CN104936966A - 新的抗菌化合物及其生物学应用 - Google Patents

新的抗菌化合物及其生物学应用 Download PDF

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Publication number
CN104936966A
CN104936966A CN201380064824.9A CN201380064824A CN104936966A CN 104936966 A CN104936966 A CN 104936966A CN 201380064824 A CN201380064824 A CN 201380064824A CN 104936966 A CN104936966 A CN 104936966A
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China
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formula
compound
reaction
compounds
alkyl
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CN201380064824.9A
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English (en)
Chinese (zh)
Inventor
D.阿塔曼尤克
V.格鲁茨
F.莫罗
V.亨利昂
J.蒙布朗
E.艾里奥
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Laboratoire Biodim SAS
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Laboratoire Biodim SAS
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Publication of CN104936966A publication Critical patent/CN104936966A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Emergency Medicine (AREA)
CN201380064824.9A 2012-10-29 2013-10-28 新的抗菌化合物及其生物学应用 Pending CN104936966A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12306350.5A EP2725029A1 (en) 2012-10-29 2012-10-29 New antibacterial compounds and biological applications thereof
EP12306350.5 2012-10-29
PCT/EP2013/072526 WO2014067904A1 (en) 2012-10-29 2013-10-28 New antibacterial compounds and biological applications thereof

Publications (1)

Publication Number Publication Date
CN104936966A true CN104936966A (zh) 2015-09-23

Family

ID=47278726

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380064824.9A Pending CN104936966A (zh) 2012-10-29 2013-10-28 新的抗菌化合物及其生物学应用

Country Status (13)

Country Link
US (1) US9975911B2 (https=)
EP (2) EP2725029A1 (https=)
JP (1) JP6389463B2 (https=)
KR (1) KR20150105300A (https=)
CN (1) CN104936966A (https=)
AU (1) AU2013339557A1 (https=)
BR (1) BR112015009546A2 (https=)
CA (1) CA2889503A1 (https=)
CL (1) CL2015000985A1 (https=)
HK (1) HK1211034A1 (https=)
MX (1) MX2015005498A (https=)
RU (1) RU2015120376A (https=)
WO (1) WO2014067904A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108484619A (zh) * 2018-04-26 2018-09-04 福建师范大学泉港石化研究院 一种罗丹明基Fe3+荧光探针及其制备方法
CN108484620A (zh) * 2018-04-26 2018-09-04 福建师范大学泉港石化研究院 一种水溶性罗丹明基Cu2+荧光探针及其合成方法
CN116905145A (zh) * 2023-08-07 2023-10-20 安徽恒益智能科技股份有限公司 一种抗菌包芯纱线及其制备方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN103796657B (zh) 2011-07-19 2017-07-11 波涛生命科学有限公司 合成官能化核酸的方法
PL2872485T3 (pl) 2012-07-13 2021-05-31 Wave Life Sciences Ltd. Asymetryczna grupa pomocnicza
BR112016016400A2 (pt) 2014-01-16 2017-10-03 Wave Life Sciences Ltd Composições de oligonucleotídeos quiralmente controlados, seu uso, sua composição farmacêutica, e métodos
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
SG11202101255UA (en) 2018-08-09 2021-03-30 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
RU2770537C1 (ru) * 2021-09-15 2022-04-18 федеральное государственное автономное образовательное учреждение высшего образования «Казанский (Приволжский) федеральный университет» (ФГАОУ ВО КФУ) Фосфорилсодержащие четвертичные соли аммония с высшими алкильными заместителями, обладающие бактерицидной и фунгицидной активностью

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206156A (en) * 1976-07-27 1980-06-03 Fujisawa Pharmaceutical Company, Limited Hydroxyaminohydrocarbonphosphonic acids
CN102186842A (zh) * 2009-01-23 2011-09-14 诺斯莱克生物制药有限责任公司 异羟肟酸衍生物
WO2012073214A2 (en) * 2010-12-01 2012-06-07 Laboratoire Biodim New heptose derivatives and biological applications thereof
WO2013006444A1 (en) * 2011-07-01 2013-01-10 The George Washington University Compounds for inhibiting 1- deoxy-d-xylulose- 5 - phosphate reductoisomerase

