CN104940827A - Traditional Chinese medicine composition for treating tetanus - Google Patents
Traditional Chinese medicine composition for treating tetanus Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating tetanus. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by mass: 9-16 parts of incised notopterygium, 3-7 parts of cicada slough, 8-15 parts of jackinthepulpit tuber, 10-16 parts of all-grass of giant typhonium, 7-14 parts of red vinespinach herb, 9-12 parts of giant typhonium rhizome, 11-14 parts of sappan wood, 9-13 parts of cavalerie mosla, 7-15 parts of root of bambooleaf seseli, 4-6 parts of scorpio, 12-20 parts of heterophylly faalsestarwort root, 1-3 parts of wild aconite root, 11-16 parts of turmeric root-tuber, 8-17 parts of asiatic pennywort herb, 10-15 parts of common rush and 8-16 parts of herb of diversifolious hemiphragma. The traditional Chinese medicine composition is scientific in compatibility, safe to take and free from toxic and side effects; the composition completely conforms to the principle of traditional Chinese medicine and has the effects of expelling wind and relieving convulsion, tranquilizing and allaying excitement, resolving lump and diminishing swelling and the like; the traditional Chinese medicine composition is low in cost, good in curative effect, high in cure rate, and capable of reducing complications.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat tetanic Chinese medicinal formulae.
Background technology
Tetanus is after invading human body wound by clostridium tetani, growth and breeding under anaerobic environment, produces and to cause addicted to neural extracellular toxin whole-body muscle tonic spasm to be the acute infectious disease of feature.Most tetanus patient all has trauma history, and wound is many first to be had or merge pyogenic infection.General wound is comparatively dark, often has foreign body and slough to remain.Some patients wound is less and hidden, is often ignored by patient and causes delay diagnosis and treatment.Average out to 6 ~ 10 days, was also shorter than 24 hours or reached 20 ~ 30, the even several months tetanic incubation period, or only extract the foreign body that to retain in body for many years as sub warhead or shell fragment after, just there is tetanus.Tetanus neonatorum is generally fallen ill about July after disconnected umbilical cord, therefore is commonly called as " tetanus neonatorum ".In general, incubation period or the prodrome persistent period shorter, symptom is more serious, and mortality rate is higher.Patient first has weak, dizzy, headache, the nervous acid of masseter is swollen, dysphoria, the prodrome such as to yawn.These prodromes generally continue 12 ~ 24 hours, and then occurring typical flesh strong contraction, is masseter at first, is facial muscle, neck flesh, dorsoventral muscle, extremity muscle group, diaphram and Intercostal muscle in turn later.Patient starts to feel to chew inconvenience, and difficulty in opening mouth, has gnathospasma subsequently, and facial expression muscle group is clonospasm, makes patient have unique " forced smile " expression.Each outbreak last for several seconds was to several minutes, and patient's complexion cyanosis, rapid breathing, spits out white foams, and sialorrhea is ground one's teeth in sleep, and head is swung back again and again, and tic of the limbs is more than, whole body dripping sweat.The tempus intercalare of outbreak, pain slightly subtracts, but muscle still can not be completely lax.Treatment tetanus mainly adopts tetanus antitoxin and combination antibiotic treatment clinically.Western medicine tetanus mainly injects tetanus antitoxin, and combination antibiotic is treated.
Publication No. CN 104208552 A(application number 201410428086.8) Chinese patent literature disclose one and treat tetanic Chinese medicine preparation, Rhizoma Arisaematis 20-30 gram, Rhizoma Gastrodiae 10-20 gram, Periostracum Cicadae 10-20 gram, Calculus Bovis 10-20 gram, Rhizoma alpiniae chinensis 10-20 gram, Fructus Chaenomelis 10-20 gram, Ramulus Cinnamomi 10-20 gram, Fructus Atriplicis Sibiricae 10-20 gram, Scolopendra 10-20 gram, Fructus Evodiae 8-15 gram, Cornu Saigae Tataricae 8-12 gram, Concretio Silicea Bambusae 8-12 gram, Herba Taraxaci 8-12 gram, Rhizoma Coptidis 8-12 gram, Radix Astragali 8-12 gram.Publication No. CN 103784795 A(application number 201410041347.0) Chinese patent literature disclose one and treat tetanic Chinese medicine, raw material has Air Bladder pseudosciaenae seu Acipenser 18g, Herba Schizonepetae 12.5g, Succus Bambusae 10g, Radix Saposhnikoviae 10g, Agkistrodon 5g, Rhizoma Typhonii 6g, Radix Scrophulariae 15g, Radix Scutellariae 9g, yellow wine 150ml.Publication No. CN 102526393 A(application number 201210011802.3) Chinese patent literature disclose one and treat tetanic Chinese medicine, crude drug proportioning is Radix Saposhnikoviae, Herba Schizonepetae, Periostracum Cicadae, Rhizoma Typhonii, Ramulus Cinnamomi, the Radix Paeoniae Alba, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Scorpio, Bombyx Batryticatus, Pheretima, Scolopendra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, the Rhizoma Pinelliae, Rhizoma Arisaematis, Radix Clematidis, Squama Manis=5: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 1: 2: 5: 1: 2.
