CN104887815A - Compound traditional Chinese medicine for young animals, method for manufacturing compound traditional Chinese medicine and application thereof - Google Patents
Compound traditional Chinese medicine for young animals, method for manufacturing compound traditional Chinese medicine and application thereof Download PDFInfo
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Abstract
The invention provides traditional Chinese medicine for treating young animals suffering from viral diarrhea. The traditional Chinese medicine comprises, by weight, 5-33 parts of cyrtomium rhizome, 2-30 parts of schisandra chinensis, 3-20 parts of pomegranate rind, 38.5-85.13 parts of flavoring agents and 4.87-34.2 parts of disintegrants. The flavoring agents comprise 4-80 parts of mannitol, 5-30 parts of cane sugar, 0.05-3 parts of potassium chloride, 0.05-0.5 part of sodium glutamate, 0.02-0.5 part of trisodium glycyrrhizinate and 0.01-0.5 part of fresh milk essence; the disintegrants comprise 3.5-26 parts of microcrystalline celluloses, 1.25-5 parts of low-substituted hydroxypropyl celluloses, 0.1-2.5 parts of magnesium stearate and 0.02-1 part of sodium dodecyl sulfate. The invention further discloses a method for manufacturing the traditional Chinese medicine. The method includes decocting the cyrtomium rhizome and the schisandra chinensis in water to obtain filter liquid, adding powder of the pomegranate rind into the filter liquid to obtain soft materials, adding the magnesium stearate into the soft materials, uniformly mixing the magnesium stearate and soft materials with one another to obtain mixtures, granulating the mixtures to obtain grains and drying the grains; adding the mannitol, the microcrystalline celluloses, the low-substituted hydroxypropyl celluloses, the sodium dodecyl sulfate, the magnesium stearate, the trisodium glycyrrhizinate and the fresh milk essence into the grains and uniformly mixing the mannitol, the microcrystalline celluloses, the low-substituted hydroxypropyl celluloses, the sodium dodecyl sulfate, the magnesium stearate, the trisodium glycyrrhizinate and the fresh milk essence with the grains. The invention further discloses application of the traditional Chinese medicine to treating the young animals suffering from viral diarrhea. The traditional Chinese medicine, the method and the application have the advantages of zero irritability and excellent curative effect.
Description
Technical field
The invention belongs to young stock diarrhea treatment field, be specifically related to a kind of young stock herbal mixture and its preparation method and application; More specifically relate to a kind of Chinese medicine and the preparation method and application that treat young stock viral diarrhea.
Background technology
Young stock is suffered from diarrhoea, the especially early stage viral diarrhea of the young stock of transmissible gastroenteritis and so on, has prevention difficult, and morbidity is anxious, the features such as the course of disease is short.Be the technical barrier always perplexing livestock culturing for a long time, especially in recent years, young stock viral diarrhea is sickness rate or the mortality rate after falling ill is all the trend risen year by year.Therefore, effective treatment of this disease has very important realistic meaning to livestock culturing.Anti-system at present to young stock viral diarrhea, takes symptomatic treatment usually, both prevents secondary infection and electrolyte supplement and water by injecting antimicrobial drug; This traditional remedies, morbidity young stock is often owing to suffering from diarrhoea control not in time, and strong diarrhoea causes dehydration, or pathogen is caused organ edema or exhaustion by the bacterial endotoxin that rear release killed by antimicrobial drug, finally collapses and dies; The stress simultaneously also caused to young stock with the administration of repeatedly injecting has some relations.Treat this sick, antibacterial or antiviral " effects a permanent cure " and corrects electrolyte balance with antidiarrheal and " take stopgap measures " very important, meanwhile, prevents young stock stress also very important; , existing common injection, solution, paste, powder, powder etc. all by compulsory mode administration, and functionally also can only not all possess infection, antidiarrheal, removing toxic substances, electrolyte supplement function, need to repeat to different medicines.Such administering mode not only difficulty is high, and workload is large, and the stress caused the young stock of just birth is also very large.
Therefore, solve a difficult problem for young stock diarrhoea, medicine used needs to possess following function:
(1) there is outstanding antidiarrheal, removing toxic substances, bactericidal action;
(2) there is outstanding electrolyte supplement function;
(3) young stock can be made initiatively to enter medicine, not produce stress;
(4) Release Performance is good, and disintegrating property is good, is easy to young stock and absorbs.