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1580899A (en) 1976-07-27 1980-12-10 Fujisawa Pharmaceutical Co Hydroxyaminohydrocarbonphosphonic acid derivatives and production and use thereof
JPS5463024A (en) * 1977-10-27 1979-05-21 Fujisawa Pharmaceut Co Ltd 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use
JPS5562019A (en) * 1978-09-14 1980-05-10 Fujisawa Pharmaceut Co Ltd Antibacterial
US4693742A (en) 1983-12-20 1987-09-15 Rohm And Hass Company Herbicidal hydroxyamino phosphonic acids and derivatives
CA1340588C (en) 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
US6949528B1 (en) 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
BR9912062A (pt) * 1998-07-15 2001-04-03 Hassan Jomaa Compostos orgânicos fosforosos e seu uso
US6911450B1 (en) 2001-01-29 2005-06-28 Universite De Geneve Pyrimidine acyclonucleoside derivatives, preparation method and use thereof
FR2872158B1 (fr) 2004-06-28 2006-11-03 Merck Sante Soc Par Actions Si Nouveaux composes diazeniumdiolates, leur procede de preparation et leur utilisation therapeutique
EP1669365A1 (en) 2004-12-03 2006-06-14 Mutabilis SA Method for preparing enzymatic substrate analogs as inhibitors of bacterial heptosyl-transferases
WO2008033747A2 (en) 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
AU2007301607A1 (en) 2006-09-25 2008-04-03 Mutabilis Sa Substituted heterocyclylcarbonylamino-acetic-acid-derivatives as inhibitors of bacterial heptose synthesis, methods for their preparation and biological applications of said inhibitors
EP2141164A1 (en) 2008-07-01 2010-01-06 Mutabilis New 1,2,4-triazine derivatives and biological applications thereof
WO2011045703A2 (en) 2009-10-13 2011-04-21 Pfizer Inc. C-linked hydroxamic acid derivatives useful as antibacterial agents
EP2377853A1 (en) 2010-04-09 2011-10-19 Universite de Rouen 7,11-Methanocycloocta[b]quinoline derivative as highly functionalizable acetylcholinesterase inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206156A (en) * 1976-07-27 1980-06-03 Fujisawa Pharmaceutical Company, Limited Hydroxyaminohydrocarbonphosphonic acids
CN102186842A (zh) * 2009-01-23 2011-09-14 诺斯莱克生物制药有限责任公司 异羟肟酸衍生物
WO2012073214A2 (en) * 2010-12-01 2012-06-07 Laboratoire Biodim New heptose derivatives and biological applications thereof
WO2013006444A1 (en) * 2011-07-01 2013-01-10 The George Washington University Compounds for inhibiting 1- deoxy-d-xylulose- 5 - phosphate reductoisomerase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FORET, JOHANNA ET AL: "Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
逯南南等: "LpxC抑制物抗菌活性研究", 《食品与药品》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108484619A (zh) * 2018-04-26 2018-09-04 福建师范大学泉港石化研究院 一种罗丹明基Fe3+荧光探针及其制备方法
CN108484620A (zh) * 2018-04-26 2018-09-04 福建师范大学泉港石化研究院 一种水溶性罗丹明基Cu2+荧光探针及其合成方法
CN116905145A (zh) * 2023-08-07 2023-10-20 安徽恒益智能科技股份有限公司 一种抗菌包芯纱线及其制备方法

Also Published As

Publication number Publication date
WO2014067904A1 (en) 2014-05-08
EP2912043B1 (en) 2016-11-30
KR20150105300A (ko) 2015-09-16
AU2013339557A1 (en) 2015-04-30
MX2015005498A (es) 2016-01-08
EP2912043A1 (en) 2015-09-02
US20150291636A1 (en) 2015-10-15
HK1211034A1 (en) 2016-05-13
US9975911B2 (en) 2018-05-22
JP2015536928A (ja) 2015-12-24
BR112015009546A2 (pt) 2017-07-04
RU2015120376A (ru) 2016-12-20
JP6389463B2 (ja) 2018-09-12
EP2725029A1 (en) 2014-04-30
CA2889503A1 (en) 2014-05-08
CL2015000985A1 (es) 2016-05-13

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