Easily there is allergy in antitetanic extract for treating tetanus, the death of patient can be caused, and source is few, price is high, can not be applicable to all tetanus patients, Chinese traditional treatment is safe and reliable, applied widely, and the tetanic Chinese medicine formula of associated therapy, some curative effect waits checking, therefore, there are needs to develop a kind of determined curative effect and treat tetanic traditional Chinese medical science formula reliably.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare the tetanic Chinese medicinal formulae for the treatment of that is simple, determined curative effect.
Technical scheme of the present invention is:
Treat tetanic Chinese medicinal formulae, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Et Radix Notopterygii 9-16, Periostracum Cicadae 3-7, Rhizoma Arisaematis 8-15, Herba Typhonii gigantei 10-16, Herba basellae rubrae 7-14, Rhizoma Typhonii 9-12, Lignum Sappan 11-14, Herba Moslae Cavaleriei 9-13, rasix seseli 7-15, Scorpio 4-6, Radix Pseudostellariae 12-20, Radix Aconiti Kusnezoffii 1-3, Radix Curcumae 11-16, Herba Centellae 8-17, Medulla Junci 10-15, Herba hemipharagmatis heterophylli 8-16.
In preferred scheme, Rhizoma Et Radix Notopterygii 11-14, Periostracum Cicadae 4-6, Rhizoma Arisaematis 10-13, Herba Typhonii gigantei 12-14, Herba basellae rubrae 9-12, Rhizoma Typhonii 10-11, Lignum Sappan 12-13, Herba Moslae Cavaleriei 10-12, rasix seseli 9-13, Scorpio 4.5-5.5, Radix Pseudostellariae 14-18, Radix Aconiti Kusnezoffii 1.5-2.5, Radix Curcumae 13-14, Herba Centellae 10-15, Medulla Junci 11-14, Herba hemipharagmatis heterophylli 10-14.
Be more preferably, Rhizoma Et Radix Notopterygii 12.5, Periostracum Cicadae 5, Rhizoma Arisaematis 11.5, Herba Typhonii gigantei 13, Herba basellae rubrae 10.5, Rhizoma Typhonii 10.5, Lignum Sappan 12.5, Herba Moslae Cavaleriei 11, rasix seseli 11, Scorpio 5, Radix Pseudostellariae 16, Radix Aconiti Kusnezoffii 2, Radix Curcumae 13.5, Herba Centellae 12.5, Medulla Junci 12.5, Herba hemipharagmatis heterophylli 12.
The tetanic Chinese medicinal formulae of described treatment, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, rolling bubble taking-up after 10 minutes in vinegar, section, then putting into frying pan, moderate heat heats, and fries to when having fragrance to overflow, and sprays saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci decontamination, clean, add water and slightly soak 20 minutes, take out, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, obtain powder.
The preparation method of the tetanic Chinese medicinal formulae powder of described treatment, step (4) was pulverized 140-200 mesh sieve and (preferably, was pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves).
The tetanic Chinese medicinal formulae of described treatment, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae roguing are cleaned, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction at 75% ethanol 60 DEG C twice (mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1), each dipping 8-10 hour is (preferred, each dipping 9 hours), centre is constantly stirred, and finally collects extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize and sieve together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, add adjuvant, soft material processed, granulates, dry, granulate, tabletting, obtains tablet.
The preparation method of the tetanic Chinese medicinal formulae tablet of described treatment, step (5) was pulverized 80-140 mesh sieve and (preferably, was pulverized 100-120 mesh sieve; Be more preferably, pulverized 110 mesh sieves).
