CN108112994A - A kind of rose collagen broken wall composition and its preparation method and application - Google Patents
A kind of rose collagen broken wall composition and its preparation method and application Download PDFInfo
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- CN108112994A CN108112994A CN201711486302.4A CN201711486302A CN108112994A CN 108112994 A CN108112994 A CN 108112994A CN 201711486302 A CN201711486302 A CN 201711486302A CN 108112994 A CN108112994 A CN 108112994A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Polymers & Plastics (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of rose collagen broken wall compositions and its preparation method and application.By the component of following parts by weight through broken wall, freeze drying is prepared the broken wall composition：1~6 part of rose is enucleated 1~5 part of jujube, and 1~3 part of arillus longan, 1~2 part of the fruit of Chinese wolfberry, 1~5 part of collagen protein powder, the grain diameter of the broken wall composition is 20~80 mesh.Broken wall composition compatibility provided by the invention has rose, jujube, arillus longan, the fruit of Chinese wolfberry and collagen protein powder, number of dropouts with preferable recuperating qi-blood, maintaining beauty and keeping young and preferable supplement human collagen albumen, and it easily absorbs, it is in good taste, achieve the effect that healthy maintenance, skin maintenance on the whole.Preparation method provided by the invention successfully prepares the broken wall composition grain of the specified particle size for not destroying original ingredient completely by the freeze drying special process such as pelletize, simple for process, cost is relatively low, and suitable for industrialized production and application, market prospects are good.
Description
Technical field
The present invention relates to broken wall compositions field, more particularly to a kind of rose collagen broken wall composition and its preparation
Methods and applications.
Background technology
With the change of Modern human populations health care idea, integration of drinking and medicinal herbs is given birth to nourishment maintenance, particularly edible flower,
As a kind of fashion.Natural flower beverage sells well market, wherein popular kind has rose, sunflower flower and chrysanthemum beverage
Deng since with moisturizing, maintaining beauty and keeping young, spy is favored by ladies.
Rose is the dry flower of rosaceous plant Rosa rugosa Thunb., has promoting qi circulation and removing obstruction in the collateral and blood, analgesic
Effect is chiefly used in the diseases such as stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, deficiency of food evil of vomitting, irregular menstruation.In work and life stress increasing today, women
It drinks some rose teas more, can pacify, set the mind at rest, but the production method bitterness of traditional rose tea is highly seasoned, and color, smell and taste are light,
Mouthfeel is bad；On the other hand rose flower beverage in the market is formulated single mostly, and preparation process is simple and crude, utilization rate of active components
It is low, pigment, essence and preservative are added mostly, it is difficult to play health maintenance, the effect or ineffective of skin maintenance.
Collagen is the important component in skeleton, especially soft tissue.For population, at 25 years old
After, in vivo collagen begins to gradually be lost in, especially women, since hormone in vivo caused by the age is lacked of proper care, is lost in
Speed is than male block number times.Therefore, the best approach for maintaining body health is exactly that collagen is replenished in time.But rich in collagen
The object of the food of albumen as a kind of " growing greasy ", easily hinders stomach Qi, influences appetite, influence absorption of nutrient ingredients, directly merely into
Speed may be intended to without reaching by eating these foods, can not make full use of the nutritive value of food.
Therefore, exploitation is a kind of has preferable skin maintenance effect, rich in collagen and non-greasy, the medicine food for being easy to absorption
Dual-purpose product has important research significance and promotional value.
The content of the invention
It is an object of the invention to overcome beautifying face and moistering lotion product in the prior art it is ineffective, it is greasy, be not easy to what is absorbed
Defect and deficiency provide a kind of rose collagen broken wall composition.Broken wall composition provided by the invention passes through each component
Compatibility not only has effects that preferable recuperating qi-blood, beautifying face and moistering lotion, the preferably number of dropouts supplemented with human collagen albumen,
And easily absorb, it is in good taste, achieve the effect that healthy maintenance, skin maintenance on the whole.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of rose collagen broken wall composition, by the component of following parts by weight through broken wall, prepared by freeze drying granulation
It forms：
1~6 part of rose
It is enucleated 1~5 part of jujube
1~3 part of arillus longan
1~2 part of the fruit of Chinese wolfberry
1~5 part of collagen protein powder,
The grain diameter of the broken wall composition is 20~80 mesh.
