CN104940871A - Traditional Chinese medicine composition for treating nephritis of pigs and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating nephritis of pigs and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating nephritis of pigs. The traditional Chinese medicine composition is prepared from poria cocos, polyporus, atractylodes macrocephala koidz, alisma plantago-aquatica, astragalus membranaceus, radix stephaniae tetrandrae, prepared common monkshood daughter root, liquorice, dried ginger and Chinese yam, and can be an aqueous solution. The traditional Chinese medicine composition is prepared through the following steps: (1), weighing all traditional Chinese medicines according to the formula ratio and putting the traditional Chinese medicines into an extracting tank; (2), adding water into the extracting tank for stewing for 2-12 h, wherein the amount of water is 5-15 times of that of the traditional Chinese medicines; (3), filtering to remove herb residues and retaining filtrate for standby application; (4), putting the herb residues into the extracting tank again and adding water into the extracting tank for stewing for 2-12 h, wherein the amount of water is 5-15 times of that of the herb residues; (5), filtering to remove herb residues, and mixing obtained liquid with the extracting solution obtained at the first time; (6), concentrating under reduced pressure at 40-80 DEG C until the volume is 10%-50% of the original volume; (7), filtering to remove residues and filling, wherein each bottle is filled with 200-500 ml of the medical solution. The traditional Chinese medicine composition provided by the invention has the efficacy of inducing diuresis for removing edema, invigorating the spleen, tonifying qi, nourishing Yin and kidney, and powerfully tonifying spleen and kidney-yang and the cure rate of the traditional Chinese medicine composition for nephritis of pigs can reach 95% or above.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind ofly treat Chinese medicine composition of Ren sus domestica inflammation and preparation method thereof.
Background technology
Nephritis typically refers to the general designation of glomerule, renal tubules or interstitial tissue of kidney's being inflamed property pathological change.The cause of disease of nephritis is illustrated not yet completely, thinks that the factor such as the generation of disease and infection, poisoning and allergy is relevant at present.Pig eats moldy feed, drink poison sewage, or eats poisonous plants by mistake, and flu is caught cold or abdominal part is played and fallen down and is upset, and can fall ill.In addition, some infectious disease, as influenza, anthrax, infectious pleurisy, bovine pasteurellosis, tuberculosis, swine fever, pig erysipelas, foot and mouth disease, canine distemper and streptococcal infection etc. all can secondary, concurrent nephritis.Sick pig main manifestations is that spirit is depressed, loss of appetite, and body temperature raises, and palpitates quickly, and difficulty is slightly felt in walking, and the back of a bow is bent over, and under when standing, extremity opening type combines in abdomen, outside compressing kidney district sensitivity increases, and pain is obvious.Edema is had between extremity, scrotum.Frequent micturition, hypourocrinia, indivedual sick pig sees there is anuria phenomenon.Urine color is secretly dense, and when containing a large amount of erythrocyte in urinating, urine is pink colour, even occurs hematuria.In urine, protein content increases, and proportion increases, and microscopy can find urinary cast, kidney epithelium and erythrocyte.When the course of disease is longer, there is edema in whole body, some secondary uremias.Renal pelvis and excess of the kidney matter are acute inflammation change, the comparable normal nephrauxe of holonephros volume about a times.Treatment not in time or improper much dead.
The therapy that current treatment Ren sus domestica inflammation is commonly used is antibiotic therapy, eliminates infect with medicines such as penicillin, streptomycin, kanamycin.In recent years in view of the important function of immunoreation in nephritis morbidity, start clinically to apply some immunosuppressant treatment nephritis.Also need when there being obvious edema to add diuretic.The drawback of these western medicines is that side effect is large.The research for the treatment of by Chinese herbs Ren sus domestica inflammation was fewer in the past, and effect neither be clearly.Therefore exploitation effectively can treat the Chinese medicine preparation of Ren sus domestica inflammation is this area problem demanding prompt solution.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of Chinese medicine composition evident in efficacy.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of Ren sus domestica inflammation.
