 years old; The course of disease 8 months-10 years, average 26.1 ± 10.2 months; New York Heart Association, II grade of 13 example, III grade of 21 example, IV grade of 6 example.2 groups of ages, sex, the course of disease and cardiac functional gradings are through statistical procedures, and there was no significant difference (P>0.05), has comparability.
2, diagnostic criteria:
Doctor trained in Western medicine meets the cardiomyopathy criteria for classification and definition that the sick association (ISFC) of nineteen ninety-five World Health Organization (WHO)/World Heart proposes.
Tcm diagnosis is with reference to " Chinese Internal Medicine " standard, and dialectical is type of deficiency of both QI and YIN.Disease is seen: sensation of oppression over the chest with shortness of breath, spiritlessness and weakness, dynamic then outstanding acute, severe palpitation, few dreaminess of sleeping, and xerostomia is drunk less, or vertigo tinnitus; Tongue is dim red, thin fur or HONGGUANG no fur, thready and hesitant pulse or count accurately.This type sees myocardiac relatively stable period.
3, Excluded cases standard:
(1) due to heart failure person that liver and kidney failure causes;
(2) gestation or women breast-feeding their children;
(3) Liver and kidney and the severe primary such as endocrine, hemopoietic system disease and psychotic patient is merged;
(4) to the known composition allergy sufferers of this medicine.
4, Therapeutic Method:
Two groups all give western medicine routine treatment, comprise restriction sodium salt, reduce physical exertion, to diuretic, angiotensin converting enzyme inhibitor (ACEI) beta-blocker, Folium Digitalis Purpureae, nitrate esters etc.Treatment group takes granule prepared by the embodiment of the present invention 3 on Western medicine colligation treatment basis, every bag containing crude drug amount 0.5g, every day 3 times, each 1 bag, after meal half an hour warm water delivery service.
Within two weeks, be a course for the treatment of, after treating 2 courses for the treatment of, carry out therapeutic evaluation.
4, curative effect determinate standard:
Effective in cure judging quota all meet curative effect determinate standard in " new Chinese medicine guideline of clinical investigations ".
Effective: all symptoms, sign and decentraction function are all significantly improved, and cardiac function is improved to more than II grade;
Effective: symptom, sign and cardiac function all make moderate progress, cardiac function is improved to more than I level;
Invalid: the various clinical symptoms of patient all do not obtain any improvement, the phenomenon increased the weight of even in addition.
Total effective rate=obvious effective rate+effective percentage.
5, therapeutic outcome:
In clinical observation process, 80 routine patients all complete clinical observation.Effective 20 examples (50%) of the routine patient for the treatment of group 40, effective 18 examples (45%), invalid 2 examples (5%), total effective rate 95%, clinical effectiveness is remarkable; Effective 12 examples (30%) of the routine patient of matched group 40, effective 19 examples (47.5%), no effect 9 (25%), total effective rate 77.5%, two groups of total effective rates compare, and have significant difference, observation group is significantly better than matched group.LVED (Left Ventricular End Systolic Dimension) (LVEDD) and ejection fraction (EF) situation of change as can be seen from Table 2.Compare with before treatment, P < 0.05, two groups treatment front and back LVEFD and EF self more all has clear improvement and between group, comparison therapy group is all better than matched group, and prompting treatment group LVEFD and EF improvement is better than matched group.
Table 1. liang group symptom comparitive study
| Group | n | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 40 | 20 | 18 | 2 | 38(95％) |
| Matched group | 40 | 12 | 19 | 9 | 31(77.5％) |
Before and after table 2. liang group treatment, cardiac function compares
Note: compare with before treatment
☆p < 0.05,
☆ ☆p < 0.01; Compare with matched group
△p < 0.05,
△ △p < 0.01.
