CN104940883A - Lung warming chemical fiber granule and preparation method thereof - Google Patents
Lung warming chemical fiber granule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a lung warming chemical fiber granule which comprises, by mass, 10-15 parts of prepared rehmannia roots, 10-15 parts of cornu cervi degelatinatum, 9 parts of baked ginger charcoal, 4 parts of cinnamon, 8-10 parts of Chinese ephedra, 8-10 parts of honey-fried licorice roots and 10 parts of red flowers. A preparation method of the lung warming chemical fiber granule comprises the steps that decoction, concentration, alcohol precipitation and drying are conducted on all the traditional Chinese medicine to obtain dry powder, after the dry powder is mixed with dextrin, acesulfame is added into the mixture, a granule is prepared, and a finished product is obtained. The lung warming chemical fiber granule is a pure traditional Chinese medicine preparation, the side effects are few, and the price is low; according to the preparation method, the decoction is conducted for two times, the effective constituents of the medicine can be effectively extracted to prepare the granule to be used conveniently.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of warming the lung chemical fibre granule and preparation method thereof.
Background technology
The clinical manifestation of idiopathic pulmonary fibrosis is agnogenic chronic exertional dyspnea, and with cough, two base of lung crackles rale and drumstick finger, hypoxemia.The traditional Chinese medical science thinks that the patient of idiopathic pulmonary fibrosis mostly is innate deficiency of YANG in the body, or after being long-term chronic cough or serious disease prolonged illness, undermines lungs life, lung qi deficiency and coldness, can not cloth Tianjin, or is that disease is to the later stage, involve the sun of the spleen kidney heart, occur edema due to YANG-insufficiency, or deficiency of YIN affecting YANG, deficiency of both YIN and YANG, cause accumulatively wet raise phlegm, cold blood stasis, forming yang deficiency is this, and the expectorant stasis of blood is the card of mark, therefore Therapeutic Method focuses on warming YANG to expel cold, reduce phlegm clots absorbing.So whole process is theoretical for instructing with warming the lung, with warming YANG legislation, initiative " warming the lung chemical fibre granule ".Doctor trained in Western medicine think idiopathic pulmonary fibrosis be a kind of agnogenio, with Diffuse alveolar the scorching and disorderly disease finally causing interstitial pulmonary fibrosis to be feature of alveolar structure.The international practice guidelines of 2011 idiopathic pulmonary fibrosises explicitly points out except lung transplantation, that a kind of medicine can treat idiopathic pulmonary fibrosis effectively not have evidence to confirm, and up-to-date fibrosis doctor trained in Western medicine has just entered large-scale clinical trial in China at present as pirfenidone, uncertain therapeutic efficacy is cut, and expensive (880 yuan, a box), a month minimum expenditure of 20,000 yuan, patient economy burden weight.And this medicine side effect is many, serious to infringements such as liver functions.
Summary of the invention
In order to overcome, prior art Chinese medicine and western medicine drug effect is imprecise, side effect is large, expensive defect, provides a kind of warming the lung chemical fibre granule and preparation method thereof.
The present invention is realized by following proposal:
A kind of warming the lung chemical fibre granule, in mass parts, comprises following component: Radix Rehmanniae Preparata 10-15 part, Cornu Cervi Degelatinatum 10-15 part, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, Herba Ephedrae 8-10 part, Radix Glycyrrhizae Preparata 8-10 part, 10 parts, Flos Carthami.
In mass parts, this warming the lung chemical fibre granule also comprises following component: Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.
In mass parts, this warming the lung chemical fibre granule also comprises 8 parts, Semen Persicae.
A preparation method for warming the lung chemical fibre granule, comprises the following steps:
The first step, taking Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum, carbonized Rhizoma Zingiberis (processed), Cortex Cinnamomi, Herba Ephedrae, Radix Glycyrrhizae Preparata, all taste Chinese medicine of Flos Carthami decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, adds ethanol to concentrated solution and carries out precipitate with ethanol, then filter, and being concentrated into density is 1.14g/mL, and then drying obtains dry powder;
3rd step, adds acesulfame potassium after being mixed by dry powder with dextrin, then adds the ethanol drying that volume fraction is 85%, then adds water and make granule, namely obtain warming the lung chemical fibre finished granule.