Another technical problem that the present invention will solve is: the preparation method providing the water preparation of above-mentioned Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of Ren sus domestica inflammation, is characterized in that: be prepared from by the raw material of following mass fraction: Poria 10-20 part, Polyporus 9-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Alismatis 8-15 part, Radix Astragali 9-15 part, Radix Stephaniae Tetrandrae 4-10 part, Radix Aconiti Lateralis Preparata 7-12 part, Radix Glycyrrhizae 4-7 part, Rhizoma Zingiberis 5-10 part, Rhizoma Dioscoreae 6-15 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows: 20 parts, Poria, Polyporus 12 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Rhizoma Alismatis 11 parts, the Radix Astragali 13 parts, Radix Stephaniae Tetrandrae 5 parts, Radix Aconiti Lateralis Preparata 7 parts, 4 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 5 parts, Rhizoma Dioscoreae 10 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, described preparation can be water preparation.
Further, the preparation method of the water preparation of said composition is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 5 ~ 15 times amount decocting in water is added 2 ~ 12 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 5 ~ 15 times amount decocting in water 2 ~ 12 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 40 ~ 80 DEG C are evaporated to original volume 10% ~ 50%; (7) filter cleaner fill, every bottle of 200 ~ 500ml.
The advantage that the present invention has and good effect are:
(1) this prescription is according to tcm theory, and scientific compatibility, selects dampness diuretic, spleen invigorating QI invigorating, YIN nourishing to support the natural Chinese medicine of kidney, adopt simple and easy to do method to obtain a kind of Chinese medicinal aqua.Water preparation obtained by the present invention being used for clinical trial, reaching more than 95% to the cure rate of Ren sus domestica inflammation, be better than traditional Western medicine therapy, and overcome antibiotic and easily produce drug resistance, the shortcoming that side effect is large, is a kind of Novel veterinary drug of environmental protection.
(2) pharmacology of each raw material of Chinese medicine of the present invention is:
Poria: this product sweet in the mouth and light, Gan Zeneng mends, light, can ooze, mild in medicine property and, both can be eliminating evil, again can righting, diuretic and do not hinder healthy energy is the key medicine of inducing diuresis to remove edema.The various edema of cold and heat and asthenia and sthenia can be controlled.Edema, dysuria that treatment retention of water-damp in the body is caused, normal being equal to Rhizoma Alismatis, Polyporus, the Rhizoma Atractylodis Macrocephalae, is used.Poria sweet in the mouth, is apt to into spleen channel, and energy spleen invigorating invigorating middle warmer, is equipped with the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, treatment weakness of the spleen and stomach, fatigue and weakness, lack of appetite loose stool.
Polyporus: sweet light the oozing of this product is let out, diuretic effect is comparatively strong, can be used for the various edema of retention of water-damp, single application and desirable effect.Often be equal to Rhizoma Alismatis, Poria, the Rhizoma Atractylodis Macrocephalae with treating the caused edema of retention of water-damp in the body, dysuria.
The Rhizoma Atractylodis Macrocephalae: this product sweetness and bitterness is warm in nature, main returns taste warp, and with spleen invigorating, dampness for Main Function, what praised by forefathers is " spleen air making-up and spleen enlivening first key medicine ".The spleen has the function to transport and transform nutrients, and because of deficiency of spleen-QI, transporting is lost strong, and often water is wet interior raw, causes all cards of lack of appetite, edema.The Rhizoma Atractylodis Macrocephalae had both been longer than QI invigorating and had been transported with multiple spleen, again can dampness, diuresis is with except damp.Can be same with controlling edema due to deficiency of the spleen with Poria.
Rhizoma Alismatis: this product is light oozes, its diuretic effect is comparatively strong, the wet edema of stopping poultry for the treatment of water, dysuria, often and Poria, Polyporus, Rhizoma Atractylodis Macrocephalae adapted.
The Radix Astragali: the sweet temperature of this product, is apt to into taste, is invigorating the spleen and replenishing QI key medicine.Can invigorating the spleen and replenishing QI, again can inducing diuresis to remove edema, treating both the principal and secondary aspects of a disease, for controlling the key medicine of deficiency of vital energy edema, the product compatibility of the normal and inducing diuresis to remove edema such as the Rhizoma Atractylodis Macrocephalae, Poria.
