CN1049834C - Medicine for curing hepatitis and its prepn process - Google Patents

Abstract

The present invention relates to a new medicine liver recovery medicinal granule for treating hepatitis, which is made by that the raw materials of linearleaf thistle roots or flowers, ant, sodium sulfate, giant knotweed rhizomes, milkvetch roots, orange fruits, herba agastachis, Indian madder roots, selenium, etc. are respectively pretreated and proportionally prepared by different processing methods according to different characteristics of the traditional Chinese medicines, and the medicinal granule is made by sterilization. The present invention has the advantages of unique formulation and makkng method, remarkable therapeutic effect and good therapeutic effects on hepatitis, liver cirrhosis and liver ascitic fluid.

Description

The medicine and the preparation method of treatment hepatitis

The present invention relates to a kind of medicine for the treatment of hepatitis, is to be the Chinese patent medicine of feedstock production with the Chinese herbal medicine, the invention still further relates to this process for preparing medicine.

Hepatitis is the common infectious disease of serious harm human health, and the prevalence height is cured difficulty.Treatment hepatitis does not still have ideal specific drug both at home and abroad at present, what curative effect was more satisfactory is interferon (Western medicine), and it has the broad-spectrum antivirus action, can optionally suppress duplicating of virus, hinder the diffusion of virus, but still have some problems: not lasting as hepatitis virus resisting, hepatitis B virus is appeared again in the drug withdrawal bleeding from anus liver, has side effect simultaneously, patient generally can not tolerate heavy dose of long-term treatment, and the medicine high price is expensive, and the medicine source is tighter, and clinical practice is restricted.

Treatment by Chinese herbs hepatitis is a kind of effective way, also becomes a focus of domestic medical research, and report is arranged when curing the clinical report of hepatitis with Chinese medicine.Consult Chinese patent literature, the Chinese medicine patent application about treatment hepatitis in recent years just has tens kinds." a kind of medicine of preventing and treating hepatitis B " of publication number CN1083712A adopts 9 flavor Chinese prescriptions such as the Radix Astragali, Radix Pseudostellariae, Fructus Lycii, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Polygoni Cuspidati, Radix Et Rhizoma Rhei, and hepatitis B virus is suppressed stable more lasting.Jilin Province Dunhua pharmaceutical factory adopts fiber crops back of the body Herba Senecionis cannabifolii, Radix Curcumae, the Radix Paeoniae Alba, Rhizoma Polygonati, Fructus Hordei Germinatus prescription treating the liver inflammation.The Chinese medicine for the treatment of the liver inflammation also has Herba Solani Nigri, pulls out chinaroot greenbrier, Radix Sophorae Tonkinensis; The leaf of Cycas revoluta, stem or root; Herba Oxalidis Corniculatae and Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.); Phyllanthus plant and Herba Ecliptae; Coring Semen Nelumbinis, Rhizoma Phyllostachydis henonis and root of Herba Macleayae Cordatae; Herba Artemisiae Scopariae, Herba Scutellariae Barbatae, Fructus Schisandrae Chinensis, Fructus Gardeniae, Radix Glycyrrhizae or the like.Therefore, the Chinese crude drug and the rational formula of excavation treatment hepatitis are significant.

The purpose of this invention is to provide and a kind ofly have easing the affected liver spleen invigorating, blood circulation promoting competent silt, clearing away heat-damp and promoting diuresis, enhancing human body immunity function, suppress virus, to viral hepatitis, liver cirrhosis therapeutic effect Remidies for hepatitis preferably.

Another object of the present invention provides this Remidies for hepatitis and preparation method.

Technical scheme of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to incidence of hepatitis mechanism, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out blood circulation promoting competent silt, easing the affected liver spleen invigorating, heat-clearing and toxic substances removing, zymosthenic material, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance quicken the liver microcirculation blood flow, the biosynthesis of control hepatitis B virus DNA, RNA, make the T lymphocyte transformation, impelling B is that lymphocyte produces the antibody ability, and it is synthetic to increase hepatocyte nucleic acid, strengthen immune function of human body, quicken liver cell regeneration and recover.