In a first step, described all taste Chinese medicine decocts with water and is divided into twice, the first time of twice decoction decocts as 80-100 minute, and second time decocts as 100-120 minute, merges and be concentrated into the concentrated solution that density is 1.1g/mL after twice decoction after being filtered by twice decocting liquid respectively.
In second step, in concentrated solution, add ethanol to volume fraction of ethanol is 60% carry out precipitate with ethanol.
In the third step, the mass ratio of dry powder, dextrin and acesulfame potassium is 400-600:800-1300:3.
In a first step, in mass parts, take following all taste Chinese medicine: Radix Rehmanniae Preparata 10-15 part, Cornu Cervi Degelatinatum 10-15 part, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, Herba Ephedrae 8-10 part, Radix Glycyrrhizae Preparata 8-10 part, 10 parts, Flos Carthami.
In a first step, also add Semen Sinapis Albae, Eupolyphaga Seu Steleophaga, Rhizoma Chuanxiong, Pheretima, Semen Persicae decoct together, in mass parts, take Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts, 8 parts, Semen Persicae respectively.
Beneficial effect of the present invention is:
1. a kind of warming the lung chemical fibre granule pure Chinese medicinal preparation of the present invention, few side effects, low price, easily promotes, really played the traditional Chinese medical science " test, letter, just, honest and clean " special advantage.And improve that patient is uncomfortable in chest, the clinical symptoms such as to breathe hard, the quality of life of patient is improved, and slows down the disease progression of patient, adds the life confidence of patient, and the treatment for idiopathic pulmonary fibrosis provides a kind of feasible system of selection;
2. the preparation method of a kind of warming the lung chemical fibre granule of the present invention is by twice decoction, and effectively can extract the effective ingredient of medicine, the granule made is easy to use.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described:
Embodiment 1
A kind of warming the lung chemical fibre granule, in mass parts, comprises following component: Radix Rehmanniae Preparata 15 parts, Cornu Cervi Degelatinatum 12 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 8 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 10 parts, 10 parts, Flos Carthami.In mass parts, this warming the lung chemical fibre granule also comprises 8 parts, Semen Persicae.
A preparation method for warming the lung chemical fibre granule, comprises the following steps:
The first step, in mass parts, takes following all taste Chinese medicine: Radix Rehmanniae Preparata 15 parts, Cornu Cervi Degelatinatum 12 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 8 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 10 parts, 10 parts, Flos Carthami, 8 parts, Semen Persicae.All taste Chinese medicine decocts with water twice, it is 90 minutes that the first time of twice decoction decocts, it is 100 minutes that second time decocts, merging after respectively twice decocting liquid being filtered after twice decoction and be concentrated into the concentrated solution that density is 1.1g/mL, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 60% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, and then drying obtains dry powder;
3rd step, adds acesulfame potassium after being mixed by dry powder with dextrin, and then add the ethanol drying that volume fraction is 85%, then add water and make granule, namely obtain warming the lung chemical fibre finished granule, wherein, the mass ratio of dry powder, dextrin and acesulfame potassium is 600:1000:3.
In clinical, Semen Sinapis Albae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Pheretima are that doctor adds according to dialectical the taking the circumstances into consideration afterwards of typing.Through being in hospital and outpatient procedures, all side effect is there is not in warming the lung chemical fibre granule of the present invention in Jiangxi hospital.
Monarch drug in side: Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum.
Radix Rehmanniae Preparata, sweet tepor, yin nourishing of enriching blood, life essence-filling, marrow-benefitting; Cornu Cervi Degelatinatum salty in the mouth is warm in nature, can reinforcing the kidney and supporting YANG.Reuse Radix Rehmanniae Preparata temperature compensation nutrient blood in side, life essence-filling, marrow-benefitting, and probably vegetation is merciless, power is difficult sufficient, again with the genus of the tangible essence and blood of Cornu Cervi Degelatinatum to support it.Two medicines share, warming YANG and invigorating blood, are monarch drug altogether.
