CN104940039A - Compound ketoconazole lotion for hair - Google Patents
Compound ketoconazole lotion for hair Download PDFInfo
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- CN104940039A CN104940039A CN201510405857.6A CN201510405857A CN104940039A CN 104940039 A CN104940039 A CN 104940039A CN 201510405857 A CN201510405857 A CN 201510405857A CN 104940039 A CN104940039 A CN 104940039A
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- Prior art keywords
- ketoconazole
- clobetasol propionate
- hair
- lotion
- antioxidant
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- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 title claims abstract description 58
- 229960004125 ketoconazole Drugs 0.000 title claims abstract description 58
- 239000006210 lotion Substances 0.000 title claims abstract description 29
- 210000004209 hair Anatomy 0.000 title claims abstract description 25
- 150000001875 compounds Chemical class 0.000 title abstract description 8
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims abstract description 42
- 229960004703 clobetasol propionate Drugs 0.000 claims abstract description 42
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 15
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 15
- 239000008213 purified water Substances 0.000 claims abstract description 13
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 10
- 239000004064 cosurfactant Substances 0.000 claims abstract description 10
- 239000004088 foaming agent Substances 0.000 claims abstract description 10
- 239000000049 pigment Substances 0.000 claims abstract description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 45
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical group [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 12
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 12
- 150000001768 cations Chemical group 0.000 claims description 11
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical group [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 9
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 9
- 229920002907 Guar gum Polymers 0.000 claims description 8
- 239000000665 guar gum Substances 0.000 claims description 8
- 229960002154 guar gum Drugs 0.000 claims description 8
- 235000010417 guar gum Nutrition 0.000 claims description 8
- 235000010265 sodium sulphite Nutrition 0.000 claims description 8
- 230000003648 hair appearance Effects 0.000 abstract description 5
- 210000003780 hair follicle Anatomy 0.000 abstract description 4
- 229920002545 silicone oil Polymers 0.000 abstract description 3
- 239000003381 stabilizer Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001143 conditioned effect Effects 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 description 15
- 238000003756 stirring Methods 0.000 description 15
- 239000000463 material Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 210000004761 scalp Anatomy 0.000 description 7
- 230000002538 fungal effect Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- -1 methyl sterols Chemical class 0.000 description 4
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 3
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 3
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 231100000284 endotoxic Toxicity 0.000 description 2
- 230000002346 endotoxic effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000008686 ergosterol biosynthesis Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 235000014593 oils and fats Nutrition 0.000 description 2
- 230000001662 opsonic effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 201000009862 superficial mycosis Diseases 0.000 description 2
- 206010052366 systemic mycosis Diseases 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 231100000759 toxicological effect Toxicity 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a compound ketoconazole lotion for hair. The compound ketoconazole lotion comprises, by weight, 1-2% of ketoconazole, 0.02-0.03% of clobetasol propionate, 20-26.5% of surfactant, 3-7% of cosurfactant, 0.2-0.5% of conditioner, 6-10% of foaming agent, 0.05-0.15% of ethylenediamine tetraacetic acid disodium salt, 0.5-3% of antioxidant, 0.01-0.03% of pigment and the balance purified water. Accessories used in the compound ketoconazole lotion for hair include the surfactant, the cosurfactant, the conditioner, the foaming agent, the antioxidant and the ethylenediamine tetraacetic acid disodium salt serving as the antioxidant synergist, the stabilizer and the softener. A proper number of accessories are matched with the ketoconazole and the clobetasol propionate so that the characters and the performance of the compound ketoconazole lotion for hair can be stable, the antibacterial activity of the ketoconazole and the clobetasol propionate can be brought into full play, in addition, compound ketoconazole lotion does not contain silicone oil or essence, the hair quality can be well conditioned, and the hair follicles cannot be damaged.
Description
Technical field
The present invention relates to a kind of hair lotion, more specifically relate to a kind of Ketoconazol/Clobetasol Propionate hair lotion.
