CN104922404B - A kind of externally applied drug and preparation method thereof for treating osteoproliferation - Google Patents
A kind of externally applied drug and preparation method thereof for treating osteoproliferation Download PDFInfo
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Abstract
The present invention relates to a kind of externally applied drugs and preparation method thereof for treating osteoproliferation, belong to the field of Chinese medicines, and the externally applied drug for the treatment of osteoproliferation of the invention is mainly made of following component in parts by weight：10~20 parts of camphor, 15~25 parts of cape jasmine, 10~20 parts of leek, 15~25 parts of glutinous rice wine, 10~20 parts of borneol, 25~35 parts of vaseline.The externally applied drug includes camphor, borneol and cape jasmine of set composition by weight etc.；The effect of all medicine simultaneously using both cold and hot drugs play promoting blood circulation to remove blood stasis, remove obstruction in channels to relieve pain altogether can cure mainly the pain caused by osteoproliferation pressuring nerve, the symptoms such as numbness；The application method of external application can be used in the externally applied drug so that drug goes directly affected part, and drug effect is apparent, and medication is direct, will not cause suffering to patient.It is prepared in addition, the externally applied drug is realized using operations such as grinding, mixing and stirrings, entire preparation method is simple, at low cost.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of externally applied drug and preparation method thereof for treating osteoproliferation.
Background technology
Osteoproliferation（Hypertrophic osteoarthropathy）Refer to due to degeneration of joint, so that articular cartilage is destroyed and causes
Chronic joint disease, also known as degenerative arthritis, osteoarthritis and hypertrophiarthritis etc..
Hypertrophic osteoarthropathy has primary and two kinds secondary.Primary is also known as idiopathic, is with human body natural's aging
It is main, it is more rare；And it is secondary then based on the chronic strain day after tomorrow and wound, it is more common.The Basic disease cause of primary osteoarthropathy
It is the gradual aging and retrogression after human body maturation, the performance in terms of Bones and joints.Secondary osteoarthrosis refers to because of certain
Cartilage destruction or joint structure change caused by known reason, such as wound, operation or other apparent factors.Due to joint
Face rubs or the factors such as pressure imbalance, causes the retrogression of articular surface.
Osteoproliferation onset is slow, no constitutional symptom, mostly 50 years old or more person in middle and old age.It often falls ill for multi-joint, also has
The person of being a single joint disease.Affected joints can have duration secret anguish, activity to aggravate when increasing, improve after rest.Pain is not often serious, gas
It is aggravated when pressure drop is low, it is related with climate change.Sometimes there may be acute pain episodes, while having joint stiff sense, occasionally it can be found that
It is intra-articular to have crunch.The stiff exacerbation of sitting posterior joint slightly improves after activity, and someone is referred to as " rest pain ".Later stage swollen joint
Swollen, increase and limitation of movement, seldom complete tetanus normally behave as bone retardance sign.
In the related technology, the therapy most important and most basic for osteoproliferation be subtract it is pauciarticular heavy burden and excessively
It is significantly movable, diseased joints are treasured, to delay the process of lesion.Overweight people should lose weight, to subtract pauciarticular load,
Delay the development of lesion.Joint of lower extremity can use crutch or walking stick when having a lesion, to mitigate the burden in joint.
In addition, patient can also do physical therapy and exercise appropriate, to keep the scope of activities in joint, folder can be used when necessary
Plate brace and walking stick etc. help to control acute stage symptom.In terms of the drug for the treatment of osteoproliferation, generally with anti-inflammatory analgesic
Externally applied drug is relatively conventional, however, anti-inflammation and analgesic drugs can mitigate or control symptom, but it can not directly act on affected part, cannot
The progress for changing lesion, only serves during acute pain episodes and takes stopgap measures.In addition, to more serious patient, in whole body
Situation is resistant under conditions of operation, and it is to eliminate pain, correction deformity, improve the effective of bone function to carry out artificial joint replacement
Method, however this method is of high cost, pain is larger caused by patient, and the postoperative time for needing to recuperate is long.
