CN104983588B - Children's bacteriostatic skin-care hand cleanser containing soft pearl and preparation method thereof - Google Patents
Children's bacteriostatic skin-care hand cleanser containing soft pearl and preparation method thereof Download PDFInfo
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- CN104983588B CN104983588B CN201510407607.6A CN201510407607A CN104983588B CN 104983588 B CN104983588 B CN 104983588B CN 201510407607 A CN201510407607 A CN 201510407607A CN 104983588 B CN104983588 B CN 104983588B
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- soft pearl
- skin
- stirring
- emollient
- bacteriostatic
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- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000000306 component Substances 0.000 claims abstract description 46
- 239000000375 suspending agent Substances 0.000 claims abstract description 30
- 239000003974 emollient agent Substances 0.000 claims abstract description 29
- 239000002280 amphoteric surfactant Substances 0.000 claims abstract description 27
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 27
- 239000003755 preservative agent Substances 0.000 claims abstract description 27
- 230000002335 preservative effect Effects 0.000 claims abstract description 27
- 239000003381 stabilizer Substances 0.000 claims abstract description 27
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 25
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000003756 stirring Methods 0.000 claims description 41
- -1 propyl hydroxy sulfo Chemical group 0.000 claims description 18
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 11
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical group COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 9
- 229920006397 acrylic thermoplastic Polymers 0.000 claims description 9
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 9
- 238000013019 agitation Methods 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 238000012856 packing Methods 0.000 claims description 8
- 238000005070 sampling Methods 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical group OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 7
- 229920002125 Sokalan® Polymers 0.000 claims description 7
- 229960005323 phenoxyethanol Drugs 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 239000004006 olive oil Substances 0.000 claims description 6
- 235000008390 olive oil Nutrition 0.000 claims description 6
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims description 5
- 239000005770 Eugenol Substances 0.000 claims description 5
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims description 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 5
- 229960002217 eugenol Drugs 0.000 claims description 5
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 5
- 235000015424 sodium Nutrition 0.000 claims description 5
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical group CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 claims description 4
- UFCONGYNRWGVGH-UHFFFAOYSA-N 1-hydroxy-2,2,3,3-tetramethylpiperidine Chemical compound CC1(C)CCCN(O)C1(C)C UFCONGYNRWGVGH-UHFFFAOYSA-N 0.000 claims description 3
- 150000001860 citric acid derivatives Chemical class 0.000 claims description 3
- 101100164201 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-4 gene Proteins 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 4
- 238000005202 decontamination Methods 0.000 abstract description 3
- 230000003588 decontaminative effect Effects 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000006641 stabilisation Effects 0.000 abstract description 2
- 238000011105 stabilization Methods 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000000344 soap Substances 0.000 description 9
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 7
- 230000033228 biological regulation Effects 0.000 description 7
- 241000207836 Olea <angiosperm> Species 0.000 description 6
- 229940049964 oleate Drugs 0.000 description 6
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 6
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 125000002252 acyl group Chemical group 0.000 description 5
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 5
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 5
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 4
- UITSPQLTFPTHJZ-UHFFFAOYSA-N 2-[[3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound COC1OC(COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-UHFFFAOYSA-N 0.000 description 4
- BKXKFUBMGJKSQZ-ZRVYWVIDSA-L N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].C(CCCCCCCCCCC)(=O)N.[Na+] Chemical compound N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].C(CCCCCCCCCCC)(=O)N.[Na+] BKXKFUBMGJKSQZ-ZRVYWVIDSA-L 0.000 description 4
- ZPPUFLOQBUUTRJ-UHFFFAOYSA-L S(=O)(=O)(O)C(C(=O)[O-])CC(=O)[O-].[Na+].[Na+].C(CC(O)(C(=O)O)CC(=O)O)(=O)O Chemical compound S(=O)(=O)(O)C(C(=O)[O-])CC(=O)[O-].[Na+].[Na+].C(CC(O)(C(=O)O)CC(=O)O)(=O)O ZPPUFLOQBUUTRJ-UHFFFAOYSA-L 0.000 description 4
- 108010077895 Sarcosine Proteins 0.000 description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical group OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 235000013985 cinnamic acid Nutrition 0.000 description 4
- 229930016911 cinnamic acid Natural products 0.000 description 4