Medicine of the present invention is made (consumption is a weight portion) by following component:

Herba Cirsii linearis 25-30 part Formica fusca 8-10 part Natrii Sulfas 10-15 part

Rhizoma Polygoni Cuspidati 15-20 part Radix Astragali 20-25 part Fructus Aurantii 5-6 part

Radix agastaches 5-6 part Radix Aucklandiae 5-6 part Radix Rubiae 5-10 part

Selenium element 0.03-0.05 part

The formula optimization weight proportion scope of preparation medicine of the present invention is:

10 parts in 10 parts of Natrii Sulfas of 30 portions of Formica fuscas of Herba Cirsii linearis

5 parts of 20 parts of Fructus Aurantiis of 20 parts of Radixs Astragali of Rhizoma Polygoni Cuspidati

5 parts of 5 parts of Radix Rubiae of 5 parts of Radix Aucklandiae of Radix agastaches

30 parts of 0.03 part of white sugar of selenium element.

Above-mentioned component is made medicine production method of the present invention is:

1, Formica fusca is processed process of preparing Chinese medicine powdered according to a conventional method; Formica fusca can substitute with Squama Manis.

2, get Rhizoma Polygoni Cuspidati, Herba Cirsii linearis drying and crushing to 240 order fine powder;

3,, put into pot and add water 1.5-2 and doubly boiled filtering extracting liquid 10-15 minute with Fructus Aurantii, Radix agastaches, the Radix Aucklandiae, Radix Rubiae, Radix Astragali drying and crushing;

4, get Natrii Sulfas, the selenium element is put into medicinal liquid and was boiled 10-15 minute, makes its dissolving; Add Herba Cirsii linearis again, Giant Knotweed Rhizome stirs evenly and does patent medicine group;

5, medicine is rolled into a ball at 100-110 ℃ of following sterilizing-drying; Formica fusca powder is pulverized together with medicine group, made former powder, can be made into pill, tablet, also can add white sugar and make electuary with former powder.

An important feature of the present invention is: contain multiple steroid saponin in the medicine, can control virus; Contain volatile oil, can help metabolism, contain cirsilinein A and B, can increase the liver cell nuclear acid metabolic, the selenium element is the important component part of glutathion peroxidase, can strengthen the activity of enzyme, and the effect of performance cyclic adenosine monophosphate (CAMP), suppress the effect of virus, and be one of indispensable trace element of liver; Broken hard the loosing of Natrii Sulfas amassed, and diuresis is rushed down down, removing toxic substances and promoting subsidence of swelling, furunculosis carbuncle.The former powder of medicine of the present invention is pale brown color or sepia, and finished product palm fibre white has peat-reek and plant flavour of a drug, temporarily name " GANFUKANG ".

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, this product indication is wide, to treatment first, second, third, fourth, hepatitis E; Liver cirrhosis, hepatic ascites all have curative effect preferably;

2, each component of this product meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment hepatitis of the Chinese medicine of respectively distinguishing the flavor of, and no chemicals is nontoxic to human body;

3, this medicine does not have bitterness sense, taking convenience, and cost is low;

4, it is shorter to obey this medication journey, and hepatitis B clothes 2-3 month are the longest 6 months; The hepatitis A clothes 1-2 month, generally can make two double turning out cloudy property.

For showing the therapeutic effect of this medicine to hepatitis, 1993-1995 the present invention is through the clinical observation of 50 routine systems, age 4-60 year, and medical history 1-20, selecting medical history, the state of an illness, suitable hepatitis 50 examples of age is matched group.The hepatitis diagnostic criteria of working out by the viral hepatitis meeting of the May nineteen ninety whole nation: hepatitis B is HBsAg, HBeAg lasting masculin more than 1 year, continues or increases more than half a year repeatedly with serum glutamic pyruvic transminase.Hepatitis A: the HAV positive, TTT＜6, TFT-, transaminase＞35.

Test group 50 examples are taken medicine of the present invention " GANFUKANG " electuary, and service once every day sooner or later, and boiled water is taken after mixing it with water, each 10 grams.Children's is cut down according to the circumstance.

Matched group 50 examples are taken home-made Yiganling electuary, hepatitis miraculous cure thing and vitamin drug and injection anti-hepatitis B immune ribonucleic acid.

