CN105724892B - Promote stem cell proliferation and increases the feed supplements of telomerase activation - Google Patents
Promote stem cell proliferation and increases the feed supplements of telomerase activation Download PDFInfo
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Abstract
The present invention provides feed supplements that are a kind of anti-ageing and rejuvenating, wherein the feed supplements include the additive of placenta extract, oils and rest part as provided by animal or plant as provided by mammal or plant.Additive is containing selected at least one from the group that collagen class, algae, plant extract and queen bee cream class are constituted.Feed supplements that are anti-ageing and rejuvenating of the invention can promote CD34+ stem cell, fat stem cell hyperplasia, and increase telomerase activation.
Description
Technical field
It, can be with especially with regard to feed supplements that are a kind of anti-ageing and rejuvenating the present invention relates to a kind of feed supplements
Promote CD34+Candidate stem cell, fat stem cell hyperplasia, and increase telomerase activation, and then reach anti-aging, delay senility,
Skin maintenance and cosmetic benefits and enhancing vitality effect.
Background technique
Treatment effect in terms of stem cell (stem cells) is applied to disease is increasingly taken seriously, and is mended by nutrition
Food is filled to help the research achievement of human stem cell quantity hyperplasia, is even more attracted attention by medical circles.Stem cell be a group not by
The cell broken up completely at another ability with identical cell itself and is divided into a variety of spies with division growth
Determine the characteristic of the body cell of function.It is proved by long-term experiment, stem cell antidotal therapy is to delaying senility, enhance vitality
There is very magical effect.
The mankind have stem cell once being born in vivo, and the age is lighter, and stem cell is more.With the gradually aging of human body, body
Intracorporal stem cell population can not only be reduced, but also the fertility of stem cell population and differentiation capability also can be reduced constantly.Cancer
The chronic diseases such as disease, diabetes, arthritis but will weaken the function of stem cell.Therefore, it is allowed in health intracorporal dry thin
Born of the same parents' hyperplasia facilitates health care, the anti-aging, return of spring.
Candidate stem cell (Hematopoietic stem cells) is considered playing the part of the function of hematopoiesis in blood all the year round,
And then promote human longevity.This cell characteristic is there is a CD34+Mark.In human body, CD34+Stem cell is in blood
Occupy 0.01%~0.03%, limited amount.Therefore how to increase CD34 in blood+The amount of stem cell becomes anti-aging
Important key.In addition, telomerase activation (telomerase activity) is also related with hyperplasia and survival, cell can be held
It is continuous to lose telomerase activation, and in DNA mending course, telomeric dna can be also lost, therefore telomerase activation and cell senescence have absolutely
Pair association.
Furthermore the adipose-derived interstital stem cell of more and more research discoveries (adipose-derivedstem cell,
ADSC) there is the abilities of cell differentiations such as direction fat similar with stem cell, muscle, skeletonization, cartilage and nerve and control
Treatment ability.ADSC be it is a kind of be present in the matrix of adipose tissue, proliferative capacity is strong, and with Multidirectional Differentiation potentiality at soma
Cell.ADSC contains high concentration thrombocyte plasma (Platelet Rich Plasma, PRP) growth factor, can stimulate collagen egg
Bai Zengsheng keeps skin more careful smooth.In addition, ADSC can be divided into endothelial cell and possible new vessels.Therefore,
ADSC will be that the research center of gravity of the following anti-ageing medicine is also extensively used for diabetes, apoplexy and that shaves one's head control in addition to this
It treats.
Summary of the invention
In view of this, having can increase the purpose of the present invention is to provide feed supplements that are a kind of anti-ageing and rejuvenating
CD34 in blood cell+The amount of candidate stem cell simultaneously make ADSC hyperplasia and increase telomerase activation, and then reach it is anti-aging,
The effect of health care.
Viewpoint of the invention is to provide a kind of anti-ageing and the return of spring the feed supplements, includes 10%~80% placenta extraction
Take object, 10%~60% oils and the additive of rest part.Placenta extract is provided by mammal or plant.
Oils is provided by animal or plant.Additive is containing from collagen class, algae, plant extract and queen bee cream class structure
At group in selected at least one.
Further, mammal is pig, ox, sheep, horse or deer.
Further, plant is containing selected from the group that soybean, corn, potato, "Hami" melon and rye are constituted
At least one.
Further, oils be containing from olive oil, evening primrose oil, soybean oil, sesame oil, sunflower oil, brown rice germ oil,
Wheat-germ oil, Avocado Oil, safflower oil, herb mixtures tea oil, linseed oil, perilla herb oil, corn oil, cod-liver oil, fish oil and shrimp sauce are constituted
Group in selected at least one.
