CN104873544A - Pure sheep placenta powder and its preparation method and use - Google Patents
Pure sheep placenta powder and its preparation method and use Download PDFInfo
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- CN104873544A CN104873544A CN201410540068.9A CN201410540068A CN104873544A CN 104873544 A CN104873544 A CN 104873544A CN 201410540068 A CN201410540068 A CN 201410540068A CN 104873544 A CN104873544 A CN 104873544A
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Abstract
The invention discloses a preparation method of pure sheep placenta powder. The preparation method comprises the following steps of 1, taking sheep placenta as a raw material, carrying out cleaning to remove impurities and carrying out freeze drying, 2, crushing the sheep placenta at a temperature of 0-5 DEG C to obtain crude powder and 3, further crushing the sheep placenta crude powder by an ultrafine grinding device until the powder has particle sizes less than or equal to 3 microns. The preparation method of the pure sheep placenta powder utilizes the ultrafine grinding device to break cell walls so that medical components of the sheep placenta go through the broken cell nucleuses and cell walls and are fully released, and active components are maximally dissolved thereby being well absorbed by the human body. Through a vacuum freeze drying technology, the medical active components are retained maximally.
Description
Technical field
The present invention relates to field of biological product, be specifically related to pure powder of a kind of Placenta caprae seu ovis and its preparation method and application.
Technical background
The needs of modern healthy, in field of traditional Chinese in succession, revive and develop middle formation numerous Chinese medicine old established firm brand, as Tongrentang (1669), Hu Qingyu Pharmaceutical Workshop (1874), large life auspicious (1885), Han Xingtang (1901), Fu Tong (1644), Fructus Pruni and hall (1600), public good is large, Chen Zhi father-in-law, bosom moral crane (1948), old man and Tai, father-in-law Changchun (1699), Fu Jichun, refined vegetarian (between bright year in Wanli year), first-class and the Chinese medicine health-care tea old established firm brand of Lei Yun is as ten thousand safe units (1860), Zhu Qiansheng, roc red sun, universe Thailand is poly-, wherein ten thousand safe first tea No. win ten thousand state's World's Fair gold medals in 1915 especially, the first-class Grand Prix of nineteen twenty-six U.S. Philadelphia World's Fair and nineteen twenty-nine first West Lake Exposition gold medal.
China utilizes the various organs of animal, tissue and metabolite to carry out curing the disease, diseases prevention and health care with a long history, existing complete pharmacy ancient books and records-" legendary god of farming's book on Chinese herbal medicine opinion " just has the record of the many animals medicines such as Calculus Bovis, Cornu rhinocerotis, Cornu Cervi Pantotrichum, Colla Corii Asini.Describe China on pharmaceutical technology, to utilize animal pharmaceuticals to carry out processing already, extract, refiningly form comparatively pure medicament.
Placenta caprae seu ovis, also known as foster afterbirth, is the Chinese medicine organization that sheep Embryo Production stage of development fetus and parent carry out mass exchange.Placenta caprae seu ovis contains abundant nutritional labeling and various bioactivators.Placenta caprae seu ovis contains protein more than 80%, and its amino acid content is abundant, A wide selection of colours and designs, reasonable mixture ratio, fat content about 10%, wherein containing abundant phosphate ester, polysaccharide ester.Placenta caprae seu ovis is also containing immunoglobulin, Multiple Antibodies and interferon, and containing various active polypeptide, the factor relevant with coagulation process, promotes auxin, the active substance relevant with endocrine regulation functional disorder and the various active enzyme of regeneration of erythrocytes.Therefore, Placenta caprae seu ovis can be used as medicine, health product, food, beverage, cosmetic material and additive.Use traditional method to eat, such as by or steam or the Placenta caprae seu ovis that eaten by human body after boiling or stewing, its nutritive value possessed is with the meat not too big-difference of general animal, and above-mentioned a lot of nutritional labeling is also not easy to be absorbed by the body.
Summary of the invention
For prior art Problems existing, the object of the present invention is to provide the preparation method of the pure powder of a kind of Placenta caprae seu ovis, obtained pure powder footpath≤3 micron of Placenta caprae seu ovis, can stripping active ingredient to greatest extent, be more conducive to absorption of human body.
A first aspect of the present invention, provides the preparation method of the pure powder of a kind of Placenta caprae seu ovis, it is characterized in that, comprise the following steps:
Step one: getting Placenta caprae seu ovis is raw material, cleaning, removes impurity, vacuum lyophilization;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 0 ~ 5 DEG C;
Step 3: pulverized further through research of super-pine crush equipment by Placenta caprae seu ovis coarse powder, until diameter of particle≤3 micron, obtains the pure powder of Placenta caprae seu ovis.
Preferably, the temperature of the vacuum lyophilization of described step one is-30 DEG C ~-20 DEG C, and cooling time is 1 ~ 4 hour, and vacuum to absolute pressure is 40 ~ 60Pa.