In addition, when treating young stock viral diarrhea, usually can only adopt Western medicine (chemicals), cost is comparatively high, also rarely has the corresponding dosage form being applicable to young stock and taking.Therefore, how to utilize the comparatively cheap Chinese traditional herbs of cost to prepare a kind of medicine being applicable to young stock viral diarrhea, become this area and urgently study and the problem with quite challenge.
Summary of the invention
For shortcoming and this area problem demanding prompt solution of prior art, an object of the present invention is to provide a kind of Chinese medicine for the treatment of young stock viral diarrhea, and by weight, this medicine comprises:
Rhizoma Osmundae 5-33 part
Fructus Schisandrae Chinensis 2-30 part
Pericarpium Granati 3-20 part.
In Chinese medicine, multi-flavor medicine has been had to be commonly used to carry out the treatment of antidiarrheal and removing toxic substances, but, for the viral diarrhea of young stock, general prescription is but difficult to play excellent effect, and its reason is: (1) Chinese medicine possesses bad smell usually, and young stock is very easy to produce irritability to unfavorable stimulation (as medicine bitterness), once irritability produces, not only make curative effect of medication decline, also can cause adverse effect to the physiological equilibrium of young stock; (2) curative effect of single medicinal material is often inadequate, and Chinese medicine is very exquisite to the compatibility of medicine, the improper antagonism often caused between medicine of compatibility, not only can not heighten the effect of a treatment to make curative effect lower on the contrary; (3) in Chinese medicine, the proportioning of each medicine is very important, proportionate relationship not right, is very easy to significantly reduce drug effect, even produces opposite effect.
The present inventor, by groping in a large number, in numerous Chinese medicine, finds that Rhizoma Osmundae, Fructus Schisandrae Chinensis and the Pericarpium Granati viral diarrhea to young stock has synergism.But as shown in the present invention's experimental example, above-mentioned three taste medicine interworkings might not be produced good therapeutic effect, once ratio is not right, therapeutic effect will sharply reduce.
Preferably, described medicine also comprises:
4-80 part mannitol, 5-30 part sucrose, 0.05-3 part potassium chloride, 0.05-0.5 part sodium glutamate, 0.02-0.5 part sodium glycyrrhetate, 0.01-0.5 part fresh milk essence;
Preferred, described medicine also comprises
3.5-26 part microcrystalline cellulose, 1.25-5 part low-substituted hydroxypropyl cellulose, 0.1-2.5 part magnesium stearate, 0.02-1 part sodium lauryl sulphate.
Correctives of the present invention (sucrose, mannitol, sodium glutamate, potassium chloride, sodium glycyrrhetate, fresh milk essence) obtains through numerous experiments for Chinese medicine formula used and young stock characteristic for inventor, its object is to make young stock initiatively enter medicine.In addition, inventor also finds, after the present invention three taste medicine and the present invention's electrolyte replenisher used (correctives Glutamic Acid sodium etc. are electrolyte replenisher) coupling, ill young stock can be made to fully recover at short notice.As shown in the present invention's experimental example, the proportioning that correctives respectively forms has strict requirement, once exceed proportion of the present invention, flavored action will be lost, and young stock no longer initiatively enters medicine.
The present inventor finds, be directed to medicine of the present invention (containing three taste Chinese medicine and correctivess), disintegrating agent mannitol, MCC, sucrose and L-HPC, SDS use in conjunction have synergism; Particularly the application of SDS, improves disintegration rate especially greatly, and disintegration time was sharply reduced to several seconds from tens seconds.
Preferably, by weight, this medicine comprises:
Rhizoma Osmundae 5-28 part
Fructus Schisandrae Chinensis 7-30 part
Pericarpium Granati 3-15 part
Correctives 52.1-85.13 part
Disintegrating agent 4.87-25.9 part
25-80 part mannitol, 5-24 part sucrose, 0.05-2 part potassium chloride, 0.05-0.4 part sodium glutamate, 0.02-0.3 part sodium glycyrrhetate, 0.01-0.4 part fresh milk essence;
3.5-20 part microcrystalline cellulose, 1.25-4 part low-substituted hydroxypropyl cellulose, 0.1-1.5 part magnesium stearate, 0.02-0.4 part sodium lauryl sulphate.
