CN104435097A - Medicinal sponge for emergency hemostasis for outdoor injuries and preparation method thereof - Google Patents

Medicinal sponge for emergency hemostasis for outdoor injuries and preparation method thereof Download PDF

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CN104435097A
CN104435097A CN201410604193.1A CN201410604193A CN104435097A CN 104435097 A CN104435097 A CN 104435097A CN 201410604193 A CN201410604193 A CN 201410604193A CN 104435097 A CN104435097 A CN 104435097A
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herba
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张晓莉
李建菊
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
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    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses medicinal sponge for emergency hemostasis for outdoor injuries. The sponge is prepared from the following main raw materials in parts by weight: 3-7 parts of argyreia acuta lour, 4-8 parts of Japanese thirstle root, 2-6 parts of sedum aizoon, 3-7 parts of tropic ageratum herb, 0.1-0.4 part of procaine, 1-5 parts of lonicera japonica, 2-6 parts of peppermint and 60-80 parts of gelatin. The medicinal sponge is simple in preparation method and low in raw material cost, has a remarkable effect on traumatic hemostasis, and can be used for quickly killing bacteria and stopping bleeding.

Description

A kind of medicinal sponge for the injured hemostasis in open air and method for making
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of medicinal sponge for the injured hemostasis in open air and method for making.
Background technology
Wound, refers to the outer damage that health or object cause due to the erosion etc. of the strike of external object, collision or chemical substance.Refer to the emotions such as the indignant worry because producing by external irritant.To record in " numerous Lu Xuntianzhi in spring and autumn road " as Han dynasty Dong Zhong relaxes: " with happy person, outside raw, Thailand also; Spirit person, fills also within raw; If outer Thailand not in fill, much less wound? angryly sympathize melancholy hatred person, the wound of life also; With say the person of encouraging people to do good, life support also.”
Wound, language goes out " Plain Questions distracting patient’s attention to change the flow of QI-blood opinion ".1. one of injury symptoms classification.Refer generally to pounce on the damage of skin caused by tumbling down, muscle, muscles and bones.2., for internal injury caused by excess of seven emotions, refer to that six climate exopathogens exopathogen hindered, as cold, typhoid fever, affection of dampness, Sunstroke etc.Wound comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc.The wounds such as bullet, Jin Ren, traumatic injury, injury by overexertion, can cause integumentary musculature swelling and pain due to blood stasis, hemorrhage, or injury of tendon and muscle fracture, dislocation.Heavy then damage internal organs, or Massive Bleeding, the serious change such as stupor, tic, YANG-depletion collapse can be caused.How burn and scald, caused by high temperature article, boiling water or deep fat or burn and scald etc.The lighter damages skin, red in injury, swollen, hot, bitterly, xerosis cutis or get blister, severe pain; Severe burn and scald then muscle injury, muscles and bones can make analgesis, and wound surface is as leather sample, or wax is white, sallow or carbonization; Serious burn and scald, then it is excessive to hinder face, and apart from outside local symptom, Chang Yin has an intense pain, fire-toxin inside fire attack, body fluid evaporation or ooze out, and can occur that dysphoria, heating, xerostomia are thirsty, oliguria etc., even dead.Cold injury, refers to that human body is damaged by the general caused by low temperature invasion and attack or locality.General cold injury, because of cold being a kind of YIN pathogen, easy impairment of YANG gas, YIN-cold crosses Sheng, and yang-energy is impaired, and lose in warm and promotion blood, then shiver with cold, body temperature declines gradually, pale complexion, bluish lip, and fingernail is livid purple, stolidity, spiritlessness and weakness, or lethargy, hypopnea, and slow pulse is thin.If do not given treatment to, easily lethally to die.Part frozen, mostly occurs in hands, foot, auricle, nose and face position.Fall ill from the beginning of, position of enduring cold is because of cold main spasm, and passages through which vital energy circulates contraction is anxious, and coagulation of QI-blood is smooth, and impact is endured cold the warm and nutrition of local, and cause local skin pale, cold fiber crops, the then swelling that continues is livid purple, itches bitterly scorching hot, or occurs the blister etc. that differs in size, normal easy infection after diabrosis.Insect-animal injury, comprises poisonous snake, the beast of prey, mad dog bites, or scorpion, bee sting wound etc.Swelling and ache, appear in light then local damage, hemorrhage etc.; Heavy then damage internal organs, or Massive Bleeding and dead.Then there is systemic toxicity profiles symptom in venom, as given treatment to not in time, often causes being poisoned to death.Mad dog is bitten, from the beginning of rarely seen local pain, hemorrhage, after wound healing, through one period of incubation period, then can occur agitation, greatly alarmed, gnathospasma, tic, hydrophobia, the probably disease such as wind.
