CN104940978A - Preparation method of antimicrobial and breathable dressing - Google Patents
Preparation method of antimicrobial and breathable dressing Download PDFInfo
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- CN104940978A CN104940978A CN201510323072.4A CN201510323072A CN104940978A CN 104940978 A CN104940978 A CN 104940978A CN 201510323072 A CN201510323072 A CN 201510323072A CN 104940978 A CN104940978 A CN 104940978A
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Abstract
The invention discloses a preparation method of antimicrobial and breathable dressing. The preparation method comprises the following steps: mixing sodium carboxymethylcellulose, butanediol and chitosan in parts by weight, performing ultrasound treatment to obtain a mixture I; mixing a lotus leaf extract, mannitol, acrylamide and a plasticizer, heating to be 70-110 DEG C within 20-30 min, performing heat preservation, cooling to room temperature to obtain a mixture II; adding the mixture II to the mixture I to be subjected to ultrasound treatment, cooling, placing into a stirrer, dropwise adding an acid solution until the PH value is 5-6, uniformly stirring to obtain a mixture III; soaking absorbent gauze in the mixture III, placing into a dryer for drying, sealing, packaging and sterilizing to obtain the antimicrobial and breathable dressing. The antimicrobial and breathable dressing prepared by adopting the preparation method provided by the invention not only has an excellent antimicrobial performance, but also can improve the water vapor permeability to achieve the effect of air permeability, therefore the preparation method can be extensively applied to the clinic treatment.
Description
Technical field
The present invention relates to field of medical materials, the preparation method of particularly a kind of antibacterial, ventilating dressing.
Background technology
Dressing refers to the auxiliary genus material outside for article major ingredient, and a critical function of Morden wound dressing, is the critical function that replacing damaged skin, and acts on to wound healing and skin lesion healing always.It can be resisted mechanical factor (as foul, collision, inflammation etc.), resist pollution and chemical stimulation; Prevent two degree of infection; Prevent dry and body fluid loss (electrolyte loss); Prevent heat from losing; Initiatively affect wound healing process by debridement, create the microenvironment promoting wound healing.
But existing dressing in use, breathability is poor, and wound surface easily causes superinfection, causes antibacterial to breed at wound, affects the treatment.
Summary of the invention
In order to overcome above-mentioned defect, the technical problem that the present invention solves provides a kind of preparation method of antibacterial, ventilating dressing, obtained dressing not only has excellent anti-microbial property, can moisture-vapor transmission be improved simultaneously, reach ventilative effect, can be widely used in clinical treatment.
The technical solution used in the present invention is:
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, 5-17 part sodium carboxymethyl cellulose, 20-26 part butanediol and 39-56 part chitosan are mixed, after ultrasonic, obtains mixture one;
(2) 2-8 part Folium Nelumbinis extract, 13-21 part mannitol, 3-8 part acrylamide and 1-12 part plasticiser are mixed, in 20-30min, be heated to 70-110 DEG C, insulation, obtains mixture two after being cooled to room temperature;
(3) mixture two is added carry out in mixture one ultrasonic, cooling, then being placed in agitator, to drip acid solution to PH be 5-6, obtains mixture three after stirring;
(4) be soaked in mixture three by absorbent carbasus, be placed in drying machine drying, sealing, packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
In above-mentioned steps (1), ultrasonic time is 10-25min, and temperature is 60-80 DEG C.
In above-mentioned steps (2), plasticiser is the compositions of one or more in epoxy soybean oil, citric acid tri butyl ester, tributyl 2-acetylcitrate.
In above-mentioned steps (2), temperature retention time is 30-50min.
In above-mentioned steps (3), ultrasonic time is 20-40min, and temperature is 40-70 DEG C.
Above-mentioned steps (3) acid solution is hydrochloric acid.
In above-mentioned steps (3), agitator speed is 800-1200r/min.
In above-mentioned steps (4), soak time is 60-90min.
In above-mentioned steps (4), in dehydrator, temperature is set to 70-100 DEG C, and the time is 20-30min.
beneficial effect
The dressing staphylococcus aureus sterilizing rate that the present invention obtains is between 92.5-98.9%, escherichia coli sterilizing rate is between 98.0-99.3%, citrobacter sterilizing rate is between 95.2-97.8%, moisture-vapor transmission is between 434-456 g/m2/24h, due to the synergism between component, not only there is excellent anti-microbial property, can moisture-vapor transmission be improved simultaneously, reach ventilative effect, can be widely used in clinical treatment.