Ministerial drug in side: Cortex Cinnamomi, carbonized Rhizoma Zingiberis (processed), Semen Persicae, Flos Carthami.
Cortex Cinnamomi, the pungent temperature of the carbonized Rhizoma Zingiberis (processed) property of medicine, all enter blood system, warming YANG to expel cold, warming the meridian and promoting blood circulation, leads Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum straight as it, with Cheng Qigong.Flos Carthami is warm in nature, promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing." book on Chinese herbal medicine converge with speech ": " Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.”
Semen Persicae is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.All parts of the country are generally cultivated.There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.Semen Persicae is sweet flat, and blood circulation promoting and blood stasis dispelling, controls cloperastine and breathe heavily." Bencao Jingshu ": " Semen Persicae, property is apt to removing blood stasis, falls apart and does not receive, rush down and do not mend." Flos Carthami, Semen Persicae share feasible blood and dissolving stasis, makes blood unobstructed.
Adjuvant drug in side: Semen Sinapis Albae, Herba Ephedrae, Rhizoma Chuanxiong, Pheretima, Radix Salviae Miltiorrhizae.
The pungent temperature of Semen Sinapis Albae, can reach outside flesh side film, warming for resolving cold-phlegm, activating collaterals and eliminating stagnation; A small amount of Herba Ephedrae Xin Wendawei, the logical hair key of a surname, open the flesh natural fibre line of meat, cold expelling coagulates.The pungent temperature of Rhizoma Chuanxiong, blood-activating and qi-promoting, is " the gas medicine in blood ", has sensible QI and blood effect; Pheretima moral character walks string, is good at current meridians; Eupolyphaga Seu Steleophaga removing blood stasis.
Chinese medicine compound is a very complicated system, the principle of disease therapy is just by number of ways and link, act on multiple target spot produce Integrate adjustment and play therapeutical effect, from single effective ingredient, its physiologically active may be strong not as Western medicine, but multiple composition together plays physiologically active, people are referred to as visually " canister shot is theoretical ".A large amount of clinical practice shows that the compound effect formed under guidance of traditional Chinese medicine theory will be far superior to several modern pharmacology experiment to prove to have the Chinese medicine simple combination of certain effect.This is because the Chinese medicine under instruction of Chinese Medicine theory, especially compound recipe, any one active component all can not reflect its overall curative effect embodied comprehensively, and this is the maximum characteristic of Chinese medicine.Many research also finds that the active ingredient of Chinese herbs obtained through complicated purification process is purer, and pharmacological action is poorer, and therefore, in most cases, the active component units of Chinese medicine should be divided into master with assembly.
Embodiment 2
A kind of warming the lung chemical fibre granule, in mass parts, comprises following component: Radix Rehmanniae Preparata 10 parts, Cornu Cervi Degelatinatum 15 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 9 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 8 parts, 10 parts, Flos Carthami.In mass parts, this warming the lung chemical fibre granule also comprises 8 parts, Semen Persicae.
In mass parts, this warming the lung chemical fibre granule also comprises following component: Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.
A preparation method for warming the lung chemical fibre granule, comprises the following steps:
The first step, in mass parts, take following all taste Chinese medicine: Radix Rehmanniae Preparata 10 parts, Cornu Cervi Degelatinatum 15 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 9 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 8 parts, 10 parts, Flos Carthami, 8 parts, Semen Persicae, Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.All taste Chinese medicine decocts with water twice, it is 80 minutes that the first time of twice decoction decocts, it is 120 minutes that second time decocts, merging after respectively twice decocting liquid being filtered after twice decoction and be concentrated into the concentrated solution that density is 1.1g/mL, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 60% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, and then drying obtains dry powder;
3rd step, adds acesulfame potassium after being mixed by dry powder with dextrin, and then add the ethanol drying that volume fraction is 85%, then add water and make granule, namely obtain warming the lung chemical fibre finished granule, wherein, the mass ratio of dry powder, dextrin and acesulfame potassium is 400:1300:3.