The tetanic Chinese medicinal formulae of described treatment, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae decontamination, clean, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction twice at 75% ethanol 60 DEG C, each dipping 8-10 hour (preferred, each dipping 9 hours), middle constantly stirring, finally collect extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize 120 mesh sieves together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, dry, pulverize, encapsulated, obtain capsule.
The preparation method of the tetanic Chinese medicinal formulae capsule of described treatment, the mass ratio of step (4) 75% ethanol and institute's impregnated raw material medicine is that 6:1-8:1(is preferred, and the mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1).
The tetanic Chinese medicinal formulae of described treatment, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) step (1) (2) made crude drug is put into marmite, after the big fire that adds water boils 45 minutes, add clean Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci, and step (3) made crude drug, big fire is boiled rear little fire and is decocted 28-44 minute (preferred, big fire is boiled rear little fire and decocted 32-40 minute; Be more preferably, big fire is boiled rear little fire and is decocted 36 minutes), filter, collect medicinal liquid, medicinal residues add water and again decoct, and big fire is boiled rear little fire and decocted 30 minutes, merges twice medicinal liquid, obtains decoction.
The preparation method of the tetanic Chinese medicinal formulae decoction of described treatment, step (4) amount of water is the 7-9 of total raw material medicine quality doubly (preferred, amount of water is 8 times of total raw material medicine quality).
The tetanic Chinese medicinal formulae scientific formula for the treatment of provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, compatibility science of the present invention, takes safety, without any side effects;
2, this prescription meets Chinese medicine principle completely, have expelling wind and relieving convulsion, the effect such as tranquillizing and allaying excitement, mass dissipating and swelling eliminating;
3, cost of the present invention is low, good effect, and cure rate is high, can reduce the generation of complication.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Et Radix Notopterygii: base is former: be the root and rhizome of samphire Rhizoma Et Radix Notopterygii, Radix et Rhizoma Notopterygii or angelica.Nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Function cures mainly: cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Periostracum Cicadae: base is former: be the shell after the emergence of cicada Cryptotympana atrata Fabr..Nature and flavor: sweet, cold.Gui Jing: return lung, Liver Channel.Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Rhizoma Arisaematis: base is former: be the tuber of aroid Rhizoma Arisaematis, arisaema amurense Maxim or Arisaema heterophyllum B1. etc.Nature and flavor: bitter, pungent, temperature; Poisonous.Gui Jing: return lung, liver, spleen channel.Function cures mainly: drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.
Herba Typhonii gigantei: base is former: be the herb of aroid Herba Typhonii gigantei.Function cures mainly: control venom, scrofula, traumatic injury.
Herba basellae rubrae: base is former: be leaf or the herb of Basellaceae plant Herba basellae rubrae.Nature and flavor: sweet, light, cool.Gui Jing: GUIXIN, liver, spleen, large and small intestinal warp.Function cures mainly: heat-clearing and toxic substances removing, bone-setting pain stopping.For appendicitis, dysentery, constipation, cystitis; Fracture is controlled in external, traumatic injury, traumatic hemorrhage, burn and scald.
Rhizoma Typhonii: base is former: be the tuber of aroid Herba Typhonii gigantei.Nature and flavor: pungent, temperature; Poisonous.Gui Jing: return stomach, Liver Channel.Function cures mainly: dispel the wind expectorant, and arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens pain relieving.Stop up for middle wind-phlegm, facial hemiparalysis, language is puckery stuttering, and syncope due to accumulation of phlegm is had a headache, migraine and general headache, sore throat pharyngalgia, tetanus; External treatment scrofula sucutaneous nodule, venom.
Lignum Sappan: base is former: be the dry duramen of leguminous plant Lignum Sappan.Nature and flavor: sweet, salty are flat.Gui Jing: GUIXIN, liver, spleen channel.Function cures mainly: promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.
Herba Moslae Cavaleriei: base is former: be the herb of labiate spire Herba Moslae Cavaleriei.Nature and flavor: pungent, temperature.Function cures mainly: control mad dog, venom, skin eczema, sore.