Preferred, by weight, this medicine comprises:
Rhizoma Osmundae 19 parts
Fructus Schisandrae Chinensis 16 parts
Pericarpium Granati 11 parts
Correctives 65.8 parts
Disintegrating agent 16.2 parts
53 portions of mannitol, 11 portions of sucrose, 1.2 parts of potassium chloride, 0.2 part of sodium glutamate, 0.2 part of sodium glycyrrhetate, 0.2 part of fresh milk essence;
12 parts of microcrystalline celluloses, 3 parts of low-substituted hydroxypropyl celluloses, 1 part of magnesium stearate, 0.2 part of sodium lauryl sulphate.
Above-mentioned preferred scheme not only can make young stock initiatively enter medicine, and ill young stock can be made to fully recover at short notice.
Described medicine is that pharmacy meaning is taken up an official post one dosage type low temperature.Preferably, described dosage form is tablet.
Another object of the present invention is to provide preparation a kind of preparation method for the treatment of the Chinese medicine of young stock viral diarrhea, and the method comprises:
By weight,
1) 5-33 part Rhizoma Osmundae and 2-30 part Fructus Schisandrae Chinensis are added to the water, boil rear decoction, get filtrate; Get filtering residue to be added to the water, boil rear decoction, get filtrate; Get filtering residue to be added to the water, boil rear decoction; Concentrate after merging three filtrates;
2) 5-30 part sucrose, 0.05-3 part potassium chloride, 0.05-0.5 part sodium glutamate is added to step 1) gains, mixing;
3) get 3-20 part Pericarpium Granati, after pulverizing, join step 2) in gains, mixing, makes soft material, makes 60 order granules with granulator;
4) add 0.5-1.25 part magnesium stearate to step 3) gains, mixing, upper spheronizator is round as a ball is prepared into rounded grain, in 35 DEG C ~ 70 DEG C oven dry;
5) 4-80 part mannitol, 3.5-26 part microcrystalline cellulose, 1.25-5 part low-substituted hydroxypropyl cellulose, 0.02-1 part sodium lauryl sulphate, 0.5-1.25 part magnesium stearate, 0.02-0.5 part sodium glycyrrhetate, 0.02-1 part fresh milk essence is added to step 4), mixing, make pharmacy meaning to take up an official post one dosage type low temperature, be preferably tablet.
Time preferred, by weight, Rhizoma Osmundae described in step 1) is 5-28 part, and described Fructus Schisandrae Chinensis is 7-30 part; Step 2) described sucrose is 5-34 part, described potassium chloride is 0.05-2 part, and described sodium glutamate is 0.05-0.4 part; Pericarpium Granati described in step 3) is 3-15 part; Magnesium stearate described in step 4) is 0.05-0.75 part; Mannitol described in step 5) is 25-80 part, described microcrystalline cellulose is 3.5-20 part, described low-substituted hydroxypropyl cellulose is 1.25-4 part, described sodium lauryl sulphate is 0.02-0.4 part, described magnesium stearate is 0.05-0.75 part, described sodium glycyrrhetate is 0.02-0.3 part, and described fresh milk essence is 0.01-0.4 part.
Preferably, in step 1), when first time decocts, the total amount adding water is Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 3 times, decocts 1 hour; When second time decocts, the total amount adding water is Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 2.5 times, decocts 40 minutes; Third time, when decocting, the total amount adding water was Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 2 times, decocts 20 minutes; Be concentrated into 1/3 medical material amount volume.
When adopting said method to decoct the present invention three taste medical material, the effective ingredient of medicine effectively can be extracted.
Preferred, by weight, Rhizoma Osmundae described in step 1) is 19 parts, and described Fructus Schisandrae Chinensis is 16 parts; Step 2) described sucrose is 11 parts, described potassium chloride is 1.2 parts, and described sodium glutamate is 0.2 part; Pericarpium Granati described in step 3) is 11 parts; Magnesium stearate described in step 4) is 0.5 part; Mannitol described in step 5) is 53 parts, and described microcrystalline cellulose is 12 parts, and described low-substituted hydroxypropyl cellulose is 3 parts, and described sodium lauryl sulphate is 0.2 part, and described magnesium stearate is 0.5 part, and described sodium glycyrrhetate is 0.2 part, and described fresh milk essence is 0.2 part.
Another object of the present invention is to provide the application of said medicine in treatment young stock viral diarrhea.
Beneficial effect of the present invention:
(1) young stock can be made initiatively to enter medicine, not produce irritability;
(2) effectively can play detoxification, sterilization, antidiarrheal and equilibrium water and electrolytical function, make to get well in the ill young stock short time;
(3) short time can discharge medicine, extremely be beneficial to absorption.