《The Yellow Emperor's Canon of Internal Medicine》It says：" woman seven years old, kidney qi are contained, dental transition hair length.Two or seven and menarche, conception vessel lead to, taichong channel contain,
Regular menstrual cycle, therefore have son ... seventy-seven, conception vessel is empty, and taichong channel, which declines, to be lacked, the menopause, menostasia, therefore shape is gone bad and s.m.p.”
Due to the special physilogical characteristics of women, factors, most of women such as modern life rhythm is accelerated in addition, operating pressure increases hold very much
Easily lead to the cards such as deficient qi and blood, sallow complexion, liver-qi depression, temperish.It can be seen that dispersing stagnated hepatoqi, invigorating QI and blood are to female
The importance of property.
The formula composition of the present invention follows strictly the dialectical maintenance of traditional Chinese medicine, health care's principle of reasonable compatibility, focuses on thin
Liver solution is strongly fragrant, based on benefiting qi and nourishing blood.The promoting qi circulation and removing obstruction in the collateral of monarch drug in a prescription rose and blood and relieving pain, promoting blood circulation for regulating menstruation in side；The sweet temperature of jujube, bowl spares benefit
Gas, nourishing blood and tranquilization are harmonizing the spleen and stomach common medicine；Arillus longan work(is apt to tonifying heart and spleen, nourishing blood and tranquilization, neither grow it is greasy, and do not stop up it is stagnant, it is real
For tonic medicine；The fruit of Chinese wolfberry is sweet in flavor mild-natured, not only the moon of filling liver kidney, but also has the work(of blood-nourishing, compatibility application jujube, arillus longan and matrimony vine
The effect of son not only enhances rose recuperating qi-blood, beautifying face and moistering lotion, and jujube, arillus longan and the fruit of Chinese wolfberry are sweet, it can be very well
Improve the mouthfeel of rose.Again plus with collagen protein powder, the number of dropouts of human collagen albumen, and compatibility are not only supplemented very well
Rose, jujube with promoting the circulation of qi tonifying spleen effect etc. also more preferably promote the absorption of collagen constituents, so that perfect square reaches
It is raised to a health, the effect of skin maintenance.Simultaneously it has also been found that most of female middle-aged patient is taking in clinical practice
Inventive formulation for a period of time after, not only sleep quality is improved, and the diseases such as climacteric syndrome, constipation also obtain centainly
The alleviation of degree.
Preferably, the broken wall composition is prepared by the component of following parts by weight：
1~3 part of rose
It is enucleated 2~4 parts of jujube
1~2 part of arillus longan
1~2 part of the fruit of Chinese wolfberry
2~5 parts of collagen protein powder.
It is further preferable that the broken wall composition is prepared by the component of following parts by weight：
1 part of rose
It is enucleated 3 parts of jujube
2 parts of arillus longan
1 part of the fruit of Chinese wolfberry
3 parts of collagen protein powder.
Preferably, the grain size of the broken wall composition is 30 mesh.
The preparation method of above-mentioned broken wall composition, includes the following steps：
S1：Rose, stoning jujube, arillus longan and the fruit of Chinese wolfberry are subjected to chilling treatment；
S2：By rose, stoning jujube, arillus longan, the fruit of Chinese wolfberry and collagen protein powder wall cell disruption powder at a temperature of -30~-5 DEG C
It is broken into the broken wall powder that granularity D90 is 20~75 μm；
S3：Broken wall powder obtained by S2 is subjected to freeze drying granulation, it is the broken wall that grain size, which is made, as the particle of 20~80 mesh
Composition；The condition of freeze drying granulation is：Pressure roller rotating speed be 9~30rpm, platen pressure be 90~180bar, two-stage
Granulation rotating speed is 70~180rpm；And temperature of the broken wall powder in freeze drying pelletization is controlled as 10~0 DEG C of ﹣,
Relative humidity is 5~20%.
The particle that the present invention is prepared by specification can be dispensed and packed through particle packaging machine, obtain rose collagen
Albumen broken wall composition finished product, is easy to preserve.