Radix Stephaniae Tetrandrae: profit falls in this product bitter cold, energy clearing away heat and promoting diuresis, is apt to away descending and rushes down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-heat in the urinary bladder, being especially suitable for lower limbs edema, dysuria person.With Poria, the Radix Astragali with knowing swollen with the whole body can be controlled, oliguria.
Radix Aconiti Lateralis Preparata: this product is pungent sweet warm, have high complement sun, the effect of boosting source of fire for eliminating abundance of yin, all kidneys, spleen, the heart all dirty decline of YANG QI weak persons all can apply.Be equal to use with Poria, the Rhizoma Atractylodis Macrocephalae, can deficiency of spleen-YANG and kidneyYANG be controlled, in aqueous vapor, stop caused dysuria, limbs edema.
Radix Glycyrrhizae: this product sweet in the mouth, is apt to, into middle Jiao, to have the power of invigoration spleen qi.Because its effect relaxes, should as adjuvant use, normal with Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, the Radix Astragali etc. invigorating the spleen and replenishing QI medicine compatibility for the card of deficiency-weakness of spleen-QI.Radix Glycyrrhizae also can Radix Aconiti Lateralis Preparata poison is strong in the side of reduction property in addition.
Rhizoma Zingiberis: this product is hot, enters the heart, spleen, kidney channel, in having warming YANG to keep, and effect that recuperating depleted YANG is promoted blood circulation.Be often use with Radix Aconiti Lateralis Preparata mutual reinforcement between, control deficiency of heart-YANG and kidney-YANG, yin-cold excess caused YANG-depletion is fainted inverse, faint pulse being about to disappear person.
Rhizoma Dioscoreae: this product nature and flavor are sweet flat, energy invigorating the spleen and replenishing QI, nourishes spleen the moon, is used for deficiency-weakness of spleen-QI or deficiency of both QI and YIN, becomes thin weak, lack of appetite.This product can also the kidney invigorating gas, doublely can nourish kidney yin, to all empty persons of spleen kidney, its mend also contribute to the day after tomorrow supplementing nutrition congenital.Be applicable to the soreness of the waist and knees of deficiency of kidney-QI, nocturia.
The traditional Chinese medical science is thought, nephritis is unbalance relevant with vital QI being weakened and pathogen being violent, and the kidney being the origin of congenital constitution, and kidney is that the essence of five ZANG-organs and six FU-organs hides it.It is not solid that deficiency of the kidney then seals Tibetan, and vital essence leaks, and can not collect the essence of five ZANG-organs and six FU-organs gas.Above-mentioned ten taste medicine compatibilities use, and have invigorating the spleen and replenishing QI, YIN nourishing supports kidney, effect of high spleen reinforcing nephrons sun, can control edema caused by deficiency of spleen-YANG and kidneyYANG, vital essence deficiency, dysuria, all cards of albuminuria.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
Treat a Chinese medicinal aqua for Ren sus domestica inflammation, the parts by weight of each raw material are as follows: 20 parts, Poria, Polyporus 12 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Rhizoma Alismatis 11 parts, the Radix Astragali 13 parts, Radix Stephaniae Tetrandrae 5 parts, Radix Aconiti Lateralis Preparata 7 parts, 4 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 5 parts, Rhizoma Dioscoreae 10 parts.Its preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 10 times amount decocting in water is added 6 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 10 times amount decocting in water 6 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 60 DEG C are evaporated to original volume 10%; (7) filter cleaner fill, every bottle of 200ml.
Embodiment 2
Treat a Chinese medicinal aqua for Ren sus domestica inflammation, the parts by weight of each raw material are as follows: 18 parts, Poria, Polyporus 9 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Rhizoma Alismatis 8 parts, the Radix Astragali 15 parts, Radix Stephaniae Tetrandrae 6 parts, Radix Aconiti Lateralis Preparata 8 parts, 5 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 6 parts, Rhizoma Dioscoreae 10 parts.Its preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 10 times amount decocting in water is added 6 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 10 times amount decocting in water 6 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 60 DEG C are evaporated to original volume 10%; (7) filter cleaner fill, every bottle of 200ml.
