CN104888173A - Medicine composition for treating diarrhea-predominant pattern irritable bowel syndrome - Google Patents
Medicine composition for treating diarrhea-predominant pattern irritable bowel syndrome Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine, in particular to a medicine composition for treating diarrhea-predominant pattern irritable bowel syndrome and a preparation method thereof. The medicine composition comprises the following components: tortoise plastron, mother-of-pearl, semen coicis, poria cocos, agilawood, fructus akebiae, radix linderae, prepared dried ginger, fructus mume and radix curcumae. The medicine composition for treating diarrhea-predominant pattern irritable bowel syndrome is reasonable in formula, simple in preparation process, convenient to take, has significant effects on invigorating the spleen, soothing the liver, regulating qi, eliminating dampness and checking diarrhea, has a better therapeutic effect on irritable bowel syndrome, especially diarrhea-predominant pattern irritable bowel syndrome, and is worthy of clinical promotion and application.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of irritable bowel syndrome and preparation method thereof.
Background technology
Irritable bowel syndrome is a kind of chronic gastrointestinal dysfunction disease, main with abdominal discomfort symptoms such as stomachache, abdominal distention, long-term or recurrent exerbation, with bowl evacuation habit and stool exception, with the nervous symptoms of the psychological problems such as anxiety in various degree, cardiopalmus, insomnia, be digestive system commonly encountered diseases and frequently-occurring disease.Irritable bowel syndrome mainly contains diarrhea-type, constipation type, alternating diarrhea and constipation type and uncertain type, wherein clinical common with diarrhea-type.Doctor trained in Western medicine thinks that the easy syndrome of diarrhea-type intestinal belongs to multifactorial Physiological Psychology disease, stress, dietary factor and gastrointestinal infection all can cause it to occur, in treatment, adopt is improved gastrointestinal tract dynamia medicine, calcium-channel antagonists and regulating plant function of nervous system class medicine and to be suited the medicine to the illness Supporting Therapy more, and effect is not satisfactory.
Diarrhea type irritable bowel syndrome, according to its clinical manifestation characteristic, belongs to that Chinese medicine " is had loose bowels ", " stomachache " category, and the cause of disease mostly is being invaded by exogenous pathogen, seven emotions are got along well and weakness of the spleen and stomach etc., and sick position is at large intestine, dirty closely related with liver, spleen two.How insufficiency of the spleen by ferritic or temperance for food and drink, overstrain internal injury do not cause weakness of the spleen and stomach the traditional Chinese medical science thinks that stagnation of liver-QI with deficiency of the spleen is its main pathogenesis; Or because of being unable to satisfy the wants, disgruntled nervous anxiety and cause depression of liver-QI, spleen loses transporting, retention of water-damp in the body, clear QI failing to ascend, and turbid QI failing to descend, forms and have loose bowels, functional activity of QI being not smooth therefore stomachache, abdominal distention, borborygmus, to have loose bowels.Chinese traditional treatment primary disease has long historical tradition, have accumulated abundant clinical experience, and Chinese medicine is cured the disease exquisite dialectically to treat, determined curative effect, side effect is little, therefore uses for reference traditional Chinese medical science ancient prescription, and the Chinese medicine preparation of the effective treatment primary disease utilizing modern science and technology development more advanced is necessary.
Summary of the invention
The invention provides one, to have prescription rigorous, and compatibility science is evident in efficacy, can play curative effect of medication to greatest extent, and easy to prepare, and patient compliance is good, pharmaceutical composition of the treatment diarrhea type irritable bowel syndrome that toxic and side effects is little and preparation method thereof.
For achieving the above object, technical scheme provided by the invention is the pharmaceutical composition of described treatment irritable bowel syndrome, it is characterized in that described pharmaceutical composition is made up of the medicine of following weight proportion: Carapax et Plastrum Testudinis 12-16g, Concha Margaritifera 10-12g, Semen Coicis 10-12g, Poria 8-13g, Lignum Aquilariae Resinatum 6-8g, Fructus Akebiae 12-14g, Radix Linderae 10-12g, Rhizoma Zingiberis Preparatum 8-12g, Fructus Mume 10-12g, Radix Curcumae 10-14g.