Detailed description of the invention
Embodiment 1
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 5 parts of sodium carboxymethyl cellulose, 20 parts of butanediols and 39 parts of chitosan mixing, at 60 DEG C of temperature, after ultrasonic 10min, mixture one is obtained;
(2) by 2 parts of Folium Nelumbinis extracts, 13 portions of mannitol, 3 parts of acrylamides and 1 part of epoxy soybean oil mixing, in 20min, be heated to 70 DEG C, insulation 30min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 20min at 40 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 800r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 60min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 70 DEG C, and the time is 20min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Embodiment 2
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 17 parts of sodium carboxymethyl cellulose, 26 parts of butanediols and 56 parts of chitosan mixing, at 80 DEG C of temperature, after ultrasonic 25min, mixture one is obtained;
(2) by 8 parts of Folium Nelumbinis extracts, 21 portions of mannitol, 8 parts of acrylamides and 12 parts of citric acid tri butyl ester mixing, in 30min, be heated to 110 DEG C, insulation 50min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 40min at 70 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 1200r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 90min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 100 DEG C, and the time is 30min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Embodiment 3
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 7 parts of sodium carboxymethyl cellulose, 22 parts of butanediols and 41 parts of chitosan mixing, at 65 DEG C of temperature, after ultrasonic 15min, mixture one is obtained;
(2) by 3 parts of Folium Nelumbinis extracts, 15 portions of mannitol, 4 parts of acrylamides and 3 parts of tributyl 2-acetylcitrate mixing, in 22min, be heated to 75 DEG C, insulation 35min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 25min at 45 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 900r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 70min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 75 DEG C, and the time is 22min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Embodiment 4
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 14 parts of sodium carboxymethyl cellulose, 25 parts of butanediols and 52 parts of chitosan mixing, at 75 DEG C of temperature, after ultrasonic 22min, mixture one is obtained;
(2) by 7 parts of Folium Nelumbinis extracts, 18 portions of mannitol, 7 parts of acrylamides and 9 parts of tributyl 2-acetylcitrate mixing, in 28min, be heated to 100 DEG C, insulation 40min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 30min at 60 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 1100r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 80min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 90 DEG C, and the time is 25min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Embodiment 5
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 12 parts of sodium carboxymethyl cellulose, 24 parts of butanediols and 46 parts of chitosan mixing, at 70 DEG C of temperature, after ultrasonic 20min, mixture one is obtained;
(2) by 6 parts of Folium Nelumbinis extracts, 17 portions of mannitol, 5 parts of acrylamides and 8 parts of plasticiser mixing, in 25min, be heated to 90 DEG C, insulation 40min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 35min at 60 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 1000r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 70min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 80 DEG C, and the time is 25min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Comparative example 1
Do not add Folium Nelumbinis extract with the difference of embodiment 5.
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 12 parts of sodium carboxymethyl cellulose, 24 parts of butanediols and 46 parts of chitosan mixing, at 70 DEG C of temperature, after ultrasonic 20min, mixture one is obtained;
(2) by 17 portions of mannitol, 5 parts of acrylamides and 8 parts of plasticiser mixing, in 25min, be heated to 90 DEG C, insulation 40min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 35min at 60 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 1000r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 70min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 80 DEG C, and the time is 25min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Comparative example 2
Do not add acrylamide with the difference of embodiment 5.