Background technology
Scalp is the soft tissue be covered in outside skull, and healthy scalp ecological environment is maintained by the balance of finance, credits and materials: oils and fats, flora, metabolic balance.Skin fat secretion is unbalance right overhead, and scalp fuel-displacedly will become greasy; When scalp flora environment is unbalance, harmful bacteria grows in a large number, just there will be the phenomenon of head pruritus; And scalp stratum corneum is too fast, comes off and just form dandruff.Ketoconazole hair lotion can maintain the balance of oils and fats, flora and this three of metabolism, ensures the health of scalp.Existing ketoconazole hair lotion, in order to keep stablizing and playing the effect improving hair quality of lotion, need to add silicone oil in lotion, but silicone oil has certain damage to hair follicle.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of not silicate-containing oil and essence, stable performance and the Ketoconazol/Clobetasol Propionate hair lotion of non-scalp irritation.
In order to reach above-mentioned technique effect, technical scheme of the present invention is as follows:
Ketoconazol/Clobetasol Propionate hair lotion, comprises by weight percentage
The ketoconazole of 1% ~ 2%
The clobetasol propionate of 0.02% ~ 0.03%
The surfactant of 20% ~ 26.5%
Surfactant comprises alkyl polyglucoside, cocamido propyl betaine, Coco monethanolamide
The cosurfactant of 3% ~ 7%, cosurfactant is propylene glycol
The conditioner of 0.2% ~ 0.5%, conditioner is cation guar gum
The foaming agent of 6% ~ 10%, foaming agent is ammonium lauryl sulfate
The disodiumedetate of 0.05% ~ 0.15%
The antioxidant of 0.5% ~ 3%, antioxidant is sodium sulfite
The pigment of 0.01% ~ 0.03%
Surplus is purified water.
In some embodiments, total amount be 20% ~ 26.5% surfactant comprise: the alkyl polyglucoside of 16% ~ 18%, the cocamido propyl betaine of 2% ~ 4%, 2% ~ 4.5% Coco monethanolamide.
In some embodiments, comprise by weight percentage the ketoconazole of 1.5%, 0.025% clobetasol propionate, 0.45% cation guar gum, 17% alkyl polyglucoside, the cocamido propyl betaine of 3%, the Coco monethanolamide of 3% and 1.5% sodium sulfite, 3% propylene glycol, the ammonium lauryl sulfate of 9%, the disodiumedetate of 0.1% and 0.02% pigment, surplus is purified water.
Its beneficial effect is: the present invention is Ketoconazol/Clobetasol Propionate hair lotion is compound preparation, and major ingredient comprises ketoconazole and clobetasol propionate.Ketoconazole is widely used in the treatment of superficial part and deep mycosis and has good effect, ketoconazole is mainly through the necessary material of interference cell institute, namely ergosterol biosynthesis and play a role, and disturb other membrane lipids, cause the accumulation of C-14 methyl sterols, thus selectivity toxicological effect is occurred to fungal cell, it also suppresses peroxidase system, and the peroxide making fungal cell endotoxic gathers that to cause fungal cell completely downright bad.Clobetasol propionate is novel potent corticosteroid, has powerful antiinflammatory, antiallergic and antipruritic function.The deficiency that ketoconazole and complementary two prescriptions of clobetasol propionate use in conjunction energy are solely applied, thus expand the scope of application.Clobetasol propionate assists Oral Treatment With Ketoconazole superficial mycosis, can alleviate rapidly and significantly inflammation and the pruritus in fungus change portion, thus plays synergism, heightens the effect of a treatment, and can alleviate the skin irritation of ketoconazole.Ketoconazole has amide groups and the ether of very easily oxidation stain, and antioxidant sodium sulfite can prevent ketoconazole to be oxidized.Conditioner cation guar gum has softness, anlistatig effect under low concentration, improves hair quality.The adjuvant that the present invention uses in Ketoconazol/Clobetasol Propionate hair lotion has surfactant, cosurfactant, conditioner, foaming agent and antioxidant, as the disodiumedetate of antioxidant synergist, stabilizing agent and softening agent.Appropriate amount of auxiliary materials and ketoconazole and clobetasol propionate cooperatively interact, make character and the stable performance of Ketoconazol/Clobetasol Propionate hair lotion, the bacteriostasis of ketoconazole and clobetasol propionate can be given full play to, in addition, while not silicate-containing oil and essence, good opsonic action can be had to hair quality, and can not damage be caused to hair follicle.
Detailed description of the invention
Below in conjunction with specific embodiment, Ketoconazol/Clobetasol Propionate hair lotion of the present invention is further described.
