CN104906337A - Fritillary bulb prepared from liquorice and snow pears and preparation method thereof - Google Patents
Fritillary bulb prepared from liquorice and snow pears and preparation method thereof Download PDFInfo
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- CN104906337A CN104906337A CN201510375918.9A CN201510375918A CN104906337A CN 104906337 A CN104906337 A CN 104906337A CN 201510375918 A CN201510375918 A CN 201510375918A CN 104906337 A CN104906337 A CN 104906337A
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- bulbus fritillariae
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Abstract
The invention relates to a fritillary bulb prepared from liquorice and snow pears and a preparation method thereof; the fritillary bulb is prepared from the liquorice and the snow pears; due to compatibility of medicines, the fritillary bulb, the liquorice and the snow pears are promoted and assisted mutually and take effect together; the effects of clearing heat, moistening lung, eliminating phlegm and relieving cough of the fritillary bulb are increased; simultaneously, the fritillary bulb has a certain effect of relieving asthma; by means of compatibility, the three kinds of medicines are prepared by the invention; therefore, the effects of clearing heat, moistening lung, eliminating phlegm, relieving cough and preventing asthma of the fritillary bulb are effectively increased; furthermore, the property of the fritillary bulb tends to have sweet taste and neutral nature; the mouth feel of the fritillary bulb is improved; and therefore, the fritillary bulb is easily taken by people.
Description
Technical field
The present invention relates to a kind of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis, additionally provide the preparation method of said preparation simultaneously, belong to food and field of pharmaceutical technology.
Background technology
Bulbus Fritillariae Ussuriensis is the dry bulb of liliaceous plant Bulbus Fritillariae Ussuriensis Fritillaria ussuriensis Maxim..Bulbus Fritillariae Ussuriensis has another name called level ground shellfish, Bulbus Fritillariae Uninbracteatae, flat shellfish.There are clearing heat and moistening lung, the effect of relieving cough and resolving phlegm, for a kind of conventional Chinese medicine, Fritillaria is belonged to together with Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, but pharmaceutically there is certain difference, mainly be distributed in the Mountain Areas of Southern, the normal pulse Xiaoxinanlin Mountains, Changbai Mountain of the Northeast, the provinces such as main product Heilungkiang, Jilin, Liaoning and Shanxi, Shaanxi, Hebei.
Bulbus Fritillariae Ussuriensis reason act as: 1, Bulbus Fritillariae Ussuriensis extractum has central inhibitory action to experimental animal models.Bulbus Fritillariae Ussuriensis total alkaloids, pingpeimine A all have and significantly eliminate the phlegm and hypotensive activity.2 Bulbus Fritillariae Ussuriensis total alkali 3mg/100g, 1.5mg/100g rat skin lower injections all have certain inhibitory action to pyloric ligation ulcers ulcer, lumbar injection to indometacin type ulcer and stress ulcer, and these effects may be relevant with its suppression pepsin activity.
Bulbus Fritillariae Ussuriensis meridian distribution of property and flavor: bitter, sweet, is slightly cold.Return lung, heart channel.Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.Its effect is close with Bulbus Fritillariae Cirrhosae, and medicinal effects is weak compared with Bulbus Fritillariae Cirrhosae, and in recent years because Bulbus Fritillariae Cirrhosae belongs to wild rare medicinal herbs, resource is exhausted year by year.Because its Bulbus Fritillariae Ussuriensis has ripe artificial cultivation technique, can plant in a large number, for improving the medicinal effects of Bulbus Fritillariae Ussuriensis, improve Bulbus Fritillariae Ussuriensis effect in lung moistening, relieving cough and asthma by traditional Chinese medicine processing method, reaching the effect close with Bulbus Fritillariae Cirrhosae.Thus raising medical value protects wild Bulbus Fritillariae Cirrhosae to have positive meaning.