Embodiment 3
A kind of warming the lung chemical fibre granule, in mass parts, comprises following component: Radix Rehmanniae Preparata 12 parts, Cornu Cervi Degelatinatum 10 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 10 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 9 parts, 10 parts, Flos Carthami.In mass parts, this warming the lung chemical fibre granule also comprises following component: Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.In clinical practice, if patient has the situation of diarrhoea, then do not add Semen Persicae, in order to avoid increase the weight of diarrhoea.
A preparation method for warming the lung chemical fibre granule, comprises the following steps:
The first step, in mass parts, takes following all taste Chinese medicine: Radix Rehmanniae Preparata 12 parts, Cornu Cervi Degelatinatum 10 parts, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, 10 parts, Herba Ephedrae, Radix Glycyrrhizae Preparata 9 parts, 10 parts, Flos Carthami, Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.All taste Chinese medicine decocts with water twice, it is 100 minutes that the first time of twice decoction decocts, it is 110 minutes that second time decocts, merging after respectively twice decocting liquid being filtered after twice decoction and be concentrated into the concentrated solution that density is 1.1g/mL, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, in concentrated solution, add ethanol to volume fraction of ethanol is 60% carry out precipitate with ethanol, and then filter, being concentrated into density is 1.14g/mL, and then drying obtains dry powder;
3rd step, adds acesulfame potassium after being mixed by dry powder with dextrin, and then add the ethanol drying that volume fraction is 85%, then add water and make granule, namely obtain warming the lung chemical fibre finished granule, wherein, the mass ratio of dry powder, dextrin and acesulfame potassium is 500:800:3.
Following is a list several clinical case to be described in detail to warming the lung chemical fibre granule of the present invention.
Case 1: beam so-and-so, female, 73 years old, first visit on June 12 in 2012.There is asthma uncomfortable in chest without obvious inducement before patient tells March, after activity more so, next level namely need have a rest, and occur cough, with dry be main without hemoptysis, without chest pain, then go to a doctor in certain province Grade A hospital, the inspection of row breast CT point out interstitial pneumonia.Pulmonary function prompting disperse reduces because patient previously has diabetic history 10 years, and in more than 20 years of osteoporosis medical history, should not give glucocorticoid treatment, spy comes me and institute seeks Chinese traditional treatment.Be admitted to hospital and see: tachypnea uncomfortable in chest, after activity more so, cough, based on dry cough, dizzy, xerostomia, bitter taste, fear of cold, night hyperhidrosis, receive can, sleep is general, and just put down, tongue is dark red, and tongue is white, deep-thready pulse.Have a medical check-up: two thorax are symmetrical, and intercostal space is not broadening, both sides vocal fremitus is symmetrical, percussion sore throat relieving, and the two pulmonary respiration sound of auscultation is clear, two lower lung audible and rale.After being admitted to hospital, patient adheres to taking warming the lung chemical fibre granule of the present invention, and on June 29th, 2012, state of an illness improvement was left hospital.See when leaving hospital: even have cough, cough a little sticky expectorant, movable metathorax stifling is short obviously to be improved, not dizzy, xerostomia, bitter taste, fear of cold, the disease such as sweating at night alleviates, receive can, peace of sleeping night, two just flat tongue is dark red, and tongue is white, and deep-thready pulse adheres to after leaving hospital taking former side treatment in outpatient service always, still can manage household affairs.
Case 2: man, 38 years old, first visit on January 30 in 2012. patient told and occurred cough and asthma symptom before 2 year, with dry cough for main companion's white foam expectorant, rose morning and coughed very, pant with time upstairs and power-walking time obvious.Once symptom of coughing after local hospital diagnosis and treatment slightly alleviates, but dry cough still sustainable existence repeatedly increasing the weight of.This time medically suffered from cold before 10 days, when examining, patient's dry cough companion white foam expectorant, breathes out of breath, exhales to inhale few more, and emaciated physique, aversion to cold is lossless, and conjunctival congestion is full of the blood streak, and pale tongue is dark, Bao Bai, thready and stringy pulse.After patient takes warming the lung chemical fibre granule of the present invention, with examining check after one month, patient's dry cough symptom is obviously alleviated, and without obvious asthma uncomfortable in chest, asthma symptom is also not obvious upstairs, erythrocyte sedimentation rate and c reactive protein are all in normal range, blood gas analysis: PH7.36, partial pressure of carbon dioxide 43mmHg, partial pressure of oxygen 80mmHg, Morbidity control is stablized, and patient is back on the job.