In view of this, special propose the present invention.
Invention content
An object of the present invention is to provide a kind of externally applied drug for treating osteoproliferation, the externally applied drug of the treatment osteoproliferation
Camphor, borneol and cape jasmine including set composition by weight etc.；All medicine simultaneously using both cold and hot drugs play promoting blood circulation to remove blood stasis altogether, the work(removed obstruction in channels to relieve pain
Effect, can cure mainly the pain caused by osteoproliferation pressuring nerve, the symptoms such as numbness；What the externally applied drug can be used external application uses prescription
Formula so that drug goes directly affected part, and drug effect is apparent.
The second object of the present invention is to provide the preparation method of the externally applied drug of above-mentioned treatment osteoproliferation, and this method is adopted
The preparation of the externally applied drug is realized with operations such as grinding, mixing and stirrings, entire preparation method is simple, at low cost, and
Medication is direct, will not cause suffering to patient.
In order to achieve the goal above, the present invention is special to use following technical scheme：
A kind of externally applied drug for treating osteoproliferation is made of following component in parts by weight：
10~20 parts of camphor, 15~25 parts of cape jasmine, 10~20 parts of leek, 15~25 parts of glutinous rice wine, borneol 10
~20 parts, 25~35 parts of vaseline.
In the externally applied drug, camphor：Pungent-warm, external application have antipruritic, analgesic, the effect of local anaesthesia；Borneol：Xin Han.Heat-clearing stops
Bitterly；Cape jasmine：Bitter cold.Swelling and pain relieving.《Compendium of Materia Medica》Recorded " ... traumatic blood stasis ".Leek：Smell is pungent, has and dissipates stasis of blood work
Stagnant effect is led in blood, promoting the circulation of qi, can external curing traumatic injury, blood stasis and swelling pain.Glutinous rice wine：Pungent-warm perfume (or spice) dissipates.It is living with cold extermination clearing damp
The effect of blood stagnation resolvation.Vaseline has the function of all medicines of bonding, and specific shape is formed convenient for external used medicine.According to set weight
After ratio compatibility, the effect of each component plays drug effect jointly, and all medicine simultaneously using both cold and hot drugs play promoting blood circulation to remove blood stasis, remove obstruction in channels to relieve pain altogether.It can cure mainly
Pain caused by osteoproliferation pressuring nerve, the symptoms such as numbness；And the application method of external application can be used in the externally applied drug so that medicine
Object goes directly affected part, and drug effect is apparent.
Preferably, in parts by weight, the externally applied drug its be made of following component：
12~18 parts of camphor, 18~22 parts of cape jasmine, 12~17 parts of leek, 18~22 parts of glutinous rice wine, borneol 12
~15 parts, 28~32 parts of vaseline.Externally applied drug with said ratio, drug effect are especially pronounced.
Preferably, in order to enable the promoting blood circulation to remove blood stasis and analgesic effect of the externally applied drug are more preferable, optional Moschus 0.04~
0.08 part of component as the externally applied drug.Moschus：Pungent-warm, promoting blood circulation to remove blood stasis and relieve pain.《Compendium of Materia Medica》It is recorded " ... open through
Network, saturating flesh bone "；After it is with set parts by weight and camphor and cape jasmine mixture, it can assign that externally applied drug is antipruritic, relieves pain, disappears
Swollen and local anaesthesia effect.
A method of the externally applied drug preparing treatment osteoproliferation includes the following steps：
1）, will camphor, borneol, cape jasmine grinding after mix, obtain first material；
2）, leek is smashed to pieces after mix with the first material, obtain second material；
3）, glutinous rice wine and vaseline are added in the second material, and stir to paste, obtain for treating hyperostosis
Raw externally applied drug.