Preparation method provided by the invention can be protected preferably and using the various active ingredients of raw material, be broken made from this method
Wall composition has effects that preferable toxin-expelling and face nourishing, recuperating qi-blood.After conventional water or alcohol extracting part active ingredient
The mode of preparations shaping again, not only rapid wear become estranged the active ingredients such as essential oil destroyed in rose, it is and contained big in the dregs of a decoction
Amount polyphenol, flavonoids, polysaccharide and protein-based nutritional ingredient be simply discarded should not, cause greatly to waste.
In order to solve the problems such as active ingredients such as above-mentioned essential oil are easily destroyed and application is insufficient, broken wall crushing can be used
Mode, can not only be fully dissolved out active ingredient, and be a kind of using all kinds of nutritional ingredients contained in each component dregs of a decoction
Preferable retained fraction active ingredient mode.But the inventors found that these three raw materials of jujube, arillus longan, the fruit of Chinese wolfberry are easy
The moisture absorption becomes sticky, even if being ground into 60 mesh coarse powder also non-availability under normal conditions, therefore the present invention is by carrying out each component
Chilling treatment and in low temperature（- 30~-5 DEG C）Under the conditions of broken wall, each component broken wall is successfully obtained into broken wall powder, broken wall powder
Granularity D90 for 20~75 μm, and each component moisture absorption during broken wall is broken can be avoided.However, the wall cell disruption powder after broken wall crushing
Since its specific surface area has increased up to ten thousand times compared with the specific surface area before broken wall, moisture absorption conglomeration is more easy to, is placed under normal condition
Such as rice sugar shape is bonded within 10~20 seconds, therefore conventional wet granulation shaping can not be used at all.
Then, the present invention is attempted by the way of dry granulation.But found in research process, which is done
During legal system grain, very big difficulty is equally existed.Each group during the grain size of the yield rate of dry granulation and particle obtained is both formulated
Divide the influence of dosage, and by granulation conditions（Process conditions and Temperature and Humidity Control）Influence；On the other hand must also consider
The performance of the science and each component effect that are entirely formulated.The present inventor has found by test of many times, in specific components
With freeze drying granulation is carried out under when granulation conditions, the particle of appropriate particle size, and high yield rate can be just obtained.
In preparation method provided by the invention, raw material is dosed into preparations shaping and obtains finished product whole process in low temperature or room temperature item
Carried out under part, entire production process raw material all do not contact it is any wet and hot, completely without using wet（Water, alcohol）And heat（Decoct,
It is dry）The processing technology of destructibles ingredient is waited, the characteristic of raw material has been taken into full account in preparation process, has not only saved rose well
The ingredients such as essential oil, polyphenol, flavonoids in the raw materials such as rare flower avoid the processing of the techniques such as heated raw material, humidification, decoction so as to make
Into the loss of active ingredient；And cold water or warm water takes after mixing it with water delicate mouthfeel, and what is taken full advantage of is previous to being abandoned as the dregs of a decoction
Polysaccharide, amino acid, dietary fiber isoreactivity ingredient and nutriment make the utilization of material composition more comprehensively, more fully.The preparation
It is simple for process, cost is relatively low, suitable for industrialized production and application, there are good market prospects.
Preferably, rose temperature is refrigerated to 0~4 DEG C in S1；Jujube is enucleated in refrigeration to 5~0 DEG C of ﹣；Arillus longan is refrigerated to ﹣
10 DEG C of 5~﹣；The fruit of Chinese wolfberry is refrigerated to 30 DEG C of 5~﹣ of ﹣.
Preferably, the time of refrigeration is 12h~36h.
Preferably, the time that broken wall crushes in S2 is 15min~45min.
Preferably, pressure roller rotating speed is 18rpm in S3, and platen pressure 105bar, two-stage granulation rotating speed is 100rpm.
Preferably, temperature of the broken wall powder in freeze drying pelletization is controlled in S3 as 5 DEG C of ﹣, relative humidity
For 10%.
Preferably, the environment temperature that freeze drying is pelletized in S3 is 20~24 DEG C, and relative humidity is 10~20%.
Application of the above-mentioned broken wall composition in skin maintenance drug or food is prepared is also in protection scope of the present invention
It is interior.
