CN104902754A - 在肾损伤的受试者中用泊马度胺治疗癌症 - Google Patents

在肾损伤的受试者中用泊马度胺治疗癌症 Download PDF

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Publication number
CN104902754A
CN104902754A CN201380069405.4A CN201380069405A CN104902754A CN 104902754 A CN104902754 A CN 104902754A CN 201380069405 A CN201380069405 A CN 201380069405A CN 104902754 A CN104902754 A CN 104902754A
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CN
China
Prior art keywords
cancer
pomalidomide
administered
dexamethasone
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380069405.4A
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English (en)
Chinese (zh)
Inventor
克劳迪娅·伊芙·卡塞拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CN104902754A publication Critical patent/CN104902754A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380069405.4A 2012-11-05 2013-11-04 在肾损伤的受试者中用泊马度胺治疗癌症 Pending CN104902754A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261722722P 2012-11-05 2012-11-05
US61/722,722 2012-11-05
US201361764466P 2013-02-13 2013-02-13
US61/764,466 2013-02-13
PCT/US2013/068237 WO2014071280A1 (en) 2012-11-05 2013-11-04 Treatment of cancer with pomalidomide in a renally impaired subject

Publications (1)

Publication Number Publication Date
CN104902754A true CN104902754A (zh) 2015-09-09

Family

ID=50628132

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380069405.4A Pending CN104902754A (zh) 2012-11-05 2013-11-04 在肾损伤的受试者中用泊马度胺治疗癌症

Country Status (15)

Country Link
US (1) US20150297579A1 (enExample)
EP (1) EP2914112A4 (enExample)
JP (1) JP2015535291A (enExample)
CN (1) CN104902754A (enExample)
AU (1) AU2013337352A1 (enExample)
BR (1) BR112015010039A2 (enExample)
CA (1) CA2889987A1 (enExample)
EA (1) EA201590883A1 (enExample)
HK (1) HK1214552A1 (enExample)
IL (1) IL238563A0 (enExample)
MX (1) MX2015005548A (enExample)
NI (1) NI201500063A (enExample)
PH (1) PH12015501002A1 (enExample)
SG (1) SG11201503456TA (enExample)
WO (1) WO2014071280A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071460A (zh) * 2016-03-02 2018-12-21 转化药物开发有限责任公司 氨基苯并咪唑衍生物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201507759WA (en) * 2013-04-02 2015-10-29 Celgene Corp Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers
EP3297674B1 (en) * 2015-05-22 2023-01-04 Translational Drug Development Llc Benzamide and active compound compositions and methods of use
CN105456232A (zh) * 2015-09-08 2016-04-06 刘剑 一种泊马度胺速溶膜剂及其制备方法
WO2018013689A1 (en) * 2016-07-13 2018-01-18 Celgene Corporation Solid dispersions and solid forms comprising 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, method of preparation and use thereof
CN108721304B (zh) * 2017-04-17 2020-10-16 北京大学 用于治疗肿瘤的药物组合物及其用途
US11236052B2 (en) * 2017-09-06 2022-02-01 Translational Drug Development, Llc Aminobenzimidazole derivatives, treatments, and methods of inhibiting histone deacetylase
AR119715A1 (es) 2019-04-12 2022-01-05 Celgene Corp Métodos para tratar linfoma no hodgkin con el uso de 2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3-morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona
GB202012160D0 (en) * 2020-08-05 2020-09-16 Vicore Pharma Ab New compositions
WO2023158486A2 (en) * 2022-02-15 2023-08-24 The Broad Institute, Inc. Cell-type specific targeting contractile injection system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
JP5339588B2 (ja) * 2008-11-10 2013-11-13 国立大学法人 新潟大学 サリドマイドまたはその誘導体を有効成分とする統合失調症の治療薬
JP5553275B2 (ja) * 2010-03-31 2014-07-16 国立大学法人金沢大学 金属錯体およびこれを有効成分として含有する抗がん剤
EP2699909A1 (en) * 2011-04-18 2014-02-26 Celgene Corporation Biomarkers for the treatment of multiple myeloma
MX353482B (es) * 2011-04-29 2018-01-16 Celgene Corp Metodos para el tratamiento del cancer y enfermedades inflamatorias utilizando cereblon como predictor.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109071460A (zh) * 2016-03-02 2018-12-21 转化药物开发有限责任公司 氨基苯并咪唑衍生物

Also Published As

Publication number Publication date
AU2013337352A1 (en) 2015-05-21
EP2914112A4 (en) 2016-06-15
NI201500063A (es) 2015-09-10
WO2014071280A1 (en) 2014-05-08
HK1214552A1 (zh) 2016-07-29
MX2015005548A (es) 2016-01-15
EP2914112A1 (en) 2015-09-09
IL238563A0 (en) 2015-06-30
SG11201503456TA (en) 2015-05-28
CA2889987A1 (en) 2014-05-08
PH12015501002A1 (en) 2015-07-27
JP2015535291A (ja) 2015-12-10
US20150297579A1 (en) 2015-10-22
EA201590883A1 (ru) 2015-09-30
BR112015010039A2 (pt) 2017-07-11

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