Case 3: patient, female, 71 years old, because gas uncomfortable in chest forces April, increases the weight of first quarter moon and is admitted to hospital on August 16th, 2012.To be admitted to hospital disease opinion: spiritlessness and weakness, gas uncomfortable in chest is forced, and walk level road sense difficulty, cough and expectoration is not obvious, and expectorant is few, and xerostomia is for drink, and overall pain, without fever with aversion to cold, poor appetite, night sleeps not good enough, and two just put down, and red tongue is secretly purple, white and thin fur, thready and stringy pulse.There is myelomatosis multiplex history.Have a medical check-up: two pulmonary respiration sound is thick, twice lung audibles and obviously Velcro rale, drumstick finger.Lab testing: blood gas analysis (oxygen uptake 3L/min): arterial blood acid/base degree (pH): 7.45, partial pressure of carbon dioxide (PaCO2): 37mmHg, partial pressure of oxygen (PaO2): 68mmHg; Erythrocyte sedimentation rate (ESR): 28mm/h; C reactive protein (CRP): 10.42mg/L; Blood cell analysis is normal, pulmonary function: diffusion reduces.Breast CT is pointed out: interstitial pulmonary fibrosis changes.Western medicine diagnose: interstitial pulmonary fibrosis; Tcm diagnosis: consumptive lung disease.According to patient's disease, tongue, arteries and veins, dialectical is the yang deficiency expectorant stasis of blood, controls and reduces phlegm with warming YANG, the method for blood circulation promoting and blood stasis dispelling, selects warming the lung chemical fibre granule of the present invention, coordinates Breviscapini injection blood circulation promoting and blood stasis dispelling, SHENMAI ZHUSHEYE reinforcing body resistance, acetylcysteine effervescent tablet fibrosis.After nearly 20 doses of patient consumes, asthma uncomfortable in chest alleviates, and slightly coughs, coughs up phlegm, and red tongue is dark, white and thin fur, thready pulse stringy and rolling pulse.ESR, CRP are all in normal range in check, blood gas analysis (oxygen uptake 3L/min): pH value 7.39, PaCO2 36mmHg, PaO2 90mmHg, improve leave hospital in the JIUYUE state of an illness on the 5th.After this patient treats 6 courses for the treatment of (2 weeks per courses for the treatment of) at undergraduate course continuously, and patient chest stifling is forced and is comparatively before clearly better, can stair activity alone, occasionally have cough, expectoration, feasible simple housework, quality of life significantly improves, life confidence obviously strengthens, and the check lung CT prompting state of an illness does not further develop.Adhere to that taking warming the lung chemical fibre soup in undergraduate course outpatient service is main treatment at present.In present case, patient is old women, weak weakened body resistance, and source is lost in the hair growth promoting of lungs yang-energy, and replenishing vital QI with drugs of warm nature is incompetent, and gasify unable, then spiritlessness and weakness, gas uncomfortable in chest is forced; Pneumonopathy and spleen, dysfunction of the spleen in transportation and transformation, undermines kidney yang, lung, spleen, insufficiency of kidney-YANG, gasifies unable, and the raw expectorant of body fluid cohesion is raw wet, occurs expectoration symptom; Yang deficiency then blood is unfavorable, the solidifying then thrombosis of expectorant, and blood stasis is at tongue, then red tongue is purple dark, blood stasis at arteries and veins, then thready and stringy pulse; Blood stasis stagnation of phlegm, with the passing of time can strongly fragrant and heat-transformation, consumption of body fluid by heat therefore occur xerostomia.The basic pathogenesis of primary disease is yang deficiency cold coagulation, the stagnant blood stasis of expectorant, and through warming the lung chemical fibre soup treatment warming YANG to expel cold, reduce phlegm clots absorbing, strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental, and this routine Morbidity control, clinical efficacy is satisfaction comparatively.Though patient is even xerostomia, the partially dry symptom of stool, regulate through adequate diet, above-mentioned symptom multipotency is corrected in time, does not occur other scorching symptom always, though illustrate that warming the lung chemical fibre soup temperature is not dry.