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 4
- JVOYGBUYQTYMEZ-UHFFFAOYSA-N dodecanamide;sodium Chemical group [Na].CCCCCCCCCCCC(N)=O JVOYGBUYQTYMEZ-UHFFFAOYSA-N 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229930005346 hydroxycinnamic acid Natural products 0.000 description 4
- 235000010359 hydroxycinnamic acids Nutrition 0.000 description 4
- 229940100485 methyl gluceth-10 Drugs 0.000 description 4
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 4
- 229940048098 sodium sarcosinate Drugs 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 229960003500 triclosan Drugs 0.000 description 4
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000005864 Sulphur Substances 0.000 description 3
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229920000570 polyether Polymers 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical class C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 240000007817 Olea europaea Species 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019114 Hand fracture Diseases 0.000 description 1
- 101100380548 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-2 gene Proteins 0.000 description 1
- 101100436382 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-6 gene Proteins 0.000 description 1
- 101100436302 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) apg-8 gene Proteins 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229940071190 laureth sulfosuccinate Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940031722 methyl gluceth-20 Drugs 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
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- Cosmetics (AREA)
Abstract
The present invention relates to children's bacteriostatic skin-care hand cleanser containing soft pearl and preparation method thereof.Soft pearl containing active matter is not easy to stabilization in the liquid system of washing one's hands non-stimulated to child skin.The present invention is compounded by amphoteric surfactant, APG, emollient, anion surfactant, suspending agent, triethanolamine, the soft pearl containing active component, preservative, water, stabilizer, bacteriostatic agent and is made.The present invention to the gentle surfactant of child skin fanout free region using as decontamination composition, containing emollient in formula, while both hands are cleaned, can moisten, moisturizing children's hand skin；Soft pearl can be dispersed in system within the shelf-life, and the hand cleanser has decontamination, antibacterial, skin-care effect, non-stimulated to child skin.
Description
Technical field
The present invention relates to a kind of hand cleanser, and in particular to a kind of containing children's bacteriostatic skin-care hand cleanser of soft pearl and its preparation side
Method.
Background technology
For a long time, people are washed one's hands using soap or perfumed soap, but because solid soap becomes easily infected by upper dirt in use
Dirt and bacterium, so as to cause secondary pollution.And hand cleanser has clear advantage compared to solid soap：（1）Hand cleanser, which avoids, to be made
The cross pollution of used time；（2）Hand cleanser products composition diversification, the active component of a variety of moisturizings, pH and human body skin can be contained
Skin pH value is adapted, and is easily received by skin；（3）Solid soap can soften after being used for multiple times, soap lye easily flows damage, and soap body is used surplus
20% or so would generally be wasted.And hand cleanser be able to will not then be wasted by abundant use；（4）Practicality is stronger, on the one hand fertilizer
The solids such as soap, perfumed soap are compared with skating, and volume is also larger, particularly disadvantageous to be held with a firm grip in child, old man, and hand cleanser then avoids this and asked
Topic；Another aspect hand cleanser foaming abundancy is fine and smooth, not only water-saving but also time saving.Therefore, hand cleanser receives liking for more and more people.
Child skin compared to adult not yet reach maturity, compared with adult, skin be more vulnerable to it is hot and cold, moist, dry with
And the damage of excessive Exposure to Sunlight.The hand wash for children of the soft pearl containing active matter can be broken in hand washing process with the friction of both hands, soft pearl
It is broken, wherein the active component included discharges, moisturizing, moisturizing, nutrition and other effects can be played.And the outward appearance of the product makes
Child is easier to receive, so as to cultivate its good hand cleanser custom.But the soft pearl containing active matter is stingless to child skin
Be not easy in sharp liquid system of washing one's hands stabilization, accordingly it is desirable to it is a kind of it is non-stimulated to child skin, have bacteriostasis efficacy, work
The soft pearl composition of property can be stably dispersed in the hand wash for children in system.
The content of the invention
It is therein soft it is an object of the invention to provide a kind of children's bacteriostatic skin-care hand cleanser containing soft pearl and preparation method thereof
Pearl dispersed within the shelf-life will not can settle in the product, have bacteriostasis property.
