CN1049123C - Compound Ilex pubescens injection - Google Patents
Compound Ilex pubescens injection Download PDFInfo
- Publication number
- CN1049123C CN1049123C CN93114604A CN93114604A CN1049123C CN 1049123 C CN1049123 C CN 1049123C CN 93114604 A CN93114604 A CN 93114604A CN 93114604 A CN93114604 A CN 93114604A CN 1049123 C CN1049123 C CN 1049123C
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- Prior art keywords
- injection
- hours
- ethanol
- compound
- water
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000002347 injection Methods 0.000 title claims abstract description 16
- 239000007924 injection Substances 0.000 title claims abstract description 16
- 150000001875 compounds Chemical class 0.000 title claims abstract description 15
- 235000003365 Ilex pubescens Nutrition 0.000 title claims description 8
- 241001100932 Ilex pubescens Species 0.000 title claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 66
- 238000002360 preparation method Methods 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 claims abstract description 17
- 241000411851 herbal medicine Species 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 239000000706 filtrate Substances 0.000 claims description 14
- 239000010231 banlangen Substances 0.000 claims description 13
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 13
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 12
- 238000001802 infusion Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 11
- 238000004321 preservation Methods 0.000 claims description 10
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000000796 flavoring agent Substances 0.000 claims description 9
- 235000019634 flavors Nutrition 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 229910021529 ammonia Inorganic materials 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000008215 water for injection Substances 0.000 claims description 5
- 238000004821 distillation Methods 0.000 claims description 4
- 238000012869 ethanol precipitation Methods 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 206010057190 Respiratory tract infections Diseases 0.000 abstract description 3
- 206010046306 Upper respiratory tract infection Diseases 0.000 abstract description 3
- 208000036142 Viral infection Diseases 0.000 abstract description 3
- 208000002672 hepatitis B Diseases 0.000 abstract description 3
- 235000003332 Ilex aquifolium Nutrition 0.000 abstract 7
- 235000002296 Ilex sandwicensis Nutrition 0.000 abstract 7
- 235000002294 Ilex volkensiana Nutrition 0.000 abstract 7
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 239000013583 drug formulation Substances 0.000 description 4
- 206010006448 Bronchiolitis Diseases 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 241000702670 Rotavirus Species 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention belongs to a medicinal formula and a preparation method thereof, particularly to a compound hairy holly injection which is proportionally prepared from various Chinese herbal medicines. A preparation method for the compound hairy holly injection comprises: the Chinese herbal medicines are processed by sieving, decocting, concentrating, ethanol precipitating, etc. The compound hairy holly injection is suitable for treating various kinds of virosis, and particularly has obvious curative effects on hepatitis B in initial stage, autumn diarrhea, upper respiratory tract infection and infant's capillary bronchitis. The total effective rate of the compound hairy holly injection reaches 96.7%. The compound hairy holly injection is an important medicine for paediatrics. The compound hairy holly injection has the advantages of stable effect and no toxic side effect, and has clinical practicality and pertinence. Thereby, the compound hairy holly injection is a good medicine with a special effect treating virosis.
Description
The invention belongs to a kind of drug formulation and manufacture method thereof with the various viral diseases of treatment by Chinese herbs.
The disease (as: upper respiratory tract infection, rotavirus enteritis, infantile bronchiolitis and hepatitis B etc.) that state's internal therapy viral infection at present the causes western medicine schemes that adopt based on antiinflammatory more, therapeutic effect is not good, and side effect is also bigger.Though there are indivedual Chinese medicine preparation to come out, all are oral administrations, it is slower to take effect, and is not suitable for emergency case.Treatment does not still have special effect medicine at present to viral disease.
The drug formulation and the manufacture method thereof that the purpose of this invention is to provide a kind of treatment by Chinese herbs viral disease.
The present invention is made up of four kinds of Chinese medicines, and its drug formulation ratio is as follows:
Radix Ilicis Pubescentis 30-50%, Folium Isatidis 10-20%, Radix Isatidis 10-20%, each component of Herba Houttuyniae 15-30% and be 100% (weight).