Although done comparatively detailed elaboration to technical scheme of the present invention and enumerated; be to be understood that; to those skilled in the art; amendment is made to above-described embodiment or adopts equivalent replacement scheme; this is apparent to those skilled in the art; these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (9)
1. a warming the lung chemical fibre granule, is characterized in that, in mass parts, comprises following component: Radix Rehmanniae Preparata 10-15 part, Cornu Cervi Degelatinatum 10-15 part, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, Herba Ephedrae 8-10 part, Radix Glycyrrhizae Preparata 8-10 part, 10 parts, Flos Carthami.
2. a kind of warming the lung chemical fibre granule according to claim 1, is characterized in that, in mass parts, this warming the lung chemical fibre granule also comprises following component: Semen Sinapis Albae 10 parts, Eupolyphaga Seu Steleophaga 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts.
3. a kind of warming the lung chemical fibre granule according to claim 2, is characterized in that: in mass parts, and this warming the lung chemical fibre granule also comprises 8 parts, Semen Persicae.
4. a preparation method for warming the lung chemical fibre granule, is characterized in that, comprises the following steps:
The first step, taking Radix Rehmanniae Preparata, Cornu Cervi Degelatinatum, carbonized Rhizoma Zingiberis (processed), Cortex Cinnamomi, Herba Ephedrae, Radix Glycyrrhizae Preparata, all taste Chinese medicine of Flos Carthami decocts with water, being concentrated into decocting after the decocting liquid obtained filters the concentrated solution that density is 1.1g/mL;
Second step, adds ethanol to concentrated solution and carries out precipitate with ethanol, then filter, and being concentrated into density is 1.14g/mL, and then drying obtains dry powder;
3rd step, adds acesulfame potassium after being mixed by dry powder with dextrin, then adds the ethanol drying that volume fraction is 85%, then adds water and make granule, namely obtain warming the lung chemical fibre finished granule.
5. a kind of warming the lung chemical fibre granule according to claim 4, it is characterized in that: in a first step, described all taste Chinese medicine decocts with water and is divided into twice, the first time of twice decoction decocts as 80-100 minute, second time decocts as 100-120 minute, merges and be concentrated into the concentrated solution that density is 1.1g/mL after twice decoction after being filtered by twice decocting liquid respectively.
6. a kind of warming the lung chemical fibre granule according to claim 4, is characterized in that: in second step, and in concentrated solution, add ethanol to volume fraction of ethanol is 60% carry out precipitate with ethanol.
7. a kind of warming the lung chemical fibre granule according to claim 4, is characterized in that: in the third step, and the mass ratio of dry powder, dextrin and acesulfame potassium is 400-600:800-1300:3.
8. a kind of warming the lung chemical fibre granule according to claim 4, it is characterized in that, in a first step, in mass parts, take following all taste Chinese medicine: Radix Rehmanniae Preparata 10-15 part, Cornu Cervi Degelatinatum 10-15 part, carbonized Rhizoma Zingiberis (processed) 9 parts, Cortex Cinnamomi 4 parts, Herba Ephedrae 8-10 part, Radix Glycyrrhizae Preparata 8-10 part, 10 parts, Flos Carthami.
9. a kind of warming the lung chemical fibre granule according to claim 4, it is characterized in that: in a first step, also add Semen Sinapis Albae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Pheretima, Semen Persicae decoct together, in mass parts, take Semen Sinapis Albae 10 parts, Radix Salviae Miltiorrhizae 8 parts, Rhizoma Chuanxiong 10 parts, Pheretima 10 parts, 8 parts, Semen Persicae respectively.
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|---|---|---|---|---|
| CN117257913A (en) * | 2023-11-23 | 2023-12-22 | 江西中医药大学附属医院 | Lung-warming chemical fiber granule and preparation method thereof |
| CN117257913B (en) * | 2023-11-23 | 2024-01-26 | 江西中医药大学附属医院 | Lung-warming chemical fiber granule and preparation method thereof |
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Application publication date: 20150930 |