Clinical observation result shows, and treatment group symptom obvious effective rate, total effective rate, cardiac function improve situation and be all obviously better than matched group, and this Chinese medicine preparation improves obviously DCM (dilated cardiomyopathy) clinical symptoms as seen.Simultaneously in safety evaluatio, the routine blood test before and after treatment group patient consumes, routine urinalysis etc. inspections do not find obvious exception.Illustrate that using Chinese medicine preparation of the present invention treatment DCM (dilated cardiomyopathy) particularly to treat belongs to syndrome of deficiency of both qi and yin DCM (dilated cardiomyopathy) determined curative effect thus, safe and reliable, can be used as the effective ways for the treatment of gas sun two deficiency syndrome DCM (dilated cardiomyopathy), be worth of widely use in clinical.
Claims (8)
1. treat the Chinese medicine preparation of dilated cardiomyopathy for one kind, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Astragali 16-18 part, Radix Codonopsis 8-10 part, Herba Epimedii 4-6 part, Ramulus Cinnamomi 10-12 part, Cortex Moutan 7-9 part, Radix Salviae Miltiorrhizae 14-16 part, Cortex Mori 12-14 part, Semen Lepidii (Semen Descurainiae) 6-8 part, Bulbus Lilii 3-5 part, Radix Asparagi 8-10 part.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, it is obtained by the crude drug of following weight portion: the Radix Astragali 17 parts, Radix Codonopsis 9 parts, Herba Epimedii 5 parts, Ramulus Cinnamomi 11 parts, Cortex Moutan 8 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Mori 13 parts, Semen Lepidii (Semen Descurainiae) 7 parts, Bulbus Lilii 4 parts, Radix Asparagi 9 parts.
3. the Chinese medicine preparation as described in any one of claim 1-2, it is also containing pharmaceutically acceptable carrier.
4. Chinese medicine preparation as claimed in claim 3, it is characterized in that, described Chinese medicine preparation is capsule, tablet or granule.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described Chinese medicine preparation is preferably granule.
6. one kind prepare as arbitrary in claim 1-2 as described in the method for Chinese medicine preparation, it is characterized in that, it comprises the following steps: the crude drug of above-mentioned weight portion was pulverized 80 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6-8 times amount, each 2 hours, filter cleaner extracting juice merges, and the filtrate after merging is concentrated, adding ethanol to alcohol content is again 60%v/v, limit edged stirs, leave standstill 24 hours, get supernatant, reclaim ethanol, when being concentrated into 75 DEG C, its relative density is the clear paste of 1.11-1.18, to add again on pharmaceutics acceptable adjuvant routinely technique be prepared into required preparation.
7. the purposes of the Chinese medicine preparation as described in as arbitrary in claim 1-2 in the medicine of preparation treatment dilated cardiomyopathy.
8. the purposes of the Chinese medicine preparation as described in as arbitrary in claim 1-2 in the medicine of preparation treatment type of deficiency of both QI and YIN dilated cardiomyopathy.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
| CN102698192A (en) * | 2012-05-29 | 2012-10-03 | 成都绿迪科技有限公司 | Traditional Chinese medicament for treating dilated cardiomyopathy |
| CN103263566A (en) * | 2013-04-29 | 2013-08-28 | 青岛市市立医院 | Traditional Chinese medicine composition for treating bone dilated cardiomyopathy |
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2015
- 2015-07-27 CN CN201510447206.3A patent/CN104984037A/en active Pending
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| CN101322801A (en) * | 2007-06-15 | 2008-12-17 | 河北以岭医药研究院有限公司 | Use of Chinese medicinal composition in preparing medicament for treating dilated cardiomyopathy |
| CN102698192A (en) * | 2012-05-29 | 2012-10-03 | 成都绿迪科技有限公司 | Traditional Chinese medicament for treating dilated cardiomyopathy |
| CN103263566A (en) * | 2013-04-29 | 2013-08-28 | 青岛市市立医院 | Traditional Chinese medicine composition for treating bone dilated cardiomyopathy |
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Application publication date: 20151021 |