Rasix seseli: base is former: be the root of samphire seseli mairei Wolff, Folium Pini west wind celery and Seseli delavayi Franch..Nature and flavor: acrid in the mouth, micro-sweet, slightly warm in nature.Gui Jing: return lung, liver, spleen channel.Function cures mainly: expelling wind and dampness, pain relieving relieving convulsion.Main flu, headache, toothache, epigastric distending pain, has loose bowels, rheumatic arthralgia, paralysis, tetanus, infantile convulsion, rubella, eczema, and skin ulcer swells.
Scorpio: base is former: be the dry Scorpio of Buthidae animal Scorpio.Nature and flavor: pungent are flat; Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Radix Pseudostellariae: base is former: be the tuber of pinkwort pseudostellaria heterophylla.Nature and flavor: sweet, micro-hardship are flat.Gui Jing: return spleen, lung meridian.Function cures mainly: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Radix Aconiti Kusnezoffii: base is former: be the tuber of ranunculaceae plant Aconitum carmichjaelii Debx. (wild species), Aconitum kusnezoffii Reichb or other multiple congeners.Nature and flavor: pungent, heat, poisonous.Gui Jing: enter liver, spleen, lung meridian.Function cures mainly: search wind prevailing over dampness, and dispersing cold for relieving pain opens expectorant, detumescence.Control anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, carbuncle, furuncle, scrofula.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Nature and flavor: pungent, bitter, cold.Gui Jing: return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Herba Centellae: base is former: be herb or the whole herb with root of samphire Herba Centellae.Nature and flavor: bitter, acrid, cold.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Medulla Junci: base is former: be stem pith or the herb of rush family plant Medulla Junci.Nature and flavor: sweet, light, are slightly cold.Gui Jing: GUIXIN, lung, small intestine meridian.Function cures mainly: clearing away heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.
Herba hemipharagmatis heterophylli: base is former: be herb or the root of goatweed diversifolious hemiphragma herb.Nature and flavor: light are flat.Function cures mainly: promoting blood flow to regulate menstruation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness.For amenorrhea, menoxenia, pulmonary tuberculosis, tonsillitis, traumatic injury, lumbago due to pathogenic wind-dampness; Eczema is controlled in external, skin infection, stomatitis.
embodiment 1treat tetanic Chinese medicinal formulae, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 9 parts, Periostracum Cicadae 3 parts, Rhizoma Arisaematis 8 parts, Herba Typhonii gigantei 10 parts, Herba basellae rubrae 7 parts, Rhizoma Typhonii 9 parts, Lignum Sappan 11 parts, Herba Moslae Cavaleriei 9 parts, rasix seseli 7 parts, Scorpio 4 parts, Radix Pseudostellariae 12 parts, Radix Aconiti Kusnezoffii 1 part, Radix Curcumae 11 parts, Herba Centellae 8 parts, Medulla Junci 10 parts, Herba hemipharagmatis heterophylli 8 parts.
The preparation method of the tetanic Chinese medicinal formulae powder of above-mentioned treatment is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, rolling bubble taking-up after 10 minutes in vinegar, section, then putting into frying pan, moderate heat heats, and fries to when having fragrance to overflow, and sprays saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci decontamination, clean, add water and slightly soak 20 minutes, take out, dry, pulverized 170 mesh sieves together with step (1) (2) (3) made crude drug, obtain powder.
embodiment 2treat tetanic Chinese medicinal formulae, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 16 parts, Periostracum Cicadae 7 parts, Rhizoma Arisaematis 15 parts, Herba Typhonii gigantei 16 parts, Herba basellae rubrae 14 parts, Rhizoma Typhonii 12 parts, Lignum Sappan 14 parts, Herba Moslae Cavaleriei 13 parts, rasix seseli 15 parts, Scorpio 6 parts, Radix Pseudostellariae 20 parts, Radix Aconiti Kusnezoffii 3 parts, Radix Curcumae 16 parts, Herba Centellae 17 parts, Medulla Junci 15 parts, Herba hemipharagmatis heterophylli 16 parts.
The preparation method for the treatment of tetanic Chinese medicinal formulae tablet is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae roguing are cleaned, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction at 75% ethanol 60 DEG C twice (mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1), each dipping 9 hours, middle constantly stirring, finally collect extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize 110 mesh sieves together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, add adjuvant, soft material processed, granulates, dry, granulate, tabletting, obtains tablet.
