CN104922225A - Application of traditional Chinese medicine composition in preparation of drugs for treating or preventing oral ulcer - Google Patents
Application of traditional Chinese medicine composition in preparation of drugs for treating or preventing oral ulcer Download PDFInfo
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- CN104922225A CN104922225A CN201510316609.4A CN201510316609A CN104922225A CN 104922225 A CN104922225 A CN 104922225A CN 201510316609 A CN201510316609 A CN 201510316609A CN 104922225 A CN104922225 A CN 104922225A
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Abstract
The invention relates to application of a traditional Chinese medicine composition in preparation of drugs for treating or preventing oral ulcer. The traditional Chinese medicine composition is prepared from 18 parts of thesium chinense, 20 parts of stem of falsenettleleaf pepper, 15 parts of phellinus igniarius, 20 parts of radix of mirabilis jalapa, 16 parts of rhizome of antenoron neofiliforme, 18 parts of cuspidat mnium and 20 parts of stem of Chinese viburnum. The application of the traditional Chinese medicine composition in preparation of drugs for treating or preventing oral ulcer is disclosed for the first time and remarkable progress is realized.
Description
Technical field
The present invention relates to the novelty teabag of Chinese medicine composition, particularly relate to the application of Chinese medicine composition in preparation treatment or preventing canker sore medicine.
Background technology
Recurrent oral ulceration is modal disease in diseases of oral mucosa.The first place of prevalence office diseases of oral mucosa.Sircus (1975) investigates 1587 people, and prevalence is 20%.As can be seen here, oral ulcer patient is a very huge colony.The cause of disease of recurrent oral ulceration is complicated, still indefinite so far, may be relevant with the factor such as the endocrine regulation of viral infection, bacteriological infection and body, immune dysfunction.The primary treatment measure of oral ulcer comprises topical therapeutic and whole body therapeutic, and because topical therapeutic toxic and side effects is lower, the people therefore obtaining people can.Although the buccal tablets that the local that occurs in recent years uses carries, easy to use, mouthfeel and compliance better, as lysozyme buccal tablet, watermelon crystal buccal tablet, cydiodine etc., these medicines emphasize particularly on different fields in sterilization, antiinflammatory, pain relieving etc.
Summary of the invention
The object of the present invention is to provide the application of Chinese medicine composition in preparation treatment or preventing canker sore medicine.
The application of Chinese medicine composition in preparation treatment or preventing canker sore medicine, described Chinese medicine composition is prepared by the raw material of following parts by weight: Herba Thesii 18 parts, blue 20 parts of Spica piperis betlis, Phellinus igniarius (L. ex Fr.) Quel. 15 parts, Radix Mirabilis 20 parts, Rhizoma Polygoni suffulti 16 parts, Mnium cuspidatum Hedw. 18 parts, Caulis Viburni Macrocephali 20 parts.
The preparation method of described Chinese medicine composition is: get above-mentioned Chinese medicine, decocts with water 2 times, and amount of water is 10 times amount of medical material weight for the first time, decocts 2 hours, second time amount of water is 8 times amount of medical material weight, decocts 1 hour, collecting decoction, concentrated, dry, pulverize to obtain traditional Chinese medicine particle.
In the preparation method of described Chinese medicine composition, concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
Herba Thesii is the herb of Santalaceae plant Herba Thesii ThesiumchinenseTurcz..Blazon South China, northern various places.: heat-clearing and toxic substances removing, separate administration.For enteritis, lung abscess, tonsillitis, middle administration, acute mastitis, tuberculous lymphadenitis, acute cystitis.
Spica piperis betlis is blue, and Piperaceae Piper plant folium urticae Fructus Piperis, is used as medicine with Herb.The whole year can adopt, and section is dried.Regulating QI to relieve pain.For flu, stomachache, dysmenorrhea, traumatic injury, rheumatic ostalgia.