Most preferred technique scheme of the present invention is that pharmaceutical composition of the present invention is obtained by the material medicine of following weight proportion: Carapax et Plastrum Testudinis 14g, Concha Margaritifera 11g, Semen Coicis 11g, Poria 10g, Lignum Aquilariae Resinatum 7g, Fructus Akebiae 13g, Radix Linderae 11g, Rhizoma Zingiberis Preparatum 10g, Fructus Mume 11g, Radix Curcumae 12g.
The dosage form of aforementioned pharmaceutical compositions is oral formulations.
Above-mentioned oral formulations is tablet, capsule or granule.
Above-mentioned oral formulations is that the preparation method step of tablet is as follows: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, and reclaim ethanol to concentrated, cold drying, is ground into fine powder, adds appropriate amount of auxiliary materials, compress tablet coating.
Above-mentioned oral formulations is that the preparation method step of capsule is as follows: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, and reclaim ethanol to concentrated, cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
Above-mentioned oral formulations is that the preparation method step of granule is as follows: take above Chinese medicine component according to aforesaid ratio and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, reclaims ethanol to concentrated, adds pharmaceutic adjuvant mix homogeneously, cold drying, granulate, make granule and pack.
The present invention, relative to prior art, has following clear superiority:
First, pharmaceutical composition prescription of the present invention mainly develops according to the pathogenic characteristic of irritable bowel syndrome patients, for irritable bowel syndrome especially diarrhea type irritable bowel syndrome prescription, and Carapax et Plastrum Testudinis in side, Concha Margaritifera, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney; Semen Coicis, Poria, heat clearing away spleen invigorating, promoting diuresis to eliminate damp pathogen; Lignum Aquilariae Resinatum, Fructus Akebiae, the Radix Linderae, promoting the circulation of QI to relieve pain, soothing liver-QI stomach function regulating, warming kidney for dispelling cold; Rhizoma Zingiberis Preparatum, Fructus Mume, warming middle-JIAO to stop diarrhea, astringing intestine to stop diarrhea promotes the production of body fluid; Radix Curcumae, regulating qi to disperse stagnation, heart fire-clearing upset-relieving.All medicines share play altogether spleen reinforcing, soothing the liver, regulate the flow of vital energy, Eradicates is wet, the merit of antidiarrheal, can tonify deficiency eliminating evil again, treating both the principal and secondary aspects of a disease.Through clinical practice checking, it is evident in efficacy, mild in medicine property and, toxic and side effects is little, and safety coefficient is high.Chinese medicine preparation of the present invention adopts advanced extraction equipment and technique, abundant effective component extracting, can be made into and facilitates Chinese medicine preparation that is oral or that carry.
Further, in pharmaceutical composition of the present invention, the function of each crude drug cures mainly:
Carapax et Plastrum Testudinis, salty sweet, flat.Enter liver, kidney channel.YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Control deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spit blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.
Concha Margaritifera is salty, cold.Return liver, heart channel.Suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Semen Coicis is sweet light, cool.Enter spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Poria is sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Lignum Aquilariae Resinatum, pungent, bitter, tepor.Return spleen, stomach, kidney channel.Promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Fructus Akebiae, hides micro-hardship, and property is put down.Return liver, stomach, urinary bladder channel.Liver; Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.
The Radix Linderae, pungent; Temperature.Spleen; Stomach, liver, kidney, bladder.Promoting the circulation of QI to relieve pain; Warming kidney for dispelling cold.Main fullness in the chest and hypochondrium is vexed; Abdominal distention; Headache; Colic of cold type pain; Dysmenorrhea and puerperal abdonimal pain; Frequent micturition; The enuresis.
Rhizoma Zingiberis Preparatum, bitter in the mouth; Pungent; Warm in nature.Spleen; Stomach; Liver Channel.Warming middle-JIAO to stop diarrhea; Warming the meridian for stopping bleeding.Main deficient cold type epigastric pain; Vomiting; Dysentery; Spit blood; Have blood in stool; Metrorrhagia.
Fructus Mume is sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Radix Curcumae, pungent, bitter, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
The present invention also asks the purposes protecting aforementioned pharmaceutical compositions in the medicine of preparation treatment irritable bowel syndrome.In clinical observation process, 100 routine Patients with Diarrhea Irritable Bowel Syndromes use Drug therapy of the present invention, and after a course for the treatment of terminates, clinical effectiveness shows, patient can be significantly improved by symptom after taking medicine composite for curing of the present invention.And serious untoward reaction is not found in whole therapeutic process, and show that the clinical application of we is safe and reliable, can research promotion further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 tablet
The each raw material of the present invention is taken: Carapax et Plastrum Testudinis 14g, Concha Margaritifera 11g, Semen Coicis 11g, Poria 10g, Lignum Aquilariae Resinatum 7g, Fructus Akebiae 13g, Radix Linderae 11g, Rhizoma Zingiberis Preparatum 10g, Fructus Mume 11g, Radix Curcumae 12g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, reclaim ethanol to concentrated, cold drying, is ground into fine powder, add appropriate amount of auxiliary materials, compress tablet coating, make Tablets.
When using medicine composite for curing irritable bowel syndrome of the present invention, take prepared tablet, every sheet is containing crude drug amount 0.1g, and every day 3 times, each 2-4 sheet, takes after meal half an hour.
Embodiment 2 capsule
The each raw material of the present invention is taken: Carapax et Plastrum Testudinis 14g, Concha Margaritifera 11g, Semen Coicis 11g, Poria 10g, Lignum Aquilariae Resinatum 7g, Fructus Akebiae 13g, Radix Linderae 11g, Rhizoma Zingiberis Preparatum 10g, Fructus Mume 11g, Radix Curcumae 12g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, reclaim ethanol to concentrated, cold drying, is ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates, and makes capsule of the present invention.
When using medicine composite for curing irritable bowel syndrome of the present invention, take prepared capsule, every contains crude drug amount 0.1g, and every day 3 times, each 2-4 grain, takes after meal half an hour.
Embodiment 3 granule
The each raw material of the present invention is taken: Carapax et Plastrum Testudinis 14g, Concha Margaritifera 11g, Semen Coicis 11g, Poria 10g, Lignum Aquilariae Resinatum 7g, Fructus Akebiae 13g, Radix Linderae 11g, Rhizoma Zingiberis Preparatum 10g, Fructus Mume 11g, Radix Curcumae 12g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, reclaims ethanol to concentrated, cold drying, granulate, makes granule pack, make granule of the present invention.
When using medicine composite for curing irritable bowel syndrome of the present invention, take prepared granule, containing crude drug amount 0.5g, every day 2 times, each 1 bag, take half an hour after meal for every bag.
Embodiment 4 tablet
The each raw material of the present invention is taken: Carapax et Plastrum Testudinis 12g, Concha Margaritifera 10g, Semen Coicis 10g, Poria 8g, Lignum Aquilariae Resinatum 6g, Fructus Akebiae 12g, Radix Linderae 10g, Rhizoma Zingiberis Preparatum 8g, Fructus Mume 10g, Radix Curcumae 10g by following weight proportion.
Preparation technology is with embodiment 1.
Embodiment 5 tablet
The each raw material of the present invention is taken: Carapax et Plastrum Testudinis 16g, Concha Margaritifera 12g, Semen Coicis 12g, Poria 13g, Lignum Aquilariae Resinatum 8g, Fructus Akebiae 14g, Radix Linderae 12g, Rhizoma Zingiberis Preparatum 12g, Fructus Mume 12g, Radix Curcumae 14g by following weight proportion.
Preparation technology is with embodiment 1.
The clinical experimental data of the chronic irritable bowel syndrome patients of test example 6 invention pharmaceutical composition
1, case-data: choose taste section of hospital of traditional Chinese hospital 100 Patients Patients with Diarrhea Irritable Bowel Syndrome, meet Chinese medical discrimination syndrome of stagnation of liver qi and spleen deficiency.Be divided into 2 groups of each 50 examples at random.Treatment group man 23 example, female 26 example, 18 years old-60 years old age, 36 years old mean age, the course of disease 1 year-8 years, average 4 years; Observation group man 25 example, female 25 example, 19 years old-58 years old age, 35 years old mean age, the course of disease 8 months-9 years, average 4 years.The equal not statistically significant of difference (equal P > 0.05) such as age, sex, the state of an illness of two groups of cases, has comparability.
2, diagnostics and maintenance standard:
Diagnostic criteria and the documentation standards in 2.1 Western medicine diagnose standards reference Rome III are formulated.Have per month stomachache and/or the malaise symptoms of 3d recurrent exerbation in nearest 3 months at least, and there are following 2 or more: after (1) defecation, stomachache and/or malaise symptoms improve; (2) simultaneously with the frequency shift of defecation; (3) with the change of feces appearance character.Following symptom supports the diagnosis of diarrhea type irritable bowel syndrome: the frequency anomaly of (1) defecation, every day defecation > 3 times; (2) feces appearance character is abnormal: loose stool (mushy stool) or watery stool account for stool amount >=25%, firmly just or bulk just account for stool amount < 25%; (3) mucus is arranged just; (4) there is sense of urgency during defecation or have defecation to feel not to the utmost; (5) abdominal distention.Diagnostic criteria builds on patient and at least before diagnosis, occurs symptom in June, at nearest 3 months sustainable existences, and gets rid of the organic disease causing above-mentioned symptom.
" irritable bowel syndrome Chinese traditional medical diagnose National Consensus " syndrome of stagnation of liver qi and spleen deficiency of having loose bowels of 2.2 TCM syndrome diagnostic criterias reference " new Chinese medicine guideline of clinical investigations " and the spleen-stomach disease branch of China Association of Traditional Chinese Medicine formulation in 2010: primary symptom: (1) stomachache is then rushed down, rush down rear alleviation of pain, outbreak is normal relevant to emotion; (2) being irritable and getting angry easily, kind sigh.Secondary disease: (1) two side of body distension; (2) anorexia nausea; (3) stringy and thready pulse, there is indentation on the fat limit of light red tongue.
2.3 exclusion standards:: (1) meets diagnostic criteria, but based on constipation, or be mixed into main patient with constipation and diarrhoea; (2) patient of cardiovascular and cerebrovascular vessel, Liver and kidney and disease of hematopoietic system is associated with; (3) diabetes, hypertensive patient is associated with; (4) gestation or women breast-feeding their children; (5) age is less than 18 years old or patient more than 60 years old.
3, Therapeutic Method:
Treating all continuously for two groups 4 weeks was 1 course for the treatment of; Light, regular diet, avoids drinking and pungent stimulation and greasy food.
Treatment group: take the tablet prepared by embodiment 1, every sheet is containing crude drug amount 0.1g, and every day 3 times, each 2-4 sheet, takes after meal half an hour.
Matched group: montmorillonite powder (Beaufour-lpsen (Tianjin) pharmaceutical Co. Ltd, accurate word H20000690, the 3g/ bag of traditional Chinese medicines), 6g/ time, 3 times/d).
4, curative effect determinate standard:
Criterion of therapeutical effect is with reference to the criterion of therapeutical effect of having loose bowels in " new Chinese medicine guideline of clinical investigations " (trying).
Clinical cure: stool amount and character recover normal, simultaneous phenomenon and sign disappear.
Effective: times of defecation every day time, to be approximately shaped, or loose stool but every day only secondary, more than simultaneous phenomenon and sign total mark reduce before comparatively treating.
Effective: times of defecation and matter take a favorable turn, more than simultaneous phenomenon and sign total mark reduce before comparatively treating.
Invalid: not reach above-mentioned standard person.
Total effective rate=(clinical cure number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%.
5, follow up a case by regular visits to: terminate latter 3 months the course for the treatment of, Effect of follow-up visit by telephone is carried out to recovery from illness patient, observe the situation of stomachache, abdominal discomfort, stool, times of defecation.
6, therapeutic outcome:
100 routine patients all complete clinical observation, without coming off case.Clinical effectiveness shows, after a course for the treatment of terminates, and follows up a case by regular visits to 3 months, the routine Patients with Diarrhea Irritable Bowel Syndrome clinical cure rate 44% for the treatment of group 50, total effective rate 94%; Matched group reaches 72% to 50 routine Patients with Diarrhea Irritable Bowel Syndrome clinical cure rates 20%, total effective rate.Therapeutic effect treatment group is obviously better than matched group, visible the present invention has significant therapeutic effect to syndrome of stagnation of liver qi and spleen deficiency Patients with Diarrhea Irritable Bowel Syndrome tool, and treatment group treatment front and back blood, urine, electrocardiogram, liver function, kidney function test is all without exception, untoward reaction is not found in therapeutic process, toleration is better, and showing that the clinical application of we is safe and reliable, is a kind of medicine of ideal treatment diarrhea-type syndrome of stagnation of liver qi and spleen deficiency irritable bowel syndrome.Be worth further research promotion.
Concrete therapeutic outcome is in table 1.
Table 1. liang group Clinical efficacy comparison
| Group | Clinical cure/example | Cure rate | Effective/example | Effectively/example | Invalid/example | Total effective rate |
| Treatment group | 22 | 44％ | 15 | 10 | 3 | 94％ |
| Matched group | 10 | 20％ | 13 | 13 | 14 | 72％ |
Claims (8)
1. treat the pharmaceutical composition of diarrhea type irritable bowel syndrome for one kind, it is characterized in that, the composition of its primary raw material medicine and proportioning are: Carapax et Plastrum Testudinis 12-16g, Concha Margaritifera 10-12g, Semen Coicis 10-12g, Poria 8-13g, Lignum Aquilariae Resinatum 6-8g, Fructus Akebiae 12-14g, Radix Linderae 10-12g, Rhizoma Zingiberis Preparatum 8-12g, Fructus Mume 10-12g, Radix Curcumae 10-14g.
2. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as claimed in claim 1, it is characterized in that, the composition of its primary raw material medicine and proportioning are: Carapax et Plastrum Testudinis 14g, Concha Margaritifera 11g, Semen Coicis 11g, Poria 10g, Lignum Aquilariae Resinatum 7g, Fructus Akebiae 13g, Radix Linderae 11g, Rhizoma Zingiberis Preparatum 10g, Fructus Mume 11g, Radix Curcumae 12g.
3. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as described in claim 1,2, it is characterized in that, described pharmaceutical composition is oral formulations.
4. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as claimed in claim 3, it is characterized in that, described oral formulations is tablet, capsule or granule.
5. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as claimed in claim 4, it is characterized in that, the preparation method of described tablet has the following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, and reclaim ethanol to concentrated, cold drying, is ground into fine powder, adds appropriate amount of auxiliary materials, compress tablet coating.
6. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as claimed in claim 4, it is characterized in that, the preparation method of described capsule has the following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, and reclaim ethanol to concentrated, cold drying, be ground into middle powder, add appropriate amount of auxiliary materials, mix homogeneously incapsulates.
7. a kind of pharmaceutical composition for the treatment of irritable bowel syndrome as claimed in claim 4, it is characterized in that, the preparation method of described granule has the following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively; Add the water of medical material gross weight 8 times amount, soak 3h, decocting time is 2h, decocts 2 times; Merge decoction liquor, filter; When filtrate is concentrated into 55 DEG C, relative density is the extractum of 1.10 ~ 1.15, and adding ethanol to alcohol content is 75%v/v, leaves standstill 72 hours, gets supernatant, reclaims ethanol to concentrated, adds pharmaceutic adjuvant mix homogeneously, cold drying, granulate, make granule and pack.
8. the purposes of the pharmaceutical composition as described in claim 1,2 in the medicine of preparation treatment diarrhea type irritable bowel syndrome.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028071A (en) * | 2012-12-30 | 2013-04-10 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for treating diarrhea-dominant irritable bowel syndrome and preparation method of traditional Chinese medicine composition |
| CN104069459A (en) * | 2014-07-03 | 2014-10-01 | 张新红 | Traditional Chinese medicine composition for treating irritable bowel syndrome and preparation method thereof |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028071A (en) * | 2012-12-30 | 2013-04-10 | 青岛恒波仪器有限公司 | Traditional Chinese medicine composition for treating diarrhea-dominant irritable bowel syndrome and preparation method of traditional Chinese medicine composition |
| CN104069459A (en) * | 2014-07-03 | 2014-10-01 | 张新红 | Traditional Chinese medicine composition for treating irritable bowel syndrome and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 李国霞 等: "疏肝健脾法治疗腹泻型肠易激综合征的疗效观察", 《承德医学院学报》 * |
| 王金玲 等: "健脾抑肝止泻汤治疗腹泻型肠易激综合征40例疗效观察", 《北京中医药》 * |
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