Preferably, described step 3 is pulverized at low temperatures, and control temperature is at-40 ~-60 DEG C.
Preferably, described research of super-pine crush equipment is jet mill or vibrator.
Preferably, the technological parameter of described jet mill is Air oxygen consumption 1 ~ 5m
3/ min, pulverize pressure 1 ~ 2Mpa, feed pressure is 0.4 ~ 1Mpa, and charging rate is 1 ~ 5kg/h.。
Preferably, the technological parameter of described vibrator is ratio of grinding media to material 1:0.1 ~ 1:5, and ball radius is 1 ~ 120 millimeter, and Ball-milling Time is 1 ~ 500 hour, and the rotating speed of ball mill is 15 revs/min ~ 450 revs/min.
A second aspect of the present invention, provides a kind of Placenta caprae seu ovis obtained by above-mentioned preparation method pure powder, and measuring its particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
A third aspect of the present invention, the application of the pure powder of the Placenta caprae seu ovis providing above-mentioned preparation method to obtain, prepares the kidney warming benefit essence, benefiting QI and nourishing blood, treatment asthenia weakness and emaciation, impotence and seminal emission, women's vim and vigour is not enough, the medicine of infertile or newborn few body.
Beneficial effect of the present invention:
1. breaking cellular wall potentiation: carry out cell wall breaking by research of super-pine crush equipment, makes the efficacy component of Placenta caprae seu ovis through the nucleus of fragmentation and cell wall, can discharge fully completely, increase substantially drug effect;
2. adopt Vacuum Freezing & Drying Technology, retain drug activity composition, make drug activity composition obtain maximum reservation.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment one
Step one: getting Placenta caprae seu ovis 10kg is raw material, cleaning, remove impurity, vacuum lyophilization, temperature is-30 DEG C, and cooling time is 1 hour, and vacuum to absolute pressure is 40Pa;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 0 DEG C;
Step 3: pulverized further through jet mill by Placenta caprae seu ovis coarse powder, technological parameter is temperature-40 DEG C, Air oxygen consumption 1m
3/ min, pulverize pressure 1Mpa, feed pressure is 0.4Mpa, and charging rate is 1kg/h, until diameter of particle≤3 micron, obtains the pure powder of Placenta caprae seu ovis.
Measuring superfine powder particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
Embodiment two
Step one: getting Placenta caprae seu ovis 10kg is raw material, cleaning, remove impurity, vacuum lyophilization, temperature is-20 DEG C, and cooling time is 4 hours, and vacuum to absolute pressure is 60Pa;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 3 DEG C;
Step 3: pulverized further through jet mill by Placenta caprae seu ovis coarse powder, technological parameter is temperature-60 DEG C, Air oxygen consumption 5m
3/ min, pulverize pressure 2Mpa, feed pressure is 1Mpa, and charging rate is 5kg/h, until diameter of particle≤3 micron, obtains the pure powder of Placenta caprae seu ovis.
Measuring superfine powder particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
Embodiment three
Step one: getting Placenta caprae seu ovis 10kg is raw material, cleaning, remove impurity, vacuum lyophilization, temperature is-25 DEG C, and cooling time is 3 hours, and vacuum to absolute pressure is 50Pa;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 3 DEG C;
Step 3: Placenta caprae seu ovis coarse powder is pulverized further through vibrator, technological parameter is temperature-50 DEG C, ratio of grinding media to material 1:0.1, ball radius is 120 millimeters, and Ball-milling Time is 500 hours, and the rotating speed of ball mill is 450 revs/min, until diameter of particle≤3 micron, obtain the pure powder of Placenta caprae seu ovis.
Measuring superfine powder particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
Embodiment four
Step one: getting Placenta caprae seu ovis 10kg is raw material, cleaning, remove impurity, vacuum lyophilization, temperature is-30 DEG C DEG C, and cooling time is 4 hours, and vacuum to absolute pressure is 60Pa;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 5 DEG C;
Step 3: pulverized further through vibrator by Placenta caprae seu ovis coarse powder, technological parameter is ratio of grinding media to material 1:5, and ball radius is 50 millimeters, and Ball-milling Time is 200 hours, and the rotating speed of ball mill is 200 revs/min, until diameter of particle≤3 micron, obtains the pure powder of Placenta caprae seu ovis.
Measuring superfine powder particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
Comparative example one
The preparation method of this comparative example is not except having vacuum lyophilization, and other steps are all identical with the step of the preparation method of embodiment one.
Comparative example two
The preparation method of this comparative example is pulverized except (i.e. step 3) except not having research of super-pine crush equipment further, and other steps are all identical with the step of the preparation method of embodiment 1.
Comparative example three
The preparation method of this comparative example is not except having vacuum lyophilization, research of super-pine crush equipment and pulverizing further, and other steps are all identical with the step of the preparation method of embodiment 1.
