CN104940576A - Traditional Chinese medicine composition for treating congestive heart failure and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating congestive heart failure and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a congestive heart failure and a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following medicines in parts by weight: 20-45 parts of astragalus membranaceus, 6-15 parts of radix ophiopogonis, 10-20 parts of schisandra chinensis, 10-20 parts of poria cocos, 6-15 parts of roasted white atractylodes rhizome, 6-15 parts of ligusticum wallichii, 10-20 parts of radix rehmanniae preparata, 1-3 parts of leech powder (mixed) and 15-40 parts of semen lepidii as raw materials. The preparation method of the traditional Chinese medicine composition comprises the following steps: soaking the medicines except for the leech powder with clean water for an hour; decocting with water and boiling with a high-temperature fire, and then slowly decocting with a low fire for half an hour; removing residues, taking the juice, and further mixing decoction medicine juices of twice employing the method; and mixing the leech powder with the medicine liquid when taking. A clinical experiment shows that the composition disclosed by the invention has the effect of treating the congestive heart failure, is expected to be used for preparing a medicine preparation for treating the congestive heart failure, and has a medicinal prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of congestive heart failure and its preparation method and application, belong to technical field of Chinese medicines.
Background technology
Congestive heart failure is common in the end stage eventually of multiple organic heart disease, refers to myocardial contraction and/or diastolic dysfunction, and then causes cardiac output decline, surrounding tissue hypoperfusion, can not meet a kind of syndrome of tissue metabolism's needs.Clinical onset rate and fatality rate, in gesture soaring year by year, have a strong impact on the quality of life even threat to life of patient.The medicine of current congestive heart failure is mainly diuretic, angiotensin-convertion enzyme inhibitor, Angiotensin Ⅱ receptor antagonist, aldosterone antagonists and beta-blocker etc., but many Western medicine have obvious side effect, and improve not obvious to the clinical symptoms of some congestive heart failure case, late result needs to be verified further.Increasing evidence shows, Chinese medicine congestive heart failure, not only obviously can improve the clinical symptoms of patient, improves cardiac function and improve patients ' life quality, and have the features such as side effect is little.Inventor studies through long-term clinical practice, sums up a kind of Chinese medicine composition effectively can treating congestive heart failure.
Summary of the invention
In order to overcome above-mentioned the deficiencies in the prior art, the invention provides a kind of Chinese medicine composition for the treatment of congestive heart failure and its preparation method and application.
For achieving the above object, the technical solution used in the present invention is as follows:
Treat a Chinese medicine composition for congestive heart failure, be by Radix Astragali 20-45 mass parts, Radix Ophiopogonis 6-15 mass parts, Fructus Schisandrae Chinensis 10-20 mass parts, Poria 10-20 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 6-15 mass parts, Rhizoma Chuanxiong 6-15 mass parts, Radix Rehmanniae Preparata 10-20 mass parts, Hirudo powder 1-3 mass parts (punching), Semen Lepidii (Semen Descurainiae) 15-40 mass parts be that raw material is made.
Treat a Chinese medicine composition for congestive heart failure, be by Radix Astragali 20-40 mass parts, Radix Ophiopogonis 9-12 mass parts, Fructus Schisandrae Chinensis 12-18 mass parts, Poria 12-18 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 9-12 mass parts, Rhizoma Chuanxiong 9-12 mass parts, Radix Rehmanniae Preparata 12-18 mass parts, Hirudo powder 1.5-2.5 mass parts (punching), Semen Lepidii (Semen Descurainiae) 20-35 mass parts be that raw material is made.
Treat a Chinese medicine composition for congestive heart failure, be by the Radix Astragali 30 mass parts, Radix Ophiopogonis 10 mass parts, Fructus Schisandrae Chinensis 15 mass parts, Poria 15 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 10 mass parts, Rhizoma Chuanxiong 12 mass parts, Radix Rehmanniae Preparata 15 mass parts, Hirudo powder 2 mass parts (punching), Semen Lepidii (Semen Descurainiae) 30 mass parts be that raw material is made.
Treat a preparation method for the Chinese medicine composition of congestive heart failure, be: except Hirudo powder, other medical material water purification soaks 1 hour, after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, remove slag after extracting juice and continue this method, mix twice decocting medicine juice, to take after mixing it with water Hirudo powder with medicine juice when taking.
