CN101433556A - Health product composition containing placenta component and preparation method - Google Patents
Health product composition containing placenta component and preparation method Download PDFInfo
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- CN101433556A CN101433556A CNA2008101477737A CN200810147773A CN101433556A CN 101433556 A CN101433556 A CN 101433556A CN A2008101477737 A CNA2008101477737 A CN A2008101477737A CN 200810147773 A CN200810147773 A CN 200810147773A CN 101433556 A CN101433556 A CN 101433556A
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Abstract
The invention relates to a health-care product composition containing a placenta component and a preparation method thereof. The composition uses ganoderma lucidum polysaccharide and human placenta powder as basic effective components which can be formed together with at least one of vitamin E and vitamin C when necessary and pharmaceutically acceptable assistant components, wherein the weight ratio of the ganoderma lucidum polysaccharide to the human placenta powder expressed by amount of protein in the effective components is between 1 to 0.1 and 1 to 5, preferably between 1 to 0.1 and 1 to 1. Through tests, the composition not only can enhance immunological competence of human body, but also can delay senility, has remarkable fading effect on senile plaque or chloasma, and is remarkably superior to the prior homogeneous medicament and/or health-care products containing the placenta component on effect.
Description
Technical field
The present invention relates to a kind of Halth-care composition that strengthens human body immunity and function of delaying senility that has, specifically is a kind of Halth-care composition that contains placenta component, and the preparation method of these health product.
Background technology
Having in the natural materials that strengthens human body immunity and function of delaying senility of existing research at present, Ganoderma, particularly its effective ingredient ganoderan, has the multiple bioactive ingredients that human body is had health-care effect, as can activated immune system and inducing interferon function, the intravital tumor cell of people is constrained, the hormone of cell also can produce indirect action, thereby the growth of blocking-up tumor cell makes death of neoplastic cells reach anticancer purpose; Can improve the side effect that medicine becomes radiation cure to cause, significant to treatment and prevention of tumour; High/low blood pressure there is dual regulation; Improve hyperlipemia, hypoglycemic activity; Antianaphylaxis or the like.At present existing Ganoderma lucidum polysaccharides health-care product use in reality, thereby its main effect is to improve immunity to strengthen body constitution.
On the other hand, mammiferous Placenta Hominis, people's Placenta Hominis particularly, because of containing naturally occurring endogenous bioactive substances such as many important aminoacid, hormone, somatomedin with physiological function and biologic activity, very early as a kind of important source material that can have the medicine and/or the health product of multiple physiologically active and beneficial functional, as, with animal Placenta Hominiss such as Placenta caprae seu oviss is the multiple medicine of raw material or the goods of health product, and contains Placenta Hominis capsule, people's Placenta Hominis Tabellae, Plancenta Histolysate of people's placenta component etc.Because endogenous bioactive substance goods can be avoided the untoward reaction, particularly people's Placenta Hominis of many other types medicines in application, a kind of especially important and good humanized's medicament sources is much accounted of day by day and extensive studies and application is arranged.For example, people's placental article is used to treat climacteric syndrome and multiple chronic disease in extensive use in department of dermatologry, gynecological, surgery on the clinical medicine at present.Chinese medicine thinks that more already it can have effects such as strengthening by means of tonics, nourishing blood and replenishing essence, happiness kidney and enhancing body, replenishing QI to invigorate the spleen, can be used for the treatment of aspects such as malnutrition, inappetence, neurasthenia, insufficiency of blood body void, refreshing empty sexual impotence, freckle, black all endocrine disturbance of reaching of the dark skin of face.
Research is also found, because the animal Placenta Hominis is compared with people's Placenta Hominis, aspect a lot of, still there are a lot of differences, particularly very big-difference is arranged at aspects such as main components such as aminoacid, hormone, somatomedin and ratios, thereby its nutritive value and curative effect have been influenced, and because of it contains non-humanized's foreign protein, rejection etc. takes place easily.The health food that for example contains the animal placenta component at present mainly also just is used to suppress aspects such as senile plaque or chloasma.People's Placenta Hominis then is a kind of good humanized's medicine, meets adjusting and treatment to human biology most.But because when people's Placenta Hominis raw material is handled, traditional drying mode is adopt to steam, boil or means such as baking, thereby the destruction that can cause being subjected to as enzyme, hormone etc. thermally labile component, influenced the performance of its effect, also wasted the not abundant valuable source in source.