Detailed description of the invention
Below by embodiment, the present invention is specifically described; what be necessary to herein means out is that following examples are just for being further detailed the present invention; limiting the scope of the invention can not be interpreted as; some nonessential improvement and adjustment that the person skilled in the art in this field makes according to foregoing invention content, still belong to protection scope of the present invention.
Embodiment 1
A difficult problem for Chinese medicine is consumption, and the drug effect of Chinese medicine and consumption are also non-uniform, and the different drug effect of consumption is also different, and even action direction is contrary; In Chinese medicine compound, the proportioning of various medicine is different, and the change of prescription function is abundanter.For medication medication, supplementary product kind, consumption and auxiliary material combination etc. are the key factors of medicine, they be directly connected to can obtain this medicine and obtain the quality of drug quality.For the present invention (hereinafter referred to as " electrolysis octicin solution "), main inspection target is drug effect, palatability and disintegration rate.In order to prepare the fast electrolysis octicin solution of determined curative effect, good palatability, disintegration rate, between the present invention, pharmaceutical formulation screens.
(1) preparation of different formulations product
Different electrolysis octicin solutions is prepared respectively by following composition and engineering.
Formula: in table 1.
Technique: get Rhizoma Osmundae, Fructus Schisandrae Chinensis, adds 3 times of water gagings, and big fire is boiled rear little fire and decocted 1h, filters, gets filtrate; Medicinal residues add about 2.5 times of water gagings again, and big fire is boiled rear little fire and decocted 40min, filters, gets filtrate; Medicinal residues add 2 times of water gagings again, and big fire is boiled rear little fire and decocted 20min, filters, gets filtrate; Merge 3 gained medicinal liquids, be concentrated into 1/3 medical material amount volume; Add sucrose while hot, potassium chloride, sodium glutamate, mixing; Get Pericarpium Granati, pulverize, cross No. 9 sieves; Both are mixed, makes soft; 60 order fine graineds are made with oscillating granulator; Add magnesium stearate, mixing, upper spheronizator is round as a ball is prepared into rounded grain; 35 DEG C ~ 70 DEG C oven dry; With mannitol, MCC, L-HPC, SDS, magnesium stearate, sodium glycyrrhetate and fresh milk essence, mixing, tabletting.
Embodiment 2
Get Rhizoma Osmundae 7kg, Fructus Schisandrae Chinensis 28kg, add 105L water, big fire is boiled rear little fire and is decocted 1h, filters, gets filtrate; Medicinal residues add 90L water again, and big fire is boiled rear little fire and decocted 40min, filters, gets filtrate; Medicinal residues add 70L water again, and big fire is boiled rear little fire and decocted 20min, filters, gets filtrate; Merge 3 gained medicinal liquids, be concentrated into 12L; Add sucrose 5kg while hot, potassium chloride 0.08kg, sodium glutamate 0.07kg, mixing; Get Pericarpium Granati 5kg, pulverize, cross No. 9 sieves; Both are mixed, makes soft; 60 order fine graineds are made with oscillating granulator; Add magnesium stearate 0.1kg, mixing, upper spheronizator is round as a ball is prepared into rounded grain; 35 DEG C ~ 70 DEG C oven dry; With mannitol 78kg, microcrystalline cellulose (MCC) 3.6kg, low-substituted hydroxypropyl cellulose (L-HPC) 1kg, sodium lauryl sulphate (SDS) 0.02kg, magnesium stearate 0.1kg, sodium glycyrrhetate 0.02kg and fresh milk essence 0.01kg, mixing, is pressed into 100,000 (every sheet is equivalent to crude drug 0.33g).
Embodiment 3
Get Rhizoma Osmundae 14kg, Fructus Schisandrae Chinensis 21kg, add 105L water, big fire is boiled rear little fire and is decocted 1h, filters, gets filtrate; Medicinal residues add 90L water again, and big fire is boiled rear little fire and decocted 40min, filters, gets filtrate; Medicinal residues add 70L water again, and big fire is boiled rear little fire and decocted 20min, filters, gets filtrate; Merge 3 gained medicinal liquids, be concentrated into 12L; Add sucrose 10 kg while hot, potassium chloride 0.1kg, sodium glutamate 0.2kg, mixing; Get Pericarpium Granati 9kg, pulverize, cross No. 9 sieves; Both are mixed, makes soft; 60 order fine graineds are made with oscillating granulator; Add magnesium stearate 0.3kg, mixing, upper spheronizator is round as a ball is prepared into rounded grain; 35 DEG C ~ 70 DEG C oven dry; With mannitol 64kg, MCC 7kg, L-HPC 2kg, SDS 0.1kg, magnesium stearate 0.2kg, sodium glycyrrhetate 0.05 kg and fresh milk essence 0.05 kg, mixing, is pressed into 100,000 (every sheet is equivalent to crude drug 0.44g).