Wound, inevitable in people's daily life, traumatic hemorrhage can cause very large impact to the health of people, when treatment wound, stops blooding, wraps up, fixes, carrying is four basic fundamentals that wound is given first aid to.When implementing the rescue of on-the-spot wound, Field Force will in line with the spirit of humanitarianism of healing the wounded and rescue the dying, and is notifying that nearby while hospital, want calm, promptly carry out field first aid work, its principle is: first rob and rescue afterwards, light after first heavy, slow after first anxious, far away after first near; First stop blooding and wrap up afterwards, more fixing rear carrying.Stop blooding as the first step for the treatment of wound, most important, therefore, trauma hemostasis medicine used and sponge just become most important.
The Chinese patent literature of publication number CN 1097980A (application number 93108804.6) discloses a kind of " chitosan gelatin sponge " by name, and it is made up of gelatin, chitosan, hydrochloric acid, sodium hydroxide, formaldehyde, distilled water.Authorization Notice No. is that the Chinese patent literature of CN 101574539B (application number 200910087274.8) discloses a kind of " a kind of gelfoam and preparation method thereof " by name, it becomes gelatin hydrogel by first carrying out crosslinking with radiation to aqueous gelatin solution, then carries out swelling, lyophilization and forms.
In a word, Chinese medicine achieves certain effect in development gelfoam, but also there is following problem: existing gelfoam, not for trauma hemostasis development, not good enough to the therapeutic effect of trauma hemostasis, needs to be improved further.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is that providing a kind of prepares a kind of medicinal sponge for the injured hemostasis in open air simple, easy to use, there is effect of quick-acting haemostatic powder, bactericidal antiphlogistic, to the treatments for bleeding Be very effective that wound causes.
Another object of the present invention is to provide the preparation method of above-mentioned wound gelfoam.
Technical scheme of the present invention is:
For a medicinal sponge for the injured hemostasis in open air, take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 3-7 part, cirsii japonici,radix 4-8 part, Herba Senecionis Chrysanthemoidis 2-6 part, Herba Agerati Conyzoidis 3-7 part, procaine 0.1-0.4 part, Flos Lonicerae 1-5 part, Herba Menthae 2-6 part, gelatin 60-80 part.
A kind of medicinal sponge for the injured hemostasis in open air, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 4-6 part, cirsii japonici,radix 5-7 part, Herba Senecionis Chrysanthemoidis 3-5 part, Herba Agerati Conyzoidis 4-6 part, procaine 0.2-0.3 part, Flos Lonicerae 2-4 part, Herba Menthae 3-5 part, gelatin 65-75 part.
For a medicinal sponge for the injured hemostasis in open air, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 5 parts, cirsii japonici,radix 6 parts, Herba Senecionis Chrysanthemoidis 4 parts, Herba Agerati Conyzoidis 5 parts, procaine 0.25 part, Flos Lonicerae 3 parts, Herba Menthae 4 parts, 70 parts, gelatin.
For a preparation method for the medicinal sponge of the injured hemostasis in open air, preferred scheme is: step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 30-40 DEG C, 1-3 days is soaked in sealing, and take out on the iron plate that is put in and burns heat, little fire dries 10-20 minute slowly, dries in the air coolly to grind to form smalls to cross 60-80 mesh sieve stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 50-70 minute slowly, and filter, filtering residue is exposed to the sun 1-5 day under being placed in daylight, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 18-25 hour, obtain sponge, in 120-150 DEG C of dry heat sterilization 3-7 minute, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
Foregoing preparation method, preferred scheme is, step (1) adds the Chinese liquor (preferred, to add the Chinese liquor of 35 DEG C) of 33-38 DEG C.
Foregoing preparation method, preferred scheme is: step (1) smalls crosses 65-75 mesh sieve (preferred, smalls crosses 70 mesh sieves).
Foregoing preparation method, preferred scheme is: step (2) little fire is decocted 55-65 minute (preferred, little fire decocts 60 minutes slowly) slowly.
Foregoing preparation method, preferred scheme is: be exposed to the sun 2-4 day under step (2) filtering residue is placed in daylight (preferred, filtering residue is exposed to the sun under being placed in daylight 3).