Summary of the invention
The invention provides a kind of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis, the effect of Bulbus Fritillariae Ussuriensis in clearing heat and moistening lung, cough-relieving can be strengthened with crossing the present invention, being provided with certain antiasthmatic effect simultaneously.
a kind of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis of the present invention, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Sucus Glycyrrhizae 5 ~ 40, snow pear juice 5 ~ 80, Bulbus Fritillariae Ussuriensis 5 ~ 100.
the preparation method of a kind of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis of the present invention, comprises the steps:
1) to make even Bulbus Fritillariae Uninbracteatae raw material, pick decontamination, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content less than 20%;
2) dry rhizome and the root of choosing glycyrrhizic legume clean, infiltrate, cut into slices, and add 3 ~ 6 times of soak by water 2 ~ 3 times, each 15 ~ 30 minutes, filter, collecting decoction and Sucus Glycyrrhizae;
3) choose the squeezing of fresh pear, filter, add 1 ~ 3 times of clear water and obtain snow pear juice;
4) by step 2) and 3) to obtain Radix Glycyrrhizae snow pear juice for subsequent use for mix homogeneously;
5) Bulbus Fritillariae Ussuriensis is put into Radix Glycyrrhizae snow pear juice temperature prepared by step 4) to control 10 ~ 30 DEG C of infuses 2 ~ 48 hours, period stirred 1 time every 6 hours, made it be evenly distributed, and soaked into Bulbus Fritillariae Ussuriensis and absorbed Radix Glycyrrhizae snow pear juice completely;
6) Bulbus Fritillariae Ussuriensis after infuse is dried to water content less than 15%, obtains final product.
In above-mentioned any technical scheme, Sucus Glycyrrhizae is 5 ~ 40 weight portions, preferably 5 ~ 30 weight portions, more preferably 5 ~ 20 weight portions, more preferably 10 ~ 20 weight portions; Snow pear juice is 5 ~ 80 weight portions, preferably 5 ~ 70 weight portions, more preferably 40 ~ 70 weight portions, more preferably 50 ~ 70 weight portions; Bulbus Fritillariae Ussuriensis raw material is 5 ~ 100 weight portions, preferably 20 ~ 100 weight portions, more preferably 30 ~ 70 weight portions, more preferably 40 ~ 70 weight portions;
Preparation method of the present invention also can adopt the preparation method of the conventional formulation of medicine and pharmacology.
[usage and dosage] 3 ~ 9g; Levigation is taken after mixing it with water, a 1 ~ 2g.
[function cures mainly] clearing heat and moistening lung, reduce phlegm, cough-relieving.
[indication] for lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
[attention] should not with Radix Aconiti, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata should not with Aconitum medical material with use with using.
pharmacological effect side of the present invention separates as follows:
Radix Glycyrrhizae, another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome.Sweet in the mouth, flat, GUIXIN, lung, spleen, stomach warp, tool invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of relieving spasm to stop pain.Medicine can relax the property of medicine after Sucus Glycyrrhizae system, reduces toxicity.As Sucus Glycyrrhizae boils Radix Polygalae, Fructus Evodiae.
Pear, pears, also eat also medicine, sweet, the micro-acid of nature and flavor, cold; Attach to the lung and stomach meridians.Have and moisturize, promote the production of body fluid, heat clearing away, effect of reducing phlegm, is usually used in hyperactivity of fire caused by deficiency of YIN, dryness-heat impairing the lung, and dry cough expectorant sticks, the auxiliary treatment that Tianjin wound is thirsty.Record according to Compendium of Material Medica, " pears person, also, its property is fluently descending for profit." there is the effect of lung moistening clearing away dryness, relieving cough and resolving phlegm, nourishing blood and promoting granulation.Therefore the throat occurred the patient of pharyngitis, acute tracheitis and upper respiratory tract infection is done, itch, bitterly, hoarseness, expectorant are thick etc. all good effect.Pear sweet in the mouth, cold in nature, tool promote the production of body fluid moisturize, effect of removing heat-phlegm, nourishing blood and promoting granulation, be particularly suitable for eating autumn.Pears can be eaten something rare, and squeeze the juice and drink, and also may be used for the processing aids increasing medicine lung moistening function.
