CN104857554A - Sponge for traumatic hemostasis and preparation method thereof - Google Patents
Sponge for traumatic hemostasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a sponge preparation for traumatic hemostasis. The sponge preparation is characterized by being prepared from the following main raw materials in parts by weight: 6 parts of herba seu radix cirsii japonici, 7 parts of flos chrysanthemi indici, 5 parts of radix scutellariae, 6 parts of radix isatidis, 1.3 parts of procaine and 18 parts of starch. The sponge preparation for traumatic hemostasis is simple in preparation method, low in cost of selected raw materials and significant in traumatic hemostasis effect, and can be used for better sterilization and hemostasis.
Description
this case is divisional application, original applying number 2014104067621; Original application day 2014.08.19, title is used for sponge preparation and the preparation method of trauma hemostasis.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of sponge preparation for trauma hemostasis and preparation method.
Background technology
Wound, refers to the outer damage that health or object cause due to the erosion etc. of the strike of external object, collision or chemical substance.Refer to the emotions such as the indignant worry because producing by external irritant.To record in " numerous Lu Xuntianzhi in spring and autumn road " as Han dynasty Dong Zhong relaxes: " with happy person, outside raw, Thailand also; Spirit person, fills also within raw; If outer Thailand not in fill, much less wound? angryly sympathize melancholy hatred person, the wound of life also; With say the person of encouraging people to do good, life support also.”
Wound, language goes out " Plain Questions distracting patient’s attention to change the flow of QI-blood opinion ".1. one of injury symptoms classification.Refer generally to pounce on the damage of skin caused by tumbling down, muscle, muscles and bones.2., for internal injury caused by excess of seven emotions, refer to that six climate exopathogens exopathogen hindered, as cold, typhoid fever, affection of dampness, Sunstroke etc.Wound comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc.The wounds such as bullet, Jin Ren, traumatic injury, injury by overexertion, can cause integumentary musculature swelling and pain due to blood stasis, hemorrhage, or injury of tendon and muscle fracture, dislocation.Heavy then damage internal organs, or Massive Bleeding, the serious change such as stupor, tic, YANG-depletion collapse can be caused.How burn and scald, caused by high temperature article, boiling water or deep fat or burn and scald etc.The lighter damages skin, red in injury, swollen, hot, bitterly, xerosis cutis or get blister, severe pain; Severe burn and scald then muscle injury, muscles and bones can make analgesis, and wound surface is as leather sample, or wax is white, sallow or carbonization; Serious burn and scald, then it is excessive to hinder face, and apart from outside local symptom, Chang Yin has an intense pain, fire-toxin inside fire attack, body fluid evaporation or ooze out, and can occur that dysphoria, heating, xerostomia are thirsty, oliguria etc., even dead.Cold injury, refers to that human body is damaged by the general caused by low temperature invasion and attack or locality.General cold injury, because of cold being a kind of YIN pathogen, easy impairment of YANG gas, YIN-cold crosses Sheng, and yang-energy is impaired, and lose in warm and promotion blood, then shiver with cold, body temperature declines gradually, pale complexion, bluish lip, and fingernail is livid purple, stolidity, spiritlessness and weakness, or lethargy, hypopnea, and slow pulse is thin.If do not given treatment to, easily lethally to die.Part frozen, mostly occurs in hands, foot, auricle, nose and face position.Fall ill from the beginning of, position of enduring cold is because of cold main spasm, and passages through which vital energy circulates contraction is anxious, and coagulation of QI-blood is smooth, and impact is endured cold the warm and nutrition of local, and cause local skin pale, cold fiber crops, the then swelling that continues is livid purple, itches bitterly scorching hot, or occurs the blister etc. that differs in size, normal easy infection after diabrosis.Insect-animal injury, comprises poisonous snake, the beast of prey, mad dog bites, or scorpion, bee sting wound etc.Swelling and ache, appear in light then local damage, hemorrhage etc.; Heavy then damage internal organs, or Massive Bleeding and dead.Then there is systemic toxicity profiles symptom in venom, as given treatment to not in time, often causes being poisoned to death.Mad dog is bitten, from the beginning of rarely seen local pain, hemorrhage, after wound healing, through one period of incubation period, then can occur agitation, greatly alarmed, gnathospasma, tic, hydrophobia, the probably disease such as wind.