Embodiment 3
Treat a Chinese medicinal aqua for Ren sus domestica inflammation, the parts by weight of each raw material are as follows: 14 parts, Poria, Polyporus 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Alismatis 10 parts, the Radix Astragali 10 parts, Radix Stephaniae Tetrandrae 10 parts, Radix Aconiti Lateralis Preparata 10 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 8 parts, Rhizoma Dioscoreae 12 parts.Its preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 10 times amount decocting in water is added 6 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 10 times amount decocting in water 6 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 60 DEG C are evaporated to original volume 10%; (7) filter cleaner fill, every bottle of 200ml.
Embodiment 4
Treat a Chinese medicinal aqua for Ren sus domestica inflammation, the parts by weight of each raw material are as follows: 10 parts, Poria, Polyporus 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Alismatis 15 parts, the Radix Astragali 12 parts, Radix Stephaniae Tetrandrae 7 parts, Radix Aconiti Lateralis Preparata 9 parts, 7 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 7 parts, Rhizoma Dioscoreae 6 parts.Its preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 10 times amount decocting in water is added 6 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 10 times amount decocting in water 6 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 60 DEG C are evaporated to original volume 10%; (7) filter cleaner fill, every bottle of 200ml.
Embodiment 5
Treat a Chinese medicinal aqua for Ren sus domestica inflammation, the parts by weight of each raw material are as follows: 11 parts, Poria, Polyporus 12 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Alismatis 12 parts, the Radix Astragali 9 parts, Radix Stephaniae Tetrandrae 4 parts, Radix Aconiti Lateralis Preparata 12 parts, 5 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 10 parts, Rhizoma Dioscoreae 15 parts.Its preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 10 times amount decocting in water is added 6 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 10 times amount decocting in water 6 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) 60 DEG C are evaporated to original volume 10%; (7) filter cleaner fill, every bottle of 200ml.
Clinical trial
Experiment 1:
Shandong Province villager has raised 10 sows.For reducing expenses, what this foster householder will throw something and feed is the mixed fodder will prepared with a small amount of Semen Maydis powder, wheat flour, rapeseed cake, pomace etc. after corn straw, Caulis et Folium Oryzae bubble system.Had 1 sow to occur not eating or drinking before one week, constipation, the phenomenon such as hematuria, urine color in early days in aubergine, afterwards in kermesinus.Owing to not treating in time, this sow is dead within 3 days.Cut open the visible kidney serious swelling of inspection sick dead pig, about larger than normal kidney 2 ~ 3 times, other organs are without significant change.Find again that similar clinical symptoms has appearred in 2 sows recently.Analyzing reason may be improper relevant with feeding manner.Because the nutritive value in straw, Caulis et Folium Oryzae is lower, great majority can not be absorbed by pig body, cause the noxious substance needing metabolism to increase.In addition, may be mouldy or rotten when corn straw and Caulis et Folium Oryzae soak retting in water, even produce some noxious substances, form renal inflammation, time serious, there will be hematuria phenomenon.So stop corn straw and the Caulis et Folium Oryzae of feeding retting immediately, and use the water preparation obtained by the embodiment of the present invention 1 to treat.According to 200ml water preparation: the sick pig of ratio mixing relief of 150Kg drinking water is freely drunk, and drinks 7 days continuously.By treating timely and effectively, 2 sows return to one's perfect health, and spirit, appetite, urine all recover normal, and no longer include new cases.
Test 1 result and prove to use the scorching determined curative effect of water preparation treatment Ren sus domestica obtained by the embodiment of the present invention 1, if treatment can make disease pig fully recover in time.