The preparation method, which uses the operating procedures such as grind, smash to pieces and stir and different medicine materials is made, can be used for controlling
Treat the externally applied drug of osteoproliferation；This method is easy to operate, easily controllable, and manufacturing cost is low so that the cost of manufactured externally applied drug
Also corresponding relatively low.
In addition, for the externally applied drug, during use, applied in affected part（Painful area）, and Solecare is multiple
State selectes daily application number and the number of days for the treatment of.
In addition, during specific prepare, step 1）In camphor, borneol, cape jasmine ground after can mixing, can also
It is remixed after grinding respectively.In step 2）In, operation is smashed to pieces for leek, is preferably smash leek to paste, in this way contained by it
Active ingredient can be precipitated as much as possible completely, be conducive to improve externally applied drug drug effect.
In further technical solution, in order to enable manufactured externally applied drug have preferably it is antipruritic, analgesic, detumescence and
The effect of local anaesthesia, it is preferred that in step 3）In, it specifically includes：
Glutinous rice wine and vaseline are first added in the second material, after stirring to paste, on the surface of pasty mixture
Moschus is applied, externally applied drug is obtained.Moschus is in the surface of pasty mixture, and it is straight to be especially advantageous for Moschus during medication in this way
It connects and penetrates into affected part, to improve curative effect.
It is further preferred that in step 3）In, it specifically includes：
Glutinous rice wine and vaseline are first added in the second material, and is wrapped up with gauze bag after stirring to paste, in yarn
The surface of cloth bag applies Moschus, obtains externally applied drug.
For needing application time longer patient, borneol is easy to melt, so that externally applied drug is thinning, is unfavorable for pasting
It applies；Therefore during preparation, rice wine and vaseline will be added in second material, and with gauze bag packet after stirring to paste
It wraps up in, then Moschus is applied on the surface of gauze bag, obtain externally applied drug；All drugs are integrated in one by gauze, prevent its point
It dissipates.And since Moschus sprays on gauze bag surface, when medication, the Moschus on surface can be contacted directly with affected part,
Realize under the premise of accelerating the infiltration rate of drug, prevent externally applied drug due to the topical application of drug time is long and caused by dilute dissipate scatter
Situation.
In addition, in order to accelerate the preparation efficiency of externally applied drug, and make each component grinding of externally applied drug abundant, it is preferred that institute
Grinding is stated to complete using mortar.
Preferably, in step 2）In：During the mixing, the leek smashed to pieces and the first material are stirred
It mixes.By stirring operation, it is abundant can so that the leek smashed to pieces and first material mix.
Preferably, in step 3）In, the stirring is completed using blender.
Whipping process uses pony mixer or food blending machine, to improve the efficiency of stirring, saves the time, and be conducive to
Each component mixing is abundant.
Preferably, in step 3）In, the alcoholic strength of the glutinous rice wine is 5%~15%.
Alcoholic strength be 5%~15% glutinous rice wine, with may help to after other component mixtures improve externally applied drug cold extermination clearing damp,
Effect promoting blood circulation and removing blood stasis；But also tool helps to improve the effect of cape jasmine swelling and pain relieving.
Compared with prior art, technique effect of the invention includes the following aspects：
1）, the externally applied drug due to component selection rationally it is appropriate, assigning it can the effect of removing obstruction in channels to relieve pain with promoting blood circulation to remove blood stasis
Cure mainly the pain caused by osteoproliferation pressuring nerve, the symptoms such as numbness.
2）, the drug be externally applied drug, medication is convenient, and can go directly affected part, therefore has better drug effect.
3）, the medicine components be Chinese medicine, it is safe to the human body harmless, and with effecting a permanent cure effect, with traditional operation
The mode for the treatment of osteoproliferation is compared, and has the advantages of cost-effective, can to reduce patient suffering.
4）, the preparation process of entire externally applied drug it is simple, it is easily operated, special large scale equipment is not necessarily to, so that entire system
For the of low cost of process.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument, which are not specified, prepares manufacturer person, is
The conventional products that can be obtained by commercially available purchase.
