CN104883908A - 用于改善大脑的合生素组合物 - Google Patents

用于改善大脑的合生素组合物 Download PDF

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Publication number
CN104883908A
CN104883908A CN201380069118.3A CN201380069118A CN104883908A CN 104883908 A CN104883908 A CN 104883908A CN 201380069118 A CN201380069118 A CN 201380069118A CN 104883908 A CN104883908 A CN 104883908A
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China
Prior art keywords
oligosaccharides
glutamine
baby
bifidobacterium breve
infants
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Pending
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CN201380069118.3A
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English (en)
Chinese (zh)
Inventor
J·加森
R·范埃尔堡
N·巴特克
A·D·格拉内费尔德
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Nutricia NV
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Nutricia NV
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Application filed by Nutricia NV filed Critical Nutricia NV
Priority to CN201711281376.4A priority Critical patent/CN107853705A/zh
Publication of CN104883908A publication Critical patent/CN104883908A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/519—Breve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria

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  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pediatric Medicine (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380069118.3A 2012-11-02 2013-11-04 用于改善大脑的合生素组合物 Pending CN104883908A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711281376.4A CN107853705A (zh) 2012-11-02 2013-11-04 用于改善大脑的合生素组合物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261721833P 2012-11-02 2012-11-02
EP12191171.3 2012-11-02
US61/721,833 2012-11-02
EP12191171 2012-11-02
PCT/NL2013/050785 WO2014070016A2 (en) 2012-11-02 2013-11-04 Synbiotics combination for brain improvement

Related Child Applications (1)

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CN104883908A true CN104883908A (zh) 2015-09-02

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CN201380069118.3A Pending CN104883908A (zh) 2012-11-02 2013-11-04 用于改善大脑的合生素组合物

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US (2) US9974816B2 (enExample)
EP (2) EP2914136B1 (enExample)
CN (2) CN107853705A (enExample)
AU (1) AU2013338705B2 (enExample)
BR (1) BR112015009579B1 (enExample)
ES (1) ES2884223T3 (enExample)
IN (1) IN2015DN03862A (enExample)
MY (1) MY173726A (enExample)
PH (1) PH12015500904B1 (enExample)
PL (1) PL2914136T3 (enExample)
RU (1) RU2630905C2 (enExample)
WO (1) WO2014070016A2 (enExample)

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Publication number Priority date Publication date Assignee Title
CN108289492A (zh) * 2015-12-15 2018-07-17 雀巢产品技术援助有限公司 Hmo的混合物
CN109069555A (zh) * 2016-04-13 2018-12-21 株式会社明治 面向新生儿的用于改善脑功能的组合物
CN109715169A (zh) * 2016-07-28 2019-05-03 方塔拉合作集团有限公司 乳制品和工艺
CN109789174A (zh) * 2016-05-31 2019-05-21 森永乳业株式会社 脑功能改善剂
CN109963569A (zh) * 2016-10-05 2019-07-02 科尔生公司 用基于氨基酸的营养组合物喂养的婴儿或幼儿中肠道微生物群组成的正常化
CN110087661A (zh) * 2016-11-29 2019-08-02 森永乳业株式会社 苷元产生促进剂
CN110545678A (zh) * 2017-02-01 2019-12-06 N·V·努特里奇亚 脑功能的膳食调节
CN111447936A (zh) * 2017-12-11 2020-07-24 N·V·努特里奇亚 用于治疗出生后双歧杆菌延迟定殖的组合物
CN113025677A (zh) * 2021-03-12 2021-06-25 长春大学 一种以海参为原料制备免消化海参蛋白质的方法

