CN104869981B - 用于协调微粒性质的干燥方法 - Google Patents

用于协调微粒性质的干燥方法 Download PDF

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Publication number
CN104869981B
CN104869981B CN201280077831.8A CN201280077831A CN104869981B CN 104869981 B CN104869981 B CN 104869981B CN 201280077831 A CN201280077831 A CN 201280077831A CN 104869981 B CN104869981 B CN 104869981B
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CN
China
Prior art keywords
particulate
bioactivator
poly
polymer
drying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280077831.8A
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English (en)
Chinese (zh)
Other versions
CN104869981A (zh
Inventor
J·L·阿特金森
B·K·查姆博斯
M·E·哈德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Corp
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Evonik Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
CN201280077831.8A 2012-11-09 2012-11-09 用于协调微粒性质的干燥方法 Expired - Fee Related CN104869981B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/064482 WO2014074114A1 (en) 2012-11-09 2012-11-09 Drying methods for tuning microparticle properties

Publications (2)

Publication Number Publication Date
CN104869981A CN104869981A (zh) 2015-08-26
CN104869981B true CN104869981B (zh) 2018-05-08

Family

ID=47222324

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280077831.8A Expired - Fee Related CN104869981B (zh) 2012-11-09 2012-11-09 用于协调微粒性质的干燥方法

Country Status (10)

Country Link
EP (1) EP2916825A1 (ru)
JP (1) JP6184508B2 (ru)
CN (1) CN104869981B (ru)
AU (2) AU2012393962A1 (ru)
BR (1) BR112015010434A2 (ru)
CA (1) CA2890833A1 (ru)
HK (1) HK1208623A1 (ru)
IL (1) IL238720A0 (ru)
RU (1) RU2015121799A (ru)
WO (1) WO2014074114A1 (ru)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596316B2 (en) * 1998-12-30 2003-07-22 Alkermes Controlled Therapeutics, Inc. Ii Preparation of microparticles having a selected release profile

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471036B2 (en) 1989-05-04 2004-06-23 Southern Research Institute Encapsulation process
CA2172509C (en) * 1993-10-22 2010-08-24 Jeffrey L. Cleland Methods and compositions for microencapsulation of antigens for use as vaccines
US6913767B1 (en) * 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
WO2001078687A1 (en) * 2000-04-18 2001-10-25 Peptron Inc. Injectable sustained release pharmaceutical composition and processes for preparing the same
WO2005003180A2 (en) 2003-04-10 2005-01-13 Pr Pharmaceuticals A method for the production of emulsion-based micro particles
US20050220887A1 (en) * 2004-01-20 2005-10-06 Alkermes Controlled Therapeutics, Inc. Method for milling frozen microparticles
AU2008231093A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596316B2 (en) * 1998-12-30 2003-07-22 Alkermes Controlled Therapeutics, Inc. Ii Preparation of microparticles having a selected release profile

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TNT过滤干燥器;周格;《医药工程设计》;19920131(第1期);第46页 *

Also Published As

Publication number Publication date
WO2014074114A1 (en) 2014-05-15
JP2015536980A (ja) 2015-12-24
IL238720A0 (en) 2015-06-30
EP2916825A1 (en) 2015-09-16
CA2890833A1 (en) 2014-05-15
BR112015010434A2 (pt) 2017-07-11
CN104869981A (zh) 2015-08-26
JP6184508B2 (ja) 2017-08-23
AU2012393962A1 (en) 2015-05-28
HK1208623A1 (en) 2016-03-11
RU2015121799A (ru) 2017-01-10
AU2018203710A1 (en) 2018-06-14

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