Foregoing preparation method, preferred scheme is: step (3) standing and drying 20-23 hour (preferred, standing and drying 21 hours).
Foregoing preparation method, preferred scheme is: step (3) was in 130-140 DEG C of dry heat sterilization 4-6 minute (preferred, in 135 DEG C of dry heat sterilizations 5 minutes).
Using method: time injured out of doors, get one piece of medicinal sponge for the injured hemostasis in open air directly by being pressed in bleeding part, just can stop blooding immediately for 1-3 minute.
The pharmacological effect of each crude drug is respectively:
Cortex Hibisci: base is former: be the stem and leaf of Convolvulaceae Caulis et Folium Argyreia eacutae platymiscium Caulis et Folium Argyreia eacutae.The property of medicine " Guangxi book on Chinese herbal medicine a collection of selected materials ": " mildly bitter flavor, sweet, property is put down." function cures mainly: exempt from numbness diuretic, dissipating blood stasis stops blooding, removing toxic substances and promoting tissue regeneration.Cure mainly rheumatic arthralgia, edema, tympanites, cough with asthma, spit blood, leukorrhagia, metrorrhagia, traumatic injury, acute mastitis, furuncle abscess, eczema.
Cirsii japonici,radix: another name horse Ji, brave Ji, cat Ji, field thistle, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), field thistle dish etc.Flavor efficacy is sweet, bitter, the cooler profit of property.Merit arrogates to oneself removing heat from blood, hemostasis, is applicable to treat the multiple hemorrhage caused by bleeding due to blood-heat, as spitting of blood, epistaxis, metrorrhagia, hematuria etc.; Be longer than blood stasis dispelling again, subduing inflammation, granulation promoting evacuation of pus.Can be used for treatment hemorrhoidal hamorrhage acute appendicitis, pain infections toxic swelling, furuncle, scrofula tuberculosis etc.
Herba Senecionis Chrysanthemoidis: base is former: be root or the herb of Compositae Radix Gynurae platymiscium chrysanthemum leaf Radix Notoginseng.Composition: root is containing alkaloid: aureine., senlciphylline, sineciphyllinine, seneciphyllinine etc.Aerial parts contains PEARLITOL 25C, succinic acid, 5-methyl uracil, adenine, ammonium chloride, Radix gynurae segeti bases, rutin.The property of medicine: sweet, micro-hardship, temperature.Function cures mainly: removing blood stasis, detumescence, hemostasis, pain relieving.Cure mainly treating swelling and pain by traumatic injury, traumatic hemorrhage, congestion is spitted blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, dysmenorrhea, stomachache of being retarded by silt puerperal, rheumatalgia, carbuncle sore cellulitis furuncle, worm venom.
Herba Agerati Conyzoidis: base is former: be the herb of Compositae Ageratum plant Ageratum conyzoides.Composition: herb is containing flavonoid: Herba Agerati Conyzoidis flavone A, B, C, Nobiletin, senensetin, lindera pyrite B, etc.Alkaloid: Lycopodium clavatum amine, Echinatin.Triterpenoid compound: freidelin.Sterols: stigmasterol etc.Volatile oil: Herba Agerati Conyzoidis chromene, coumarin etc.Aerial parts contains chromene class: 7-methoxyl group-2,2-dimethyl chromogen alkene, 7,8-dimethoxy-2 etc.The property of medicine: micro-hardship, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, hemostasis, pain relieving.Cure mainly cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, spitting of blood, epistaxis, metrorrhagia, epigastric pain, rheumatic arthralgia, traumatic injury, traumatic hemorrhage, thrush, carbuncle furuncle, eczema pruritus.
Procaine is local anesthetic.Clinical its hydrochlorate conventional, also known as " novocain ".White crystals or crystalline powder, soluble in water.Toxicity ratio cocaine is low.Add micro-epinephrine in injection, can action time be extended.For infiltration anesthesia, lumbar anesthesia, " block therapy " etc.Except over administration causes central nervous system and cardiovascular system reaction, accidental anaphylaxis, should make skin anaphylactic test before medication.Its metabolite aminobenzoic acid (PABA) can weaken the antibacterial efficacy of sulfonamides.