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WO2015160234A1 (en) * 2014-04-17 2015-10-22 N.V. Nutricia Composition for brain improvement
US20150305359A1 (en) * 2014-04-24 2015-10-29 Mead Johnson Nutrition Company Nutritional compositions directed to subjects having cow's milk protein allergies
WO2016013928A1 (en) * 2014-07-24 2016-01-28 N.V. Nutricia Prevention or treatment of food allergy in infants and toddlers
WO2016043583A1 (en) * 2014-09-15 2016-03-24 N.V. Nutricia Reducing anxiety in progeny
RU2761533C2 (ru) * 2014-09-25 2021-12-09 Сосьете Де Продюи Нестле С.А. Система детской смеси с адаптивными концентрациями олигосахаридов грудного молока (огм)
WO2016086157A1 (en) * 2014-11-26 2016-06-02 Abbott Laboratories Infant formula comprising human milk oligosaccharides, polyunsaturated fatty acids, nucleotides, and lutein
CN108348493B (zh) 2015-10-02 2022-03-29 荷兰纽迪希亚公司 甘氨酸用于过敏性患者的耐受性诱导
EP3629769A1 (en) * 2017-05-24 2020-04-08 Société des Produits Nestlé S.A. Composition comprising human milk oligosaccharides (hmo) for use in the improvement of short term memory and other cognitive benefits
RU2019141902A (ru) * 2017-05-24 2021-06-17 Сосьете Де Продюи Нестле С.А. Композиция, содержащая олигофруктозу (of), для применения в улучшении кратковременной памяти и получении других когнитивных преимуществ
EP4159224A1 (en) * 2017-06-30 2023-04-05 N.V. Nutricia Synbiotic composition for preventing chronic inflammation
WO2019068356A1 (en) * 2017-10-06 2019-04-11 N.V. Nutricia PROMOTION OF COGNITIVE FUNCTIONS AFTER BIRTH OF CAESAREAN
US20210299193A1 (en) 2018-07-13 2021-09-30 Council Of Scientific & Industrial Research Synbiotic composition for improving immune response and antioxidant capacity during aging and a process for the preparation thereof
IT201900000043A1 (it) * 2019-01-03 2020-07-03 Watt S R L Sostituto della prima colazione
CN110214887B (zh) * 2019-06-28 2022-10-11 浙江大学 针对液体自冷型超高压杀菌的装置及方法
JP7406325B2 (ja) * 2019-08-08 2023-12-27 森永乳業株式会社 分離不安障害の予防又は改善のための組成物
GB2590624B (en) * 2019-12-20 2023-08-30 Green Bioactives Ltd Composition comprising one or more fructooligosaccharide(s) and L-theanine
EP3932415A1 (en) 2020-07-01 2022-01-05 Fundació Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI) Gut microbiota composition and uses thereof
US20240358763A1 (en) * 2021-06-02 2024-10-31 N.V. Nutricia Supplement for human milk from allergic women
CN114533765B (zh) * 2022-03-17 2023-08-25 江南大学 短双歧杆菌ccfm1025在调节幼年神经发育中的应用
WO2024254188A2 (en) * 2023-06-05 2024-12-12 Infinant Health, Inc. Methods for treating enteric injury
GB2632345A (en) * 2023-08-03 2025-02-05 Mjn Us Holdings Llc Human milk fortifier micronutrient supplementation kit
WO2025027192A1 (en) * 2023-08-03 2025-02-06 Mjn U.S. Holdings Llc Human milk fortifier micronutrient supplementation kit
WO2025058081A1 (ja) * 2023-09-14 2025-03-20 江崎グリコ株式会社 総合注意力、認知柔軟性及び／又は実行機能を改善するための組成物
WO2025242902A1 (en) * 2024-05-24 2025-11-27 N.V. Nutricia Oligosaccharide mixture for brain development
WO2025257135A1 (en) * 2024-06-10 2025-12-18 N.V. Nutricia Non-digestible oligosaccharide mixture for infants at risk of brain injury

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CN1127070A (zh) * 1995-06-18 1996-07-24 侯润安 新型保健营养奶粉及其生产方法
CN101668437A (zh) * 2007-03-13 2010-03-10 N.V.努特里奇亚 使用含有非消化性糖的组合物改善能力的方法
CN101801220A (zh) * 2007-06-15 2010-08-11 努特里希亚公司 含有非活的双歧杆菌和非消化性寡糖的营养物
CN102665444A (zh) * 2009-12-07 2012-09-12 雀巢产品技术援助有限公司 含有益生菌和婴儿营养配方的婴儿配方奶粉传递系统

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FR2853908B1 (fr) 2003-04-16 2005-06-03 Gervais Danone Sa Produit immunomodulateur obtenu a partir d'une culture de bifidobacterium et compositions le contenant
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