The present invention provides a kind of externally applied drugs for treating osteoproliferation, in parts by weight, are made of following component：
10~20 parts of camphor, 15~25 parts of cape jasmine, 10~20 parts of leek, 15~25 parts of glutinous rice wine, borneol 10
~20 parts, 25~35 parts of vaseline.Preferably, it is made of following component：12~18 parts of camphor, cape jasmine 18~
22 parts, 12~17 parts of leek, 18~22 parts of glutinous rice wine, 12~15 parts of borneol, 28~32 parts of vaseline.In addition, being
Improve the effect of the promoting blood circulation to remove blood stasis of externally applied drug, it is preferred that medicine components further include 0.04~0.08 part of Moschus.
Method provided by the present invention for preparing above-mentioned externally applied drug comprising following steps：
1）, will camphor, borneol, cape jasmine grinding after mix, obtain first material；
2）, leek is smashed to pieces after mix with the first material, obtain second material；
3）, glutinous rice wine and vaseline are added in the second material, and stir to paste, obtain for treating hyperostosis
Raw externally applied drug.
This method will first mix after camphor, borneol, cape jasmine grinding so that the active ingredient of three herbal medicine mixes, secondly
The first material of three herbal medicines composition is mixed with leek again, obtains second material, glutinous rice wine and all is added in second material
Intellectual circle, the externally applied drug that obtains paste by the adhesive effect of stirring and vaseline and can directly stick.
Next, enumerating reality in detail below to the externally applied drug and preparation method thereof for the treatment of osteoproliferation provided by the invention
Apply example：
Embodiment 1
It will be mixed after 10 g of camphor, 10 g of borneol, cape jasmine 15 g grindings, obtain first material；After 10 g of leek is smashed to pieces
It is mixed with the first material, obtains second material；
Glutinous rice wine 15 g and vaseline 25g are added in the second material, and stirs to paste, obtains for treating bone
The externally applied drug of matter hyperplasia.
Embodiment 2
It is mixed after 20 g of camphor, 20 g of borneol, 25 g of cape jasmine are utilized respectively mortar grinder, obtains first material；By fragrant-flowered garlic
20 g of dish is mixed after smashing to pieces with the first material, obtains second material；
Glutinous rice wine 25 g and vaseline 35g are added in the second material, and stirs to paste, and in pasty mixture
Surface spread Moschus 0.08g, obtain the externally applied drug for treating osteoproliferation.
Embodiment 3
It is mixed after 15 g of camphor, 15 g of borneol, 20 g of cape jasmine are utilized respectively mortar grinder, obtains first material；By fragrant-flowered garlic
15 g of dish is mixed after smashing to pieces with the first material, obtains second material；
Glutinous rice wine 20 g and vaseline 30g are added in the second material, and is wrapped up with gauze bag after stirring to paste,
The surface of gauze bag apply 0.06 g of Moschus to get.
Embodiment 4
It is mixed after 18 g of camphor, 22 g of borneol, 20 g of cape jasmine are utilized respectively mortar grinder, obtains first material；By fragrant-flowered garlic
17 g of dish is mixed after smashing to pieces with the first material, obtains second material；
Glutinous rice wine 17 g and vaseline 25g are added in the second material, and is wrapped up with gauze bag after stirring to paste,
0.05 g of Moschus is applied on the surface of gauze bag, obtains the externally applied drug for treating osteoproliferation.
Embodiment 5
After 18 g of camphor, 22 g of borneol, 20 g of cape jasmine are mixed, profit after being grinded with a mortar, obtains first material together；It will
17 g of leek is mixed after smashing to pieces with the first material, obtains second material；
16 g of glutinous rice wine is added in the second material（Alcoholic strength is 10%）With vaseline 25g, and hand operated mixing to paste
It is wrapped up with gauze bag after shape, and 0.05 g of Moschus is applied on the surface of gauze bag, obtain the externally applied drug for treating osteoproliferation.