Further, the content of additive is 10%~60%.
Further, collagen class be containing from fish scale collagen, collagen, chicken cartilage collagen,
Selected at least one in the group that porcine collagen and bovine collagen albumen are constituted.
Further, algae is containing selected from the group that green algae, brown algae, red algae and blue algae are constituted
It is at least one.
Further, plant extract is containing from Chinese yam extract, white high extract, pine bark extract and grape
Selected at least one in the group that seed extracts are constituted.
Further, queen bee cream class be containing from royal jelly, queen bee cream, bee milk, royal jelly and royal jelly reproduced goods constitute
Group in selected at least one.
Further, additive also includes carbohydrate, and the carbohydrate is containing from glucan, black algae
Selected at least one in the group that sugar, ganoderma lucidum polysaccharide, mannose, fucose and trehalose are constituted.
Further, placenta extract is placenta powder, Condensed Extractive Liquid of Placenta, placenta jelly crystalline flour or placenta polypeptide.
Further, feed supplements that are of the invention anti-ageing and rejuvenating be soft capsule, powder, particle, liquid, colloid or
Lotion.
The above embodiment of the present invention has the beneficial effect that: the present invention proposes food supplement that is a kind of anti-ageing and rejuvenating
Product, CD34 in blood cell can be increased by having+The amount of candidate stem cell simultaneously makes ADSC hyperplasia and increases telomerase activation,
And then achieve the effect that anti-aging, health care.
Detailed description of the invention
In order to illustrate more clearly of the embodiment of the present invention or technical solution in the prior art, below will to embodiment or
Attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
Some embodiments of the present invention without creative efforts, may be used also for those of ordinary skill in the art
To obtain other drawings based on these drawings.
Fig. 1 is feed supplements A of the present invention to CD34 in blood+The datagram of the knots modification of stem cell population.
Fig. 2 is datagram of the feed supplements A of the present invention to the knots modification of blood Telomerase Activity.
Fig. 3 is datagram of the feed supplements A of the present invention to the knots modification of ADSC survival rate.
Specific embodiment
Above-mentioned and other technology contents, feature and effect for the present invention, it is following cooperation with reference to schema one preferably
In the detailed description of embodiment, can clearly it present.
One embodiment of the invention is to provide feed supplements that are a kind of anti-ageing and rejuvenating, including 10%~80% placenta
Extract, 10%~60% oils and the additive of rest part.In the field of the present invention, food that is anti-ageing and rejuvenating is mended
The ingredient and proportion for filling product are not limited to this.
In this embodiment, " placenta extract " is various forms of placenta extracts or placenta reproduced goods, includes but not
Be limited to: placenta powder, Condensed Extractive Liquid of Placenta, placenta freeze crystalline flour or placenta polypeptide.The placenta extract is by various mammals
Or plant is provided, mammal is including but not limited to pig, ox, sheep, Ma Jilu.The placenta as provided by mammal
Extract is to have effects that promote cell activation, anti-oxidant, improvement organ dysfunction, promote liver toxin expelling and be metabolized.By soybean,
Placenta extract provided by the plants such as corn, potato, "Hami" melon, rye is with promoting cells grown (including to promote dry
Hyperplasia), and the effect of strengthen immunity.It can also promote skin to manufacture collagen, can enduringly possess health
Smooth skin.
In this embodiment, the weight ratio of placenta extract is 10%~80%；In the preferred embodiment, placenta extracts
The component ratio for taking object is 10%~40%.For the ingredient of placenta extract, extraction is in mammal and extraction in plant
The weight ratio of object is 2:1.In the field of the present invention, the ingredient of placenta extract and proportion are not limited to this.
In this embodiment, " oils " is various applicable oils, includes animal oil or vegetable oil.Animal oil includes pig
Oil, fish oil, shrimp sauce, cod-liver oil etc.；Vegetable oil includes olive oil, evening primrose oil, soybean oil, sesame oil, sunflower oil etc..Oils is simultaneously
It is not limited to edible oils.In the preferred embodiment, oils is selected from by olive oil, evening primrose oil, soybean oil, sesame oil, sunflower
Oil, brown rice germ oil, wheat-germ oil, Avocado Oil, safflower oil, herb mixtures tea oil, linseed oil, perilla herb oil, corn oil, cod-liver oil,
Group composed by fish oil and shrimp sauce.In this embodiment, the weight ratio of oils is 10%~60%；In preferred embodiment
In, oils may include more than one oils, for example, wheat-germ oil, Avocado Oil, and the weight ratio of oils is 50%~
60%.In the field of the present invention, the ingredient of oils and proportion are not limited to this.