Model case: xxx, man, 36 years old.Main suit: left hand is stabbed by bonding jumper, occur slightly weak after 10 days, the root of the tongue hardens, head and neck can not rotate freely, and masticatory muscles is stiff, occurs that facial muscle are twitched afterwards, in forced smile shape, the muscle spasm of nape portion, there is opisthotonus in head layback, paroxysmal whole-body muscle is twitched, each lasting about 20 seconds, examination in hospital, body temperature 38.5 DEG C, hand wound, without symptom of obviously suppurating, is diagnosed as tetanus.
Take the present embodiment gained and treat tetanic Chinese medicinal formulae tablet, every day 2 times, each 3-5 sheet, warm water delivery service, 7 days courses for the treatment of.After taking one day, temperature recovery is normal, and after taking a course for the treatment of, tic symptom alleviates, and after taking two courses for the treatment of, occasionally have tic, muscular tension obviously reduces, and after taking three courses for the treatment of, all diseases of patient disappear entirely, and without complication, patient fully recovers.
embodiment 3treat tetanic Chinese medicinal formulae, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 11 parts, Periostracum Cicadae 4 parts, Rhizoma Arisaematis 10 parts, Herba Typhonii gigantei 12 parts, Herba basellae rubrae 9 parts, Rhizoma Typhonii 10 parts, Lignum Sappan 12 parts, Herba Moslae Cavaleriei 10 parts, rasix seseli 9 parts, Scorpio 4.5 parts, Radix Pseudostellariae 14 parts, Radix Aconiti Kusnezoffii 1.5 parts, Radix Curcumae 13 parts, Herba Centellae 10 parts, Medulla Junci 11 parts, Herba hemipharagmatis heterophylli 10 parts.
The preparation method for the treatment of tetanic Chinese medicinal formulae capsule is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae decontamination, clean, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction at 75% ethanol 60 DEG C twice (mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1), each dipping 9 hours, centre is constantly stirred, and finally collects extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize 120 mesh sieves together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, dry, pulverize, encapsulated, obtain capsule.
Model case: xxx, female, 53 years old.Accidentally fall when walking, right lower limb, by ferrum punctured wound, occurs that face is forced a smile after 9 days, gnathospasma, masseter is medium stiff, difficulty in opening mouth, can not diet, then there is face and limb muscle tic, neck and lumbodorsal muscle spasm, health is opisthotonus, limb rigidity, examination in hospital, body temperature 37.8 DEG C, wound does not heal, but without suppuration symptom, is diagnosed as tetanus.
Take the present embodiment gained and treat tetanic Chinese medicinal formulae capsule, adopt every day 2 times, each 3-4 grain, with warm water delivery service, 7 days courses for the treatment of.Take two days later, temperature recovery is normal, and after taking 5 days, tic number of times reduces, and decreased duration, takes 10 days, and twitch and substantially eliminate, after having taken two courses for the treatment of, all diseases of patient disappear entirely, and without complication, patient fully recovers.
embodiment 4treat tetanic Chinese medicinal formulae, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 14 parts, Periostracum Cicadae 6 parts, Rhizoma Arisaematis 13 parts, Herba Typhonii gigantei 14 parts, Herba basellae rubrae 12 parts, Rhizoma Typhonii 11 parts, Lignum Sappan 13 parts, Herba Moslae Cavaleriei 12 parts, rasix seseli 13 parts, Scorpio 5.5 parts, Radix Pseudostellariae 18 parts, Radix Aconiti Kusnezoffii 2.5 parts, Radix Curcumae 14 parts, Herba Centellae 15 parts, Medulla Junci 14 parts, Herba hemipharagmatis heterophylli 14 parts.
The preparation method for the treatment of tetanic Chinese medicinal formulae decoction is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) step (1) (2) made crude drug is put into marmite, after the water big fire adding up crude drug quality 8 times boils 45 minutes, add clean Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci, and step (3) made crude drug, big fire is boiled rear little fire and is decocted 36 minutes, filter, collect medicinal liquid, medicinal residues add water and again decoct, and big fire is boiled rear little fire and decocted 30 minutes, merge twice medicinal liquid, obtain decoction.