Summary of the invention
In view of the foregoing, the present invention will provide a kind of Halth-care composition that contains placenta component, to give full play to the effect that it strengthens human body immunity and slow down aging.The present invention further also will provide a kind of preparation method of these health product.
The present invention contains the Halth-care composition of placenta component, be to be basic effective constituents with ganoderan and people's Placenta Hominis powder, form jointly with acceptable auxiliary element in the pharmacy, the weight ratio of people's Placenta Hominis powder that ganoderan is represented with albumen quality in the effective ingredient is 1/ (0.1～5), and preferred proportion is 1/ (0.1～1).
In above-mentioned composition, said people's Placenta Hominis powder is the ultra-micro powder of 1 μ m～50 μ m to adopt particle diameter, and particularly the people's Placenta Hominis drying ultra-micro powder that obtains in the freezing and sublimation mode under-40 ℃～-45 ℃ and 15Pa～25Pa condition is good.
Different according to application target and application in the composition of above-mentioned composition, further can also be added at least a in vitamin E, the vitamin C in the said effective ingredient.The amount of adding can determine that for example vitamin E can be by 20～100mg/ days usage ratio according to the safe level scope of health food regulation, and vitamin C can add by 50～300mg/ days usage ratio.
The Halth-care composition that the present invention is above-mentioned can be made the product of multiple different concrete forms, as different dosage form forms such as soft capsule, hard capsule, tablets.Test shows, be good wherein to adopt the soft capsule preparation form that is prepared into by said effective ingredient and auxiliary element, because the preparation of soft capsule itself is a closed system, can cover bad smell, guarantee that dosage is accurate, oxygen in simultaneously can secluding air, help keeping protein, hormone and vitamin etc. stable in ganoderan and the placenta component, guaranteed curative effect, improved safety.When wherein preparing soft capsule in the optional PEG400 of used auxiliary element, the polyethylene glycol 6000 one or both, or vegetable oil, wherein optional in soybean oil, Semen Maydis oil, sunflower oil, Oleum Bulbus Allii, perilla oil one or more of vegetable oil.
The above-mentioned preparation that contains the Halth-care composition of placenta component of the present invention, can adopt following manner to carry out: with people's Placenta Hominis after fully freezing under-40 ℃～-45 ℃ conditions, after 15Pa～25Pa lyophilization, being crushed to particle diameter is the ultra-micro powder of 1 μ m～50 μ m, mixes and make the product of forms such as capsule, tablet then with ganoderan.Also can be with the ultra-micro powder and the ganoderan of resultant people's Placenta Hominis, and again with vitamin E, vitamin C at least a the mixing after, make corresponding product.Wherein, preferred mode is ultra-micro powder and the ganoderan with people's Placenta Hominis, or add the blending constituent after at least a in vitamin E, the vitamin C again, with in non-oleaginous base PEG400, the polyethylene glycol 6000 one or both, or one or more of soybean oil in the vegetable oil, Semen Maydis oil, sunflower oil, Oleum Bulbus Allii, perilla oil are prepared into the soft capsule product for auxiliary element.
Comparative test result shows that the Halth-care composition of the above-mentioned form of the present invention can keep the bioactive ingredients in people's Placenta Hominis to greatest extent.By pressing the mode of operation of radioimmunoassay medicine box description regulation, measure the interstitialcellstimulating hormone (ICSH) (LH) in the people's placenta component that obtains with conventional process mode and aforesaid way of the present invention respectively, the result of the ripe hormone (FSH) of short folliculus, estradiol (E2), progesterone (P) people Chorionic Gonadotrophin 5 kinds of hormones such as (HCG), as shown in table 1.
The measurement result of hormone-content in the goods after the table 1 different disposal method
| Processing method | LH (Ng/ml) | FSH (mg/ml) | E2 (mg/ml) | P (pg/ml) | HCG (ng/ml) |
| Traditional method | 4 | 2.6 | 39.1 | 6.0 | 1.2 |
| The inventive method | 72.4 | 5.9 | 45.6 | 11.4 | 6.8 |
The result of table 1 shows, adopt the content of each composition in people's Placenta Hominis that the inventive method obtains all to be higher than or apparently higher than the product of traditional method, especially the reservation result with LH is the most remarkable, thereby it not only can strengthen the human body immunity, and delaying sanility, senile plaque or chloasma etc. also all there is the effect that significantly disappears, can obviously be better than the similar medicine and/or the health product that contain placenta component of use at present on the effect, also greatly saved people's Placenta Hominis raw material resources.