Embodiment 6
It is mixed after 150 g of camphor, 150 g of borneol, 200 g of cape jasmine are utilized respectively mortar grinder, obtains first material；It will
150 g of leek is mixed after smashing to pieces with the first material, obtains second material；
Glutinous rice wine 250 g and vaseline 350g are added in the second material, is stirred to paste using pony mixer
It is wrapped up afterwards with gauze bag, and Moschus 0.8g is applied on the surface of gauze bag, obtain the externally applied drug for treating osteoproliferation.
Embodiment 7
It is mixed after 200 g of camphor, 200 g of borneol, 250 g of cape jasmine are utilized respectively mortar grinder, obtains first material；It will
180 g of leek is mixed after smashing to pieces with the first material, obtains second material；
250 g of glutinous rice wine is added in the second material（Alcoholic strength is 5%）With vaseline 350g, and stirred using small-sized
The machine of mixing is wrapped up after stirring to paste with gauze bag, and applies Moschus 0.8g on the surface of gauze bag, is obtained for treating hyperostosis
Raw externally applied drug.
Embodiment 8
It is mixed after 100 g of camphor, 200 g of borneol, 200 g of cape jasmine are utilized respectively mortar grinder, obtains first material；It will
190 g of leek is mixed after smashing to pieces with the first material, obtains second material；
Glutinous rice wine is added in the second material（Alcoholic strength is 15%）300 g of 150 g and vaseline, is stirred using small-sized
The machine of mixing is wrapped up after stirring to paste with gauze bag, and applies 0.6 g of Moschus on the surface of gauze bag, is obtained for treating hyperostosis
Raw externally applied drug.
For the externally applied drug that can be used for treating osteoproliferation that above-described embodiment is prepared into, during use, with reality
It is a patch to apply the externally applied drug that a 1-5 is provided, and is pasted again once every three days, and general 3 patch can fully recover.
Case 1
Text so-and-so, female, 58 years old.Lumbocrural pain 3 months, limitation of activity.It is found through x-ray inspection in county hospital Orthopeadic Surgery, the
5,6 lumbar vertebrae hyperosteogenies.Then lumbar traction and drug therapy one month, but less effective are carried out.Afterwards with this side（Embodiment 3 carries
For）One patch pain is substantially reduced, and all diseases all disappear and accuse recovery from illness after two patches.
Case 2
Pueraria lobota so-and-so.Man, 62 years old.Headache, dizzy, left arm numbness half a year.In the People's Hospital of city the 3rd is found through x-ray inspection,
4,5 cervical vertebrae hyperosteogenies, and have no positive effect through traction and acupuncture and moxibustion therapy.Still see dizziness headache with nausea, left arm fiber crops
The wooden night is especially heavy, arrives here then through this prescription（Embodiment 3 provides）After external application for curing three pastes, no headache, dizzy and numb, until
The present not yet recurs.
Case 3
Section so-and-so, female, 55 years old.With right gonalgia, it is unfavorable to bend and stretch walking, is found to county people's hospital through x-ray inspection
Right knee kneecap osteoproliferation.Through hormone, does not improve after anodyne treatment, pasted later through this side's external application for curing three（Embodiment 1 carries
For）Afterwards, pain symptom all disappears, and activity is freely.
In conclusion the externally applied drug of this treatment osteoproliferation provided by the invention, all medicines（Component）Simultaneously using both cold and hot drugs are played altogether
Promoting blood circulation to remove blood stasis the effect of removing obstruction in channels to relieve pain, can cure mainly the pain caused by osteoproliferation pressuring nerve, the symptoms such as numbness；The external application
The application method of external application can be used in medicine so that drug goes directly affected part, and drug effect is apparent.It is of high cost to overcome artificial joint replacement,
Pain is larger caused by patient, and the postoperative defect for needing the time recuperated length.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (11)
1. a kind of externally applied drug for treating osteoproliferation, which is characterized in that in parts by weight, be made of following component：
10~20 parts of camphor, 15~25 parts of cape jasmine, 10~20 parts of leek, 15~25 parts of glutinous rice wine, 10~20 parts of borneol, vaseline
25~35 parts.
