CN103357061B - Production method of surgical dressing by irradiation sterilization - Google Patents
Production method of surgical dressing by irradiation sterilization Download PDFInfo
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- CN103357061B CN103357061B CN201310252067.XA CN201310252067A CN103357061B CN 103357061 B CN103357061 B CN 103357061B CN 201310252067 A CN201310252067 A CN 201310252067A CN 103357061 B CN103357061 B CN 103357061B
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- vaseline
- compound
- irradiation
- wound
- gauze
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 12
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 12
- 229940099259 vaseline Drugs 0.000 claims abstract description 39
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 31
- 206010052428 Wound Diseases 0.000 claims abstract description 30
- 230000029663 wound healing Effects 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 13
- 206010061218 Inflammation Diseases 0.000 claims abstract description 10
- 230000004054 inflammatory process Effects 0.000 claims abstract description 10
- 230000001737 promoting effect Effects 0.000 claims abstract description 10
- 239000002131 composite material Substances 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 36
- 229920001661 Chitosan Polymers 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 14
- 239000000835 fiber Substances 0.000 claims description 13
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- 210000000589 cicatrix Anatomy 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 8
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 8
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 8
- 239000011425 bamboo Substances 0.000 claims description 8
- 229920002101 Chitin Polymers 0.000 claims description 7
- 241001264174 Cordyceps militaris Species 0.000 claims description 7
- 229920000742 Cotton Polymers 0.000 claims description 7
- 244000269722 Thea sinensis Species 0.000 claims description 5
- 235000010410 calcium alginate Nutrition 0.000 claims description 5
- 229960002681 calcium alginate Drugs 0.000 claims description 5
- 239000000648 calcium alginate Substances 0.000 claims description 5
- 239000004744 fabric Substances 0.000 claims description 5
- 238000012986 modification Methods 0.000 claims description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 4
- 235000013824 polyphenols Nutrition 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 3
- 238000003618 dip coating Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 239000003792 electrolyte Substances 0.000 abstract description 2
- 208000014674 injury Diseases 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract 2
- 208000032544 Cicatrix Diseases 0.000 abstract 1
- 208000003322 Coinfection Diseases 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 230000037387 scars Effects 0.000 abstract 1
- 241001330002 Bambuseae Species 0.000 description 7
- 238000007664 blowing Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000010410 dusting Methods 0.000 description 4
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- -1 compound calcium alginate Chemical class 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 208000023329 Gun shot wound Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004078 waterproofing Methods 0.000 description 1
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- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a production method of a surgical dressing by irradiation sterilization, and relates to the technical field of production of surgical dressings. The production method is characterized in that natural-occurring substance powder with the functions of fighting bacteria, diminishing inflammation, reducing scars, promoting wound healing and relieving pain is mixed with vaseline to obtain composite vaseline, the vaseline is combined with a medical gauze, and then the processed medical gauze is sterilized in an irradiation manner, thus the surgical dressing by irradiation sterilization has outstanding coverage, and can prevent a wound from mechanical injury, polluting and chemical stimulation, resist dry, moisture and secondary infection, reduce the loss of electrolyte and energy, actively promote the wound healing, and change the micro-environmental impact; in addition, the surgical dressing cannot be adhered with the wound, so that the wound healing is promoted, and no second damage is brought to the wound during dressing change.
Description
Technical field
The present invention relates to the production technical field of medical dressing.
Background technology
People's skin is made up of three layers of epidermis, corium and subcutaneous tissue, has the invasion of the outer pathogenetic bacteria of opposed body, and excretion human body waste prevents that body moisture evaporation scatters and disappears, and mediator's temperature is experienced the critical function such as stimulation of pressure, temperature, chemicals.Because of wound, gunshot wound, when burn and festering etc. causes skin damage, be easy to germ contamination, moisture content runs off, there is inflammation, the complication such as pain, when treatment, need to protect wound surface and wound healing with medical dressing, the absorbent cotton that traditional medical dressing is conventional or cotton gauze processed, the medical dressing that viscose rayon etc. are processed into, in use, directly be applied on wound, by pressing the effect of playing hemostasis and covering wound, but wound is in the time of healing, often there will be dressing and wound to stick together, unsuitable wound healing, while changing dressings, can bring secondary to destroy to wound, bring misery to patient, trauma wounds feature Intradermal tissue exposes, easily infect, wound also has a large amount of blood or effluent.