The technical solution adopted in the present invention is：
Children's bacteriostatic skin-care hand cleanser containing soft pearl, it is characterised in that：
It is prepared by the component of following mass percent：
Amphoteric surfactant 3-15%；
APG 0.1-8%；
Emollient 0.5-5%；
Anion surfactant 0.1-5%；
Suspending agent 0.5-5%；
Triethanolamine 0.02-1.0%；
Soft pearl 0.02-1.5% containing active component；
Preservative 0.001-0.5%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.001-0.3%；
Bacteriostatic agent 0.001-0.8%.
The amphoteric surfactant is cocounut oil acyl both sexes base diethyl acid disodium, Cocoamidopropyl betaine or lauroyl
Amine hydroxysultaine.
The carbon chain lengths of the APG are C8-12Or C10Or C8-16Or C8-14Or C12-14。
The anion surfactant is lauramide sodium sarcosinate, lauramide sodium glutamate, PEG-7 olive oil
Carboxylic acid sodium, sodium methyl cocoyl taurate, PEG-5 laruyl alcohols citrate sulfosuccinate disodium or laureth sulphur
Base succinate disodium.
The emollient is PEG-7 olives oleate, PEG-10 olives oleate, PEG-7 glyceryl cocoates, methyl Portugal
Sugar alcohol polyethers -20 or methyl gluceth -10；
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer or
VISCOLAM CK1；
The preservative is Phenoxyethanol or methylisothiazolinone.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES RE-
508、UNISPHERES SYE、UNISPHERES SGE、UNISPHERES SRE、UNISPHERES NT-2202、Sp-
BkFEB41, Sp-VEaTR41, Sp-SfOVEaUMDC41, Sp-VEaDC56, Sp-VApGP41, Sp-UM41 or Sp-AOPL41.
The bacteriostatic agent is Triclosan, eugenol, cinnamic acid, P-Cymene, o-Ben Ji phenol or isopropyl first
Base phenol；
The stabilizer is benzene azoles sulfonate derivatives, has general structure C16H16N3O4Sna；Or it is three (tetramethyl hydroxyls
Phenylpiperidines alcohol) citrate or four (dibutyl hydroxy cinnamic acid hydrogen season pentyl esters).
The preparation method of children's bacteriostatic skin-care hand cleanser containing soft pearl, it is characterised in that：
Comprise the following steps：
Step 1：Each component is stocked up by following mass percent：
Amphoteric surfactant 3-15%；
APG 0.1-8%；
Emollient 0.5-5%；
Anion surfactant 0.1-5%；
Suspending agent 0.5-5%；
Triethanolamine 0.02-1.0%；
Soft pearl 0.02-1.5% containing active component；
Preservative 0.001-0.5%；
Stabilizer 0.001-0.3%；
Bacteriostatic agent 0.001-0.8%；
Water surplus；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 60-70 DEG C,
Stir；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 6.0-7.5；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：40 ± 2 DEG C are cooled to while stirring, stir 10-15min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 30-40min；
Step 7：Sampling Detection, finished product packing.
The amphoteric surfactant is cocounut oil acyl both sexes base diethyl acid disodium, Cocoamidopropyl betaine or lauroyl
Amine hydroxysultaine；
The carbon chain lengths of the APG are C8-12Or C10Or C8-16Or C8-14Or C12-14；
The anion surfactant is lauramide sodium sarcosinate, lauramide sodium glutamate, PEG-7 olive oil
Carboxylic acid sodium, sodium methyl cocoyl taurate, PEG-5 laruyl alcohols citrate sulfosuccinate disodium or laureth sulphur
Base succinate disodium；
The emollient is PEG-7 olives oleate, PEG-10 olives oleate, PEG-7 glyceryl cocoates, methyl Portugal
Sugar alcohol polyethers -20 or methyl gluceth -10；
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer or
VISCOLAM CK1；
The preservative is Phenoxyethanol or methylisothiazolinone；
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES RE-
508、UNISPHERES SYE、UNISPHERES SGE、UNISPHERES SRE、UNISPHERES NT-2202、Sp-
BkFEB41, Sp-VEaTR41, Sp-SfOVEaUMDC41, Sp-VEaDC56, Sp-VApGP41, Sp-UM41 or Sp-AOPL41；
The bacteriostatic agent is Triclosan, eugenol, cinnamic acid, P-Cymene, o-Ben Ji phenol or isopropyl first
Base phenol；
The stabilizer is benzene azoles sulfonate derivatives, has general structure C16H16N3O4Sna。
The present invention has advantages below：
1st, the present invention is using being used as decontamination composition to the gentle surfactant of child skin fanout free region, containing moistening in formula
Skin agent, while both hands are cleaned, it can moisten, moisturizing children's hand skin.