Compared with prior art, the present invention has the advantages that：
Rose collagen broken wall composition provided by the invention, compatibility have rose, jujube, arillus longan, the fruit of Chinese wolfberry and glue
Former albumen powder has effects that preferable recuperating qi-blood, beautifying face and moistering lotion, can preferably supplement the loss of human collagen albumen
Amount, and easily absorb, it is in good taste, achieve the effect that healthy maintenance, skin maintenance on the whole.Preparation method provided by the invention is led to
Cross the broken wall composition grain that the special process such as freeze drying granulation successfully prepare specified particle size, simple for process, cost
Relatively low, suitable for industrialized production and application, market prospects are good.
Specific embodiment
With reference to embodiment, the present invention is further explained.These embodiments are merely to illustrate the present invention rather than limitation
The scope of the present invention.The experimental method of actual conditions is not specified in lower example embodiment, usually according to this field normal condition or presses
The condition suggested according to manufacturer；Used raw material, reagent etc., unless otherwise specified, being can be from the business such as conventional market
The raw materials and reagents that approach obtains.The variation for any unsubstantiality that those skilled in the art is done on the basis of the present invention
And it replaces and belongs to scope of the present invention.
Embodiment 1
Rose collagen broken wall composition provided in this embodiment is enucleated 1 part of jujube by 1 part of rose, 1 part of arillus longan,
2 parts of the fruit of Chinese wolfberry, 5 parts of collagen protein powder are prepared, and specific preparation method is as follows：
（1）Rose put refrigerating chamber refrigeration 12h after to its temperature be 4 DEG C, stoning jujube be placed in refrigerating chamber refrigeration 12h after to its temperature
It spends for 0 DEG C, it is 5 DEG C of ﹣ that arillus longan, which is placed in after refrigerating chamber refrigeration 12h to its temperature, and the fruit of Chinese wolfberry is placed in after refrigerating chamber refrigeration 12h to it
Temperature is 5 DEG C of ﹣.
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, dragon to 30 DEG C of ﹣
Eye meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 15min, are crushed to D90 at 20~75 μm.
（3）In transfer roller pressure type freeze drying granulator, pressure roller rotating speed 30rpm, pressure 90bar are set, and two-stage, which is pelletized, to be turned
Fast 180rpm, the temperature of wall cell disruption powder keep 5 DEG C of ﹣, and relative humidity keeps 20%, is granulation into the composition grain of 20~80 mesh, then passes through
It hangs between rising again, controls and hang temperature between rising again as 20 DEG C, relative humidity 20% spreads out and hangs 1h and combined up to the broken wall
Object.
Embodiment 2
Rose collagen broken wall composition provided in this embodiment is enucleated 5 parts of jujube by 6 parts of rose, 3 parts of arillus longan,
1 part of 1 part of the fruit of Chinese wolfberry and collagen protein powder are prepared, and specific preparation method is as follows：
（1）Rose puts refrigerating chamber and refrigerates 12h to temperature at 4 DEG C, and for 24 hours to 2 DEG C of ﹣, arillus longan is refrigerated for 24 hours to ﹣ 7 for jujube refrigeration
DEG C, fruit of Chinese wolfberry refrigeration is for 24 hours to 20 DEG C of ﹣.
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, dragon to 20 DEG C of ﹣
Eye meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 45min, are crushed to D90 at 20~75 μm.
（3）In transfer roller pressure type freeze drying granulator, pressure roller rotating speed 25rpm, pressure 130bar are set, and two-stage, which is pelletized, to be turned
Fast 160rpm, the temperature of wall cell disruption powder keep 10 DEG C of ﹣, and relative humidity keeps 5%, is granulation into the composition grain of 20~80 mesh, then passes through
It hangs between rising again, controls and hang temperature between rising again as 24 DEG C, relative humidity 10% spreads out and hangs 2h and combined up to the broken wall
Object.
Embodiment 3
Rose collagen broken wall composition provided in this embodiment is enucleated 2 parts of jujube by 1 part of rose, 1 part of arillus longan,
5 parts of 2 parts of the fruit of Chinese wolfberry and collagen protein powder are prepared, and specific preparation method is as follows：
（1）Rose puts refrigerating chamber refrigeration for 24 hours to temperature at 0 DEG C, jujube 5 DEG C of 36h to ﹣ of refrigeration, arillus longan refrigeration 36h to ﹣ 10
DEG C, fruit of Chinese wolfberry refrigeration is for 24 hours to 15 DEG C of ﹣.