Medication period is avoided foods excitatory such as clothes raw meat, peppery, acid, few cigarette of giving up alcohol.2 months is a course of treatment, generally obeys for 2 courses of treatment, 3 courses of treatment of clothes that the course of disease is long.

During the treatment, the record clinical symptoms, sign detects the HBV sign, HBsAg, anti--HBs, HBeAg, anti--HBe, anti--HBc, HBV-DNA, ALT measured once in every month.Get same specimen when finishing each course of treatment, respectively check.

Criterion of therapeutical effect:

1, clinical cure: subjective symptoms disappears, and it is normal that every liver function test recovers, and the liver enlargement is dwindled, and does not have obvious tenderness and percussion pain, and HBsAg turns out cloudy.

2, take a turn for the better: the cardinal symptom sign takes a turn for the better, and SGPT, TTT all descend more than 80%, and the HBsAg titre descends.

3, invalid: with no change before the treatment.

Result of the test is as follows:

Table 1 liang group curative effect situation

Grouping	The example number	Cure	Take a turn for the better	Invalid	Effective percentage
							Test group	50	33	16	1	98％
Matched group	50	22	11	17	66％

Table 2 liang group contrasts cloudy commentaries on classics of HBsAg

Grouping	The example number	The routine number of the cloudy commentaries on classics of HBsAg	HBsAg titre decline routine number more than 70%	Effective percentage
						Test group	50	19	28	94％
Matched group	50	5	16	21％

Table 3 liang group is analyzed cloudy commentaries on classics of HBeAg

	The positive routine number of HBeAg	The routine number of the cloudy commentaries on classics of HBeAg	Negative conversion rate
					Test group	41	35	85％
Matched group	25	6	24％

Above efficacy result shows that the treatment group is better than matched group.In 50 examples with medicament of the present invention, clinical cure account for 66%, 32% of improvement, total effective rate 98%, the healing that patient's course of disease is long is slow, the short healing of the course of disease is fast, children's's placental infection is cured difficult.Clinical model case is as follows:

Case 1: English when, woman, 50 years old, suffer from chronic hepatitis B, the HBsAg positive, the HBeAg positive, anti--the HBc positive, TTT12, TFT+++, B ultrasonic are diagnosed as liver cirrhosis, anasarca, pain under the left and right rib, hepatomegaly following 3 centimetres in rib, spleen can touch, constipation due to dry stool, and urine is yellow, stringy pulse, yellow and thin fur, card belongs to asthenia of liver and spleen, damp-heat blocking in the body.Control suitable spleen invigorating easing the affected liver, clearing away heat-damp and promoting diuresis, eliminating turbid pathogen with aromatics, the detoxifcation of regulating the flow of vital energy.Treatment clothes GANFUKANG electuary 2 months, HBeAg, anti--HBc turn out cloudy, and the ultrasound diagnosis liver function recovery is normal, and PCR detects the HBV-DNA feminine gender, and it is normal that physical symptom recovers.

Case 2: Luo Chengyuan, man, 39 years old, the main suit: before 2 years, conscious dizziness is weak, inappetence, distending pain under the right rib, certain city center examination in hospital, the conscience function is impaired, GPT raises, HBsAg, the positive, the HBeAg positive, be diagnosed as chronic hepatitis B, ultrasound diagnosis liver parenchyma sexually transmitted disease (STD) becomes, and through the treatment of Chinese and Western patent medicine, the state of an illness does not have alleviation.Check: complexion is gloomy, and sclera is not yellow, following 2 centimetres of hepatomegaly in right rib, and spleen can touch, GPT120 unit, ZnTT18 unit, TTT15 unit, the HBsAg positive, the HBeAg positive, anti--the HBC positive.Card is seen: body of the tongue is red partially, distending pain under white and thin fur, root of the tongue white and greasy fur, thready and stringy pulse, dizzy weak, distension and fullness in the abdomen, the right rib, bitter taste poor appetite, big loose stool are thin, urine yellow skin etc.Card belongs to deficiency-weakness of spleen-QI, and is damp and hot unclear.Treatment: invigorating the spleen and benefiting QI, clearing away heat-damp and promoting diuresis, nourishing blood to suppress the hyperactive liver.Clothes GANFUKANG 2 months, appetite increases, and stool is shaped, and distending pain disappears under the rib.Look into liver function, GPT is normal, and ZnTT12 unit, TTT6 unit, HBeAg turn out cloudy, resist-the HBs positive.Continued to take 2 months, the check liver function, GPT is normal, ZnTT10 unit, TTT4 unit, HBsAg, HBeAg, anti--HBC turn out cloudy, and the liver spleen does not touch, and visits 1 year half, repeatedly checks liver function, and 2 pairs half of hepatitis B are all normal, and life and work is good.