2nd, the present invention is containing the colored soft pearl that can be crushed after rubbing, vitamin, the grease wherein contained after the soft pearl is broken
Hand skin can be further moistened, and the hand cleanser containing soft pearl can increase the interest that children wash one's hands.The present invention is using suspension
Agent and stabilizer, ensure that active soft pearl in the system of being suspended in can within the shelf-life it is dispersed without sink or on
It is floating.
Brief description of the drawings
Fig. 1 is stability test Comparative result file.
Embodiment
With reference to embodiment, the present invention will be described in detail.
Children's bacteriostatic skin-care hand cleanser of the present invention containing soft pearl, is prepared into by the component of following mass percent
Arrive：
Amphoteric surfactant 3-15%；
APG 0.1-8%；
Emollient 0.5-5%；
Anion surfactant 0.1-5%；
Suspending agent 0.5-5%；
Triethanolamine 0.02-1.0%；
Soft pearl 0.02-1.5% containing active component；
Preservative 0.001-0.5%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.001-0.3%；
Bacteriostatic agent 0.001-0.8%.
In formula：
The amphoteric surfactant is cocounut oil acyl both sexes base diethyl acid disodium, Cocoamidopropyl betaine or lauroyl
Amine hydroxysultaine.
The carbon chain lengths of the APG are C8-12Or C10Or C8-16Or C8-14Or C12-14。
The anion surfactant is lauramide sodium sarcosinate, lauramide sodium glutamate, PEG-7 olive oil
Carboxylic acid sodium, sodium methyl cocoyl taurate, PEG-5 laruyl alcohols citrate sulfosuccinate disodium or laureth sulphur
Base succinate disodium.
The emollient is PEG-7 olives oleate, PEG-10 olives oleate, PEG-7 glyceryl cocoates, methyl Portugal
Sugar alcohol polyethers -20 or methyl gluceth -10.
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer or
VISCOLAM CK1。
The preservative is Phenoxyethanol or methylisothiazolinone.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES RE-
508、UNISPHERES SYE、UNISPHERES SGE、UNISPHERES SRE、UNISPHERES NT-2202、Sp-
BkFEB41, Sp-VEaTR41, Sp-SfOVEaUMDC41, Sp-VEaDC56, Sp-VApGP41, Sp-UM41 or Sp-AOPL41.
The bacteriostatic agent is Triclosan, eugenol, cinnamic acid, P-Cymene, o-Ben Ji phenol or isopropyl first
Base phenol.
The stabilizer is benzene azoles sulfonate derivatives, has general structure C16H16N3O4Sna；Or it is three (tetramethyl hydroxyls
Phenylpiperidines alcohol) citrate or four (dibutyl hydroxy cinnamic acid hydrogen season pentyl esters).
Three (tetramethyl hydroxy piperidine alcohol) citrates, its structural formula are：
Four (dibutyl hydroxy cinnamic acid hydrogen season pentyl esters), its structural formula is：
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 60-70 DEG C,
Stir；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 6.0-7.5；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：40 ± 2 DEG C are cooled to while stirring, stir 10-15min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 30-40min；
Step 7：Sampling Detection, finished product packing.
Embodiment 1：
Amphoteric surfactant 3%；
APG 8%；
Emollient 0.5%；
Anion surfactant 5%；
Suspending agent 0.5%；
Triethanolamine 1.0%；
Soft pearl 0.02% containing active component；
Preservative 0.5%；
Water surplus.
In formula：
The amphoteric surfactant is cocounut oil acyl both sexes base diethyl acid disodium.
The carbon chain lengths of the APG are C8-12。
The anion surfactant is lauramide sodium sarcosinate.
The emollient is PEG-7 olive oleates.
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer.
The preservative is Phenoxyethanol.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES RE-
508 or UNISPHERES SYE.