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, dragon to 20 DEG C of ﹣
Eye meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 30min, are crushed to D90 at 20~75 μm.
（3）In transfer roller pressure type freeze drying granulator, pressure roller rotating speed 22rpm, pressure 110bar are set, and two-stage, which is pelletized, to be turned
Fast 110rpm, the temperature of wall cell disruption powder keep 8 DEG C of ﹣, and relative humidity keeps 15%, is granulation into the composition grain of 20~80 mesh, then passes through
It hangs between rising again, controls and hang temperature between rising again as 20 DEG C, relative humidity 15% spreads out and hangs 1h and combined up to the broken wall
Object.
Embodiment 4
Rose collagen broken wall composition provided in this embodiment is enucleated 4 parts of jujube by 3 parts of rose, 2 parts of arillus longan,
2 parts of 1 part of the fruit of Chinese wolfberry and collagen protein powder are prepared, and specific preparation method is as follows：
（1）Rose puts refrigerating chamber and refrigerates 36h to temperature at 2 DEG C, jujube 5 DEG C of 36h to ﹣ of refrigeration, arillus longan refrigeration 36h to ﹣ 10
DEG C, fruit of Chinese wolfberry refrigeration is for 24 hours to 5 DEG C of ﹣.
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, dragon to 20 DEG C of ﹣
Eye meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 20min, are crushed to D90 at 20~75 μm.
（3）In transfer roller pressure type freeze drying granulator, pressure roller rotating speed 18rpm, pressure 120bar are set, and two-stage, which is pelletized, to be turned
Fast 100rpm, the temperature of wall cell disruption powder keep 10 DEG C of ﹣, and relative humidity keeps 5%, is granulation into the composition grain of 20~80 mesh, then passes through
It hangs between rising again, controls and hang temperature between rising again as 24 DEG C, relative humidity 10% spreads out and hangs 1h and combined up to the broken wall
Object.
Embodiment 5
Rose collagen broken wall composition provided in this embodiment is enucleated 3 parts of jujube by 1 part of rose, 2 parts of arillus longan,
3 parts of 1 part of the fruit of Chinese wolfberry and collagen protein powder are prepared, and specific preparation method is as follows：
（1）Rose puts refrigerating chamber and refrigerates 36h to temperature at 3 DEG C, jujube 3 DEG C of 36h to ﹣ of refrigeration, arillus longan refrigeration 36h to ﹣ 10
DEG C, 30 DEG C of 36h to ﹣ of fruit of Chinese wolfberry refrigeration
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, longan to 20 DEG C of ﹣
Meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 20min, are crushed to D90 at 20~75 μm.
（3）In transfer roller pressure type freeze drying granulator, pressure roller rotating speed 18rpm, pressure 105bar are set, and two-stage, which is pelletized, to be turned
Fast 100rpm, the temperature of wall cell disruption powder keep 5 DEG C of ﹣, and relative humidity keeps 5%, is granulation into the composition grain of 20~80 mesh, then passes through
It hangs between rising again, controls and hang temperature between rising again as 20 DEG C, relative humidity 10% spreads out and hangs 1h and combined up to the broken wall
Object.
The yield rate of broken wall composition prepared by various embodiments of the present invention is not less than 95%.
Embodiment 6
By taking the broken wall composition that embodiment 5 provides as an example, rose collagen broken wall composition provided by the invention is tested
Performance.
First, antioxidant effect
1st, trial drug：The concentrate that concentration is 1g/ml is made in the broken wall composition prepared in embodiment 5.
2nd, experimental animal：SPF grades of kunming mices, female, each half of male, 15~18g of weight
3rd, test reagent：0.9% sodium chloride injection (Guizhou world medicine company Co., Ltd)；SOD, MDA and GSH-PX are tried
Agent box builds up Bioengineering Research Institute by Nanjing and provides.
4th, test method：It takes SPF grades of kunming mices 30, after fasting 12h, is randomly divided into 2 groups, every group 15, is respectively
Observation group and control group, observation group's gavage granule concentrate, 0.46g/kg, 1 time/d, control group gavage physiological saline 6ml/
Kg weight, broken end take blood, measure above-mentioned indices, assay method is illustrated to carry out by kit.