Phellinus igniarius (L. ex Fr.) Quel., Latin is called Phellinus igniarius (L.ex Fr.) Qeul., being a kind of fungus, gaining the name because parasitizing mulberry.Sporophore stockless, the flat hemispherical of cap or the shape of a hoof, wooden, shallow liver brown to lead or black.The trunks such as poplar, willow, birch, oak also there is growth.Heat clearing away, YIN nourishing, convergence, hemostasis.Control bleeding not during menses, stranguria with blood, proctoptosis rushes down blood, married woman strains, scrofula festers, lumps in the chest and abdomen, diarrhea due to hypofunction of the spleen.
Radix Mirabilis is the tuber of Nyctaginaceae plant Mirabilis jalapa.Diuresis, purges heat, promoting blood circulation to remove blood stasis.Control stranguria with turbid discharge, leukorrhagia, impairment of the lung caused by overstrain is spitted blood, carbuncle carbuncle on the back, acute arthritis.
Rhizoma Polygoni suffulti is the rhizome of polygonaceae plant RHIZOMA POLYGONI SUFFULTI.Loose blood, hemostasis, circulation of qi promoting, regulating menstruation.Control traumatic injury, over-strained hemoptysis, have blood in stool, metrorrhagia, menoxenia.
Mnium cuspidatum Hedw. is the herb of Mniaceae Mnium cuspidaum Hedw, has hemostasis, controls epistaxis, the effects such as metrorrhagia.
Caulis Viburni Macrocephali is the stem of caprifoliaceae plant silk ball Caulis Viburni Dilatati.Latin name: Viburnum macrocephalum Fort., dampness removing to stop itchin.Main scabies is fresh; Wet rotten pain of itching.
The purposes of the Chinese medicine composition that the present invention relates in preparation treatment or preventing canker sore medicine belongs to first public, because Chinese medicine ingredients is complicated, and its treatment or preventing canker sore active unexpectedly strong, there is not the possibility being provided any enlightenment by other Chinese medicines, possess outstanding substantive distinguishing features, to be used for the treatment of or preventing canker sore obviously has significant progress simultaneously.
Detailed description of the invention
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not by any restriction of specific embodiment, but be limited by claim.
Embodiment 1: get Herba Thesii 18g, Spica piperis betlis blue 20g, Phellinus igniarius (L. ex Fr.) Quel. 15g, Radix Mirabilis 20g, Rhizoma Polygoni suffulti 16g, Mnium cuspidatum Hedw. 18g, Caulis Viburni Macrocephali 20g; decoct with water 2 times; first time, amount of water was 10 times amount of medical material weight, and decoct 2 hours, second time amount of water is 8 times amount of medical material weight; decoct 1 hour; collecting decoction, concentrated, dry; pulverize to obtain traditional Chinese medicine particle, concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
Whether embodiment 2: Chinese medicine composition anti-oral ulcer experimental study: manufacture Oral ulcer model with phenol, gives the Chinese medicine composition of Oral ulcer model rat certain number of times every day, observing Chinese medicine composition has the effect reducing ulcer.
1, test drug: prepare test drug according to the method for above-described embodiment 1.Cydiodine (Beijing Sihuan Medicine Science and Technology Co., Ltd); Phenol; Animal: Wistar rat, male, body weight 240 ~ 280g
2, method: get rat 50, male, body weight 240 ~ 280g, 10% chloral hydrate anesthesia, dosage: 0.35ml/100g, after anesthesia, plastic dropper (internal diameter: the 3mm) lower end of 90% phenol cotton balls being flat on rats with left bicker is about on the cheek film at 1mm place, calcination 30min, namely sees the white infringement of this place about 3mm.Divide into groups immediately after 24 hours, often organize 10, divide 5 groups, i.e. model group (adjuvant 4 times/day, not drug containing); Chinese medicine composition high dose group (4 times/day, 8g crude drug amount/time); Dosage in Chinese medicine composition (4 times/day, 4g crude drug amount/time); Chinese medicine composition low dose group (4 times/day, 2g crude drug amount/time); Positive controls: cydiodine group (4 times/day, 0.5mg/ time).Chinese medicine composition and cydiodine buccal tablet pulverize before use, administration is degree of being with flap coverage.Successive administration 5 days, after the front and each administration of administration, next day observes ulcer area size (diameter in ulcer) and ulcer healing situation (being considered as healing without macroscopic ulcer), and first administration is recorded as 1,2,3,4,5,6 day respectively to last administration.Ulcer area size t checks, and ulcer healing rate X2 checks.