Embodiment 4
Get Rhizoma Osmundae 31kg, Fructus Schisandrae Chinensis 4kg, add 105L water, big fire is boiled rear little fire and is decocted 1h, filters, gets filtrate; Medicinal residues add 90L water again, and big fire is boiled rear little fire and decocted 40min, filters, gets filtrate; Medicinal residues add 70L water again, and big fire is boiled rear little fire and decocted 20min, filters, gets filtrate; Merge 3 gained medicinal liquids, be concentrated into 12L; Add sucrose 30 kg while hot, potassium chloride 3 kg, sodium glutamate 0.5 kg, mixing; Get Pericarpium Granati 18kg, pulverize, cross No. 9 sieves; Both are mixed, makes soft; 60 order fine graineds are made with oscillating granulator; Add magnesium stearate 1.5 kg, mixing, upper spheronizator is round as a ball is prepared into rounded grain; 35 DEG C ~ 70 DEG C oven dry; With mannitol 6kg, MCC 26kg, L-HPC 5kg, SDS 1kg, magnesium stearate 1kg, sodium glycyrrhetate 0.5 kg and fresh milk essence 0.5 kg, mixing, is pressed into 100,000 (every sheet is equivalent to crude drug 0.53g).
Experimental example 1
Different disintegrating agent synergy is investigated
Material: mannitol, MCC, L-HPC, sucrose and SDS(are commercially available prod); The formula 4 of embodiment 1 is shown in by unclassified stores.
Method and result: prepare test product 1 ~ test product 3 by embodiment 1 method and table 2 mix proportion scheme, evaluate disintegration respectively, the results are shown in Table 2.As shown in Table 2, disintegrating agent mannitol, MCC, sucrose and L-HPC, SDS use in conjunction have synergism; Particularly the application of SDS, improves disintegration rate especially greatly.
Experimental example 2
Different correctives synergy is investigated
Material: mannitol, MSG, potassium chloride, sucrose, sodium glycyrrhetate and fresh milk essence (being commercially available prod); The formula 4 of embodiment 1 is shown in by unclassified stores.
Method and result: (relate to the material in table 3 by embodiment 1 method, add by table 3 design flow; "-" represents does not add) prepare test product 1 ~ test product 6.Get test product 1 ~ test product 6 to healthy swinery administration, according to administrations, choose palatability grade, evaluation criterion is in table 4; The results are shown in Table 3.As can be seen from the Palatability evaluation result of table 3, along with different correctives adds with a certain proportion of, the palatability of test product improves gradually.It can thus be appreciated that above correctives, with suitable ratio conbined usage, has synergy.
Experimental example 3
The clinical tests of different pharmaceutical combination to piglet pujos blancos
Material: Rhizoma Osmundae, Pericarpium Granati and Fructus Schisandrae Chinensis (being commercially available prod); Electrolyte replenisher (by the preparation of embodiment 1 formula 4 consumption);
Case: piglet pujos blancos case 100 example of certain pig farm natural occurrence, sick pork chop white, canescence or yellow-white are smelt as of rotten fish loose stool; Be coli-infection through laboratory diagnosis.
Method: (Rhizoma Osmundae, Pericarpium Granati, Fructus Schisandrae Chinensis and electrolyte replenisher consumption press table 5, and "-" represents does not add by embodiment 1 method; The formula 4 of embodiment 1 is shown in by unclassified stores) prepare test product 1 ~ test product 4; Under identical rearing conditions, at random sick pig is divided into test 1 group, tests 2 groups, tests 3 groups, tests 4 groups and blank group; Test 1 group ~ test 4 groups to use test product 1 ~ test product 4 directly to send into piglet oral cavity by 1/kgbw respectively, every day 1 time, be used in conjunction 3 days; Blank group is raised by daily feeding manner, not administration.Following therapeutic evaluation is carried out after 3 days.