The manufacture method of compound Ilex pubescens injection:
(1) preparation of Radix Ilicis Pubescentis prefabricated solution: get Radix Ilicis Pubescentis and decoct with water three times, each two hours, merge decocting liquid, filter and be concentrated into syrupy shape.Add ethanol and be 60-65% to containing alcohol, stand at low temperature 24 hours, filtered and recycled ethanol to proportion is about 1.08.Transfer PH to 2-3 with adding 10%Hcl in the concentrated solution, place filtration in 12 hours, filtrate is transferred PH to 6-7 with 20%NaOH, filters and collects filtrate.Filtrate is concentrated into syrupy shape, with ethanol precipitate with ethanol secondary, making for the first time to contain the alcohol amount and be 70-75%, be 78-80% for the second time, place filtration in 24 hours after, reclaim ethanol to there not being the alcohol flavor, add water for injection then to full dose, transfer PH at 6.5-6.8, cold preservation was filtered in 48 hours, embedding is sterilized in the 500ml infusion bottle.Radix Ilicis Pubescentis prefabricated solution concentration is that every ml contains primary crude drug 4g.
(2) preparation of Folium Isatidis prefabricated solution: get the Folium Isatidis decocting and boil three times, each 40 minutes, merge decocting liquid, filter and be concentrated into syrupy shape, add ethanol and left standstill 48 hours to containing alcohol amount 60-65%, filtered and recycled ethanol is to there not being the alcohol flavor, in the water of impouring while hot below 5 ℃, leave standstill cold preservation 48 hours, filter and add water to full dose, embedding is sterilized in the 500ml infusion bottle.Folium Isatidis prefabricated solution concentration is that every ml contains primary crude drug 1g.
(3) preparation of Radix Isatidis prefabricated solution: get Radix Isatidis and add boiling water decoction three times, each 1 hour, decocting liquid filters, be evaporated to syrupy shape below 70 ℃, add the ethanol precipitation secondary, contain alcohol amount 60-65% for the first time, be 75% for the second time, after placing filtration respectively, reclaim ethanol and do not distinguish the flavor of, transfer PH to 8.5-9.0 to leave standstill filtration in 12 hours with ammonia to there being alcohol.Filtrate is put and is added evanescence of heat ammonia in the water-bath, and cold preservation filters, and filtrate adds 1.5% active carbon boiled 10 minutes, placed and filtered, and adds to the full amount of water for injection, and embedding is sterilized in the 500ml infusion bottle.Radix Isatidis prefabricated solution concentration is that primary crude drug is that every ml contains primary crude drug 1g.
(4) preparation of Herba Houttuyniae prefabricated solution: get the distillation of Herba Houttuyniae water vapor method, carry out redistillation behind the collection distillate, re-distilled liquid is filtered embedding in the 500ml infusion bottle, sterilize promptly, Herba Houttuyniae prefabricated solution concentration is primary crude drug 1g/ml.
(5) preparation of compound Ilex pubescens injection: get 1 part of prefabricated solution Radix Ilicis Pubescentis, 1 part of Folium Isatidis, 1 part of Radix Isatidis, Herba Houttuyniae merges mixing for 2 parts, adds 0.5% tween 80 and 1% benzyl alcohol and transfers PH to 6.5-6.8, filter, embedding, sterilization is promptly.
The invention has the advantages that: this medicine is formulated in proportion by multiple Chinese herbal medicine, its preparation method is that four kinds of medicines are screened respectively, decoct, concentrate, the alcohol precipitation, distillation, processed such as cold preservation, be prepared into prefabricated solution, through being mixed and processed, this medical instrument has fast again, efficiently, the characteristics of safety not only supply intramuscular injection, and can supply intravenous drip, remedied the deficiency of western medicines in treatment viral disease, year case clinical observations statistics up to ten thousand surplus clinical 20, this medicine is used to treat various viral diseases, especially to the hepatitis B initial stage, rotavirus enteritis, upper respiratory tract infection, the infantile bronchiolitis curative effect of disease is remarkable, total effective rate reaches 96.7%, particularly the key medicine of department of pediatrics, this drug effect are really stable, no side effects, has clinical practice, specific aim is the specially good effect good medicine of treatment viral disease, belongs to domestic initiation.