2. as described in claim 1 treatment osteoproliferation externally applied drug, which is characterized in that in parts by weight, by with
Lower component is made：
12~18 parts of camphor, 18~22 parts of cape jasmine, 12~17 parts of leek, 18~22 parts of glutinous rice wine, 12~15 parts of borneol, vaseline
28~32 parts.
3. the externally applied drug for the treatment of osteoproliferation as claimed in claim 1 or 2, which is characterized in that its component further includes：Moschus
0.04~0.08 part.
4. a kind of method for the externally applied drug preparing treatment osteoproliferation as claimed in claim 1 or 2, which is characterized in that including such as
Lower step：
1）, will camphor, borneol, cape jasmine grinding after mix, obtain first material；
2）, leek is smashed to pieces after mix with the first material, obtain second material；
3）, glutinous rice wine and vaseline are added in the second material, and stir to paste, obtain for treating osteoproliferation
Externally applied drug.
5. the method for the externally applied drug as claimed in claim 4 for preparing treatment osteoproliferation, which is characterized in that in step 3）In also
Include the steps that applying Moschus, the parts by weight of the Moschus are 0.04~0.08 part.
6. the method for the externally applied drug as claimed in claim 5 for preparing treatment osteoproliferation, which is characterized in that in step 3）In,
It specifically includes：
Glutinous rice wine and vaseline are first added in the second material to apply on the surface of pasty mixture after stirring to paste
Moschus obtains externally applied drug.
7. the method for the externally applied drug as claimed in claim 5 for preparing treatment osteoproliferation, which is characterized in that in step 3）In,
It specifically includes：
Glutinous rice wine and vaseline are first added in the second material, and is wrapped up with gauze bag after stirring to paste, in gauze bag
Surface apply Moschus, obtain externally applied drug.
8. the method for preparing the externally applied drug for the treatment of osteoproliferation such as claim 4-7 any one of them, which is characterized in that in step
Rapid 1）In, the grinding is completed using mortar.
9. the method for the externally applied drug as claimed in claim 8 for preparing treatment osteoproliferation, which is characterized in that in step 2）In,
During the mixing, the leek smashed to pieces and the first material are stirred.
10. the method for the externally applied drug as claimed in claim 8 for preparing treatment osteoproliferation, which is characterized in that in step 3）In,
The stirring is completed using blender.
11. the method for the externally applied drug as claimed in claim 8 for preparing treatment osteoproliferation, which is characterized in that in step 3）In,
The alcoholic strength of the glutinous rice wine is 5%~15%.
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| CN1372948A (en) * | 2001-03-06 | 2002-10-09 | 汪昌龙 | Exterior-applied liquid medicine for promoting blood circulation, dispelling exogenous factor of wind and relaxing pain |
| CN101036672A (en) * | 2006-03-15 | 2007-09-19 | 孙毓良 | Rheumatic oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1372948A (en) * | 2001-03-06 | 2002-10-09 | 汪昌龙 | Exterior-applied liquid medicine for promoting blood circulation, dispelling exogenous factor of wind and relaxing pain |
| CN101036672A (en) * | 2006-03-15 | 2007-09-19 | 孙毓良 | Rheumatic oil |
| CN101129468A (en) * | 2007-08-21 | 2008-02-27 | 芈永庭 | Safflower wine |
| CN101518582A (en) * | 2009-02-27 | 2009-09-02 | 河南省正骨研究院 | Traditional Chinese medicine cream for treating bone fracture diseases and preparation method thereof |
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