Summary of the invention
The medical dressing production method of the function irradiation sterilizations such as the object of the invention is to provide a kind of and has good spreadability, prevent germ contamination, have antibacterial, pain relieving simultaneously, wound healing promoting.
The compound vaseline of the present invention's dip-coating on hospital gauze, cold wind dry up, press from both sides film compound, cut into slices, pack and irradiation, described compound vaseline is by vaseline and have natural materials powder antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions and form.
The present invention will have antibacterial, diminish inflammation, reduce cicatrix, wound healing promoting, natural materials powder and the vaseline of pain-relieving functions are mixed to form compound vaseline, through being combined with hospital gauze, again through irradiation sterilization, there is excellent spreadability, also tool is resisted wound and damaged by mechanical factor, pollute and chemical stimulation, anti-drying, moist, two degree infect, reduce electrolyte and loss of power, initiatively affect wound healing, microenvironment impact etc., and there will not be dressing and wound to stick together, improve the healing effect of wound, while changing dressings, more can not bring secondary to destroy to wound.
In addition, the present invention is under 35~50 DEG C of temperature environments, in the agitator of 1000~5000r/min, by vaseline with have a natural materials superfine powder mix homogeneously antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions.
The mixing temperature of selecting and rotating speed can guarantee that natural materials superfine powder fully mixs homogeneously with vaseline.
Described have powder antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions can be in tea polyphenols, Cordyceps militaris (L.) Link., chitin, chitosan or chitosan at least any one.
Described hospital gauze is bamboo fibre gauze or chitosan gauze etc.
Hospital gauze was soaked in the compound vaseline of 40~60 DEG C, control hospital gauze containing compound vaseline amount by selected dipping temperature, the speed of soaking, and determined through clinical test of many times, the hospital gauze soaking is containing compound vaseline amount 180~280g/m
2for the best.
Antibacterial in order to ensure having, to diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions natural materials powder is in the distribution of hospital gauze and wound contact surface, the rapid condensation of compound vaseline on hospital gauze on streamline, described cold wind dries up, and cold wind temperature is-10~-30 DEG C.
In addition, in order to save the consumptions such as expensive chitin or chitosan, dry up simultaneously at cold wind, evenly spray the natural materials such as chitin or chitosan powder to hospital gauze and wound contact surface.Can make that effective ingredient concentrates on gauze with wound contact surface one side, be also beneficial to raising drug effect.
Described folder film is compound is the compound PE film that can open before use on hospital gauze and wound contact surface, in the another side composite water absorbing dressing of hospital gauze.
Described water suction dressing is calcium alginate fibre or carboxymethyl-modification cotton cloth etc.
Described irradiation is before and after adopting automatically to hospital gauze after packing, stand up piling suspension chain up and down carries out continuous irradiation, position, source coding is designated as 13855 ± 10, suspended chain speed electrical quantity is 15~25Hz, is 1.2~1.5 with batch product box unevenness, irradiation dose is 15~26KGY, guarantees that irradiation affects and in little situation, reaches again sterilization effect natural materials superfine powder effect.
The present invention's remarkable advantage compared with existing medical dressing is: 1, the present invention selects bamboo fibre, chitosan gauze, itself has fine air permeability, water absorption, has again natural antibacterial, a biocidal property.2, compound vaseline coordinates and covers wound surface with calcium alginate fibre or carboxymethyl-modification cotton cloth, because internal layer vaseline has water proofing property, is difficult for and water mixing, can prevent gauze and wound surface adhesion, and the lubricated sticky wound of tool, promotes granulation growth; Outer floor height water suction dressing can absorb again the effluent oozing out, and can keep well the certain humidity of wound surface and the favourable wound healing of microenvironment.3, select containing pain relieving, hemostasis, promotion wound healing, reduce the natural materials micropowders such as cicatrix, antibacterial tea polyphenols, Cordyceps militaris (L.) Link., chitin, chitosan, chitosan, take respectively to mix with vaseline, dust when air-cooled, be conducive to according to each natural materials physicochemical property, reasonable price utilization the more economical large effect of performance tool.4, adopt reasonable irradiation technique, can ensure that medical dressing is aseptic, guarantee again effect of natural materials.5, in technique, adopting hospital gauze to be coated with compound vaseline is the method for soaking fast, can be by temperature, soaked speed controlling gauze oil content, and favourable industrial scale is produced again.