A preparation method for antibacterial, ventilating dressing, comprises the following steps:
(1) by weight, by 12 parts of sodium carboxymethyl cellulose, 24 parts of butanediols and 46 parts of chitosan mixing, at 70 DEG C of temperature, after ultrasonic 20min, mixture one is obtained;
(2) by 6 parts of Folium Nelumbinis extracts, 17 portions of mannitol, 5 parts of acrylamides and 8 parts of plasticiser mixing, in 25min, be heated to 90 DEG C, insulation 40min, obtains mixture two after being cooled to room temperature;
(3) add in mixture one by mixture two, ultrasonic 35min at 60 DEG C of temperature, cooling, then being placed in agitator, to drip hydrochloric acid solution to PH be 5-6, obtain mixture three after stirring, wherein agitator speed is 1000r/min;
(4) be soaked in by absorbent carbasus in mixture three, the time is 70min, then is placed in drying machine drying, and wherein in dehydrator, temperature is set to 80 DEG C, and the time is 25min, sealing, and packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
Performance test:
Carry out performance test according to YY/T0471.2-2004 to the dressing that embodiment 1-5 and comparative example 1-2 makes, result is as shown in the table:
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Comparative example 1 | Comparative example 2 | |
| Staphylococcus aureus sterilizing rate (%) | 92.5 | 93.4 | 96.5 | 94.7 | 98.9 | 76.9 | 89.3 |
| Escherichia coli sterilizing rate (%) | 98.0 | 98.4 | 98.1 | 98.8 | 99.3 | 92.7 | 88.4 |
| Citrobacter sterilizing rate (%) | 95.2 | 96.7 | 97.1 | 96.9 | 97.8 | 85.5 | 78.0 |
| Moisture-vapor transmission (g/m 2/24h） | 434 | 440 | 448 | 445 | 456 | 376 | 323 |
As can be seen from the above table: the dressing staphylococcus aureus sterilizing rate that embodiment 1-5 obtains is between 92.5-98.9%, escherichia coli sterilizing rate is between 98.0-99.3%, citrobacter sterilizing rate is between 95.2-97.8%, and moisture-vapor transmission is at 434-456 g/m
2between/24h; Do not add Folium Nelumbinis extract in comparative example 1, staphylococcus aureus sterilizing rate is 76.9%, and escherichia coli sterilizing rate is 92.7%, and citrobacter sterilizing rate is 85.5%, and moisture-vapor transmission is 376 g/m
2/ 24h; Do not add acrylamide in comparative example 2, staphylococcus aureus sterilizing rate is 89.3%, and escherichia coli sterilizing rate is 88.4%, and citrobacter sterilizing rate is 78.0%, and moisture-vapor transmission is 323 g/m
2/ 24h.It can thus be appreciated that, the dressing that the present invention obtains be due to component between synergism, not only there is excellent anti-microbial property, can moisture-vapor transmission be improved simultaneously, reach ventilative effect, can be widely used in clinical treatment.
Claims (9)
1. a preparation method for antibacterial, ventilating dressing, is characterized in that, comprises the following steps:
(1) by weight, 5-17 part sodium carboxymethyl cellulose, 20-26 part butanediol and 39-56 part chitosan are mixed, after ultrasonic, obtains mixture one;
(2) 2-8 part Folium Nelumbinis extract, 13-21 part mannitol, 3-8 part acrylamide and 1-12 part plasticiser are mixed, in 20-30min, be heated to 70-110 DEG C, insulation, obtains mixture two after being cooled to room temperature;
(3) mixture two is added carry out in mixture one ultrasonic, cooling, then being placed in agitator, to drip acid solution to PH be 5-6, obtains mixture three after stirring;
(4) be soaked in mixture three by absorbent carbasus, be placed in drying machine drying, sealing, packaging, namely obtains described antibacterial, ventilating dressing after ultraviolet-sterilization.
2. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (1), ultrasonic time is 10-25min, and temperature is 60-80 DEG C.
3. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (2), plasticiser is the compositions of one or more in epoxy soybean oil, citric acid tri butyl ester, tributyl 2-acetylcitrate.
4. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (2), temperature retention time is 30-50min.
5. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (3), ultrasonic time is 20-40min, and temperature is 40-70 DEG C.
6. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: described step (3) acid solution is hydrochloric acid.
7. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (3), agitator speed is 800-1200r/min.
8. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (4), soak time is 60-90min.
9. the preparation method of antibacterial, ventilating dressing according to claim 1, is characterized in that: in described step (4), in dehydrator, temperature is set to 70-100 DEG C, and the time is 20-30min.
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| CN201510323072.4A CN104940978A (en) | 2015-06-14 | 2015-06-14 | Preparation method of antimicrobial and breathable dressing |
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| CN201510323072.4A CN104940978A (en) | 2015-06-14 | 2015-06-14 | Preparation method of antimicrobial and breathable dressing |
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| CN108992703A (en) * | 2018-08-17 | 2018-12-14 | 佛山市森昂生物科技有限公司 | A kind of preparation method of highly-breathable medical gel material |
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
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| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
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Application publication date: 20150930 |