Flos Lonicerae: Flos Lonicerae, having another name called Radix Ophiopogonis " Flos Lonicerae " one comes from Compendium of Material Medica, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Herba Menthae: Herba Menthae another name wild mint, night cease fragrant.Herbaceos perennial, is born in by hill wetland river more, and rhizome grows wild underground.The blue or green gas fragrance of Herb, the florescence 7-9 month, really October phase.Herba Menthae is Chinese conventional Chinese medicine, and young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthae can cause insomnia, but low dose of eating conduces to sleep.
Gelatin: gelatin is the faint yellow powder to yellow, translucent, micro-band gloss or thin slice; Odorless; After humidity, it is easily bacterial decomposition; In water, leaching of a specified duration and imbibition are also softening, and weight can increase 5-10 doubly.Gelatin can be divided into photograph, edible, medicinal and industrial four classes by purposes.Pharmagel selects animal skins, bone and muscle tendon, the senior glue product that the fat-free high protein that the physics and chemistry process through complexity obtains easily is absorbed by the body, have viscosity high, freeze power high, easily the physical characteristics such as to congeal.
A kind of medicinal sponge preparation method for the injured hemostasis in open air of the present invention is simple, and selected principle is cheap, and very remarkable to wound haemostatic effect, can good bactericidal haemostatic.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 one kinds of medicinal sponges for the injured hemostasis in open air, take off the primary raw material stating weight proportion and are prepared from (getting 10g for every part): Cortex Hibisci 3 parts, cirsii japonici,radix 4 parts, Herba Senecionis Chrysanthemoidis 2 parts, Herba Agerati Conyzoidis 3 parts, procaine 0.1 part, Flos Lonicerae 1 part, Herba Menthae 2 parts, 60 parts, gelatin.
The preparation method of the above-mentioned medicinal sponge for the injured hemostasis in open air, step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 30 DEG C, sealing immersion 1 day, take out on the iron plate that is put in and burns heat, little fire dries 10 minutes slowly, dries in the air coolly to grind to form smalls to cross 60 mesh sieves stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 50 minutes slowly, and filter, filtering residue is exposed to the sun under being placed in daylight 1, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 18 hours, obtains sponge, in 120 DEG C of dry heat sterilizations 3 minutes, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
Model case one: Zou XX, man, 27 years old, Harbin personage.Patient plays on de-etiolation mountain together with working together, accidentally by the small stone incised wound right crus of diaphragm thumb on Mount Huang, there is no pain at that time, catch sight of right crus of diaphragm when enjoying scenery when stopping and have pain, also have many blood to bleed, limitation of activity, oneself stops blooding with the alcohol wipe carried with, subsides adhesive bandage, effect is all not obvious, and kind colleague allows it use a kind of medicinal sponge for the injured hemostasis in open air oneself carried with.
Using a kind of medicinal sponge for the injured hemostasis in open air of the embodiment of the present invention 1 gained, by gelfoam directly by being pressed in export department position, pressing after 1 minute, hemorrhage obvious minimizing; Press 2 minutes, wound hemostasis, bleeds and stops completely.
Embodiment 2 one kinds of medicinal sponges for the injured hemostasis in open air, take off the primary raw material stating weight proportion and are prepared from (getting 15g for every part): Cortex Hibisci 7 parts, cirsii japonici,radix 8 parts, Herba Senecionis Chrysanthemoidis 6 parts, Herba Agerati Conyzoidis 7 parts, procaine 0.4 part, Flos Lonicerae 5 parts, Herba Menthae 6 parts, 80 parts, gelatin.
The preparation method of the above-mentioned medicinal sponge for the injured hemostasis in open air, step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 40 DEG C, sealing immersion 3 days, take out on the iron plate that is put in and burns heat, little fire dries 20 minutes slowly, dries in the air coolly to grind to form smalls to cross 80 mesh sieves stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 70 minutes slowly, and filter, filtering residue is exposed to the sun under being placed in daylight 5, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 25 hours, obtains sponge, in 150 DEG C of dry heat sterilizations 7 minutes, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
Embodiment 3 one kinds of medicinal sponges for the injured hemostasis in open air, take off the primary raw material stating weight proportion and are prepared from (getting 20g for every part): Cortex Hibisci 4 parts, cirsii japonici,radix 5 parts, Herba Senecionis Chrysanthemoidis 3 parts, Herba Agerati Conyzoidis 4 parts, procaine 0.2 part, Flos Lonicerae 2 parts, Herba Menthae 3 parts, 65 parts, gelatin.