Bulbus Fritillariae Ussuriensis, performance: bitter, sweet, is slightly cold.Return lung, heart channel.Clearing heat and moistening lung, reduce phlegm, cough-relieving.For lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
The present invention be according to theory of Chinese medical science basis, utilize said medicine compatibility, make Bulbus Fritillariae Ussuriensis, Radix Glycyrrhizae and the pear mutual reinforcement between mutual-assistance, jointly prove effective, improve Bulbus Fritillariae Ussuriensis clearing heat and moistening lung, eliminate the phlegm, cough-relieving effect, have certain antiasthmatic effect simultaneously.Three taste medicines by compatibility, after the present invention's preparation, reach and effectively increase Bulbus Fritillariae Ussuriensis clearing heat and moistening lung, eliminate the phlegm, cough-relieving, while antiasthmatic effect, make again the performance of Bulbus Fritillariae Ussuriensis be tending towards sweet flat, improve the mouthfeel of Bulbus Fritillariae Ussuriensis, the crowd of taking more easily is taken.
for proving that the effectiveness of this invention has carried out pharmacological evaluation from pharmacodynamics aspect, be reported as follows:
1, cough-relieving experiment (ammonia draws the method for coughing) sees the following form:
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis cough-relieving Benefit Transfer
Note: compare with model control group: * p<0.05.
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis all can reduce mouse cough response rate as seen from the above table, with model control group comparing difference significance (p<0.05), and Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis group antitussive action is better than Bulbus Fritillariae Ussuriensis group and liquorice liquid group, and suitable with codeine group.
2, to eliminate the phlegm experiment (phenol red method)
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis phlegm-dispelling functions compare (
)
Compare with model control group: * p<0.05, * * p<0.01; Compare with Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis group: #p<0.05
As seen from the above table: the OD value of each administration group compares with model control group that there were significant differences (p<0.05 or p<0.01), illustrative experiment group all has good phlegm-dispelling functions, and the phlegm-dispelling functions of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis group is obviously better than Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group.
3, to relieving asthma experiment (spraying causes the method for breathing heavily)
Bulbus Fritillariae Ussuriensis, liquorice liquid, Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis antiasthmatic effect compare (
)
Compare with model group: * p<0.05, * * p<0.01; Compare with Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis group: #p<0.05
As seen from the above table: Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group mice occur
order reaction has prolongation trend incubation period, but not obvious with model control group comparing difference (p>0.05), Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis group then obviously can extend mice
order reaction incubation period (p<0.05), points out its antiasthmatic effect to be obviously better than Bulbus Fritillariae Ussuriensis group and Radix Glycyrrhizae group.
The cough-relieving of the Bulbus Fritillariae Ussuriensis of comprehensive above 3 pharmacological action contrast experiments after the present invention concocts, eliminate the phlegm, antiasthmatic effect has the effect significantly strengthened compared with Bulbus Fritillariae Ussuriensis primary crude drug and Radix Glycyrrhizae.
good effect of the present invention is further illustrated below in conjunction with clinical:
One, diagnostic criteria
:
Be diagnosed as according to " Diagnostics of Chinese Medicine ": lung-heat type cough, dry cough insufficiency of blood, deficiency of YIN chronic cough, sputum with blood.
Two, inclusive criteria:
The above-mentioned standard of all genus all can be included in clinical.Three, using method:
In composition of prescription, compatibility uses or folk prescription use.Four, curative effect judging standard:
Patients symptomatic is improved by all reaching after Bulbus Fritillariae Ussuriensis treatment processed.
good effect of the present invention is:the present invention is according to theory of Chinese medical science basis, utilizes said medicine compatibility relationship the nourishing the lung to arrest cough of Radix Glycyrrhizae and pear to be promoted the production of body fluid to moisturize, removing heat-phlegm mutual reinforcement between mutual-assistance effect, jointly proves effective, with improve Bulbus Fritillariae Ussuriensis lung moistening, heat clearing away, eliminate the phlegm, cough-relieving effect.Three taste medicines by compatibility, after the present invention's preparation, reach and effectively increase Bulbus Fritillariae Ussuriensis lung moistening, heat clearing away, eliminate the phlegm, while antitussive action, make again the performance of Bulbus Fritillariae Ussuriensis be tending towards sweet flat, improve the mouthfeel of Bulbus Fritillariae Ussuriensis, the crowd of taking more easily is taken.Under same dose, the object of potentiation can be reached, to the rare medicine resource of conservation and utilization, there is very big meaning.