Model case: xxx, man, 42 years old.Before two weeks, because of carelessness the right hand was hurt, after one week during dry farm work, conscious weak, masticatory muscles is nervous, difficulty in opening mouth,, then there is limb muscle spasm, rigidity of the neck in gnathospasma, eye mouth is crooked, examination in hospital, and right hand wound heals substantially, extremity paroxysmal is twitched, profuse sweating, red tongue, yellow and greasy fur, stringy and rolling pulse, is diagnosed as tetanus.
Take the present embodiment gained and treat tetanic Chinese medicinal formulae decoction, adopt every day 2 times, each 200-400ml(is warm), 7 days courses for the treatment of.After taking 5 days, tic number of times and persistent period obviously reduce, and muscular tension declines, and after taking two courses for the treatment of, twitch and disappear, occur without complication, patient fully recovers.
embodiment 5treat tetanic Chinese medicinal formulae, be prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 12.5 parts, Periostracum Cicadae 5 parts, Rhizoma Arisaematis 11.5 parts, Herba Typhonii gigantei 13 parts, Herba basellae rubrae 10.5 parts, Rhizoma Typhonii 10.5 parts, Lignum Sappan 12.5 parts, Herba Moslae Cavaleriei 11 parts, rasix seseli 11 parts, Scorpio 5 parts, Radix Pseudostellariae 16 parts, Radix Aconiti Kusnezoffii 2 parts, Radix Curcumae 13.5 parts, Herba Centellae 12.5 parts, Medulla Junci 12.5 parts, Herba hemipharagmatis heterophylli 12 parts.
The preparation method for the treatment of tetanic Chinese medicinal formulae powder is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, rolling bubble taking-up after 10 minutes in vinegar, section, then putting into frying pan, moderate heat heats, and fries to when having fragrance to overflow, and sprays saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci decontamination, clean, add water and slightly soak 20 minutes, take out, dry, pulverized 170 mesh sieves together with step (1) (2) (3) made crude drug, obtain powder.
test example 1gained of the present invention treats the clinical practice of tetanic Chinese medicinal formulae (embodiment 5):
In October ,-2014 in February, 2012, filter out 276 routine tetanus patients 5 hospital surgery out-patient departments, wherein women 128 example, male 148 example, age 15-56 year, the mean age (38.4 ± 4.1) year, incubation period 7-51 days, the course of disease 1-8 week.All patients all have clear and definite trauma history in various degree, and wherein 87 examples stabbed by iron nail or wood, and stone injures 32 examples by a crashing object, animal bite 54 example, and 72 examples be wound by firecrackers, injury of head 31 example.Clinical manifestation is: originally whole body type symptom for occur that whole body sleepiness is unable, headache, the root of the tongue hardens, swallow inconvenience and head and neck rotates not freely etc. that meromyarian is nervous, main masticatory muscles anxiety causes difficulty in opening mouth, then there is face, neck, trunk, limb muscle spasm, difficulty in opening mouth, gnathospasma, dysphagia, face is in " forced smile shape ".Whole-body muscle paroxysmal is twitched, and can be opisthotonus.With dripping sweat when increased heart rate, tic, twitch and frequently show effect, the persistent period of twitching can reach several minutes or longer.Laryngospasm can occur that dyspnea even suffocates.Local type symptom is near wound site or hinders limb muscle rigidity spasm, not throughout whole body.
Patient is divided into two groups at random, experimental group 160 example and matched group 116 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and every day takes twice, and each 5-10g(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, treat three courses for the treatment of.Matched group takes other medicine (conventional medication such as erythromycin enteric-coated tablet, erythromycin octadecanoate granule, erythromycin ethylsuccinate).Patient's liver function, renal function and routine blood test situation is detected before and after treatment.Period in a medicine carries out Continuous Observation to two groups of patients, record liver function, the change of gastrointestinal reaction and clinical symptoms etc.
Curative effect situation criterion: cure: General Symptoms and sign disappear, and twitch and disappear, wound healing, without complication; Effective: General Symptoms and tic basic controlling, wound does not heal completely, without complication; Invalid: General Symptoms and sign are without improvement or even increase the weight of, and twitch and still exist.
Table 1 a liang group patient treatment outcome compare
As shown in table 1 through treating two groups of results, experimental group patient, cures 131 examples (81.9%), effective 25 examples (15.6%), experimental group total effective rate 97.5%.Matched group patient, cures 71 examples (61.2%), and effective 28 examples (24.1%), matched group total effective rate is 85.3%, and the therapeutic effect of visible matched group is lower than experimental group.In therapeutic process, experimental group patient all occurs without any untoward reaction, and matched group has 8 routine patient's mild nausea and vomiting symptoms, after treatment terminates, automatically alleviates.