Wound, inevitable in people's daily life, traumatic hemorrhage can cause very large impact to the health of people, when treatment wound, stops blooding, wraps up, fixes, carrying is four basic fundamentals that wound is given first aid to.When implementing the rescue of on-the-spot wound, Field Force will in line with the spirit of humanitarianism of healing the wounded and rescue the dying, and is notifying that nearby while hospital, want calm, promptly carry out field first aid work, its principle is: first rob and rescue afterwards, light after first heavy, slow after first anxious, far away after first near; First stop blooding and wrap up afterwards, more fixing rear carrying.Stop blooding as the first step for the treatment of wound, most important, therefore, trauma hemostasis medicine used and sponge just become most important.
Publication number CN 1097980A(application number 93108804.6) Chinese patent literature disclose a kind of by name " chitosan gelatin sponge ", it is made up of gelatin, chitosan, hydrochloric acid, sodium hydroxide, formaldehyde, distilled water.Authorization Notice No. is CN 101574539 B(application number 200910087274.8) Chinese patent literature disclose a kind of by name " a kind of gelfoam and preparation method thereof ", it becomes gelatin hydrogel by first carrying out crosslinking with radiation to aqueous gelatin solution, then carries out swelling, lyophilization and forms.
In a word, Chinese medicine achieves certain effect in development gelfoam, but also there is following problem: existing gelfoam, not for trauma hemostasis development, not good enough to the therapeutic effect of trauma hemostasis, needs to be improved further.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is that providing a kind of prepares the sponge preparation for trauma hemostasis simple, easy to use, has effect of quick-acting haemostatic powder, bactericidal antiphlogistic, to the treatments for bleeding Be very effective that wound causes.
Another object of the present invention is to provide the preparation method of above-mentioned wound gelfoam.
Technical scheme of the present invention is:
For the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 3-7 part, Flos Chrysanthemi Indici 4-8 part, Radix Scutellariae 2-6 part, Radix Isatidis 3-7 part, procaine 0.5-1.5 part, starch 10-20 part.
For the sponge preparation of trauma hemostasis, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 4-6 part, Flos Chrysanthemi Indici 5-7 part, Radix Scutellariae 3-5 part, Radix Isatidis 4-6 part, procaine 0.8-1.3 part, starch 13-18 part.
For the sponge preparation of trauma hemostasis, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 5 parts, Flos Chrysanthemi Indici 6 parts, Radix Scutellariae 4 parts, Radix Isatidis 5 parts, procaine 1 part, starch 15 parts.
4, according to the preparation method of the arbitrary described sponge preparation for trauma hemostasis of claim 1-3, preferred scheme is: step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding the complete variable color of 80-90 DEG C of hot-water soak water, terrine are placed on tile, big fire decocts 1-3 hour, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-2 to-6 DEG C of freezing 24-40 hour;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter step (4) cut immerses in ethanol and soaks 3 times, immerses 0.5-1.5 hour in the ethanol of 60-80% for the first time, and second time immerses 1-3 hour in the ethanol of 70-90%, takes out stand-by in the ethanol of third time immersion 90-100% after 18-24 hour;
(6) ethanol in removing step (5) gained fritter, dry under 40-60 DEG C (preferably 50 DEG C), obturage with paper wrapper, in 100-140 DEG C of dry heat sterilization, be sealed in plastic bag, obtain final product.
Foregoing preparation method, preferred scheme is, the consumption of step (1) hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 1-5 doubly (preferred, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 2-4 doubly, be more preferably, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 3 times).