Detailed description of the invention
Following embodiment and case application, be only for example of the present invention is clearly described, and be not limitation of the invention.For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description.And thus the apparent change of amplifying out or variation be still among protection scope of the present invention.
embodiment 1:
1, get 50g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, choose the cleaning of 30g Radix Glycyrrhizae, infiltrate, cut into slices, add 120g soak by water 2 times, each 15 minutes, filter, collecting decoction and Radix Glycyrrhizae;
3, choose the fresh pear of 40g to clean, squeeze, add the filtration of 40g clear water, and obtain snow pear juice;
4, step 2 and 3 mix homogeneously are obtained Radix Glycyrrhizae snow pear juice for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) Radix Glycyrrhizae snow pear juice stirs constant temperature 25 DEG C of infuses 8 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs Radix Glycyrrhizae snow pear juice completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 3 hours, be dried to water content 12%, obtain final product.
embodiment 2:
1, get 300g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, choose the cleaning of 90g Radix Glycyrrhizae, infiltrate, cut into slices, add 200g soak by water 2 times, each 15 minutes, filter, collecting decoction and Radix Glycyrrhizae;
3, choose the fresh pear of 240g to clean, squeeze, add the filtration of 400g clear water, and obtain snow pear juice;
4, step 2 and 3 mix homogeneously are obtained Radix Glycyrrhizae snow pear juice for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) Radix Glycyrrhizae snow pear juice stirs constant temperature 25 DEG C of infuses 12 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs Radix Glycyrrhizae snow pear juice completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 4 hours, be dried to water content 15%, obtain final product.
embodiment 3:
1, get 100g Bulbus Fritillariae Ussuriensis medical material, the removal of impurity, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content 20%;
2, choose the cleaning of 50g Radix Glycyrrhizae, infiltrate, cut into slices, add 150g soak by water 2 times, each 15 minutes, filter, collecting decoction and Radix Glycyrrhizae;
3, choose the fresh pear of 50g to clean, squeeze, add the filtration of 100g clear water, and obtain snow pear juice;
4, step 2 and 3 mix homogeneously are obtained Radix Glycyrrhizae snow pear juice for subsequent use;
5, the Bulbus Fritillariae Ussuriensis raw material of step 1 drying being placed in step 4) Radix Glycyrrhizae snow pear juice stirs constant temperature 18 DEG C of infuses 8 hours, and period stirred 1 time every 4 hours, made it be evenly distributed, and soaks into Bulbus Fritillariae Ussuriensis and absorbs Radix Glycyrrhizae snow pear juice completely;
6, step 5 is processed the Bulbus Fritillariae Ussuriensis obtained and be placed in low-temperature vacuum drying case, through low temperature 23 DEG C of dryings 2 hours, be dried to water content 14%, obtain final product.
the therapeutic effect of medicine of the present invention is shown further by following model case:
case 1
Certain man, 17 years old, tcm diagnosis: dry cough, without expectorant, sooner or later increase the weight of, hectic fever, night sweat, rapid pulse is thin; Red tongue with thin fur is white; Tcm diagnosis is deficiency of lung-YIN, lung-heat type cough.
Treatment: Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis 2 grams prepared by the embodiment of the present invention 1, grinding is taken after mixing it with water, every day 3 times.
Effect: take symptom of coughing afterwards for 5 days and alleviate, hold on and take recovery from illness after 3 weeks.
case 2
Certain female, 55 years old; Tcm diagnosis: shortness of breath and fatigue, scorching, thready and weak pulse, the dry HongShaoJin(SIC) of tongue fur, belong to deficiency of lung-YIN and cause chronic cough, dry cough is with cough with asthma sound.