5th, result：As shown in table 1.
Table 1 two groups of serum GSH-PX, SOD, MDA compare
Note：Compared with the control group,* P<0.05。
Take as can be known from the above table embodiment 5 preparation broken wall composition after glutathione peroxidase (GSH-Px) vigor
And superoxide dismutase（SOD）Vigor significantly improves, Serum MDA（MDA）Vigor is remarkably decreased.
2nd, crowd's test-meal is tested：
Choose that the in poor health, tired of 60 35~45 years old ages, stress be big, facial sallow, irregular menstruation volunteer, point
Into 2 groups, every group 30, group 1 takes the rose collagen broken wall food that the embodiment of the present invention 5 is prepared, instructions of taking：
5g/ times, 2 times/d, warm water is taken after mixing it with water；Group 2 is assorted into tea bag by identical prescription, 5g/ bags, 1 time 1 bag, 2 times/d, brewed for drinking.Two
Group takes observing effect after 15 days.
As a result：
12 patient body weaknesses, tired, stress are big in group 1, face is sallow, irregular menstruation is significantly alleviated, appetite
Enhancing, complexion are ruddy；10 patient facial regions are sallow, irregular menstruation is centainly alleviated；Not only sleep quality is changed for equal readme
It is kind, and climacteric syndrome, constipation also obtain certain alleviation.Remaining effect unobvious.Experiment crowd generally reflects use
It is convenient, in good taste, it is easily accepted by, without the case that comes off.
10 patient body weaknesses, tired, stress are big in group 2, face is sallow, irregular menstruation is centainly alleviated,
Remaining effect unobvious, and reflect that mouthfeel has bitter taste, there are 3 to come off.
Reference examples 1
This reference examples selects 1 part of rose, is enucleated 3 parts of jujube, 2 parts of arillus longan, the 3 parts of progress of 1 part of the fruit of Chinese wolfberry and collagen protein powder
Wet granulation, specific preparation method are as follows：
（1）Rose puts refrigerating chamber and refrigerates 36h to temperature at 0 DEG C, jujube 5 DEG C of 36h to ﹣ of refrigeration, arillus longan refrigeration 36h to ﹣ 10
DEG C, 30 DEG C of 36h to ﹣ of fruit of Chinese wolfberry refrigeration.
（2）Wall-broken grinder, which starts, forces cold advance refrigeration to add in the foregoing rose cooled down, jujube, dragon to 20 DEG C of ﹣
Eye meat, the fruit of Chinese wolfberry and collagen powder raw material, broken wall crush 20min, are crushed to D90 at 20~75 μm.
（3）Softwood can not be manufactured as wetting agent using water or 1%~absolute ethyl alcohol, reason is：Material in slightly contact wetting and
In the case that temperature of charge is slightly increased to room temperature, wall cell disruption powder is bonded to close sticky lumps immediately, so can not use
Wet granulation.
Reference examples 2
The composition for the rose collagen broken wall composition that this reference examples provides is consistent with embodiment 5, and its preparation method is except step
Suddenly（3）Outside middle setting pressure roller rotating speed 50rpm, remaining is consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 5~110 mesh, yield rate 20%.
Reference examples 3
The composition for the rose collagen broken wall composition that this reference examples provides is consistent with embodiment 5, and its preparation method is except step
Suddenly（3）Middle setting pressure is outside 30bar, remaining is consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 10~110 mesh, yield rate 23%.
Reference examples 4
The composition for the rose collagen broken wall composition that this reference examples provides is consistent with embodiment 5, and its preparation method is except step
Suddenly（3）Middle setting two-stage pelletizes rotating speed as outside 40rpm, remaining is consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 5~120 mesh, yield rate 25%.
Reference examples 5
The composition for the rose collagen broken wall composition that this reference examples provides is consistent with embodiment 5, and its preparation method is except step
Suddenly（3）20 DEG C of the temperature of middle control wall cell disruption powder is outer, remaining is consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 10~110 mesh, yield rate 22%.
Reference examples 6
The composition for the rose collagen broken wall composition that this reference examples provides is consistent with embodiment 5, and its preparation method is except step
Suddenly（3）The middle relative humidity for controlling wall cell disruption powder is outside 40%, remaining is consistent with embodiment 5.