Foregoing preparation method, preferred scheme is: step (1) adds 73-78 DEG C of hot-water soak to room temperature (preferred, to add 75 DEG C of hot-water soaks to room temperature).
Foregoing preparation method, preferred scheme is: step (3) is put in water-bath and heated, and is heated to 50-70 DEG C and (preferably, puts in water-bath and heat, be heated to 55-65 DEG C; Be more preferably, put in water-bath and heat, be heated to 60 DEG C).
Foregoing preparation method, preferred scheme is: step (3) was-3 to-5 DEG C of freezing 30-34 hours (preferred, freezing 32 hours at-4 DEG C).
Foregoing preparation method, preferred scheme is: step (5) first time immerses 0.8-1.3 hour in the ethanol of 65-75%, second time immerses 1.5-2.5 hour in the ethanol of 75-85%, third time immerses in the ethanol of 93-98% and takes out after 20-22 hour that stand-by (preferred first time to immerse in the ethanol of 70% 1 hour, second time immerse 80% ethanol in 2 hours, third time immerse 95% ethanol in take out after 21 hours stand-by).
Foregoing preparation method, preferred scheme is: step (6) is in 110-130 DEG C of dry heat sterilization (being preferable over 120 DEG C of dry heat sterilizations).
Using method: after traumatic hemorrhage, epistaxis, gets one piece of sponge preparation for trauma hemostasis directly by being pressed in bleeding part.
The pharmacological effect of each crude drug is respectively:
Radix Cirsii Japonici: nature and flavor: sweet, bitter, cold.Gui Jing: GUIXIN, Liver Channel.Effect: cooling blood for hemostasis, removing blood stasis to reduce swelling.Cure mainly: for epistaxis.Spit blood.Hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Flos Chrysanthemi Indici: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, heart channel.Effect: heat-clearing and toxic substances removing.Cure mainly: for furuncle carbuncle, conjunctival congestion and swelling pain.Have a headache dizzy.
Radix Scutellariae: nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rushes down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Isatidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Effect: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Cure mainly: for maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Procaine is local anesthetic.Clinical its hydrochlorate conventional, also known as " novocain ".White crystals or crystalline powder, soluble in water.Toxicity ratio cocaine is low.Add micro-epinephrine in injection, can action time be extended.For infiltration anesthesia, lumbar anesthesia, " block therapy " etc.Except over administration causes central nervous system and cardiovascular system reaction, accidental anaphylaxis, should make skin anaphylactic test before medication.Its metabolite aminobenzoic acid (PABA) can weaken the antibacterial efficacy of sulfonamides.
Starch: starch is the high polymer of glucose, in catering trade also known as starch, general formula is (C6H10O5) n, and being hydrolyzed the disaccharide stage is maltose, and chemical formula is C12H22O11, and obtain monosaccharide (glucose) after complete hydrolysis, chemical formula is C6H12O6.Starch has amylose and amylopectin two class.The former is branchiess helical structure; The latter joins end to end with 24 ~ 30 glucose residues form with α-Isosorbide-5-Nitrae-glycosidic bond, is α-1,6-glycosidic bond at side chain place.Amylose meets iodine in blue, and it is aubergine that amylopectin meets iodine.This is not that starch and iodine there occurs chemical reaction (reaction), and produce and interact (interaction), but starch spiral central cavity be able to hold iodine molecule, by Van der Waals force, both form a kind of black-and-blue misfit thing.Test and prove, independent iodine molecule can not make starch become blue, and that in fact make starch become indigo plant is Iodine molecule ion (I3).Starch is the nutrient stored in plant, and be stored in seed and tuber, the content of starch in all kinds of plant is all higher.
The sponge formulation preparation method that the present invention is used for trauma hemostasis is simple, and selected principle is cheap, and very remarkable to wound haemostatic effect, can good bactericidal haemostatic.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1for the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from (getting 10g for every part): Radix Cirsii Japonici 3 parts, Flos Chrysanthemi Indici 4 parts, Radix Scutellariae 2 parts, Radix Isatidis 3 parts, procaine 0.5 part, starch 10 parts.