Ketoconazol/Clobetasol Propionate hair lotion by weight percentage, comprise the ketoconazole of 1% ~ 2%, 0.02% ~ 0.03% clobetasol propionate, the surfactant of 20% ~ 26.5%, the cosurfactant of 3% ~ 7%, the conditioner of 0.2% ~ 0.5%, the foaming agent of 6% ~ 10%, the disodiumedetate of 0.05% ~ 0.15%, the antioxidant of 0.5% ~ 3%, the pigment of 0.01% ~ 0.03%, surplus is purified water.Surfactant comprises alkyl polyglucoside, cocamido propyl betaine, Coco monethanolamide; Cosurfactant is propylene glycol; Conditioner is cation guar gum; Foaming agent is ammonium lauryl sulfate; Antioxidant is sodium sulfite.Wherein, total amount be 20% ~ 26.5% surfactant comprise: the alkyl polyglucoside of 16% ~ 18%, the cocamido propyl betaine of 2% ~ 4%, 2% ~ 4.5% Coco monethanolamide.
Preferably, every 1000g Ketoconazol/Clobetasol Propionate hair lotion comprise 1.5% ketoconazole, 0.025% clobetasol propionate, 0.45% cation guar gum, 17% alkyl polyglucoside, the cocamido propyl betaine of 3%, the Coco monethanolamide of 3% and 1.5% sodium sulfite, 3% propylene glycol, the ammonium lauryl sulfate of 9%, the disodiumedetate of 0.1% and 0.02% pigment, surplus is purified water.
Embodiment one
Purified water is added at the emulsifying pot of cleaning, unlatching is heated with stirring to 80 ~ 85 DEG C, add the alkyl polyglucoside of 170g, 90g ammonium lauryl sulfate, 30g cocamido propyl betaine, 30g Coco monethanolamide stirring and dissolving successively, then the propylene glycol medicinal liquid of 15g ketoconazole and 0.25g clobetasol propionate is added, and swing with propylene glycol and wash material dissolution pot, and washing liquid will be swung join in emulsifying pot, open stir, homogenizing 10 minutes.
Water-soluble for purification 4.5g cation melon glue and 1g disodium ethylene diamine tetra-acetic acid solution are poured in emulsifying pot, opens stirring, homogenizing 10 minutes.Then by when material is cooled to 45 DEG C in emulsifying pot, respectively the pigment of 0.2g, the aqueous solution of sodium bisulfite of 15g are added in emulsifying pot by charge door, stir 10 minutes, continue cooling, be cooled to room temperature.
Wherein, total consumption of purified water is 614.05g, and total consumption of propylene glycol is 30g.
Embodiment two
Purified water is added at the emulsifying pot of cleaning, unlatching is heated with stirring to 80 ~ 85 DEG C, add the alkyl polyglucoside of 160g, 60g ammonium lauryl sulfate, 20g cocamido propyl betaine, 20g Coco monethanolamide stirring and dissolving successively, then the propylene glycol medicinal liquid of 15g ketoconazole and 0.25g clobetasol propionate is added, and swing with propylene glycol and wash material dissolution pot, and washing liquid will be swung join in emulsifying pot, open stir, homogenizing 10 minutes.
Water-soluble for purification 2g cation melon glue and 0.5g disodium ethylene diamine tetra-acetic acid solution are poured in emulsifying pot, opens stirring, homogenizing 10 minutes.Then by when material is cooled to 45 DEG C in emulsifying pot, respectively the pigment of 0.1g, the aqueous solution of sodium bisulfite of 5g are added in emulsifying pot by charge door, stir 10 minutes, continue cooling, be cooled to room temperature.
Wherein, total consumption of purified water is 667.15g, and total consumption of propylene glycol is 50g.
Embodiment three
Purified water is added at the emulsifying pot of cleaning, unlatching is heated with stirring to 80 ~ 85 DEG C, add the alkyl polyglucoside of 180g, 100g ammonium lauryl sulfate, 40g cocamido propyl betaine, 45g Coco monethanolamide stirring and dissolving successively, then the propylene glycol medicinal liquid of 15g ketoconazole and 0.25g clobetasol propionate is added, and swing with propylene glycol and wash material dissolution pot, and washing liquid will be swung join in emulsifying pot, open stir, homogenizing 10 minutes.