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 60 DEG C, stirring
Uniformly；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 6.0；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：42 DEG C are cooled to while stirring, stir 10min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 40min；
Step 7：Sampling Detection, finished product packing.
Embodiment 2：
Amphoteric surfactant 6%；
APG 6%；
Emollient 2%；
Anion surfactant 4%；
Suspending agent 2%；
Triethanolamine 0.8%；
Soft pearl 0.4% containing active component；
Preservative 0.4%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.001%；
Bacteriostatic agent 0.8%.
In formula：
The amphoteric surfactant is Cocoamidopropyl betaine.
The carbon chain lengths of the APG are C10。
The anion surfactant is lauramide sodium glutamate.
The emollient is PEG-10 olive oleates.
The suspending agent is acrylics copolymer, trade name VISCOLAM CK1.
The preservative is methylisothiazolinone.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES SGE or
UNISPHERES SRE。
The bacteriostatic agent is Triclosan.
The stabilizer is benzene azoles sulfonate derivatives, has general structure C16H16N3O4Sna。
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 65 DEG C, stirring
Uniformly；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 6.5；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：41 DEG C are cooled to while stirring, stir 12min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 35min；
Step 7：Sampling Detection, finished product packing.
Embodiment 3：
Amphoteric surfactant 9%；
APG 4%；
Emollient 3%；
Anion surfactant 3%；
Suspending agent 3%；
Triethanolamine 0.6%；
Soft pearl 0.8% containing active component；
Preservative 0.3%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.1%；
Bacteriostatic agent 0.4%.
In formula：
The amphoteric surfactant is dodecanamide propyl hydroxy sulfo lycine.
The carbon chain lengths of the APG are C8-16。
The anion surfactant is PEG-7 olive oil carboxylic acid sodiums.
The emollient is PEG-7 glyceryl cocoates.
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer.
The preservative is Phenoxyethanol.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES NT-
2202nd, Sp-BkFEB41 or Sp-VEaTR41.
The bacteriostatic agent is eugenol.
The stabilizer is three (tetramethyl hydroxy piperidine alcohol) citrates, and its structural formula is：
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 70 DEG C, stirring
Uniformly；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 7.0；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：40 DEG C are cooled to while stirring, stir 15min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 30min；
Step 7：Sampling Detection, finished product packing.
Embodiment 4：
Amphoteric surfactant 12%；
APG 2%；
Emollient 4%；
Anion surfactant 2%；
Suspending agent 4%；
Triethanolamine 0.4%；
Soft pearl 1.2% containing active component；
Preservative 0.2%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.2%；
Bacteriostatic agent 0.2%.
In formula：
The amphoteric surfactant is Cocoamidopropyl betaine.
The carbon chain lengths of the APG are C8-14。
The anion surfactant is sodium methyl cocoyl taurate.
The emollient is methyl gluceth -20.
The suspending agent is acrylics copolymer, trade name VISCOLAM CK1.
The preservative is methylisothiazolinone.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name Sp-SfOVEaUMDC41,
Sp-VEaDC56 or Sp-VApGP41.
The bacteriostatic agent is cinnamic acid or P-Cymene.
The stabilizer is four (dibutyl hydroxy cinnamic acid hydrogen season pentyl esters), and its structural formula is：
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 65 DEG C, stirring
Uniformly；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 7.5；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：39 DEG C are cooled to while stirring, stir 12min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 35min；
Step 7：Sampling Detection, finished product packing.
Embodiment 5：
Amphoteric surfactant 15%；
APG 0.1%；
Emollient 5%；
Anion surfactant 0.1%；
Suspending agent 5%；
Triethanolamine 0.02%；
Soft pearl 1.5% containing active component；
Preservative 0.001%；
Water surplus.
Also include the component of following mass percent in formula：
Stabilizer 0.3%；
Bacteriostatic agent 0.001%.
In formula：
The amphoteric surfactant is cocounut oil acyl both sexes base diethyl acid disodium.
The carbon chain lengths of the APG are C12-14。
The anion surfactant is PEG-5 laruyl alcohols citrate sulfosuccinate disodium or laureth
Sulfosuccinate disodium.
The emollient is methyl gluceth -10.
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer.