The preparation method of the above-mentioned sponge preparation for trauma hemostasis, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding 70 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 1 times, terrine is placed on tile, big fire decocts 1 hour, turns low baking temperature and simmers 10 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 24 hours at-2 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 60% 0.5 hour, and second time to immerse in the ethanol of 70% 1 hour, third time immerse take out after 18 hours in the ethanol of 90% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 40 DEG C, obturage with paper wrapper, in 100 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
embodiment 2for the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from (getting 15g for every part): Radix Cirsii Japonici 7 parts, Flos Chrysanthemi Indici 8 parts, Radix Scutellariae 6 parts, Radix Isatidis 7 parts, procaine 1.5 parts, starch 20 parts.
The preparation method of the above-mentioned sponge preparation for trauma hemostasis, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding 80 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 5 times, terrine is placed on tile, big fire decocts 3 hours, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 40 hours at-6 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 80% 1.5 hours, and second time to immerse in the ethanol of 90% 3 hours, third time immerse take out after 24 hours in the ethanol of 100% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 60 DEG C, obturage with paper wrapper, in 140 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
model case one: Zhu XX, female, 27 years old.Patient is before 1 hour, go on a visit to the seaside together with colleague, accidentally by the little shell incised wound right crus of diaphragm thumb on seashore, in water, do not have pain at once, after disembarkation, sensation right crus of diaphragm thumb pain, also has many blood to bleed, limitation of activity, oneself stops blooding with the alcohol wipe carried with, subsides adhesive bandage, and effect is all not obvious, and kind colleague allows it use the sponge preparation for trauma hemostasis oneself carried with.
Using the embodiment of the present invention 2 gained to be used for the sponge preparation of trauma hemostasis, by gelfoam directly by being pressed in export department position, pressing after 1 minute, hemorrhage obvious minimizing; Press 3 minutes, wound hemostasis, bleeds and stops completely.
embodiment 3for the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from (getting 20g for every part): Radix Cirsii Japonici 4 parts, Flos Chrysanthemi Indici 5 parts, Radix Scutellariae 3 parts, Radix Isatidis 4 parts, procaine 0.8 part, starch 13 parts.
The preparation method of the above-mentioned sponge preparation for trauma hemostasis, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding 73 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 2 times, terrine is placed on tile, big fire decocts 1.5 hours, turns low baking temperature and simmers 15 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-3 freezing 30 hours;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 65% 0.8 hour, and second time to immerse in the ethanol of 75% 1.5 hours, third time immerse take out after 20 hours in the ethanol of 93% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 43 DEG C, obturage with paper wrapper, in 110 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
model case two: Lee XX, man, 13 years old, the student in certain middle school, from June, the always epistaxis of unknown cause, each is all wake up morning, within one week, sometimes can occur 2 times, remove examination in hospital, it is abnormal what does not find yet, but or epistaxis, neighbours see that its symptom tells its father and mother, say sponge preparation effect very good of the present invention for trauma hemostasis, go home to use to son so patient has just bought some.
Use the present embodiment 3 gained to be used for the sponge preparation of trauma hemostasis, get gelfoam directly by being pressed on nostril, after 2 minutes, hemorrhage obvious minimizing, after 4 minutes, blood flow stops.
embodiment 4for the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from (getting 25g for every part): Radix Cirsii Japonici 6 parts, Flos Chrysanthemi Indici 7 parts, Radix Scutellariae 5 parts, Radix Isatidis 6 parts, procaine 1.3 parts, starch 18 parts.
The preparation method of the above-mentioned sponge preparation for trauma hemostasis, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding 78 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 4 times, terrine is placed on tile, big fire decocts 2.5 hours, turns low baking temperature and simmers 25 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 34 hours at-5 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 75% 1.3 hours, and second time to immerse in the ethanol of 85% 2.5 hours, third time immerse take out after 22 hours in the ethanol of 98% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 55 DEG C, obturage with paper wrapper, in 130 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
embodiment 5for the sponge preparation of trauma hemostasis, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Radix Cirsii Japonici 5 parts, Flos Chrysanthemi Indici 6 parts, Radix Scutellariae 4 parts, Radix Isatidis 5 parts, procaine 1 part, starch 15 parts.