Water-soluble for purification 5g cation melon glue and 1.5g disodium ethylene diamine tetra-acetic acid solution are poured in emulsifying pot, opens stirring, homogenizing 10 minutes.Then by when material is cooled to 45 DEG C in emulsifying pot, respectively the pigment of 0.3g, the aqueous solution of sodium bisulfite of 30g are added in emulsifying pot by charge door, stir 10 minutes, continue cooling, be cooled to room temperature.
Wherein, total consumption of purified water is 512.95g, total consumption 70g of propylene glycol.
The product of embodiment one, embodiment two and embodiment three is carried out fill with the plastic flexible pipe of 50mL respectively, carries out product stability investigation by national drug standards WS-10001-(HD-0030)-2002 pairs of products.
Accelerated test: Ketoconazol/Clobetasol Propionate hair lotion was placed 6 months under 30 DEG C ± 2 DEG C and relative humidity are 75% ± 5% condition, in 0,1,2,3,6 month sampling and measuring.Investigate result: in table 1 ~ 3.
Long term test: place under the condition of temperature 25 DEG C ± 2 DEG C, relative humidity 60% ± 10%, respectively at 0,6,12,24 month sampling and measuring.Investigate result: in table 4 ~ 6.
The product accelerated test result table (30 DEG C ± 2 DEG C, 75% ± 5%) of table 1 embodiment one
The product accelerated test result table (30 DEG C ± 2 DEG C, 75% ± 5%) of table 2 embodiment two
The product accelerated test result table (30 DEG C ± 2 DEG C, 75% ± 5%) of table 3 embodiment three
Result shows: the product of each embodiment through accelerated test, indices without significant change, constant product quality.
The product long-term test results table (25 DEG C ± 2 DEG C, 60% ± 10%) of table 4 embodiment one
The product long-term test results table (25 DEG C ± 2 DEG C, 60% ± 10%) of table 5 embodiment two
The product long-term test results table (25 DEG C ± 2 DEG C, 60% ± 10%) of table 6 embodiment three
Result shows: the product of each embodiment is after 24 months, and indices has no significant change, and shows constant product quality.
The present invention is Ketoconazol/Clobetasol Propionate hair lotion is compound preparation, and major ingredient comprises ketoconazole and clobetasol propionate.Ketoconazole is widely used in the treatment of superficial part and deep mycosis and has good effect, ketoconazole is mainly through the necessary material of interference cell institute, namely ergosterol biosynthesis and play a role, and disturb other membrane lipids, cause the accumulation of C-14 methyl sterols, thus selectivity toxicological effect is occurred to fungal cell, it also suppresses peroxidase system, and the peroxide making fungal cell endotoxic gathers that to cause fungal cell completely downright bad.Clobetasol propionate is novel potent corticosteroid, has powerful antiinflammatory, antiallergic and antipruritic function.The deficiency that ketoconazole and complementary two prescriptions of clobetasol propionate use in conjunction energy are solely applied, thus expand the scope of application.Clobetasol propionate assists Oral Treatment With Ketoconazole superficial mycosis, can alleviate rapidly and significantly inflammation and the pruritus in fungus change portion, thus plays synergism, heightens the effect of a treatment, and can alleviate the skin irritation of ketoconazole.Ketoconazole has amide groups and the ether of very easily oxidation stain, and antioxidant sodium sulfite can prevent ketoconazole to be oxidized.Conditioner cation guar gum has softness, anlistatig effect under low concentration, improves hair quality.The adjuvant that the present invention uses in Ketoconazol/Clobetasol Propionate hair lotion has surfactant, cosurfactant, conditioner, foaming agent and antioxidant, as the disodiumedetate of antioxidant synergist, stabilizing agent and softening agent.Appropriate amount of auxiliary materials and ketoconazole and clobetasol propionate cooperatively interact, make character and the stable performance of Ketoconazol/Clobetasol Propionate hair lotion, the bacteriostasis of ketoconazole and clobetasol propionate can be given full play to, in addition, while not silicate-containing oil and essence, good opsonic action can be had to hair quality, and can not damage be caused to hair follicle.
Above-described is only the preferred implementation of Ketoconazol/Clobetasol Propionate hair lotion of the present invention; for those of ordinary skill in the art; under the prerequisite not paying creative work, can also make some changes and modification, these all belong to protection scope of the present invention.