The preservative is Phenoxyethanol.
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name Sp-UM41 or Sp-
AOPL41。
The bacteriostatic agent is o-Ben Ji phenol or Isopropylmethylphenol.
The stabilizer is benzene azoles sulfonate derivatives, has general structure C16H16N3O4Sna。
The preparation method of above-mentioned children's bacteriostatic skin-care hand cleanser containing soft pearl, comprises the following steps：
Step 1：Each component is stocked up by above-mentioned formula；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 60 DEG C, stirring
Uniformly；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, are stirred to after being completely dissolved
Add triethanolamine regulation pH to 7.0；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：38 DEG C are cooled to while stirring, stir 10min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 40min；
Step 7：Sampling Detection, finished product packing.
The surfactant used in the present invention is readily biodegradable, and small, foaming abundancy, exquisiteness are stimulated to human body skin.
Emollient be from olive oil, coconut oil and glucose, it is strong with human body skin biocompatibility, to human body skin
It is non-stimulated.
Suspending agent is acrylic acid (ester) analog copolymer, itself is low viscosity emulsion, easily operated, using the teaching of the invention it is possible to provide donor
The very strong yield value of system.
Stabilizer and suspending agent ensure jointly the soft pearl containing activity can certain in the period of in be dispersed in system.
Hand cleanser prepared by the present invention after placing 2 years at room temperature, still is able to be dispersed in body in clear vial
In system, and commercially available prod is under identical condition, and its soft pearl all floats.（Referring to Fig. 1）
Hand cleanser prepared by the present invention is 1 in test concentrations:1；Testing time is under 2min, according to disposable health
Articles for use sanitary standard GB 15979-2002, to the bacteriostasis rate of staphylococcus aureus and Escherichia coli more than 90%.
Present disclosure is not limited to cited by embodiment, and those of ordinary skill in the art are by reading description of the invention
And any equivalent conversion taken technical solution of the present invention, it is that claim of the invention is covered.
Claims (1)
1. the preparation method of children's bacteriostatic skin-care hand cleanser containing soft pearl, it is characterised in that：
Comprise the following steps：
Step 1：Each component is stocked up by formula：
Amphoteric surfactant 9%；
APG 4%；
Emollient 3%；
Anion surfactant 3%；
Suspending agent 3%；
Triethanolamine 0.6%；
Soft pearl 0.8% containing active component；
Preservative 0.3%；
Water surplus；
Also include the component of following mass percent in formula：
Stabilizer 0.1%；
Bacteriostatic agent 0.4%；
In formula：
The amphoteric surfactant is dodecanamide propyl hydroxy sulfo lycine；
The carbon chain lengths of the APG are C8-16；
The anion surfactant is PEG-7 olive oil carboxylic acid sodiums；
The emollient is PEG-7 glyceryl cocoates；
The suspending agent is acrylics copolymer, trade name Carbopol Aqua SF-1 Polymer；
The preservative is Phenoxyethanol；
The soft pearl containing active component is the colored soft pearl that can crush after rubbing, trade name UNISPHERES NT-2202,
Sp-BkFEB41 or Sp-VEaTR41；
The bacteriostatic agent is eugenol；
The stabilizer is three (tetramethyl hydroxy piperidine alcohol) citrates；
Step 2：Water is added into preparing tank, and is heated, then stability contorting adds suspending agent to 70 DEG C, stirring is equal
It is even；
Step 3：Anion surfactant, APG and bacteriostatic agent are added under agitation, and stirring adds to after being completely dissolved
Triethanolamine adjusts pH to 7.0；
Step 4：Add amphoteric surfactant and stabilizer, thickener, stirring is to being completely dissolved；
Step 5：40 DEG C are cooled to while stirring, stir 15min；
Step 6：Add the soft pearl containing active component, preservative and emollient stirring 30min；
Step 7：Sampling Detection, finished product packing.
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| CN111743817A (en) * | 2020-08-20 | 2020-10-09 | 广州荃智美肤生物科技研究院有限公司 | Children washing and protecting composition containing algal polysaccharide |
| CN112494366A (en) * | 2020-09-26 | 2021-03-16 | 福建省梦娇兰日用化学品有限公司 | PCMX-containing bacteriostatic hand sanitizer for children and preparation method thereof |
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