The preparation method of the above-mentioned sponge preparation for trauma hemostasis, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding 75 DEG C of hot-water soaks to room temperature, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 3 times, terrine is placed on tile, big fire decocts 2 hours, turns low baking temperature and simmers 20 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, freezing 32 hours at-4 DEG C;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter that step (4) cut immerses in ethanol and soaks 3 times, and first time to immerse in the ethanol of 70% 1 hour, and second time to immerse in the ethanol of 80% 2 hours, third time immerse take out after 21 hours in the ethanol of 95% stand-by;
(6) ethanol in removing step (5) gained fritter, dry at 50 DEG C, obturage with paper wrapper, in 120 DEG C of dry heat sterilizations, be sealed in plastic bag, obtain final product.
experimental example 1embodiment 5 gained is used for the clinical practice of the sponge preparation of trauma hemostasis: in November ,-2013 in August, 2010, hinders bleeding patients 4 hospital's screening 100 exceptions.And being divided into two groups at random, experimental group and matched group, experimental group uses the present embodiment 5 products obtained therefrom, and matched group uses other hemostasis medicine (styptic powder, adhesive bandage etc.).Using method: the sponge preparation of taking in trauma hemostasis directly presses on bleeding part.Curative effect situation criterion: recovery from illness: use 3 minutes, blood flow stops completely, and pain obviously alleviates; Effective: to use 3 minutes, blood flow reduces, and pain is alleviated to some extent; Invalid: use 3 minutes, symptom is unchanged.Result is as shown in table 1.
Table 1: haemostatic effect checking in the sponge preparation 3 minutes of embodiment 5 gained trauma hemostasis
Therapeutic effect: 46 examples (92%) of stopping blooding in using 3 minutes, effective 3 examples (6%), invalid 1 example (2%), total effective rate 98%, successful is better than matched group, uses gained of the present invention to be used for the sponge preparation of trauma hemostasis, for general traumatic hemorrhage, blood will be stopped in 3 minutes, even if hemorrhage serious patient is in 5 minutes, also blood can be stopped.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. for the sponge preparation of trauma hemostasis, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Radix Cirsii Japonici 6 parts, Flos Chrysanthemi Indici 7 parts, Radix Scutellariae 5 parts, Radix Isatidis 6 parts, procaine 1.3 parts, starch 18 parts.
2. the preparation method of the sponge preparation for trauma hemostasis according to claim 1, it is characterized in that, step is as follows:
(1) Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis are together placed in terrine, when adding the complete variable color of 80-90 DEG C of hot-water soak water, terrine are placed on tile, big fire decocts 1-3 hour, turns low baking temperature and simmers 30 minutes slowly, cover lid before ceasing fire, to be cooled to room temperature time, filter;
(2) procaine is added in step (1) gained filtrate, after melting completely, add starch, constantly stir into suspension;
(3) by step (2) gained suspension, put in water-bath and heat, constantly stir, when it becomes the pastel of homogeneous transparent, at-2 to-6 DEG C of freezing 24-40 hour;
(4) step (3) gains are placed in room temperature, make it naturally thaw, the crust formed when excising freezing, is placed in cotton gauze, and pressing makes its moisture flow out completely, needs to be cut into small pieces according to Clinical practice;
(5) fritter step (4) cut immerses in ethanol and soaks 3 times, immerses 0.5-1.5 hour in the ethanol of 60-80% for the first time, and second time immerses 1-3 hour in the ethanol of 70-90%, takes out stand-by in the ethanol of third time immersion 90-100% after 18-24 hour;
(6) ethanol in removing step (5) gained fritter, dry under 40-60 DEG C (preferably 50 DEG C), obturage with paper wrapper, in 100-140 DEG C of dry heat sterilization, be sealed in plastic bag, obtain final product.