The present invention have selected the Rhizoma Et Radix Notopterygii that cold expelling dispels the wind, the Periostracum Cicadae of loose wind heat extraction, the Rhizoma Arisaematis of mass dissipating and swelling eliminating, the Herba Typhonii gigantei of expellingging wind and relieving convulsion, the Herba basellae rubrae of heat-clearing and toxic substances removing, the Rhizoma Typhonii of jerking of calming the frightened, the Lignum Sappan of promoting the circulation of blood blood stasis dispelling, control the Herba Moslae Cavaleriei of sore, the rasix seseli of expelling wind and dampness, endogenous wind stopping antispasmodic Scorpio, the Radix Pseudostellariae of replenishing QI to invigorate the spleen, the Radix Aconiti Kusnezoffii of dispersing cold for relieving pain, the Radix Curcumae of regulating qi to disperse stagnation, the Herba Centellae of clearing away heat-damp and promoting diuresis, the Medulla Junci of clearing away heart-fire, the Herba hemipharagmatis heterophylli of relaxing muscles and tendons and activating QI and blood in the collateral, plurality of Chinese raw material shares, can play expelling wind and relieving convulsion, the effect such as tranquillizing and allaying excitement, mass dissipating and swelling eliminating.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat tetanic Chinese medicinal formulae, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Et Radix Notopterygii 9-16, Periostracum Cicadae 3-7, Rhizoma Arisaematis 8-15, Herba Typhonii gigantei 10-16, Herba basellae rubrae 7-14, Rhizoma Typhonii 9-12, Lignum Sappan 11-14, Herba Moslae Cavaleriei 9-13, rasix seseli 7-15, Scorpio 4-6, Radix Pseudostellariae 12-20, Radix Aconiti Kusnezoffii 1-3, Radix Curcumae 11-16, Herba Centellae 8-17, Medulla Junci 10-15, Herba hemipharagmatis heterophylli 8-16.
2. the tetanic Chinese medicinal formulae for the treatment of as claimed in claim 1, it is characterized in that, Rhizoma Et Radix Notopterygii 11-14, Periostracum Cicadae 4-6, Rhizoma Arisaematis 10-13, Herba Typhonii gigantei 12-14, Herba basellae rubrae 9-12, Rhizoma Typhonii 10-11, Lignum Sappan 12-13, Herba Moslae Cavaleriei 10-12, rasix seseli 9-13, Scorpio 4.5-5.5, Radix Pseudostellariae 14-18, Radix Aconiti Kusnezoffii 1.5-2.5, Radix Curcumae 13-14, Herba Centellae 10-15, Medulla Junci 11-14, Herba hemipharagmatis heterophylli 10-14 is (preferred, Rhizoma Et Radix Notopterygii 12.5, Periostracum Cicadae 5, Rhizoma Arisaematis 11.5, Herba Typhonii gigantei 13, Herba basellae rubrae 10.5, Rhizoma Typhonii 10.5, Lignum Sappan 12.5, Herba Moslae Cavaleriei 11, rasix seseli 11, Scorpio 5, Radix Pseudostellariae 16, Radix Aconiti Kusnezoffii 2, Radix Curcumae 13.5, Herba Centellae 12.5, Medulla Junci 12.5, Herba hemipharagmatis heterophylli 12).
3. the tetanic Chinese medicinal formulae for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, rolling bubble taking-up after 10 minutes in vinegar, section, then putting into frying pan, moderate heat heats, and fries to when having fragrance to overflow, and sprays saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci decontamination, clean, add water and slightly soak 20 minutes, take out, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, obtain powder.
4. the preparation method of the tetanic Chinese medicinal formulae powder for the treatment of as claimed in claim 3, is characterized in that, step (4) was pulverized 140-200 mesh sieve and (preferably, pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves).
5. the tetanic Chinese medicinal formulae for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae roguing are cleaned, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction at 75% ethanol 60 DEG C twice (mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1), each dipping 8-10 hour is (preferred, each dipping 9 hours), centre is constantly stirred, and finally collects extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize and sieve together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, add adjuvant, soft material processed, granulates, dry, granulate, tabletting, obtains tablet.