Treating an application for the Chinese medicine composition of congestive heart failure, is the pharmaceutical preparation for the preparation for the treatment of congestive heart failure.
Described pharmaceutical dosage forms can be any pharmaceutically useful peroral dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder etc.
Chinese medicine is thought, the pathogenic characteristic of primary disease is based on deficiency in origin and excess in superficiality, and basic pathogenesis is with the deficiency of vital energy, yang deficiency, the deficiency of YIN for this, and blood stasis, water retention, expectorant are turbid is mark.The Chinese medicine formula of the present invention take the Radix Astragali as the merit of monarch drug, tool QI invigorating, diuretic; Ministerial drug Poria promoting diuresis to eliminate damp pathogen, and mild in medicine property and, diuretic and do not hinder healthy energy, compatibility Rhizoma Atractylodis Macrocephalae (parched) QI invigorating, diuretic, Semen Lepidii (Semen Descurainiae) inducing diuresis to remove edema; Yin nourishing Radix Ophiopogonis, to clear away heart-fire, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, kidney calming; Hirudo removing blood stasis with potent drugs dredging collateral; Rhizoma Chuanxiong blood-activating and qi-promoting, the cloudy blood of Radix Rehmanniae Preparata nourishing the liver and kidney is adjuvant altogether.All medicines share, and play QI invigorating, diuretic, the merit that nourishes heart altogether.Clinical efficacy is satisfied, and have no side effect, cost is lower, and late result certainly, is worthy of popularization.
Detailed description of the invention
Do to illustrate in detail, intactly further to the present invention below in conjunction with embodiment.
The Radix Astragali used in following embodiment, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Poria, Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Chuanxiong, Radix Rehmanniae Preparata, Hirudo powder, Semen Lepidii (Semen Descurainiae) raw material all meet the relevant every regulation under Chinese Pharmacopoeia 2005 editions one text each medical material item.Each medical material through processed such as clean system, cutting, the process of preparing Chinese medicine, pulverizing, before feeding intake, is tested and appraised, and ingredients material object conforms to title, and quality meets state-promulgated pharmacopoeia standard (concrete Med Mat Appreciation way performs with reference to standards of pharmacopoeia).
Embodiment 1
Take Radix Astragali 20g, Radix Ophiopogonis 6g, Fructus Schisandrae Chinensis 20g, Poria 20g, Rhizoma Atractylodis Macrocephalae (parched) 6g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 20g, Hirudo powder 3g(rush), Semen Lepidii (Semen Descurainiae) 15g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 2
Take Radix Astragali 45g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 10g, Poria 10g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Rhizoma Chuanxiong 15g, Radix Rehmanniae Preparata 10g, Hirudo powder 1g(rush), Semen Lepidii (Semen Descurainiae) 40g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 3
Take Radix Astragali 30g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 15g, Poria 15g, Rhizoma Atractylodis Macrocephalae (parched) 10g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 15g, Hirudo powder 2g(rush), Semen Lepidii (Semen Descurainiae) 30g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 4
Take Radix Astragali 40g, Radix Ophiopogonis 9g, Fructus Schisandrae Chinensis 18g, Poria 12g, Rhizoma Atractylodis Macrocephalae (parched) 12g, Rhizoma Chuanxiong 9g, Radix Rehmanniae Preparata 18g, pigment 1.5g(rush), Semen Lepidii (Semen Descurainiae) 35g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 5
Take Radix Astragali 20g, Radix Ophiopogonis 12g, Fructus Schisandrae Chinensis 12g, Poria 18g, Rhizoma Atractylodis Macrocephalae (parched) 9g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 12g, pigment 2.5g(rush), Semen Lepidii (Semen Descurainiae) 35g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 6
Take Radix Astragali 40g, Radix Ophiopogonis 9g, Fructus Schisandrae Chinensis 12g, Poria 12g, Rhizoma Atractylodis Macrocephalae (parched) 9g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 15g, pigment 2.0g(rush), Semen Lepidii (Semen Descurainiae) 30g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 7
Take Radix Astragali 20g, Radix Ophiopogonis 10g, Fructus Schisandrae Chinensis 15g, Poria 15g, Rhizoma Atractylodis Macrocephalae (parched) 9g, Rhizoma Chuanxiong 12g, Radix Rehmanniae Preparata 15g, pigment 2.5g(rush), Semen Lepidii (Semen Descurainiae) 25g; Except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.