The specific embodiment below in conjunction with embodiment is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.Do not breaking away under the above-mentioned technological thought situation of the present invention, various replacements or change according to ordinary skill knowledge and customary means are made all should comprise within the scope of the invention.
The specific embodiment
Embodiment 1
Placenta Hominis powder: bright people's Placenta Hominis is cleaned bloodstain, remove amniotic membrane and umbilical cord, rub, in stainless steel disc.Place freezer dryer ,-40 ℃～-45 ℃ pre-freezes are after 10 hours, and pressure evacuation when 15Pa distilled 25 hours, was warming up to 0 ℃ gradually, kept 2 hours, adjusted pressure to 20Pa, was warming up to 25 ℃ of dryings gradually 10 hours.The lyophilizing sample is put in the super micron mill, under 5～20 ℃ of temperature, be crushed to the ultra-micro powder that particle diameter is 1 μ m～50 μ m, standby.
Embodiment 2
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 50g, add 750g PEG400 stirring and evenly mixing, make into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 3
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 50g, add 500g Polyethylene Glycol 650 and 100g polyethylene glycol 6000 stirring and evenly mixing, make into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 4
Take by weighing ganoderan 150g and Placenta Hominis powder (embodiment 1 preparation) 150g, stirring and evenly mixing adds 400g～700g soybean oil or contains in 0.5%～4% the mellisic soybean oil and makes into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 5
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 20g, stirring and evenly mixing adds in 400g soybean oil and the 350g Semen Maydis oil (or sunflower oil, Oleum Bulbus Allii, perilla oil) and makes into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 6
Take by weighing ganoderan 50g and Placenta Hominis powder (embodiment 1 preparation) 250g, vitamin E 3g, vitamin C 10g adds in 400～700g soybean oil or contains in 0.5%～4% the mellisic soybean oil, and stirring and evenly mixing makes into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 7
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 100g, vitamin E 3g, add in 400～700g soybean oil or contain in 0.5%～4% the mellisic soybean oil, stirring and evenly mixing makes into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 8
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 100g, vitamin C 10g, add in 400～700g soybean oil or contain in 0.5%～4% the mellisic soybean oil, stirring and evenly mixing makes into suspension as content; Gelatin, water, glycerol are made rubber by 1:1:0.3～0.5.Content and rubber are prepared into soft capsule, drying, granulate, and packing promptly.
Embodiment 9
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 50g, vitamin E 3g, vitamin C 10g, starch 450g, dextrin 90g, sucrose 200g, mixing is made granule.Dry below 60 ℃, add Pulvis Talci 8g, magnesium stearate 2g, mixing, the dress Capsules promptly gets hard capsule.
Embodiment 10
Take by weighing ganoderan 100～500g and Placenta Hominis powder (embodiment 1 preparation) 10～50g, vitamin e1～5g, starch 250～450g, dextrin 45～100g, sucrose 50～100g, mixing is made granule.Dry below 60 ℃, add Pulvis Talci 4～8g, magnesium stearate 0.5～2g, mixing, the dress Capsules promptly gets hard capsule.
Embodiment 11
Take by weighing ganoderan 200g and Placenta Hominis powder (embodiment 1 preparation) 100g and mix, other gets starch 45 grams, dextrin 32 grams, sucrose 10g, pulverize separately cross 100 mesh sieves, the above-mentioned raw materials mixing, add water and make soft material, cross 30 orders and granulate, dry below 60 ℃, 30 order granulate add Pulvis Talci 10g, magnesium stearate 3g, mixing, be pressed into 1000, coating promptly gets tablet.
Below prove effect of the present invention by clinical trial.
With the soft capsule that makes in the example 2, and replace people's Placenta Hominis powder, the hard capsule comparative test that makes under the identical situation of component with the Placenta caprae seu ovis powder.