Effective substance
Detected the pure powder effective ingredient of Placenta caprae seu ovis by ultraviolet-visible spectrophotometer, testing result is as follows:
From testing result, adopt the preparation method of the pure powder of Placenta caprae seu ovis of the present invention, compared with the traditional method in comparative example 1-3, effective ingredient obtains maximum reservation; It can thus be appreciated that carry out cell wall breaking by research of super-pine crush equipment, make the efficacy component of Placenta caprae seu ovis can through the nucleus of fragmentation and cell wall, discharging fully completely can stripping active ingredient to greatest extent, is more conducive to absorption of human body; Adopt Vacuum Freezing & Drying Technology, retain drug activity composition, make drug activity composition obtain maximum reservation.
Last it is noted that above each embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to foregoing embodiments to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein some or all of technical characteristic; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.
In a word, the foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to the covering scope of patent of the present invention.
Claims (9)
1. a preparation method for the pure powder of Placenta caprae seu ovis, is characterized in that, comprise the following steps:
Step one: getting Placenta caprae seu ovis is raw material, cleaning, removes impurity, vacuum lyophilization;
Step 2: Placenta caprae seu ovis is ground into coarse powder at 0 ~ 5 DEG C;
Step 3: pulverized further through research of super-pine crush equipment by Placenta caprae seu ovis coarse powder, until diameter of particle≤3 micron, obtains the pure powder of Placenta caprae seu ovis.
2. the preparation method of the pure powder of Placenta caprae seu ovis according to claim 1, is characterized in that, the temperature of the vacuum lyophilization of described step one is-30 DEG C ~-20 DEG C, and cooling time is 1 ~ 4 hour, and vacuum to absolute pressure is 40 ~ 60Pa.
3. preparation method according to claim 1, is characterized in that, described step 3 is pulverized at low temperatures, and control temperature is at-40 ~-60 DEG C.
4. preparation method according to claim 1, is characterized in that, described research of super-pine crush equipment is jet mill or vibrator.
5. preparation method according to claim 4, is characterized in that, the technological parameter of described jet mill is Air oxygen consumption 1 ~ 5m
3/ min, pulverize pressure 1 ~ 2Mpa, feed pressure is 0.4 ~ 1Mpa, and charging rate is 1 ~ 5kg/h.
6. preparation method according to claim 4, it is characterized in that, the technological parameter of described vibrator is ratio of grinding media to material 1:0.1 ~ 1:5, and ball radius is 1 ~ 120 millimeter, Ball-milling Time is 1 ~ 500 hour, and the rotating speed of ball mill is 15 revs/min ~ 450 revs/min.
7. according to the pure powder of Placenta caprae seu ovis that the arbitrary described preparation method of claim 1 to 5 obtains.
8. the pure powder of Placenta caprae seu ovis according to claim 7, measuring its particle diameter through dry laser particle size analyzer is 0.5 ~ 3 micron, and particle diameter is less than 2 micron particle accumulations and is no less than 90%.
9. the pure powder of Placenta caprae seu ovis according to claim 7 prepare the kidney warming mend essence, benefiting QI and nourishing blood, treatment asthenia weakness and emaciation, impotence and seminal emission, women's vim and vigour are not enough, infertile or newborn lack body medicine in application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410540068.9A CN104873544A (en) | 2014-10-14 | 2014-10-14 | Pure sheep placenta powder and its preparation method and use |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410540068.9A CN104873544A (en) | 2014-10-14 | 2014-10-14 | Pure sheep placenta powder and its preparation method and use |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110128A (en) * | 1994-04-14 | 1995-10-18 | 浙江康恩贝集团研究开发中心 | Method for preparation of active placenta powder |
| CN1142949A (en) * | 1995-08-15 | 1997-02-19 | 内蒙古众康实业有限责任公司 | Frozen dry powder of sheep placenta |
| CN1220143A (en) * | 1997-12-16 | 1999-06-23 | 陈大英 | Method for preparing fresh whole placenta powder capsule |
| CN101433556A (en) * | 2008-12-05 | 2009-05-20 | 成都青山利康药业有限公司 | Health product composition containing placenta component and preparation method |
-
2014
- 2014-10-14 CN CN201410540068.9A patent/CN104873544A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1110128A (en) * | 1994-04-14 | 1995-10-18 | 浙江康恩贝集团研究开发中心 | Method for preparation of active placenta powder |
| CN1142949A (en) * | 1995-08-15 | 1997-02-19 | 内蒙古众康实业有限责任公司 | Frozen dry powder of sheep placenta |
| CN1220143A (en) * | 1997-12-16 | 1999-06-23 | 陈大英 | Method for preparing fresh whole placenta powder capsule |
| CN101433556A (en) * | 2008-12-05 | 2009-05-20 | 成都青山利康药业有限公司 | Health product composition containing placenta component and preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 赵争胜等: "胎盘粉制备工艺改进", 《中成药》 * |
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Application publication date: 20150902 |