Embodiment:

Take by weighing raw material by following proportioning:

10 kilograms in 10 kilograms of Natrii Sulfas of 30 kilograms of Formica fuscas of Herba Cirsii linearis

5 kilograms of 20 kilograms of Fructus Aurantiis of 20 kilograms of Radixs Astragali of Rhizoma Polygoni Cuspidati

5 kilograms of 5 kilograms of Radix Rubiae of 5 kilograms of Radix Aucklandiae of Radix agastaches

30 kilogram of 240 order fine powder of selenium element 50 gram white sugar; Get Fructus Aurantii, Radix agastaches, the Radix Aucklandiae, Radix Rubiae, Radix Astragali drying and crushing again, put into pot and add water 1.5-2 doubly, boiled filtering extracting liquid 10-15 minute; Natrii Sulfas, selenium element are put into medicinal liquid boiled 10-15 minute, make its dissolving; Add Herba Cirsii linearis again, Giant Knotweed Rhizome stirs evenly, and does patent medicine group; Medicine is rolled into a ball at 100-110 ℃ of following sterilizing-drying; Formica fusca powder, white sugar sterilization back are pulverized together with medicine group, make electuary.Do not add white sugar and can make pill, tablet.The also available Squama Manis of Formica fusca in the raw material substitutes.Pack every bag 10 gram.

Claims (4)

1, a kind of medicine for the treatment of hepatitis is characterized in that it is the medicament of being made by the following weight proportion raw material: Herba Cirsii linearis 25-30 part Formica fusca 8-10 part Natrii Sulfas 10-15 part Rhizoma Polygoni Cuspidati 15-20 part Radix Astragali 20-25 part Fructus Aurantii 5-6 part Herba Pogostemonis 5-6 part Radix Aucklandiae 5-6 part Radix Rubiae 5-10 part selenium element 0.03-0.05 part.

2, the medicine of treatment hepatitis according to claim 1, wherein the weight proportion of each raw material is: 0.03 part of 5 parts of selenium element of 5 parts of Radix Rubiae of 5 parts of Radix Aucklandiae of 5 portions of Herba Pogostemoniss of 20 parts of Fructus Aurantiis of 20 parts of Radixs Astragali of 10 parts of Rhizoma Polygoni Cuspidati of 10 parts of Natrii Sulfas of 30 portions of Formica fuscas of Herba Cirsii linearis

3, the medicine of treatment hepatitis according to claim 1 and 2 is characterized in that said medicament is powder or electuary.

4, the preparation method of the medicine of treatment hepatitis according to claim 3 is characterized in that taking by weighing each raw material by formulation weight, earlier Formica fusca is processed process of preparing Chinese medicine powdered according to a conventional method; Get Rhizoma Polygoni Cuspidati, Herba Cirsii linearis drying and crushing to 240 order fine powder; With Fructus Aurantii, Herba Pogostemonis, the Radix Aucklandiae, Radix Rubiae, Radix Astragali drying and crushing, put into pot and add water 1.5-2 and doubly boiled filtering extracting liquid 10-15 minute; Get Natrii Sulfas, the selenium element is put into medicinal liquid and was boiled 10-15 minute, makes its dissolving; Add Herba Cirsii linearis, Giant Knotweed Rhizome again, stir evenly, do patent medicine group; Medicine is rolled into a ball at 100-110 ℃ of following sterilizing-drying; Formica fusca powder is pulverized together with medicine group, made former powder; Add white sugar and then make electuary.