Detoxification efficiency judges: medication is after 3 days, gets each group of sick pig respectively, slaughters anatomic observation gastrointestinal whether edema, or edema degree.Gastrointestinal is without edematous condition, and detoxification efficiency is judged to " excellent "; Gastrointestinal edematous condition is slight, and detoxification efficiency is judged to " good "; Gastrointestinal edematous condition is obvious, and detoxification efficiency is judged to " poor ".
Bactericidal effect judges: medication, after 3 days, is got each group of sick pig excrements respectively, done bacterium inspection.Can't check corresponding pathogen, bactericidal effect is judged to " excellent "; Detect corresponding pathogen but concentration is very low, bactericidal effect is judged to " good "; Detect corresponding pathogen and concentration is higher, bactericidal effect is judged to " poor ".
Antidiarrheal effect judges: from medication same day, observes piglet diarrhea situation.Medication same day, piglet diarrhea stops substantially, and antidiarrheal effect is judged to " excellent "; Medication took a turn for the better the same day to some extent, and piglet diarrhea was clearly better on 1, and antidiarrheal effect is judged to " good "; Medication starts to take a turn for the better on the 2nd, and piglet diarrhea was clearly better on 1, antidiarrheal effect is judged to " in "; Medication is after 3 days, and piglet diarrhea is without significant change, and antidiarrheal effect is judged to " poor ".
Water and electrolyte balance regulating effect is evaluated: in table 6.
Overall efficacy determination: medication is after 3 days, and spiritual appetite recovers normal, and symptom of diarrhea disappears, and is judged to recovery from illness; Medication is after 3 days, and spiritual appetite is normal, and symptom of diarrhea disappears, and is judged to effective; Medication is after 3 days, and spiritual appetite takes a turn for the better, clinical symptom relief, is judged to effectively; Medication is after 3 days, and symptom is not improved, and it is invalid to be judged to.
Experimental result is in table 7.
As can be seen from above result of the test, under identical using dosage, test 1 group ~ test 5 groups to strengthen successively the overall curative effect of piglet pujos blancos, illustrate that Rhizoma Osmundae, Pericarpium Granati, Fructus Schisandrae Chinensis and electrolyte replenisher use in conjunction are prevented and treated piglet pujos blancos by the present invention, there is drug effect synergism.
Experimental example 4
The each formula of embodiment 1 is evaluated.
Disintegration is evaluated: with reference to Chinese Pharmacopoeia version disintegration time mensuration method in 2010, and get the electrolysis octicin solution prepared by formula 1 ~ formula 8 in embodiment 1 table 1, take water as medium, temperature is (37.0 ± 1) DEG C, measures disintegration.The tablet contact water surface to tablet disintegrates becomes granule and is all disintegration time by the time of screen cloth.Each survey 1, measures 6 times altogether, is averaged disintegration time.The results are shown in Table 9.
Palatability quality evaluation: the electrolysis octicin solution will prepared by formula 1 ~ formula 8 in embodiment 1 table 1, for healthy swinery free choice feeding, observe and record the situation of searching for food, choose palatability grade, evaluation criterion is shown in 8.The results are shown in Table 9.
Evaluating drug effect: by the electrolysis octicin solution prepared by formula 1 ~ formula 8 in embodiment 1 table 1, for diarrhoea piglet group medication, the empirically corresponding index of example 3 evaluation methodology evaluation.The results are shown in Table 9.
Comprehensive analysis can obtain: formula 1 and formula 8 palatability all not good, even if formula 8 is also very short for disintegration, antidiarrheal effect is effective, but due to palatability poor, these two formula all do not reach designing requirement of the present invention, are judged to defective; Formula 2 ~ formula 7 is all qualified, is wherein optimum with formula 4 again.
Experimental example 5
Material: polygynax hyoscine methobromide aqueous slkali (commercially available prod); Electrolysis octicin solution (prepared by embodiment 1 formula 3).
Case: (sick pork chop white, canescence or yellow-white are smelt as of rotten fish loose stool for piglet pujos blancos case 93 example of pig farm, Pixian County natural occurrence; Be coli-infection through laboratory diagnosis).
Method: at random sick pig is divided into matched group, test group and negative control group under identical rearing conditions; Matched group by body weight 7 below kg with polygynax hyoscine methobromide aqueous slkali, 1ml/ time, is fed in direct pump intake, every day 2 times, is used in conjunction 3 days; The electrolysis octicin solution of test group embodiment 1 formula 3 directly sends into piglet oral cavity by 1/kg.bw, every day 1 time, is used in conjunction 3 days; Negative control group is raised by daily feeding manner, not administration.
