CN104906625A - Method for preparing medical hydrogel - Google Patents
Method for preparing medical hydrogel Download PDFInfo
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- CN104906625A CN104906625A CN201510262702.1A CN201510262702A CN104906625A CN 104906625 A CN104906625 A CN 104906625A CN 201510262702 A CN201510262702 A CN 201510262702A CN 104906625 A CN104906625 A CN 104906625A
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Abstract
The invention discloses a method for preparing medical hydrogel. The preparing method comprises the following steps that firstly, deionized water is taken and poured into a reactor, the reactor is heated, lemon peel pectin and gelatin are slowly added, and meanwhile mechanical stirring is carried out; secondly, after the lemon peel pectin and the gelatin are added, stirring is continued, chitosan, soybean oligosaccharides, polycaprolactone and chlorhexidine acetate are added into the reactor, and even mechanical stirring is carried out during adding; thirdly, after the materials are mixed, the hydrogel is cooled to the room temperature, and then the medical hydrogel is obtained. The medical hydrogel prepared through the method has a good biomechanical property and ventilation performance and has a very important clinical application value. The preparing method is simple in technology, the requirement for equipment is not high, the raw materials are low in cost and easy to obtain, cost is low, and industrialization is easy to achieve.
Description
Technical field
The invention belongs to medical field of new, relate to a kind of preparation method of medical aquogel.
Technical background
In field of medical article technology, along with the progress of materialogy, wound dressing there occurs revolutionary change, from normal gauze dressing, synthetic dressing and biological dressing, arrive the dressing of new medical biosynthesis again, these new pattern compress are applicable to different wound and different healing periods with plurality of raw materials, multiple dosage form, and wherein, Hydrogels dressing is exactly wherein representative one.Hydrogel, as a kind of biocompatible materials, is medically mainly used in Post operation anti, hemorrhage, fills up defective tissue, prevents tissue fluid seepage, slow releasing pharmaceutical etc.
Hydrogel refers to water to be the gel of disperse medium.Have and introduce a part of hydrophobic group in the water soluble polymer of cross-linked structure and formed can the cross linked polymer of water-swellable.Be a kind of macromolecule network system, character is soft, can keep certain shape, can absorb a large amount of water.Every water solublity or hydrophilic macromolecule, by certain chemical crosslinking or physical crosslinking, can form hydrogel.Hydrogel can be divided into natural hydrogel and synthetic water gel according to source difference; Difference according to its character can be divided into electric neutrality hydrogel, ionic hydrogels; The response situation difference that hydrogel stimulates to external world according to it is divided into conventional hydrogels and environmental sensitive hydrogels.Hydrogel has good physicochemical properties and biocompatibility, and making it have at art of pharmacy manyly should have, as the carrier of some slow releasing preparation, aqueous ointment base and new formulation.Hydrogel is used for having good breathability, absorption of perspiration, applicating property and moisture retention in the dressing of medical domain, and without sensitization, zest.Noresidue after stripping, not pollution clothes, painless, and repeatedly can take off subsides etc.
But adopt hydrogel prepared by various method at present, although possess certain imbibition ability, but its fracture strength is lower, reduce the mechanical strength of hydrogel, therefore its mechanical strength still has the space of lifting, therefore can not meet clinical needs, limit the Hydrogels dressing scope of application clinically, and by the restriction of production technology, the batch production of Hydrogels dressing is restricted, directly results in Hydrogels dressing use cost clinically, add the burden of patient.In sum, the deficiency solving prior art existence has become this area technical problem urgently to be resolved hurrily.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of preparation method of medical aquogel of good mechanical property is provided.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of medical aquogel, this preparation method comprises the following steps: (1) is removed ionized water 20-30 weight portion and poured in reactor, reactor is heated, then in reactor, slowly add pectin from lemon peel 13-15 weight portion, gelatin 5-8 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10-14 weight portion, soybean oligo saccharide 3-6 weight portion, polycaprolactone 4-8 weight portion, chlorhexidine acetate 6-9 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical aquogel.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
The temperature of step (1) reaction zone heating is 55-65 DEG C.
Compared with prior art, tool has the following advantages and beneficial effect in the present invention: the medical aquogel that (1) the inventive method obtains has good breathability, and has extraordinary biocompatibility; Have no side effect in medical application, and there is higher swelling ratio, extraordinary application has been possessed as medical gel material, the hot strength of medical gel material of the present invention is also higher simultaneously, the situation that gel rubber material can be avoided in use to occur to rupture occurs, medical gel material of the present invention can not stick on wound face after a procedure in addition, reduces the healing difficulty of wound.(2) preparation method technique of the present invention is simple, and do not have excessive demand to equipment, raw material valency is low to be easy to get, with low cost, is easy to realize industrialization.