Embodiment 8
32 routine patients according to Framingham standard, meet main standard binomial (1. paroxysmal nocturnal dyspnea and (or) sleep in suppress awake; 2. distension of jugular vein or enhancing of beating; 3. pulmonary rale and (or) diminished breath sound, especially two base of lung; 4. cardiac dilatation; 5. acute lung edema; 6. third heart sound gallop), or main standard one and minor criteria binomial (1. ankle edema or two lower limbs edema; 2. nocturnal cough; 3. after movable, dyspnea obviously or increase the weight of; 4. liver enlargement (congestion); 5. hydrothorax; 6. tachycardia (> 120 beats/min)), be diagnosed as congestive heart failure, and eliminating hinders barrier etc. with liver, kidney, the serious protopathy of lung, acute heart failure, cardiogenic shock, psychological problem or intelligence.Take any combination thing in embodiment 1-7, except Hirudo powder, other medical material water purification soaks 1 hour, and after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, continues this method, mix twice decocting medicine juice after the extracting juice that removes slag, and to take after mixing it with water Hirudo powder when taking with medicine juice.Through the treatment of 2-4 the course for the treatment of (15 days being a course for the treatment of), all diseases of patient are improved gradually, good results.
Claims (6)
1. treat a Chinese medicine composition for congestive heart failure, it is characterized in that: be by Radix Astragali 20-45 mass parts, Radix Ophiopogonis 6-15 mass parts, Fructus Schisandrae Chinensis 10-20 mass parts, Poria 10-20 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 6-15 mass parts, Rhizoma Chuanxiong 6-15 mass parts, Radix Rehmanniae Preparata 10-20 mass parts, Hirudo powder 1-3 mass parts (punching), Semen Lepidii (Semen Descurainiae) 15-40 mass parts be that raw material is made.
2. the Chinese medicine composition for the treatment of congestive heart failure according to claim 1, is characterized in that: be by Radix Astragali 20-40 mass parts, Radix Ophiopogonis 9-12 mass parts, Fructus Schisandrae Chinensis 12-18 mass parts, Poria 12-18 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 9-12 mass parts, Rhizoma Chuanxiong 9-12 mass parts, Radix Rehmanniae Preparata 12-18 mass parts, Hirudo powder 1.5-2.5 mass parts (punching), Semen Lepidii (Semen Descurainiae) 20-35 mass parts be that raw material is made.
3. the Chinese medicine composition for the treatment of congestive heart failure according to claim 2, is characterized in that: be by the Radix Astragali 30 mass parts, Radix Ophiopogonis 10 mass parts, Fructus Schisandrae Chinensis 15 mass parts, Poria 15 mass parts, Rhizoma Atractylodis Macrocephalae (parched) 10 mass parts, Rhizoma Chuanxiong 12 mass parts, Radix Rehmanniae Preparata 15 mass parts, Hirudo powder 2 mass parts (punching), Semen Lepidii (Semen Descurainiae) 30 mass parts be that raw material is made.
4. the preparation method of the Chinese medicine composition of a treatment congestive heart failure according to claim 1, it is characterized in that: except Hirudo powder, other medical material water purification soaks 1 hour, after the boiling of very hot oven decocting, low baking temperature decocts half an hour slowly, remove slag after extracting juice and continue this method, mix twice decocting medicine juice, to take after mixing it with water Hirudo powder with medicine juice when taking.
5. an application for the Chinese medicine composition for the treatment of congestive heart failure according to claim 1, is characterized in that: for the preparation of the medicine for the treatment of congestive heart failure.
6. the application of the Chinese medicine composition for the treatment of congestive heart failure according to claim 5, is characterized in that: described medicine is oral formulations.
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| CN112546148A (en) * | 2020-11-21 | 2021-03-26 | 北京恒德尔康中医研究院 | Traditional Chinese medicine formula for treating chronic heart failure and preparation method thereof |
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| US20030152588A1 (en) * | 2002-01-14 | 2003-08-14 | Hsu-Shan Huang | Chinese traditional medicines for psoriasis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546148A (en) * | 2020-11-21 | 2021-03-26 | 北京恒德尔康中医研究院 | Traditional Chinese medicine formula for treating chronic heart failure and preparation method thereof |
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