6. the preparation method of the tetanic Chinese medicinal formulae tablet for the treatment of as claimed in claim 5, is characterized in that, step (5) was pulverized 80-140 mesh sieve and (preferably, pulverized 100-120 mesh sieve; Be more preferably, pulverized 110 mesh sieves).
7. the tetanic Chinese medicinal formulae for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) by Rhizoma Et Radix Notopterygii, Radix Curcumae, Herba Typhonii gigantei and Herba Centellae decontamination, clean, 80 mesh sieves were pulverized together with step (1) (2) made crude drug, with Soakage extraction twice at 75% ethanol 60 DEG C, each dipping 8-10 hour (preferred, each dipping 9 hours), middle constantly stirring, finally collect extracting solution, decompression and solvent recovery, to without alcohol taste, obtains extractum;
(5) by going the Periostracum Cicadae of impurity, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae and Medulla Junci to pulverize 120 mesh sieves together with step (3) made crude drug, make medicated powder, then mix with step (4) made extractum, dry, pulverize, encapsulated, obtain capsule.
8. the preparation method of the tetanic Chinese medicinal formulae capsule for the treatment of as claimed in claim 7, it is characterized in that, the mass ratio of step (4) 75% ethanol and institute's impregnated raw material medicine is that 6:1-8:1(is preferred, and the mass ratio of 75% ethanol and institute's impregnated raw material medicine is 7:1).
9. the tetanic Chinese medicinal formulae for the treatment of as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Rhizoma Arisaematis and Rhizoma Typhonii decontamination, with Alumen water retting 10 hours, change a water every 2 hours, take out and dry in the air to half-dried, section, Sucus Zingberis and bean curd are added water boil, puts into Rhizoma Arisaematis sheet and Rhizoma Typhonii sheet, well-done rear taking-up, dries;
(2) get Radix Aconiti Kusnezoffii decontamination, clean, be cut into small pieces, use liquorice beverage steeped overnight, pull out, Halitum is put into pot, fry to flexibly, add Radix Aconiti Kusnezoffii block, moderate heat heating stir-fries, and fries and heaves to Radix Aconiti Kusnezoffii surface is micro-, take out, dry in the air cool;
(3) by Lignum Sappan, rasix seseli and Herba hemipharagmatis heterophylli decontamination, steep 10 minutes rolling in vinegar, take out, section, then puts into frying pan, and moderate heat heats, and fries to when having fragrance overflow, and spray saline, mixes thoroughly, fried dry, and taking-up is dried in the air cool;
(4) step (1) (2) made crude drug is put into marmite, after the big fire that adds water boils 45 minutes, add clean Rhizoma Et Radix Notopterygii, Periostracum Cicadae, Herba Typhonii gigantei, Herba basellae rubrae, Herba Moslae Cavaleriei, Scorpio, Radix Pseudostellariae, Radix Curcumae, Herba Centellae and Medulla Junci, and step (3) made crude drug, big fire is boiled rear little fire and is decocted 28-44 minute (preferred, big fire is boiled rear little fire and decocted 32-40 minute; Be more preferably, big fire is boiled rear little fire and is decocted 36 minutes), filter, collect medicinal liquid, medicinal residues add water and again decoct, and big fire is boiled rear little fire and decocted 30 minutes, merges twice medicinal liquid, obtains decoction.
10. the preparation method of the tetanic Chinese medicinal formulae decoction for the treatment of as claimed in claim 9, is characterized in that, step (4) amount of water is the 7-9 of total raw material medicine quality doubly (preferred, amount of water is 8 times of total raw material medicine quality).
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991781A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Traditional Chinese medicine preparation for treating tetanus |
| CN104435773A (en) * | 2014-10-31 | 2015-03-25 | 吴金霞 | Traditional Chinese medicine preparation for treating tetanus |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991781A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Traditional Chinese medicine preparation for treating tetanus |
| CN104435773A (en) * | 2014-10-31 | 2015-03-25 | 吴金霞 | Traditional Chinese medicine preparation for treating tetanus |
Non-Patent Citations (2)
| Title |
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| 李文瑞等: "《中药别名辞典》", 30 September 1994, 中国科学技术出版社 * |
| 王景洪等: "《张学文医学求索集》", 31 January 1996, 陕西科学技术出版社 * |
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