In this embodiment, additive contained by the anti-ageing and feed supplements rejuvenated is containing from collagen class, algae
Selected at least one in the group that class, plant extract and queen bee cream class are constituted.The weight ratio of additive be 10%~
60%, in the preferred embodiment, the weight ratio of additive is 10%~30%.In the field of the present invention, additive is not
It is limited to this.
" the collagen class " is mainly extracted in ox, pig, chicken, the skin of birds and cartilage portion, fish or plant.Glue
Weight ratio added by former protide is 5%~60%.Collagen class is preferably selected from by fish scale collagen, fish glue from skin
Group composed by former albumen, chicken cartilage collagen, porcine collagen and bovine collagen albumen.Such collagen, which has, to be promoted
Histocyte regeneration (including promoting stem cell proliferation), improvement rheumatic arthritis and other effects.In the field of the present invention, collagen egg
White class is not limited to the grade substances.
Aforementioned " algae " is selected from the group as composed by green algae, brown algae, red algae and blue algae.Algae is added
Weight ratio be 0%~60%.Because the nutritive value of algae is high, algae is added in feed supplements that are anti-ageing and rejuvenating
It can be beneficial to human health.Wherein, it is poor with blood lipid, treatment diabetes, treatment iron-deficient is reduced for belonging to the spirulina of blue algae
The functions such as blood.The sea lettuce, Hu Tai, black hair algae for belonging to green algae are with treatment Thyroid Gland Swell, treatment bronchitis, antipyretic etc.
Function.The kelp for belonging to brown algae is to have the function of to treat Thyroid Gland Swell, lowering blood pressure and blood fat, anticoagulation etc..Belong to red algae
Seaweed, agar, the Eucheuma of class are to have the function of anti-inflammatory, reducing blood lipid, blood glucose etc..Therefore, in the preferred embodiment, algae
Class is selected from the group as composed by sea lettuce, Hu Tai, black hair algae, kelp, seaweed, agar, Eucheuma and spirulina.In this hair
In bright field, algae is not limited to these substances.
" plant extract " is selected from by Chinese yam extract, white high extract, pine bark extract and grape pip
Group composed by extract.Weight ratio added by plant extract is 5%~60%.It is old with skin maintenance and cosmetic benefits, delay
Change, promote aged cells regeneration (including promoting stem cell proliferation), anti-oxidant, anti-inflammatory, strengthen angiocarpy and other effects.In this hair
In bright field, plant extract is not limited to the grade substances.
" the queen bee cream class " is is formed selected from the reproduced goods by royal jelly, queen bee cream, bee milk, royal jelly and royal jelly
Group, including but not limited to queen bee milk powder end.Weight ratio added by queen bee cream class is 5%~60%.Queen bee cream class tool
It reduces blood pressure, blood lipid, blood glucose, promotes hematopoietic function, adjustment endocrine and metabolism, delay senility, enhance tissue regeneration ability
(including promoting stem cell proliferation) and other effects.In the field of the present invention, queen bee cream class is not limited to the grade substances.
" carbohydrate " is selected from by glucan, black algae sugar (Fucose), ganoderma lucidum polysaccharide, mannose, fucose
And group composed by trehalose.Weight ratio added by carbohydrate is 0%~30%.In the field of the present invention, carbon
Hydrate is not limited to the grade substances.
[embodiment]
Although the present invention is not only defined in these embodiment hereinafter, illustrating the present invention by embodiment.
" embodiment 1: influence of the feed supplements A to human body "
With feed supplements A made of the allotment of each ingredient as shown in following table, human body is tested, observes this for human body
CD34+The influence of candidate stem cell and telomerase activation.
This test is to test 30 human bodies, wherein having 15 for control group, does not take food supplement of the invention
Product A；Other 15 are experimental group, take feed supplements A of the invention.After experiment expires, the blood of all experimenters is taken
Liquid sample carries out following test analysis, observes and records experimental data, as a result as shown in table 1 (control group) and table 2 (experimental group).
Table 1: the experimental result of control group
Table 2: the experimental result of experimental group
With CD34 in flow cytometer observation blood+The amount of stem cell.As a result such as above-mentioned table 1 and the " CD34 of table 2+Stem cell
Shown in (%) ", CD34 is represented+Stem cell ratio shared in blood cell.As a result also as shown in Figure 1, having taken food benefit
Fill the subject of product A, CD34 in blood+The more non-user of the ratio of stem cell will be higher by more than 6 times.And not by age, property
Not, the influence during taking.