Efficacy determination method: medication is after 3 days, and spiritual appetite recovers normal, and clinical symptom disappearance, is judged to recovery from illness; Medication is after 3 days, and spiritual appetite takes a turn for the better, clinical symptom relief, is judged to effectively; Medication is after 3 days, and symptom is not improved, and it is invalid to be judged to.
Experimental result: in table 10.
As can be seen from above result of the test, electrolysis octicin solution of the present invention is all better than polygynax, hyoscine methobromide aqueous slkali to the therapeutic effect of piglet pujos blancos.From whole process of the test, the convenience that electrolysis octicin solution of the present invention uses is better than polygynax, hyoscine methobromide aqueous slkali, greatly reduces the working strength of administration.
Experimental example 6
electrolysis octicin solution is to the clinical tests of piglet transmissible gastroenteritis
Material: polygynax, hyoscine methobromide aqueous slkali (commercially available prod); Vatimin B1 injection (commercially available prod); Oresol (commercially available prod); Electrolysis octicin solution (prepared by embodiment 1 formula 5).
Case: (piglet vomits piglet transmissible gastroenteritis case 106 example of pig farm, Pixian County natural occurrence, watery diarrhea, and feces is yellow, green or white; Sick pig extreme thirst, obviously dewater, body weight alleviates rapidly; Be transmissible gastroenteritis of swine through laboratory diagnosis).
Method: at random sick pig is divided into matched group, test group and negative control group under identical rearing conditions; Matched group takes conventional symptomatic treatment (at present for the viral disease of poultry, there is no clear and definite specific treatment medicine, clinically all take vaccine prevention or symptomatic treatment), namely press body weight 7 below kg with polygynax hyoscine methobromide aqueous slkali, 1ml/ time, feed in direct pump intake, every day 2 times, to piglet every the intramuscular injection Vatimin B1 injection 2--5ml of vomiting, every day 2 times, connect note 2 days; Gavage oral rehydration saline solution, supplement body fluid, each 20ml, every day 5 times; Be used in conjunction 3 days; The electrolysis octicin solution of test group embodiment 1 formula 5 preparation directly sends into piglet oral cavity by 1/kg.bw, every day 1 time, is used in conjunction 3 days; Negative control group is raised by daily feeding manner, not administration.
Efficacy determination method: medication is after 3 days, and spiritual appetite recovers normal, and clinical symptom disappearance, is judged to recovery from illness; Medication is after 3 days, and spiritual appetite takes a turn for the better, clinical symptom relief, is judged to effectively; Medication is after 3 days, and symptom is not improved, and it is invalid to be judged to.
Experimental result: in table 11.
As can be seen from above result of the test, electrolysis octicin solution of the present invention is all better than the conventional symptomatic treatment taked at present to the therapeutic effect of piglet transmissible gastroenteritis.From whole process of the test, the convenience that electrolysis octicin solution of the present invention uses is better than conventional symptomatic treatment, greatly reduces the working strength of administration.
Claims (10)
1. treat a medicine for young stock viral diarrhea, it is characterized in that, by weight, described medicine comprises:
Rhizoma Osmundae 5-33 part
Fructus Schisandrae Chinensis 2-30 part
Pericarpium Granati 3-20 part.
2. medicine according to claim 1, is characterized in that, by weight, described medicine also comprises:
4-80 part mannitol, 5-30 part sucrose, 0.05-3 part potassium chloride, 0.05-0.5 part sodium glutamate, 0.02-0.5 part sodium glycyrrhetate, 0.01-0.5 part fresh milk essence.
3. medicine according to claim 1, is characterized in that, by weight, described medicine also comprises:
3.5-26 part microcrystalline cellulose, 1.25-5 part low-substituted hydroxypropyl cellulose, 0.1-2.5 part magnesium stearate, 0.02-1 part sodium lauryl sulphate.
4. the medicine according to any one of claim 1-3, is characterized in that, by weight, described medicine comprises:
Rhizoma Osmundae 5-28 part
Fructus Schisandrae Chinensis 7-30 part
Pericarpium Granati 3-15 part
25-80 part mannitol, 5-24 part sucrose, 0.05-2 part potassium chloride, 0.05-0.4 part sodium glutamate, 0.02-0.3 part sodium glycyrrhetate, 0.01-0.4 part fresh milk essence;
3.5-20 part microcrystalline cellulose, 1.25-4 part low-substituted hydroxypropyl cellulose, 0.1-1.5 part magnesium stearate, 0.02-0.4 part sodium lauryl sulphate.