Embodiment:
Drug formulation: Radix Ilicis Pubescentis 4kg, Folium Isatidis 1Kg, Radix Isatidis 1Kg, Herba Houttuyniae 2Kg,
The medicine manufacture method:
(1) preparation of Radix Ilicis Pubescentis prefabricated solution: get Radix Ilicis Pubescentis 4kg, decocting boils three times, and each two hours, decocting liquid filtered and is concentrated into syrupy shape, and adding ethanol is 65% to containing alcohol, stand at low temperature 24 hours, and filtered and recycled ethanol is to proportion 1.08.With adding 10%Hcl to PH in the concentrated solution to 2.6, place filtration in 12 hours, filtrate is transferred PH to 6.8 with 20%NaOH, filters and collects filtrate.To filter and will be concentrated into syrupy shape, and use the ethanol precipitation secondary, containing the alcohol amount for the first time is 75%, is 80% for the second time, after placing filtration respectively, reclaim ethanol and do not distinguish the flavor of, add water for injection, transfer PH at 6.5-6.8 to 1000ml to there being alcohol, cold preservation was filtered in 48 hours, and embedding is sterilized in the 500ml infusion bottle.
(2) preparation of Folium Isatidis prefabricated solution: get Folium Isatidis 1Kg, decocting boils three times, and each 40 minutes, decocting liquid filtered and be concentrated into syrupy shape, add ethanol to containing alcohol amount 60%, left standstill 48 hours, filtered and recycled ethanol is not distinguished the flavor of to there being alcohol, in the water of impouring while hot below 5 ℃, left standstill cold preservation 48 hours, filter and add and inject water to 1000ml, embedding is sterilized in the 500ml infusion bottle.
(3) preparation of Radix Isatidis prefabricated solution: get Radix Isatidis 1kg and add boiling water decoction three times, each 1 hour.The decocting liquid filtration is evaporated to syrupy shape below 70 ℃, adds the ethanol precipitation secondary, contains alcohol amount 65% for the first time, is 75% for the second time, after placement is filtered respectively, reclaims ethanol to there not being pure flavor, transfers PH to 8.5-9.0 with ammonia, leaves standstill filtration in 12 hours.Filtrate is put and is added evanescence of heat ammonia in the water-bath, and cold preservation filters, and filtrate adds 1.5% active carbon boiled 10 minutes, placed and filtered, and adds the injection water to 1000ml, and embedding is sterilized in the 500ml infusion bottle.
(4) preparation of Herba Houttuyniae prefabricated solution: get Herba Houttuyniae 2kg and feed vapor distillation, carry out redistillation behind the collection distillate 4000ml, will collect re-distilled liquid 2000ml and filter, embedding is sterilized in the 500ml infusion bottle.
(5) preparation of compound Ilex pubescens injection: get prefabricated solution Radix Ilicis Pubescentis 1000ml, Folium Isatidis 1000ml, Radix Isatidis 1000ml, the abundant mixing of Herba Houttuyniae 2000ml adds 0.5% tween 80 and 1% benzyl alcohol and transfers PH to 6.5-6.8, filters, embedding is sterilized, promptly after the assay was approved in 2ml peace bottle.
Claims (2)
1. a compound Ilex pubescens injection is formulated in proportion by multiple Chinese herbal medicine, it is characterized in that this medicine by Radix Ilicis Pubescentis 30-50%, Folium Isatidis 10-20%, and Radix Isatidis 10-20%, Herba Houttuyniae 15-30% makes, and the summation of each component is 100% (weight).