The change of telomerase activation is observed, as a result as shown in " telomerase activation " and Fig. 2 of above-mentioned table 1 and table 2, clothes
With the subject of feed supplements A, the more non-user of blood Telomerase Activity will be higher by 35%, and not by the age,
Gender, the influence for taking period.
" embodiment 2: influence of the feed supplements A to ADSC "
" preparing mixed liquor "
Weighing feed supplements A powder 0.1g is added 1ml DMSO and becomes mixed liquor, after mixing by mixed liquor,
Reaction overnight is carried out at room temperature.By mixed liquor with 0.22 μ l membrane filtration after, take the complete training of the mixed liquor and 999 μ l of 1 μ l
Nutrient solution (DMEM of 10% fetal calf serum) after mixing, is injected in the culture plate in 96 holes.
" obtaining the fat cell comprising ADSC and culture "
The white mouse for taking 6~8 weeks is placed in the ethyl alcohol of 750ml/L and impregnates after the chloraldurate 0.2ml anesthesia of 100ml/L
5 minutes, fat 0.5g at groin was taken under aseptic condition.It is carefully cleaned with phosphate buffer (PBS), with scissors by fatty group
It knits and is cut into small pieces.At 37 DEG C, is digested 45 minutes using the collagenase type I of 2mL 0.75g/L and become digestive juice.2mL is added
Complete culture solution neutralize digestive juice, filtered with the filter of 200 sieve pores.Again with low speed 1300rpm/min centrifugation 15 minutes, obtain
Highdensity cell precipitate is obtained, the yellow tissue for removing supernatant and floating is gently toppled over, cell oscillation is mixed.Again with
After aforementioned centrifugal condition centrifugation removal supernatant, the complete culture solution of 2ml is added, is placed in the incubator of 37 DEG C, 50ml/L CO2
Interior culture.The next day change liquid, changed later every 3 days liquid 1 time.
" clean and disperse the fat cell comprising ADSC "
When cell 80%~90% merges, culture bottle is taken out from incubator, is added 10ml's along the bottle wall of culture bottle
Du Shi phosphate buffer (DPBS) cleans 1~2 time, jog culture bottle and after moistening all corners, remove DPBS.It is added
The trypsase of 2ml 0.05% reacts 3 minutes at 37 DEG C.After being slightly tilted culture bottle, the complete culture solution of 2ml is added,
Upper and lower jog culture bottle mixes.300g is taken out from culture bottle to be centrifuged 5 minutes with high speed 3000rpm/min, after removing supernatant,
The DPBS of 10ml is added, cell is broken up.
" counting cell "
Cell liquid is inhaled, is rushed, is inhaled, is rushed, is inhaled, is rushed about five times, and rinses the cell on culture bottle wall surface, up and down gently
Culture bottle is shaken to mix solution.Take the cell liquid of 20 μ l to new microcentrifugal tube, the platform phenol for then adding 20 μ l is blue
(Trypan Blue) is sufficiently mixed in every side of cell counter, each cell liquid for injecting 10 μ l, and is about put under microscope
Big 100 times are observed.
" making the adipose cell proliferation comprising ADSC "
With density 1500cells/cm2In the culture plate that cell kind is entered to 2 disk, 96 hole, after culture 24 hours.It takes out wherein
The mixed liquor prepared is added to continue culture 48 hours as experimental group in one disk cell liquid.Another disk cell liquid is then added without
Mixed liquor is as a control group, to continue culture 48 hours.Cell count is carried out with the step of above-mentioned counting cell, and is tested
The cell density of group is 1600cells/cm2, the cell density of control group is 2225cells/cm2.ADSC relative to control group
There is 100% survival after cultivation, the survival rate of the ADSC of experimental group is drawn with Fig. 3.
The ADSC quantity after above-mentioned experimental procedure is observed, as a result as shown in figure 3, to be mixed into the complete of feed supplements A
Full nutrient solution goes the survival rate of ADSC (that is, experimental group) obtained by culture, compared to the control group for not being mixed into feed supplements A
Survival rate comes get Geng Gao, ADSC hyperplasia 39%.The reason is that, potato contained in feed supplements A wins peptide, soybean wins peptide,
Chicken cartilage collagen, fish scale collagen, black hair algae extract, Chinese yam extract, white high extract, pine bark extraction
Object, queen bee cream effect helpful for the hyperplasia of ADSC.