Carry out the result of use contrast test with present composition sample and Comparative Examples:
Present composition sample is formed (0.25g/ grain): contain people's Placenta Hominis powder 12.5mg (with proteinometer), ganoderan 50mg.
Comparative example is formed (0.25g/ grain): contain Placenta caprae seu ovis powder 12.5mg, ganoderan 50mg.
Test and Selection object: every group of each 10 people, readme and external inspection symptom basically identical in person.
Instructions of taking: each oral 2, every day 3 times, statistical observation after three months, the result is as shown in table 2.
Table 2 comparative test result
| Symptom | Green around the gills | General weakness | Do not have enough sleep | Often catch a cold |
| Sample of the present invention | 10 people glowing with health | Energetic 10 people | Good 9 people sleep | Obviously reduce by 8 people |
| Comparative example | 6 people glowing with health | Energetic 5 people | Good 4 people sleep | Obviously reduce by 4 people |
The comparative test result of table 2 shows that compositions of the present invention can obviously strengthen the human body immunity, and obviously is better than the Comparative Examples goods of Placenta caprae seu ovis composition.
Claims (10)
1. the Halth-care composition that contains placenta component, it is characterized in that with ganoderan and people's Placenta Hominis powder be basic effective constituents, form jointly with acceptable auxiliary element in the pharmacy, the weight ratio of ganoderan and people's Placenta Hominis powder of representing with albumen quality is 1/ (0.1～5) in the effective ingredient.
2. the Halth-care composition that contains placenta component as claimed in claim 1 is characterized in that ganoderan in the said effective ingredient and the weight ratio of people's Placenta Hominis powder of representing with albumen quality is 1/ (0.1～1).
3. the Halth-care composition that contains placenta component as claimed in claim 1 is characterized in that said people's Placenta Hominis powder is that particle diameter is the ultra-micro powder of 1 μ m～50 μ m.
4. the Halth-care composition that contains placenta component as claimed in claim 3 is characterized in that said people's Placenta Hominis powder is the people's Placenta Hominis dried powder that obtains in the freezing and sublimation mode under-40 ℃～-45 ℃ and 15Pa～25Pa condition.
5. the Halth-care composition that contains placenta component as claimed in claim 1 is characterized in that in the said effective ingredient also having at least a in vitamin E, the vitamin C.
6. as the described Halth-care composition that contains placenta component of one of claim 1～5, it is characterized in that the soft capsule preparation form that is prepared into by said effective ingredient and auxiliary element, auxiliary element wherein is Polyethylene Glycol or vegetable oil.
7. the Halth-care composition that contains placenta component as claimed in claim 6, it is characterized in that said Polyethylene Glycol is at least a in PEG400 and the polyethylene glycol 6000, said vegetable oil is at least a in soybean oil, Semen Maydis oil, sunflower oil, Oleum Bulbus Allii and the perilla oil.
8. prepare the described method that contains the Halth-care composition of placenta component of claim 1, it is characterized in that people's Placenta Hominis after fully freezing under-40 ℃～-45 ℃ conditions, after 15Pa～25Pa lyophilization, being crushed to particle diameter is the ultra-micro powder of 1 μ m～50 μ m, is mixed and made into the product of capsule or tablet form then with ganoderan.
9. preparation method as claimed in claim 8 is characterized in that ultra-micro powder and ganoderan with resultant people's Placenta Hominis, and after at least a mixing in the vitamin E, vitamin C, makes corresponding product.
10. preparation method as claimed in claim 8 or 9, it is characterized in that ultra-micro powder and ganoderan with people's Placenta Hominis, or also add the blending constituent after at least a in vitamin E, the vitamin C, with be selected from least a in non-oleaginous base PEG400, the polyethylene glycol 6000, or be selected from least a in soybean oil, Semen Maydis oil, sunflower oil, Oleum Bulbus Allii, the perilla oil and be prepared into soft capsule for auxiliary element.
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| CN107296271A (en) * | 2017-07-11 | 2017-10-27 | 江苏希瑞干细胞技术有限公司 | A kind of placenta capsule and preparation method thereof |
| CN114712323A (en) * | 2022-05-18 | 2022-07-08 | 贵州奇源生物制品有限公司 | Human placenta tablet and preparation method thereof |
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