Detailed description of the invention
Embodiment mono-:
Step 1: compound vaseline allotment, in 38 DEG C of conditions, 3000r/min high-speed stirred vaseline situation, adds the above tea polyphenols of 400 order, Cordyceps militaris (L.) Link. micropowder.Mass ratio is: Fan Shilin ︰ tea many phenol ︰ Cordyceps militaris (L.) Link.=1000 ︰ 8 ︰ 6.5.
Step 2: compound vaseline is heated to 50 DEG C of conditions, allows bamboo fibre gauze soak fast, in the bamboo fibre gauze that Negotiation speed control was soaked, is 210g/m containing compound vaseline amount
2.
Step 3: by cooling fast the bamboo fibre gauze that is impregnated with compound vaseline, adopt the two-tube netted blowing from the top down of inside and outside layer, inner tube is for dusting, to spray micropowder be chitin, make chitin being uniformly distributed with wound contact surface one side of bamboo fibre gauze, the amount of dusting is 0.21g/m
2; Outer tube blowing, blowing temperature is-28 DEG C, guarantees that compound vaseline condenses at hospital gauze.
Step 4: folder film is compound, bamboo fibre gauze with the compound PE film that can open in use of wound contact surface one side, the high water suction of another side compound calcium alginate fiber gauze or carboxymethyl-modification cotton cloth dressing.
Step 5: slice packaging, after section, product adopts the aluminum film compounded packaging of paper, and anti-secondary pollution and vaseline ooze out.
Step 6: irradiation technique, to select automatic front and back, stand up piling suspension chain continuous irradiation mode up and down, position, source coding is designated as 13850, suspended chain speed electrical quantity is 18Hz, is 1.4 with batch product box unevenness, and irradiation dose is 23KGY.
Embodiment bis-:
Step 1: compound vaseline allotment, in 40 DEG C of conditions, 3500r/min high-speed stirred vaseline situation, adds the above chitosan of 400 order, Cordyceps militaris (L.) Link. micropowder.The mass ratio that feeds intake is: Fan Shilin ︰ shell gathers sugared ︰ Cordyceps militaris (L.) Link.=1000 ︰ 2 ︰ 6.5.
Step 2: heating to 45 DEG C of conditions at compound vaseline, chitosan gauze was soaked fast, is 220g/m containing compound vaseline amount in the chitosan gauze that Negotiation speed control was soaked
2.
Step 3: by cooling fast the chitosan gauze that is impregnated with compound vaseline, adopt the two-tube netted blowing from the top down of inside and outside layer, inner tube is for dusting, spray micropowder chitosan and be coated with compound kpetrolatum gauze and the distribution of wound contact surface, the amount of dusting is 0. 10 g/m
2; Outer tube blowing, blowing temperature is-25 DEG C, guarantees that compound vaseline condenses at hospital gauze.
Step 4: folder film is compound, scribble compound vaseline chitosan gauze with the compound PE film that can open in use of wound contact surface, the high water suction of another side compound calcium alginate fiber gauze or carboxymethyl-modification cotton cloth dressing.
Step 5: slice packaging, by semi-finished product section compound folder film, and adopt the aluminum film compounded packaging of paper, anti-secondary pollution and vaseline ooze out.
Step 6: irradiation technique, to select automatic front and back, stand up piling suspension chain continuous irradiation mode up and down, position, source coding is designated as 13850, suspended chain speed electrical quantity is 18Hz, is 1.3 with batch product box unevenness, and irradiation dose is 19KGY.