3. preparation method according to claim 2, it is characterized in that, the consumption of step (1) hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 1-5 doubly (preferred, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 2-4 doubly, be more preferably, the consumption of hot water be Radix Cirsii Japonici, Flos Chrysanthemi Indici, Radix Scutellariae and Radix Isatidis gross weight 3 times).
4. preparation method according to claim 2, is characterized in that, step (1) adds 73-78 DEG C of hot-water soak to room temperature (preferred, to add 75 DEG C of hot-water soaks to room temperature).
5. preparation method according to claim 2, is characterized in that, step (3) is put in water-bath and heated, and is heated to 50-70 DEG C and (preferably, puts in water-bath and heat, be heated to 55-65 DEG C; Be more preferably, put in water-bath and heat, be heated to 60 DEG C).
6. preparation method according to claim 2, is characterized in that, step (3) was-3 to-5 DEG C of freezing 30-34 hours (preferred, freezing 32 hours at-4 DEG C).
7. preparation method according to claim 2, it is characterized in that, step (5) first time immerses 0.8-1.3 hour in the ethanol of 65-75%, second time immerses 1.5-2.5 hour in the ethanol of 75-85%, third time immerses in the ethanol of 93-98% and takes out after 20-22 hour that stand-by (preferred first time to immerse in the ethanol of 70% 1 hour, second time immerse 80% ethanol in 2 hours, third time immerse 95% ethanol in take out after 21 hours stand-by).
8. preparation method according to claim 2, is characterized in that, step (6) is in 110-130 DEG C of dry heat sterilization (being preferable over 120 DEG C of dry heat sterilizations).
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| CN201510296155.9A Pending CN104841004A (en) | 2014-08-19 | 2014-08-19 | Sponge for arresting bleeding of trauma |
| CN201510296422.2A Pending CN104841005A (en) | 2014-08-19 | 2014-08-19 | Preparation method for sponge preparation for arresting bleeding of trauma |
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| CN201510296422.2A Pending CN104841005A (en) | 2014-08-19 | 2014-08-19 | Preparation method for sponge preparation for arresting bleeding of trauma |
| CN201510296338.0A Pending CN104840999A (en) | 2014-08-19 | 2014-08-19 | Sponge preparation for arresting bleeding of trauma |
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| CN105288699A (en) * | 2015-11-23 | 2016-02-03 | 青岛友诚高新技术有限公司 | External hemostatic sponge and preparation method thereof |
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| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
| CN102038718A (en) * | 2009-10-09 | 2011-05-04 | 伍丽娟 | Fructificatio Lasiosphaerae seu Calvatiae combined drug and applications thereof |
| CN102335449A (en) * | 2011-10-11 | 2012-02-01 | 天津工业大学 | Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing |
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| CN102125682A (en) * | 2011-03-20 | 2011-07-20 | 赵全会 | Traditional Chinese medicine for preventing and treating foot-and-mouth disease of livestock |
| CN103845418B (en) * | 2014-03-25 | 2015-08-05 | 崔新明 | A kind of Chinese medicine composition for the treatment of retinal hemorrhage and uses thereof |
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| CN101596207A (en) * | 2008-06-04 | 2009-12-09 | 上海天龙药业有限公司 | Be used for rapid hemostatic Pharmaceutical composition and preparation method |
| CN102038718A (en) * | 2009-10-09 | 2011-05-04 | 伍丽娟 | Fructificatio Lasiosphaerae seu Calvatiae combined drug and applications thereof |
| CN102335449A (en) * | 2011-10-11 | 2012-02-01 | 天津工业大学 | Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing |
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| CN104189947B (en) | 2015-11-18 |
| CN104841005A (en) | 2015-08-19 |
| CN104189947A (en) | 2014-12-10 |
| CN104841004A (en) | 2015-08-19 |
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