Detailed description of the invention
embodiment 1
A kind of preparation method of medical aquogel, this preparation method comprises the following steps: (1) is removed ionized water 20 weight portion and poured in reactor, reactor is heated, then in reactor, slowly add pectin from lemon peel 13 weight portion, gelatin 5 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10 weight portion, soybean oligo saccharide 3 weight portion, polycaprolactone 4 weight portion, chlorhexidine acetate 6 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical aquogel.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
The temperature of step (1) reaction zone heating is 55-65 DEG C.
embodiment 2
A kind of preparation method of medical aquogel, this preparation method comprises the following steps: (1) is removed ionized water 30 weight portion and poured in reactor, reactor is heated, then in reactor, slowly add pectin from lemon peel 15 weight portion, gelatin 8 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 14 weight portion, soybean oligo saccharide 6 weight portion, polycaprolactone 8 weight portion, chlorhexidine acetate 9 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical aquogel.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
The temperature of step (1) reaction zone heating is 55-65 DEG C.
embodiment 3
A kind of preparation method of medical aquogel, this preparation method comprises the following steps: (1) is removed ionized water 25 weight portion and poured in reactor, reactor is heated, then in reactor, slowly add pectin from lemon peel 14 weight portion, gelatin 6 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 12 weight portion, soybean oligo saccharide 4 weight portion, polycaprolactone 6 weight portion, chlorhexidine acetate 7 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical aquogel.In step (1), mechanical agitation rotating speed is 30-60r/min.Described pectin from lemon peel molecular weight is 20-40kDa.Described gelatine molecular weight is 25-60kDa.
The temperature of step (1) reaction zone heating is 55-65 DEG C.
Claims (5)
1. the preparation method of a medical aquogel, it is characterized in that this preparation method comprises the following steps: (1) is removed ionized water 20-30 weight portion and poured in reactor, reactor is heated, then in reactor, slowly add pectin from lemon peel 13-15 weight portion, gelatin 5-8 weight portion, while adding pectin from lemon peel and gelatin, carry out mechanical agitation; (2) after adding pectin from lemon peel and gelatin, continue to stir 10-15min, chitosan 10-14 weight portion, soybean oligo saccharide 3-6 weight portion, polycaprolactone 4-8 weight portion, chlorhexidine acetate 6-9 weight portion is added again in reactor, also carry out mechanical agitation while adding even, mechanical agitation rotating speed is 100-150r/min; (3) after above-mentioned material has mixed, hydrogel is cooled to room temperature, obtains medical aquogel.
2. the preparation method of a kind of medical aquogel according to claim 1, is characterized in that in step (1), mechanical agitation rotating speed is 30-60r/min.
3. the preparation method of a kind of medical aquogel according to claim 1, is characterized in that described pectin from lemon peel molecular weight is 20-40kDa.
4. the preparation method of a kind of medical aquogel according to claim 1, is characterized in that described gelatine molecular weight is 25-60kDa.
5. the preparation method of a kind of medical aquogel according to claim 1, is characterized in that the temperature that step (1) reaction zone is heated is 55-65 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262702.1A CN104906625A (en) | 2015-05-22 | 2015-05-22 | Method for preparing medical hydrogel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510262702.1A CN104906625A (en) | 2015-05-22 | 2015-05-22 | Method for preparing medical hydrogel |
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| CN104906625A true CN104906625A (en) | 2015-09-16 |
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| CN201510262702.1A Pending CN104906625A (en) | 2015-05-22 | 2015-05-22 | Method for preparing medical hydrogel |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
| CN109550079A (en) * | 2018-12-07 | 2019-04-02 | 中国人民解放军陆军军医大学第附属医院 | A kind of bionical matrix of cartilaginous tissue and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006780A1 (en) * | 2007-07-06 | 2009-01-15 | Bioregen Biomedical (Changzhou) Co., Ltd. | A method for the formation of a rapid-gelling biocompatible hydrogel and the preparation of a spraying agent |
| CN102127234A (en) * | 2010-12-22 | 2011-07-20 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing intumescent hydrogel |
| CN103028136A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Hydrocolloid dressing and preparation method thereof |
-
2015
- 2015-05-22 CN CN201510262702.1A patent/CN104906625A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006780A1 (en) * | 2007-07-06 | 2009-01-15 | Bioregen Biomedical (Changzhou) Co., Ltd. | A method for the formation of a rapid-gelling biocompatible hydrogel and the preparation of a spraying agent |
| CN102127234A (en) * | 2010-12-22 | 2011-07-20 | 上海纳米技术及应用国家工程研究中心有限公司 | Method for preparing intumescent hydrogel |
| CN103028136A (en) * | 2012-12-14 | 2013-04-10 | 武汉奥绿新生物科技有限公司 | Hydrocolloid dressing and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107754003A (en) * | 2017-10-19 | 2018-03-06 | 张永华 | A kind of method that bleeding-stopping dressing is prepared with hydrogel |
| CN109550079A (en) * | 2018-12-07 | 2019-04-02 | 中国人民解放军陆军军医大学第附属医院 | A kind of bionical matrix of cartilaginous tissue and preparation method thereof |
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Application publication date: 20150916 |
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