5. the medicine according to any one of claim 1-4, is characterized in that, by weight, described medicine comprises:
Rhizoma Osmundae 19 parts
Fructus Schisandrae Chinensis 16 parts
Pericarpium Granati 11 parts
Correctives 65.8 parts
Disintegrating agent 16.2 parts
53 portions of mannitol, 11 portions of sucrose, 1.2 parts of potassium chloride, 0.2 part of sodium glutamate, 0.2 part of sodium glycyrrhetate, 0.2 part of fresh milk essence;
12 parts of microcrystalline celluloses, 3 parts of low-substituted hydroxypropyl celluloses, 1 part of magnesium stearate, 0.2 part of sodium lauryl sulphate.
6. the medicine according to any one of claim 1-5, is characterized in that, described medicine is that pharmacy meaning is taken up an official post one dosage type low temperature, is preferably tablet.
7. treat a preparation method for the Chinese medicine of young stock viral diarrhea, it is characterized in that, described method comprises step:
By weight,
1) 5-33 part Rhizoma Osmundae and 2-30 part Fructus Schisandrae Chinensis are added to the water, boil rear decoction, get filtrate; Get filtering residue to be added to the water, boil rear decoction, get filtrate; Get filtering residue to be added to the water, boil rear decoction; Concentrate after merging three filtrates;
2) 5-30 part sucrose, 0.05-3 part potassium chloride, 0.05-0.5 part sodium glutamate is added to step 1) gains, mixing;
3) get 3-20 part Pericarpium Granati, after pulverizing, join step 2) in gains, mixing, makes soft material, makes 60 order granules with granulator;
4) add 0.5-1.25 part magnesium stearate to step 3) gains, mixing, upper spheronizator is round as a ball is prepared into rounded grain, in 35 DEG C ~ 70 DEG C oven dry;
5) 4-80 part mannitol, 3.5-26 part microcrystalline cellulose, 1.25-5 part low-substituted hydroxypropyl cellulose, 0.02-1 part sodium lauryl sulphate, 0.5-1.25 part magnesium stearate, 0.02-0.5 part sodium glycyrrhetate, 0.02-1 part fresh milk essence is added to step 4), mixing, make pharmacy meaning to take up an official post one dosage type low temperature, be preferably tablet.
8. method according to claim 7, is characterized in that, by weight, Rhizoma Osmundae described in step 1) is 19 parts, and described Fructus Schisandrae Chinensis is 16 parts; Step 2) described sucrose is 11 parts, described potassium chloride is 1.2 parts, and described sodium glutamate is 0.2 part; Pericarpium Granati described in step 3) is 11 parts; Magnesium stearate described in step 4) is 0.5 part; Mannitol described in step 5) is 53 parts, and described microcrystalline cellulose is 12 parts, and described low-substituted hydroxypropyl cellulose is 3 parts, and described sodium lauryl sulphate is 0.2 part, and described magnesium stearate is 0.5 part, and described sodium glycyrrhetate is 0.2 part, and described fresh milk essence is 0.2 part.
9. method according to claim 7, is characterized in that, by weight, in step 1), when first time decocts, the total amount adding water is Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 3 times, decocts 1 hour; When second time decocts, the total amount adding water is Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 2.6 times, decocts 40 minutes; Third time, when decocting, the total amount adding water was Rhizoma Osmundae and Fructus Schisandrae Chinensis gross weight 2 times, decocts 20 minutes; Be concentrated into 1/3 medical material amount volume.
10. the application of medicine in treatment young stock viral diarrhea prepared of method described in medicine described in any one of claim 1-5 or any one of claim 5-9.
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Address after: 611130 Chengdu City, Wenjiang Province, the cross-strait science and Technology Industrial Development Zone, Jin Fu Road, No. 259 Applicant after: Chengdu Qiankun animal pharmaceutical Limited by Share Ltd Address before: 611130 Chengdu City, Wenjiang Province, the cross-strait science and Technology Industrial Development Zone, Jin Fu Road, No. 259 Applicant before: Chengdu Qiankun Animal Pharmaceutical Co.,Ltd. |
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Application publication date: 20150909 |