Claims (5)
1. the medical dressing production method of an irradiation sterilization, comprise following sequential steps: on hospital gauze the compound vaseline of dip-coating, cold wind dry up, press from both sides film compound, cut into slices, pack and irradiation, described compound vaseline is by vaseline and have natural materials powder antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions and form; It is characterized in that described hospital gauze is bamboo fibre gauze or chitosan gauze; Described folder film is compound be hospital gauze with wound contact surface on the compound PE film that can open before use, in the another side composite water absorbing dressing of hospital gauze, described water suction dressing is calcium alginate fibre or carboxymethyl-modification cotton cloth; Described have natural materials powder antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions comprise in tea polyphenols, Cordyceps militaris (L.) Link., chitin, chitosan or chitosan at least any one; Hospital gauze was soaked in the compound vaseline of 40~60 DEG C, and making the hospital gauze soaking is 180~280g/m containing compound vaseline amount
2.
2. a kind of medical dressing production method of irradiation sterilization according to claim 1, it is characterized in that under 35~50 DEG C of temperature environments, in the agitator of 1000~5000r/min, by vaseline with there is natural materials powder mix homogeneously antibacterial, that diminish inflammation, reduce cicatrix, wound healing promoting, pain-relieving functions.
3. a kind of medical dressing production method of irradiation sterilization according to claim 1, is characterized in that cold wind temperature when described cold wind dries up is-10~-30 DEG C.
4. according to the medical dressing production method of a kind of irradiation sterilization described in claim 1 or 3, it is characterized in that drying up simultaneously and evenly spraying natural materials powder to hospital gauze with wound contact surface at cold wind.
5. a kind of medical dressing production method of irradiation sterilization according to claim 1, it is characterized in that described irradiation is before and after adopting automatically to hospital gauze after packing, stands up piling suspension chain up and down and carry out continuous irradiation, position, source coding is designated as 13855 ± 10, suspended chain speed electrical quantity is 15~25Hz, is 1.2~1.5 with batch product box unevenness, and irradiation dose is 15~26KGY.
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CN201310252067.XA CN103357061B (en) | 2013-06-24 | 2013-06-24 | Production method of surgical dressing by irradiation sterilization |
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CN201310252067.XA CN103357061B (en) | 2013-06-24 | 2013-06-24 | Production method of surgical dressing by irradiation sterilization |
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CN103357061A CN103357061A (en) | 2013-10-23 |
CN103357061B true CN103357061B (en) | 2014-11-26 |
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CN103550818A (en) * | 2013-11-07 | 2014-02-05 | 海安县美佳卫生用品有限公司 | Preparation method of medical sterile gauze |
CN103643382A (en) * | 2013-12-05 | 2014-03-19 | 吴江市亨德利纺织厂 | Medical binding cloth |
CN104307033B (en) * | 2014-09-23 | 2015-12-30 | 枝江奥美医疗用品有限公司 | A kind of preparation method of antibacterial ventolin dressing and antibacterial ventolin dressing |
CN106540305A (en) * | 2015-09-17 | 2017-03-29 | 珠海和凡医药股份有限公司 | A kind of preparation of Kaolin bamboo fibre gauze and its new application |
CN110559467B (en) * | 2018-06-06 | 2024-08-06 | 上海交通大学 | A micro-nano magnesium hydride antibacterial and anti-inflammatory wound dressing |
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JP4263871B2 (en) * | 2002-03-14 | 2009-05-13 | ユニチカ株式会社 | Wound dressing and method for producing the same |
TWI263501B (en) * | 2004-06-29 | 2006-10-11 | Taiwan Textile Res Inst | Sponge wound dressing made from chitin and alginate and method for forming the same |
CN103143052A (en) * | 2013-03-13 | 2013-06-12 | 潘华倩 | Medical collagen dressing as well as preparation method and use thereof |
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Non-Patent Citations (2)
Title |
---|
Studies on gelatin-based sponges.Part III:A comparative study of cross-linked gelatin/alginate,gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat;Y.S.CHOI et al.;《JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE》;20011231;第12卷;第67-73页 * |
Y.S.CHOIetal..Studiesongelatin-basedsponges.PartIII:Acomparativestudyofcross-linkedgelatin/alginate gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat.《JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE》.2001 * |
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