Treatment: Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis 2 grams prepared by the embodiment of the present invention 2, grinds the every day 3 times of taking after mixing it with water into powder, 14 days courses for the treatment of.
Effect: invention enhances antitussive action, pear has effect of lung heat clearing, Radix Glycyrrhizae relieving cough and asthma simultaneously, and after taking 7 days, cough with asthma symptom alleviates, and after taking two courses for the treatment of, chronic cough symptom is fully recovered, and shortness of breath and fatigue obtains good improvement.
case 3
Certain man, 45 years old; Tcm diagnosis, red tongue with a little fluid, thready pulse sinks, dry cough without phlegm, weak, poor appetite, dry cough, belongs to YIN-deficiency of the lung and kidney, prolonged illness impairment of YIN cough caused by dryness.
Treatment: Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis 2 grams prepared by the embodiment of the present invention 3, grinding into powder and take after mixing it with water, 3 times on the one, 14 days is a course for the treatment of.
Effect: after taking this product, 3 days dry cough symptoms alleviate, adhere to taking 2 the course for the treatment of all deficiency of YIN transference cures, recovery from illness.
Claims (2)
1. a pear processed with honey Bulbus Fritillariae Ussuriensis, it is characterized in that being made up by ratio of weight and the number of copies of following medicine:
Mel 5 ~ 60, pear 5 ~ 100, Bulbus Fritillariae Ussuriensis 5 ~ 100.
2. the preparation method of a kind of pear processed with honey Bulbus Fritillariae Ussuriensis according to claim 1, comprises the steps:
1) to make even Bulbus Fritillariae Uninbracteatae raw material, pick decontamination, clean by the method for wash quickly, be placed in low-temperature vacuum drying case, through low temperature 30 DEG C of dryings 1 hour, be dried to water content less than 20%;
2) choose Mel and add heating in pot, refine the goods obtained to 105 ~ 110 DEG C, refined honey water content is more than 30%, and color and luster is without significant change, and slightly sticking refined honey is for subsequent use;
3) choose the squeezing of fresh pear, filter, add 1 ~ 3 times of clear water and obtain snow pear juice;
4) by step 2) and 3) to obtain refined honey snow pear juice for subsequent use for mix homogeneously;
5) Bulbus Fritillariae Ussuriensis is put into refined honey snow pear juice temperature prepared by step 4) to control 10 ~ 30 DEG C of infuses 2 ~ 48 hours, period stirred 1 time every 6 hours, made it be evenly distributed, and soaked into Bulbus Fritillariae Ussuriensis and absorbed refined honey Sucus Glycyrrhizae completely;
6) Bulbus Fritillariae Ussuriensis after step 5) infuse is dried to water content less than 15%, obtains final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110787255A (en) * | 2019-11-18 | 2020-02-14 | 四川中庸药业有限公司 | Processing technology of traditional Chinese medicine decoction piece bulbus fritilariae |
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| CN101341997A (en) * | 2008-08-27 | 2009-01-14 | 王志林 | Snow pear beverage and preparation technique |
| CN101731620A (en) * | 2010-01-22 | 2010-06-16 | 郭景龙 | Food with effects of clearing and nourishing throat |
| CN103859405A (en) * | 2014-03-12 | 2014-06-18 | 四川藏域川贝生物研究中心有限公司 | Preparation method of honeyed bulbus fritillariae cirrhosae |
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| CN101341997A (en) * | 2008-08-27 | 2009-01-14 | 王志林 | Snow pear beverage and preparation technique |
| CN101731620A (en) * | 2010-01-22 | 2010-06-16 | 郭景龙 | Food with effects of clearing and nourishing throat |
| CN103859405A (en) * | 2014-03-12 | 2014-06-18 | 四川藏域川贝生物研究中心有限公司 | Preparation method of honeyed bulbus fritillariae cirrhosae |
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| CN110787255A (en) * | 2019-11-18 | 2020-02-14 | 四川中庸药业有限公司 | Processing technology of traditional Chinese medicine decoction piece bulbus fritilariae |
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