2. the manufacture method of compound Ilex pubescens injection:
(1) preparation of Radix Ilicis Pubescentis prefabricated solution: get Radix Ilicis Pubescentis and decoct with water three times, each two hours, merge decocting liquid, filter and be concentrated into syrupy shape, add ethanol and be 60-65% to containing the alcohol amount, stand at low temperature 24 hours, filtered and recycled ethanol to proportion is about 1.08, transfers pH to 2-3 with adding 10%HCl in the concentrated solution, places filtration in 12 hours, filtrate is transferred pH to 6-7 with 20%NaOH, filter and collect filtrate, filtrate is concentrated into syrupy shape, with ethanol precipitate with ethanol secondary, make for the first time and contain the alcohol amount and be 70-75%, be 78-80% for the second time, places filtered in 24 hours after, reclaim ethanol and do not have pure the flavor, add the water for injection full dose then, transfer pH at 6.5-6.8, cold preservation 48 hours is filtered, fill is sterilized in the 500ml infusion bottle
(2) preparation of Folium Isatidis prefabricated solution: get the Folium Isatidis decocting and boil three times, each 40 minutes, merge decocting liquid, filter and be concentrated into syrupy shape, add ethanol and left standstill 48 hours to containing alcohol amount 60-65%, filtered and recycled ethanol is to there not being the alcohol flavor, in the water of impouring while hot below 5 ℃, leave standstill cold preservation 48 hours, filter and add water to full dose, embedding is sterilized in the 500ml infusion bottle
(3) preparation of Radix Isatidis prefabricated solution: get Radix Isatidis and add boiling water decoction three times, each 1 hour, decocting liquid filtered, and is evaporated to syrupy shape below 70 ℃, adds the ethanol precipitation secondary, contained alcohol amount 60-65% for the first time; Be 75% for the second time, after placing filtration respectively, reclaim ethanol and do not distinguish the flavor of, transfer pH8.5-9.0 to leave standstill filtration in 12 hours with ammonia to there being alcohol, filtrate is put and is added evanescence of heat ammonia in the water-bath, cold preservation filters, and filtrate adds 1.5% active carbon and boiled 10 minutes, place and filter, add to the full amount of water for injection, embedding is sterilized in the 500ml infusion bottle
(4) preparation of Herba Houttuyniae prefabricated solution: get the distillation of Herba Houttuyniae water vapor method, carry out redistillation behind the collection distillate, re-distilled liquid is filtered embedding in the 500ml infusion bottle, sterilize promptly,
(5) preparation of compound Ilex pubescens injection: get 1 part of prefabricated solution Radix Ilicis Pubescentis, 1 part of Folium Isatidis, 1 part of Radix Isatidis, Herba Houttuyniae merges mixing for 2 parts, adds 0.5% tween 80 and 1% benzyl alcohol and transfers pH to 6.5-6.8, filter, embedding, sterilization is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93114604A CN1049123C (en) | 1993-11-10 | 1993-11-10 | Compound Ilex pubescens injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93114604A CN1049123C (en) | 1993-11-10 | 1993-11-10 | Compound Ilex pubescens injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1092678A CN1092678A (en) | 1994-09-28 |
| CN1049123C true CN1049123C (en) | 2000-02-09 |
Family
ID=4990558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93114604A Expired - Fee Related CN1049123C (en) | 1993-11-10 | 1993-11-10 | Compound Ilex pubescens injection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1049123C (en) |
-
1993
- 1993-11-10 CN CN93114604A patent/CN1049123C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 《中医杂志》30(4) 1989.1.1 罗玉桃等，"婴幼儿病毒性肺炎中西医结合治疗的临床观察---附635例分析 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1092678A (en) | 1994-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HENAN PROVINCE TIANGONG PHARMACEUTICAL FACTORY Free format text: FORMER OWNER: LIU SHIQUAN Effective date: 20031024 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20031024 Address after: 476000 No. 277, Xinjian South Road, Henan, Shangqiu Patentee after: Henan Tiangong pharmaceutical factory Address before: 476100 Shangqiu people's Hospital of Henan Province Patentee before: Liu Shiquan |
|
| ASS | Succession or assignment of patent right |
Owner name: SHANGQIU FUYUAN HAIRY HOLLY ROOT DEVELOPMENT CO., Free format text: FORMER OWNER: HENAN PROVINCE TIANGONG PHARMACEUTICAL FACTORY Effective date: 20050204 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20050204 Address after: 476000 No. 277, Xinjian South Road, Henan, Shangqiu Patentee after: Shangqiu Fuyuan Mao Dongqing Development Co. Ltd. Address before: 476100 New South Road, Shangqiu, Henan 27 Patentee before: Henan Tiangong pharmaceutical factory |
|
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |