CN104888123A - Preparation for infantile respiratory tract infection as well as preparation method and detection method thereof - Google Patents
Preparation for infantile respiratory tract infection as well as preparation method and detection method thereof Download PDFInfo
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- CN104888123A CN104888123A CN201510328317.2A CN201510328317A CN104888123A CN 104888123 A CN104888123 A CN 104888123A CN 201510328317 A CN201510328317 A CN 201510328317A CN 104888123 A CN104888123 A CN 104888123A
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Abstract
The invention belongs to the field of medicines and discloses a preparation for infantile respiratory tract infection. The preparation is prepared from the following raw materials: coptis chinensis, the root of red-rooted salvia, tree peony bark, almond, radix bupleuri, angelica sinensis, eucommia ulmoides, the root of three-nerved spicebush, pericarpium granati, felwort, the root of kudzu vine, chrysanthemum, poria cocos, the root of bidentate achyranthes, muskmelon seed, curcuma zedoary, Chinese yam, longspur epimedium, dandelion, cassia twig, root of common peony, radix ophiopogonis, common andrographis herb, honeysuckle and periostracum cicada. The preparation treats both the symptoms and root cause, is short in course of treatment and can effectively treat infantile respiratory tract infection.
Description
Technical field
The invention belongs to drug world, be specifically related to a kind of preparation for infantile respiratory tract infection and preparation and determination methods method thereof.
Background technology
Infantile respiratory tract infection is common clinical frequently-occurring disease, and the cause of disease is many caused by cause pathogeny imcrobe infection, and the pathogenic microorganism causing child to have a fever mainly contains antibacterial, virus and mycoplasma, chlamydia.Modern medicine thinks that definite pathogenesis still imperfectly understands, and is the result of many factors comprehensive function, and immunologic hypofunction is considered to one of major reason of falling ill.In prior art, (1) Physical temperature-lowering is roughly, as warm water or alcohol bath, ice bag cooling, normal saline enema etc. to the Therapeutic Method research of child's diseases caused by exogenous pathogenic factor fever; (2) drug cooling, as oral antipyretic, Metamizole nasal drip or the medicine such as intramuscular injection, intravenous drip dexamethasone, takes antibiont medicine to treat infection simultaneously; (3) herbal treatment: as oral traditional Chinese medicine preparation, the external application of Chinese medicine etc.
The common virus of respiratory tract infection is caused to have influenza virus, rhinovirus, coronavirus, parainfluenza virus, respiratory syncytial virus, adenovirus etc., wherein common with rhinovirus.The upper sense of general type: the lighter Chang Yu occurs nasal obstruction, sneeze, watery nasal discharge, dry cough and pharyngalgia after suffering from cold 1-3 days, can with heating, some morbidity can have paroxysmal umbilicus week pain in early days, relevant with adenomesenteritis with the enterospasm caused by heating, especially infant local symptom is not obvious for severe one, but General Symptoms weight, suddenly can play high heat, cough, poor appetite, companion's vomiting, diarrhoea, there is hyperpyrexia convulsion in severe patient, is commonly called as " high hot convulsion ".The visible pharyngeal congestion of health check-up, antiadoncus, pulmonary's respiratory murmur is normal.
Current more medicine is Western medicine, there is toxic and side effects large, can not treating both the principal and secondary aspects of a disease, and the shortcoming such as easily develop immunity to drugs.Developing a kind of pure Chinese herbal medicine preparation low for the toxic and side effects of infantile respiratory tract infection is the problem that we need to study.
Summary of the invention
In order to overcome the defect that prior art pharmaceutical preparation exists, the object of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, toxic and side effects are low, safe ready, cheap pharmaceutical preparation.
Present inventor according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, for the body that children's is tender, not normal to changes in temperature, exopathogen is taken advantage of a weak point and is sent out, and diseases caused by exogenous pathogenic factor seasonal pathogen, is easy to heat-transformation, the disease of repeated infection, the present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, has stronger antiviral, antipyretic and anti-inflammatory, enhancing human body immunity effect;
For realizing above-mentioned purpose of the present invention, the technical solution used in the present invention is as follows:
For a preparation for infantile respiratory tract infection, it is prepared by the raw material of following weight portion and obtains:
Rhizoma Coptidis 20-25 part, Radix Salviae Miltiorrhizae 18-20 part, Cortex Moutan 16-17 part, Semen Armeniacae Amarum 15-16 part, Radix Bupleuri 12-13 part,
Radix Angelicae Sinensis 10-12 part, Cortex Eucommiae 10-12 part, Radix Linderae 8-9 part, Pericarpium Granati 8-9 part, Radix Gentianae 7-8 part,
Radix Puerariae 7-8 part, Flos Chrysanthemi 7-8 part, Poria 6-7 part, Radix Achyranthis Bidentatae 6-7 part, Semen Melo 5-6 part,
Rhizoma Curcumae 3-4 part, Rhizoma Dioscoreae 3-4 part, Herba Epimedii 3-4 part, Herba Taraxaci 2-3 part, Ramulus Cinnamomi 2-3 part,
Radix Paeoniae Rubra 2-3 part, Radix Ophiopogonis 1-2 part, Herba Andrographis 1-2 part, Flos Lonicerae 1-2 part, Periostracum Cicadae 1-2 part.
The invention also discloses the preparation method of above-mentioned preparation, it comprises the steps:
1) each raw material for standby is taken according to weight portion;
2) Radix Puerariae is got, Flos Chrysanthemi, Poria, Herba Taraxaci and Ramulus Cinnamomi, mixing, put into volume fraction be 70% ethanol soak 30 minutes, then 70 DEG C of oven dry, then put in pulverizer and pulverize, take out and be laid into the medicated powder layer that thickness is 1cm, irradiate 10 minutes under being placed in ultraviolet, uitraviolet intensity is 3000uW/cm
2, obtain material A;
3) Rhizoma Coptidis is got, Radix Salviae Miltiorrhizae, Cortex Moutan, Semen Armeniacae Amarum, Radix Bupleuri, Radix Angelicae Sinensis, the Cortex Eucommiae, the Radix Linderae, Pericarpium Granati, Radix Gentianae, Radix Achyranthis Bidentatae, Semen Melo, Rhizoma Curcumae, Herba Epimedii, Radix Paeoniae Rubra, Radix Ophiopogonis and Herba Andrographis, mixing, adds the soak by water 2 hours of 2 times of weight, collecting by filtration filtrate, be 6.5 with the PH of the hydrochloric acid solution of 1mol/L adjustment filtrate again, then filtrate be condensed into the extractum that density is 1.2g/ml, obtain material B;
4) by Rhizoma Dioscoreae, Flos Lonicerae and Periostracum Cicadae mixing, grind into powder, crosses 200 mesh sieves, obtains material C;
5) material A, material B and material C are mixed, stir, after couveuse is dried at being then placed in 70 DEG C, be ground into 200 object powder, be uniformly mixed and incapsulate, to obtain final product.
Detection method: the present invention measures the content of each effective ingredient by high performance liquid chromatography.
Dosage form and usage: this preparation formulation is capsule formulation, 0.3 gram/, three times on the one, after meal respectively once, each three 1 week is a course for the treatment of.
The beneficial effect that the present invention obtains, mainly contain following some:
Preparation of the present invention is made up of pure Chinese medicine, and the compatibility of each taste Chinese medicine is reasonable, not containing chemical components, has no side effect, treating both the principal and secondary aspects of a disease, and short treating period, can treat infantile respiratory tract infection effectively; The present invention adopts unique Technology, adopts different processing modes, discharged to greatest extent by the effective ingredient in raw material for different raw materials, avoids the nutritional labeling waste that single processing mode causes; Extraction step of the present invention is simple to operate, is applicable to suitability for industrialized production, possesses wide application prospect.
Detailed description of the invention
Below employing specific embodiment is made further explanation to the present invention, but it is not as the restriction to initiative spirit of the present invention.
Embodiment 1
For a preparation for infantile respiratory tract infection, it is prepared by the raw material of following weight portion and obtains:
Rhizoma Coptidis 20 parts, Radix Salviae Miltiorrhizae 18 parts, Cortex Moutan 16 parts, 15 parts, Semen Armeniacae Amarum, Radix Bupleuri 12 parts,
Radix Angelicae Sinensis 10 parts, the Cortex Eucommiae 10 parts, the Radix Linderae 8 parts, Pericarpium Granati 8 parts, Radix Gentianae 7 parts,
Radix Puerariae 7 parts, Flos Chrysanthemi 7 parts, 6 parts, Poria, Radix Achyranthis Bidentatae 6 parts, Semen Melo 5 parts,
Rhizoma Curcumae 3 parts, Rhizoma Dioscoreae 3 parts, Herba Epimedii 3 parts, Herba Taraxaci 2 parts, Ramulus Cinnamomi 2 parts,
Radix Paeoniae Rubra 2 parts, Radix Ophiopogonis 1 part, Herba Andrographis 1 part, Flos Lonicerae 1 part, Periostracum Cicadae 1 part.
The preparation method of above-mentioned preparation comprises the steps:
1) each raw material for standby is taken according to weight portion;
2) Radix Puerariae is got, Flos Chrysanthemi, Poria, Herba Taraxaci and Ramulus Cinnamomi, mixing, put into volume fraction be 70% ethanol soak 30 minutes, then 70 DEG C of oven dry, then put in pulverizer and pulverize, take out and be laid into the medicated powder layer that thickness is 1cm, irradiate 10 minutes under being placed in ultraviolet, uitraviolet intensity is 3000uW/cm
2, obtain material A;
3) Rhizoma Coptidis is got, Radix Salviae Miltiorrhizae, Cortex Moutan, Semen Armeniacae Amarum, Radix Bupleuri, Radix Angelicae Sinensis, the Cortex Eucommiae, the Radix Linderae, Pericarpium Granati, Radix Gentianae, Radix Achyranthis Bidentatae, Semen Melo, Rhizoma Curcumae, Herba Epimedii, Radix Paeoniae Rubra, Radix Ophiopogonis and Herba Andrographis, mixing, adds the soak by water 2 hours of 2 times of weight, collecting by filtration filtrate, be 6.5 with the PH of the hydrochloric acid solution of 1mol/L adjustment filtrate again, then filtrate be condensed into the extractum that density is 1.2g/ml, obtain material B;
4) by Rhizoma Dioscoreae, Flos Lonicerae and Periostracum Cicadae mixing, grind into powder, crosses 200 mesh sieves, obtains material C;
5) material A, material B and material C are mixed, stir, after couveuse is dried at being then placed in 70 DEG C, be ground into 200 object powder, be uniformly mixed and incapsulate, to obtain final product.
Dosage form and usage: this preparation formulation is capsule formulation, 0.3 gram/, three times on the one, after meal respectively once, each three 1 week is a course for the treatment of.
Embodiment 2
For a preparation for infantile respiratory tract infection, it is prepared by the raw material of following weight portion and obtains:
Rhizoma Coptidis 25 parts, Radix Salviae Miltiorrhizae 20 parts, Cortex Moutan 17 parts, 16 parts, Semen Armeniacae Amarum, Radix Bupleuri 13 parts,
Radix Angelicae Sinensis 12 parts, the Cortex Eucommiae 12 parts, the Radix Linderae 9 parts, Pericarpium Granati 9 parts, Radix Gentianae 8 parts,
Radix Puerariae 8 parts, Flos Chrysanthemi 8 parts, 7 parts, Poria, Radix Achyranthis Bidentatae 7 parts, Semen Melo 6 parts,
Rhizoma Curcumae 4 parts, Rhizoma Dioscoreae 4 parts, Herba Epimedii 4 parts, Herba Taraxaci 3 parts, Ramulus Cinnamomi 3 parts,
Radix Paeoniae Rubra 3 parts, Radix Ophiopogonis 2 parts, Herba Andrographis 2 parts, Flos Lonicerae 2 parts, Periostracum Cicadae 2 parts.
The preparation method of above-mentioned preparation comprises the steps:
1) each raw material for standby is taken according to weight portion;
2) Radix Puerariae is got, Flos Chrysanthemi, Poria, Herba Taraxaci and Ramulus Cinnamomi, mixing, put into volume fraction be 70% ethanol soak 30 minutes, then 70 DEG C of oven dry, then put in pulverizer and pulverize, take out and be laid into the medicated powder layer that thickness is 1cm, irradiate 10 minutes under being placed in ultraviolet, uitraviolet intensity is 3000uW/cm
2, obtain material A;
3) Rhizoma Coptidis is got, Radix Salviae Miltiorrhizae, Cortex Moutan, Semen Armeniacae Amarum, Radix Bupleuri, Radix Angelicae Sinensis, the Cortex Eucommiae, the Radix Linderae, Pericarpium Granati, Radix Gentianae, Radix Achyranthis Bidentatae, Semen Melo, Rhizoma Curcumae, Herba Epimedii, Radix Paeoniae Rubra, Radix Ophiopogonis and Herba Andrographis, mixing, adds the soak by water 2 hours of 2 times of weight, collecting by filtration filtrate, be 6.5 with the PH of the hydrochloric acid solution of 1mol/L adjustment filtrate again, then filtrate be condensed into the extractum that density is 1.2g/ml, obtain material B;
4) by Rhizoma Dioscoreae, Flos Lonicerae and Periostracum Cicadae mixing, grind into powder, crosses 200 mesh sieves, obtains material C;
5) material A, material B and material C are mixed, stir, after couveuse is dried at being then placed in 70 DEG C, be ground into 200 object powder, be uniformly mixed and incapsulate, to obtain final product.
Dosage form and usage: this preparation formulation is capsule formulation, 0.3 gram/, three times on the one, after meal respectively once, each three 1 week is a course for the treatment of.
Embodiment 3
Preparation of the present invention is tested the impact of respiratory tract infection model mice
Cleaning grade male ICR mouse 60, body weight 17-18g.20 mices are as Normal group, and other mice is used for modeling.Respiratory tract infection model copy: the method used with reference to " practical tcm syndrome model ".Method is mouse peritoneal injection hydrocortisone 0.04mL/, and continuous 12d, causes immunologic hypofunction mouse model.Modeling mice is divided into following 2 groups at random: model control group and invention formulation group, often organizes 20.In after modeling the 2nd day, Normal group, model control group equal gavage normal saline 0.5mL/ only; The preparation 5mg/kg/d of the invention formulation group gavage embodiment of the present invention 1 preparation; Continue gavage after 1 week, pluck after eyeball gets blood, cervical dislocation puts to death mice, surveys the ratio of mice serum CD4, CD8 positive cell, in table 1.
Table 1
Group | CD4/CD8 |
Normal group | 2.13±0.12 |
Model control group | 1.17±0.19 |
Invention formulation group | 1.76±0.18 |
Therefore, invention formulation group compares with model group, mice CD4/CD8 ratio can be significantly improved, there is significant difference (P < 0.05), preparation of the present invention can the cellular immune function of remarkable enhancing body, the low state of Immune Function is corrected, with the anti-infectious immunity effect of bringing into normal play, from therapeutic purposes.
Embodiment 4
Clinical data: totally 40 examples, wherein man 22 example, female 18 example, 8 months-8 years old age, 4 years old 3 months mean age.Be divided into two groups at random, often organize 20 people.
Clinical symptoms: because of affection of exogenous wind-cold, the cold symptoms such as the nasal obstruction then occurred, watery nasal discharge, cough, part infant pharyngeal congestion, antiadoncus, two pulmonary respiration sounds are slightly coarse or not coarse; Body temperature 38.2 DEG C-40.1 DEG C, infant flushed face with red ears, uneasiness of crying and screaming.
Therapeutic Method: two groups on the basis of the conventional therapy such as liquid make-up, Physical temperature-lowering, treatment group gives preparation prepared by embodiment 2, oral 0.3 gram/at every turn, three times on the one, after meal each once, each three 1 week is a course for the treatment of.Matched group ribavirin effervescent granule 0.1g/ time, three times on the one, after meal each once, within 1 week, be a course for the treatment of.
Efficacy assessment standard: recovery from illness: after treatment, children's recovers normal completely, nothing phenomenon repeatedly within two weeks.Take a turn for the better: infant heating paresthesia disappears, and the symptoms such as nasal obstruction, watery nasal discharge, cough and pharyngeal pain do not take a turn for the better completely, have phenomenon repeatedly within two weeks.Invalid: the state of an illness is without any improvement.Concrete data see table 2.
Table 2
Group | Example time | Recovery from illness | Take a turn for the better | Invalid | Cure rate (%) |
Matched group | 20 | 11 | 5 | 4 | 55% |
Embodiment 2 groups | 20 | 17 | 3 | 0 | 85% |
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (3)
1. for a preparation for infantile respiratory tract infection, it is characterized in that, described preparation is prepared by the raw material of following weight portion and obtains:
Rhizoma Coptidis 20-25 part, Radix Salviae Miltiorrhizae 18-20 part, Cortex Moutan 16-17 part, Semen Armeniacae Amarum 15-16 part, Radix Bupleuri 12-13 part, Radix Angelicae Sinensis 10-12 part, Cortex Eucommiae 10-12 part, Radix Linderae 8-9 part, Pericarpium Granati 8-9 part, Radix Gentianae 7-8 part, Radix Puerariae 7-8 part, Flos Chrysanthemi 7-8 part, Poria 6-7 part, Radix Achyranthis Bidentatae 6-7 part, Semen Melo 5-6 part, Rhizoma Curcumae 3-4 part, Rhizoma Dioscoreae 3-4 part, Herba Epimedii 3-4 part, Herba Taraxaci 2-3 part, Ramulus Cinnamomi 2-3 part, Radix Paeoniae Rubra 2-3 part, Radix Ophiopogonis 1-2 part, Herba Andrographis 1-2 part, Flos Lonicerae 1-2 part, Periostracum Cicadae 1-2 part.
2. preparation according to claim 1, is characterized in that, preferably, the preparation method of described preparation comprises the steps:
1) each raw material for standby is taken according to weight portion;
2) get Radix Puerariae, Flos Chrysanthemi, Poria, Herba Taraxaci and Ramulus Cinnamomi, mixing, put into volume fraction be 70% ethanol soak 30 minutes, then 70 DEG C of oven dry, then put in pulverizer and pulverize, to be finally placed under ultraviolet irradiation 10 minutes, to obtain material A;
3) Rhizoma Coptidis is got, Radix Salviae Miltiorrhizae, Cortex Moutan, Semen Armeniacae Amarum, Radix Bupleuri, Radix Angelicae Sinensis, the Cortex Eucommiae, the Radix Linderae, Pericarpium Granati, Radix Gentianae, Radix Achyranthis Bidentatae, Semen Melo, Rhizoma Curcumae, Herba Epimedii, Radix Paeoniae Rubra, Radix Ophiopogonis and Herba Andrographis, mixing, adds the soak by water 2 hours of 2 times of weight, collecting by filtration filtrate, be 6.5 with the PH of the hydrochloric acid solution of 1mol/L adjustment filtrate again, then filtrate be condensed into the extractum that density is 1.2g/ml, obtain material B;
4) by Rhizoma Dioscoreae, Flos Lonicerae and Periostracum Cicadae mixing, grind into powder, crosses 200 mesh sieves, obtains material C;
5) material A, material B and material C are mixed, stir, after then drying, be ground into 200 object powder, be uniformly mixed and incapsulate, to obtain final product.
3. the medical application of preparation described in claim 1 or 2.
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Cited By (1)
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CN105816557A (en) * | 2016-04-18 | 2016-08-03 | 袁贯丽 | Infant traditional Chinese medicine fever-reducing paste and preparation method thereof |
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CN103041255A (en) * | 2012-12-31 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children |
CN103432545A (en) * | 2013-08-23 | 2013-12-11 | 王怀珍 | Medicament for allaying fever of child and preparation method thereof |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US7862838B1 (en) * | 2009-08-31 | 2011-01-04 | Qing Si Zeng | Composition and regimen for the treatment of herpes simplex and herpes zoster primarily by eliminating their pathogenetic conditions and taking into account both pathogenesis and etiology |
CN103041255A (en) * | 2012-12-31 | 2013-04-17 | 青岛华仁信息技术开发有限公司 | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children |
CN103432545A (en) * | 2013-08-23 | 2013-12-11 | 王怀珍 | Medicament for allaying fever of child and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105816557A (en) * | 2016-04-18 | 2016-08-03 | 袁贯丽 | Infant traditional Chinese medicine fever-reducing paste and preparation method thereof |
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