As described in above-described embodiment, feed supplements that are proposed by the present invention anti-ageing and rejuvenating can increase in blood cell
CD34+The amount of candidate stem cell increases telomerase activation, makes ADSC hyperplasia, and reach anti-aging, delay senility, skin maintenance and cosmetic benefits,
Lowering blood pressure and blood fat, hypoglycemic and other effects, so for diabetes, hypertension, shave one's head with curative effect.
In conclusion the contents of the present invention are had been illustrated with embodiment as above, however the present invention not only limits
Due to these embodiments.Persond having ordinary knowledge in the technical field of the present invention is not departing from spirit of the invention
In range, when various change and modification can be carried out again；For example, each technology contents illustrated by previous embodiment are subject to
Combination is changed as new embodiment, these embodiments are also considered as content belonging to the present invention certainly.Therefore, this case institute
The range to be protected also includes aftermentioned claim and its range that is defined.
Claims (4)
1. one kind promotes CD34+Stem cell, fat stem cell hyperplasia, and increase the feed supplements of telomerase activation, feature exists
In including:
30% placenta extract, the placenta extract are extractions in mammal and plant, and with placenta extract
For ingredient, extract in mammal and extraction in plant weight ratio be 2:1；
50% oils, is made of wheat-germ oil and Avocado Oil；And
20% additive is made of collagen class, black hair algae extract, plant extract and queen bee cream；Wherein
The mammal is pig；
The plant is soybean and potato；
The collagen class is chicken cartilage collagen and fish scale collagen；
The plant extract is containing constituting from Chinese yam extract, white high extract and pine bark extract；
The feed supplements can be by CD34+It is dry that stem cell is promoted to 6 times or more, telomerase activation promotion 35% and fat
Hyperplasia 39%.
2. according to claim 1 promote CD34+Stem cell, fat stem cell hyperplasia, and increase the food of telomerase activation
Complementary goods, which is characterized in that the additive also includes carbohydrate, aforementioned carbohydrate be containing from glucan,
Selected at least one in the group that black algae sugar, ganoderma lucidum polysaccharide, mannose, fucose and trehalose are constituted.
3. according to claim 1 promote CD34+Stem cell, fat stem cell hyperplasia, and increase the food of telomerase activation
Complementary goods, which is characterized in that the placenta extract is placenta powder, Condensed Extractive Liquid of Placenta, placenta jelly crystalline flour or placenta polypeptide.
4. according to claim 1 promote CD34+Stem cell, fat stem cell hyperplasia, and increase the food of telomerase activation
Complementary goods, which is characterized in that the feed supplements are soft capsule, powder, particle, liquid, colloid or lotion.
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| CN201410763539.2A CN105724892B (en) | 2014-12-11 | 2014-12-11 | Promote stem cell proliferation and increases the feed supplements of telomerase activation |
| JP2015138998A JP2016113442A (en) | 2014-12-11 | 2015-07-10 | Anti-aging rejuvenation nutritional supplement |
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| CN201410763539.2A CN105724892B (en) | 2014-12-11 | 2014-12-11 | Promote stem cell proliferation and increases the feed supplements of telomerase activation |
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| CN105724892B true CN105724892B (en) | 2019-06-18 |
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| JP6100965B1 (en) * | 2016-12-01 | 2017-03-22 | 株式会社ホルス | Method for producing oil-soluble placenta extract |
| KR102121315B1 (en) * | 2017-12-27 | 2020-06-17 | 바이오스펙트럼 주식회사 | Composition for promoting the proliferation and differentiation of adipose derived stem cell |
| JP7442079B2 (en) * | 2019-08-09 | 2024-03-04 | 株式会社東洋新薬 | Telomerase expression enhancer |
| KR102504644B1 (en) * | 2020-04-28 | 2023-03-02 | (주)팜스빌 | A food composition including atage-905 collagen and ellastin mixture showing anti-senescent activity |
| JP2021187792A (en) * | 2020-06-01 | 2021-12-13 | 株式会社山田養蜂場本社 | Agent for increasing the number of hematopoietic stem cells |
| JP7461034B2 (en) * | 2020-06-01 | 2024-04-03 | 株式会社山田養蜂場本社 | Mesenchymal stem cell proliferation agent |
| CN112807417B (en) * | 2021-04-08 | 2021-08-17 | 广州市万千粉丝化妆品有限公司 | Collagen-containing skin-whitening and anti-wrinkle medicine or cosmetic |
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| CN103961479A (en) * | 2014-06-03 | 2014-08-06 | 上海赫尔伯生物科技有限公司 | Capsule capable of removing beverage, whitening, moisturizing, resisting wrinkle and delaying senescence and preparation method of capsule |
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| JP2016113442A (en) | 2016-06-23 |
| CN105724892A (en) | 2016-07-06 |
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