Claims (3)
1. Ketoconazol/Clobetasol Propionate hair lotion, is characterized in that, comprises by weight percentage
The ketoconazole of 1% ~ 2%
The clobetasol propionate of 0.02% ~ 0.03%
The surfactant of 20% ~ 26.5%
Described surfactant comprises alkyl polyglucoside, cocamido propyl betaine, Coco monethanolamide
The cosurfactant of 3% ~ 7%, described cosurfactant is propylene glycol
The conditioner of 0.2% ~ 0.5%, described conditioner is cation guar gum
The foaming agent of 6% ~ 10%, described foaming agent is ammonium lauryl sulfate
The disodiumedetate of 0.05% ~ 0.15%
The antioxidant of 0.5% ~ 3%, described antioxidant is sodium sulfite
The pigment of 0.01% ~ 0.03%
Surplus is purified water.
2. Ketoconazol/Clobetasol Propionate hair lotion according to claim 1, it is characterized in that, described total amount be 20% ~ 26.5% surfactant comprise: the alkyl polyglucoside of 16% ~ 18%, the cocamido propyl betaine of 2% ~ 4%, 2% ~ 4.5% Coco monethanolamide.
3. Ketoconazol/Clobetasol Propionate hair lotion according to claim 1, it is characterized in that, comprise by weight percentage the ketoconazole of 1.5%, 0.025% clobetasol propionate, 0.45% cation guar gum, 17% alkyl polyglucoside, the cocamido propyl betaine of 3%, the Coco monethanolamide of 3% and 1.5% sodium sulfite, 3% propylene glycol, the ammonium lauryl sulfate of 9%, the disodiumedetate of 0.1% and 0.02% pigment, surplus is purified water.
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|---|---|---|---|
| CN201510405857.6A CN104940039B (en) | 2015-07-10 | 2015-07-10 | Ketoconazol/Clobetasol Propionate hair lotion |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510405857.6A CN104940039B (en) | 2015-07-10 | 2015-07-10 | Ketoconazol/Clobetasol Propionate hair lotion |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106018614A (en) * | 2016-06-23 | 2016-10-12 | 湖北人福成田药业有限公司 | Method for detecting related substances in ketoconazole sample and method for preparing ketoconazole preparation |
| CN108066342A (en) * | 2016-11-17 | 2018-05-25 | 江苏灵豹药业股份有限公司 | A kind of Compound Ketoconazole Cream agent and preparation method thereof |
| CN108113992A (en) * | 2016-11-29 | 2018-06-05 | 江苏灵豹药业股份有限公司 | It is a kind of to be used to treat Ketoconazol/Clobetasol Propionate lotion of tinea pedis and preparation method thereof |
| CN109833291A (en) * | 2019-04-03 | 2019-06-04 | 普霖贝利生物医药研发(上海)有限公司 | A kind of stable clobetasol propionate unguent and preparation method thereof |
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| CN102697669A (en) * | 2012-06-19 | 2012-10-03 | 广西博科药业有限公司 | Compound ketoconazole liquid shampoo |
| CN102920619A (en) * | 2012-10-09 | 2013-02-13 | 拉芳家化股份有限公司 | Conditioning shampoo composition containing small amount of sulfate anionic surfactant |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102697669A (en) * | 2012-06-19 | 2012-10-03 | 广西博科药业有限公司 | Compound ketoconazole liquid shampoo |
| CN102920619A (en) * | 2012-10-09 | 2013-02-13 | 拉芳家化股份有限公司 | Conditioning shampoo composition containing small amount of sulfate anionic surfactant |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106018614A (en) * | 2016-06-23 | 2016-10-12 | 湖北人福成田药业有限公司 | Method for detecting related substances in ketoconazole sample and method for preparing ketoconazole preparation |
| CN108066342A (en) * | 2016-11-17 | 2018-05-25 | 江苏灵豹药业股份有限公司 | A kind of Compound Ketoconazole Cream agent and preparation method thereof |
| CN108113992A (en) * | 2016-11-29 | 2018-06-05 | 江苏灵豹药业股份有限公司 | It is a kind of to be used to treat Ketoconazol/Clobetasol Propionate lotion of tinea pedis and preparation method thereof |
| CN109833291A (en) * | 2019-04-03 | 2019-06-04 | 普霖贝利生物医药研发(上海)有限公司 | A kind of stable clobetasol propionate unguent and preparation method thereof |
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