Experiment 2:
Pig farm, Shanxi Province has again part pig to fall ill after influenza, and disease sees that disease pig spirit is depressed, is slow in action, loss of appetite.Body temperature is between 38 DEG C ~ 39 DEG C.Blepharoedema, under abdomen, all visible edema in the place such as oxter, occasionally has a small amount of urine, stool magma.Happiness is sleeping, and when standing by force, wave on foot, hind leg is marked time, and keeps down again immediately.Compressing kidney district, pain is obvious.Get the chemical examination of disease pig urcine, visible obviously albuminuria.Ren sus domestica inflammation is diagnosed as according to clinical symptoms and lab test results.This pig farm successively has 52 pig morbidities, is divided into two groups to treat at random sick pig.Wherein one group 26 give the water preparation of the embodiment of the present invention 1, according to 200ml water preparation: the sick pig of ratio mixing relief of 150Kg drinking water is freely drunk, and drinks 7 days continuously.As a control group, with penicillin 1,600,000 unit, furosemide injection 8 milliliters (including furosemide 160 milligrams) two medicine mixing intramuscular injection, once a day, uses 3 ~ 7 days according to the state of an illness to another group 26.Observe each group of therapeutic effect, sick temperature of pig body recovers normal, edema extinction, and it is recovery from illness that spirit, appetite, voided volume all recover normal; What before and after treatment, symptom did not take a turn for the better even death is invalid.Two groups of therapeutic outcomes are in table 1:
Table 1: each treatment group ill pig therapeutic effect synopsis
After embodiment 1 group treats 3 days, jumpbogroup takes a turn for the better, and sick temperature of pig body recovers normal, and spirit takes a turn for the better, and starts feed, and is able to support oneself and urinates, and urine volume also increases.Continual cure is after 4 days, and sick bowel oedema disease disappears entirely, spirit, appetite, urinates and all recovers normal, touches kidney district oncontacting pain.Except one is in a bad way except death, all the other are all fully recovered, and cure rate is 96.2%.Matched group is different according to the state of an illness, and treat after 3 ~ 7 days, wherein 24 recoveries from illness, 2 invalid, and cure rate is 92.3%.Test 2 results to show, be better than traditional antibiotic therapy by the scorching curative effect of the water preparation of the embodiment of the present invention 1 treatment Ren sus domestica, and Chinese medicine preparation of the present invention safely, have no side effect.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (6)
1. treat a Chinese medicine composition for Ren sus domestica inflammation, it is characterized in that: be prepared from by the raw material of following mass fraction:
Poria 10-20 part, Polyporus 9-15 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Rhizoma Alismatis 8-15 part, Radix Astragali 9-15 part, Radix Stephaniae Tetrandrae 4-10 part, Radix Aconiti Lateralis Preparata 7-12 part, Radix Glycyrrhizae 4-7 part, Rhizoma Zingiberis 5-10 part, Rhizoma Dioscoreae 6-15 part.
2. the Chinese medicine composition for the treatment of Ren sus domestica inflammation according to claim 1, it is characterized in that, the mass fraction of optimum feed stock is as follows:
20 parts, Poria, Polyporus 12 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Rhizoma Alismatis 11 parts, the Radix Astragali 13 parts, Radix Stephaniae Tetrandrae 5 parts, Radix Aconiti Lateralis Preparata 7 parts, 4 parts, Radix Glycyrrhizae, Rhizoma Zingiberis 5 parts, Rhizoma Dioscoreae 10 parts.
3. the Chinese medicine composition for the treatment of Ren sus domestica inflammation according to claim 1, is characterized in that: described preparation can be water preparation.
4. prepare a method for the Chinese medicine composition for the treatment of Ren sus domestica inflammation as claimed in claim 3, it is characterized in that, preparation method is: (1) takes each Chinese medicine by formula ratio, puts in extraction pot; (2) in extraction pot, 5 ~ 15 times amount decocting in water is added 2 ~ 12 hours; (3) excessively filter medicinal residues, the indwelling of gained filtrate is for subsequent use; (4) medicinal residues are put in extraction pot again, add 5 ~ 15 times amount decocting in water 2 ~ 12 hours; (5) excessively filter medicinal residues, gained liquid merges with first time extracting liq; (6) concentrating under reduced pressure extracting solution; (7) filter cleaner fill, every bottle of 200 ~ 500ml.
5. a preparation method as claimed in claim 4, wherein concentrating under reduced pressure temperature is 40 ~ 80 DEG C.
6. a preparation method as claimed in claim 4, wherein concentrated volume is 10% ~ 50% of original volume.
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