This reference examples can not be molded by dry granulation.
Reference examples 7
The composition for the rose collagen broken wall composition that this reference examples provides except stoning jujube component for 13 especially, remaining group
Divide content and preparation method consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 15~120 mesh, yield rate 26%.
Reference examples 8
The composition for the rose collagen broken wall composition that this reference examples provides is except longan meat ingredient is 10 especially, remaining component
Content and preparation method are consistent with embodiment 5.The grain size for the broken wall composition that this reference examples obtains be 20~180 mesh, finished product
Rate is 27%.
Reference examples 9
The composition for the rose collagen broken wall composition that this reference examples provides is except fruit of Chinese wolfberry component is 11 especially, remaining component
Content and preparation method are consistent with embodiment 5.
The grain size for the broken wall composition that this reference examples obtains be 10~160 mesh, yield rate 21%.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of rose collagen broken wall composition, which is characterized in that by the component of following parts by weight through broken wall, freezing
Dry granulation is prepared：
1~6 part of rose
It is enucleated 1~5 part of jujube
1~3 part of arillus longan
1~2 part of the fruit of Chinese wolfberry
1~5 part of collagen protein powder,
The grain diameter of the broken wall composition is 20~80 mesh.
2. broken wall composition according to claim 1, which is characterized in that be prepared by the component of following parts by weight：
1~3 part of rose
It is enucleated 2~4 parts of jujube
1~2 part of arillus longan
1~2 part of the fruit of Chinese wolfberry
2~5 parts of collagen protein powder.
3. broken wall composition according to claim 2, which is characterized in that be prepared by the component of following parts by weight：
1 part of rose
It is enucleated 3 parts of jujube
2 parts of arillus longan
1 part of the fruit of Chinese wolfberry
3 parts of collagen protein powder.
4. broken wall composition according to claim 1, which is characterized in that the grain size of the broken wall composition is 30 mesh.
5. the preparation method of any broken wall composition of Claims 1 to 4, which is characterized in that include the following steps：
S1：Rose, stoning jujube, arillus longan and the fruit of Chinese wolfberry are subjected to chilling treatment；
S2：By rose, stoning jujube, arillus longan, the fruit of Chinese wolfberry and collagen protein powder wall cell disruption powder at a temperature of -30~-5 DEG C
It is broken into the broken wall powder that granularity D90 is 20~75 μm；
S3：Broken wall powder obtained by S2 is subjected to freeze drying granulation, it is the broken wall that grain size, which is made, as the particle of 20~80 mesh
Composition；The condition of freeze drying granulation is：Pressure roller rotating speed be 9~30rpm, platen pressure be 90~180bar, two-stage
Granulation rotating speed is 70~180rpm；And temperature of the broken wall powder in freeze drying pelletization is controlled as 10~0 DEG C of ﹣,
Relative humidity is 5~20%.
6. according to the method described in claim 5, it is characterized in that, the refrigeration of rose temperature is to 0~4 DEG C in S1；It is cold to be enucleated jujube
It hides to 5~0 DEG C of ﹣；Arillus longan is refrigerated to 10 DEG C of 5~﹣ of ﹣；The fruit of Chinese wolfberry is refrigerated to 30 DEG C of 5~﹣ of ﹣.
7. according to the method described in claim 5, it is characterized in that, the time that broken wall crushes in S2 is 15min~45min.
8. according to the method described in claim 5, it is characterized in that, pressure roller rotating speed is 18rpm in S3, platen pressure is
105bar, two-stage granulation rotating speed is 100rpm.
9. according to the method described in claim 5, it is characterized in that, the broken wall powder is controlled to pelletize in freeze drying in S3
Temperature in journey is 5 DEG C of ﹣, relative humidity 10%.
10. application of any broken wall composition of Claims 1 to 4 in skin maintenance drug or food is prepared.
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| CN109123294A (en) * | 2018-06-29 | 2019-01-04 | 中山市中智药业集团有限公司 | A kind of straight drinking particle of broken wall improving oropharynx microenvironment |
| CN109275912A (en) * | 2018-10-12 | 2019-01-29 | 常州钏世国际贸易有限公司 | Collagen food and preparation method thereof and its application |
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