3, result of the test: ulcer area compares (table 1): Chinese medicine composition high dose group compares with model group, plays off-test on the 3rd day from administration, and corresponding every day compares significant difference; Cydiodine group compares with model group, within the 3rd day, plays off-test from administration, and corresponding every day compares significant difference; In Chinese medicine composition, dosage group compares with model group, within the 3rd day, plays off-test from administration, and corresponding every day compares significant difference; Chinese medicine composition low dose group compares with model group, within the 5th day, plays off-test from administration, and corresponding every day compares significant difference; In Chinese medicine composition, dosage group compares with cydiodine group, within the 1st day, plays off-test from administration, and corresponding every day compares significant difference.
Table 1 is on the impact of rat ulcer area
Note: compare with model group, * p<0.05, * p<0.01.
Healing rate (table 2): model group and Chinese medicine composition low dose group play off-test on the 1st day from administration, and ulcer does not heal; And Chinese medicine composition high dose group was from administration the 4th day, just there is ulcer healing, to off-test, reach 92%; Cydiodine group, from administration the 4th day, has ulcer healing, to off-test, reaches 40%; In Chinese medicine composition, dosage group was from administration the 5th day, had ulcer healing, to off-test, reached 65%.
Table 2 is on the impact of rat ulcer healing time
Note: compare with model group, * p<0.05, * p<0.01.
4, conclusion: Chinese medicine composition has the effect obviously promoting oral ulcer healing.
Claims (3)
1. the application of Chinese medicine composition in treatment or preventing canker sore medicine, is characterized in that described Chinese medicine composition is prepared by the raw material of following parts by weight: Herba Thesii 18 parts, blue 20 parts of Spica piperis betlis, Phellinus igniarius (L. ex Fr.) Quel. 15 parts, Radix Mirabilis 20 parts, Rhizoma Polygoni suffulti 16 parts, Mnium cuspidatum Hedw. 18 parts, Caulis Viburni Macrocephali 20 parts.
2. the application of Chinese medicine composition in treatment or preventing canker sore medicine as claimed in claim 1, it is characterized in that the preparation method of described Chinese medicine composition is: get above-mentioned Chinese medicine, decoct with water 2 times, amount of water is 10 times amount of medical material weight for the first time, decocts 2 hours, second time amount of water is 8 times amount of medical material weight, decoct 1 hour, collecting decoction, concentrated, dry, pulverize to obtain traditional Chinese medicine particle.
3. the application of Chinese medicine composition in treatment or preventing canker sore medicine as claimed in claim 1, to is characterized in that in the preparation method of described Chinese medicine composition that concentrated condition is: when being evaporated to 65 DEG C at 0.07MPa, 60-70 DEG C, relative density is 1.30.Spray drying condition is: inlet temperature is 120 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 90 DEG C, and atomizing pressure is 0.4 MPa, and spray velocity is 10ml/s.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013180336A1 (en) * | 2012-05-30 | 2013-12-05 | 조선대학교 산학협력단 | Use for dendropanax morbifera extract for adjusting 15-hydroxyprostaglandin dehydrogenase and pge2 activity |
| CN104587034A (en) * | 2015-03-03 | 2015-05-06 | 张远强 | New application of a medicinal composition in treating oral ulcer |
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- 2015-06-10 CN CN201510316609.4A patent/CN104922225A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013180336A1 (en) * | 2012-05-30 | 2013-12-05 | 조선대학교 산학협력단 | Use for dendropanax morbifera extract for adjusting 15-hydroxyprostaglandin dehydrogenase and pge2 activity |
| CN104587034A (en) * | 2015-03-03 | 2015-05-06 | 张远强 | New application of a medicinal composition in treating oral ulcer |
Non-Patent Citations (1)
| Title |
|---|
| 陈馥馨: "《新编中成药手册》", 31 August 1992, 中国医药科技出版社 * |
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Application publication date: 20150923 |