The preparation method of the above-mentioned medicinal sponge for the injured hemostasis in open air, step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 33 DEG C, sealing immersion 1.5 days, take out on the iron plate that is put in and burns heat, little fire dries 13 minutes slowly, dries in the air coolly to grind to form smalls to cross 65 mesh sieves stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 55 minutes slowly, and filter, filtering residue is exposed to the sun under being placed in daylight 2, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 20 hours, obtains sponge, in 130 DEG C of dry heat sterilizations 4 minutes, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
Model case two: Wu XX, man, 13 years old, the student in certain middle school, when having a summer holiday, play soccer on the playground of study together with classmate, accidentally broken knee, bleed at that time very serious, junior partner is very worried for the moment, do not know how this stops blooding, pungent good Wu is self-contained gained medicinal sponge of the present invention.
Use the present embodiment 3 gained to be used for the medicinal sponge of outdoor injured hemostasis, get gelfoam directly by being pressed on hemorrhage position, after 2 minutes, hemorrhage obvious minimizing, after 3 minutes, blood flow stops.
Embodiment 4 one kinds of medicinal sponges for the injured hemostasis in open air, take off the primary raw material stating weight proportion and are prepared from (getting 25g for every part): Cortex Hibisci 6 parts, cirsii japonici,radix 7 parts, Herba Senecionis Chrysanthemoidis 5 parts, Herba Agerati Conyzoidis 6 parts, procaine 0.3 part, Flos Lonicerae 4 parts, Herba Menthae 5 parts, 75 parts, gelatin.
The preparation method of the above-mentioned medicinal sponge for the injured hemostasis in open air, step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 38 DEG C, sealing immersion 2.5 days, take out on the iron plate that is put in and burns heat, little fire dries 18 minutes slowly, dries in the air coolly to grind to form smalls to cross 75 mesh sieves stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 65 minutes slowly, and filter, filtering residue is exposed to the sun under being placed in daylight 4, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 23 hours, obtains sponge, in 140 DEG C of dry heat sterilizations 6 minutes, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
Embodiment 5 one kinds of medicinal sponges for the injured hemostasis in open air, take off the primary raw material stating weight proportion and are prepared from (getting 30g for every part): Cortex Hibisci 5 parts, cirsii japonici,radix 6 parts, Herba Senecionis Chrysanthemoidis 4 parts, Herba Agerati Conyzoidis 5 parts, procaine 0.25 part, Flos Lonicerae 3 parts, Herba Menthae 4 parts, 70 parts, gelatin.
The preparation method of the above-mentioned medicinal sponge for the injured hemostasis in open air, step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 35 DEG C, sealing immersion 2 days, take out on the iron plate that is put in and burns heat, little fire dries 15 minutes slowly, dries in the air coolly to grind to form smalls to cross 70 mesh sieves stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 60 minutes slowly, and filter, filtering residue is exposed to the sun under being placed in daylight 3, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 21 hours, obtains sponge, in 135 DEG C of dry heat sterilizations 5 minutes, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
The clinical practice of a kind of medicinal sponge for the injured hemostasis in open air of experimental example 1 embodiment 5 gained: the outdoor injured bleeding patients of screening 400 example.And being divided into two groups at random, experimental group and matched group, experimental group uses the present embodiment 5 products obtained therefrom, and matched group uses other hemostasis medicine (styptic powder, adhesive bandage etc.).Using method: time injured out of doors, get one piece of medicinal sponge for the injured hemostasis in open air directly by being pressed in bleeding part, just can stop blooding immediately for 1-3 minute.Curative effect situation criterion: recovery from illness: use 2 minutes, blood flow stops completely, and pain obviously alleviates; Effective: to use 2 minutes, blood flow reduces, and pain is alleviated to some extent; Invalid: use 2 minutes, symptom is unchanged.Result is as shown in table 1.
Table 1: haemostatic effect checking in the sponge preparation 3 minutes of embodiment 5 gained trauma hemostasis
Therapeutic effect: gained medicinal sponge of the present invention is better than matched group for the injured hemostasis successful in open air, total effective rate 99%, use a kind of medicinal sponge for the injured hemostasis in open air of gained of the present invention, for general traumatic hemorrhage, blood will be stopped in 2 minutes, even if blood, in 3 minutes, also can stop by hemorrhage serious patient.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. the medicinal sponge for the injured hemostasis in open air, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 3-7 part, cirsii japonici,radix 4-8 part, Herba Senecionis Chrysanthemoidis 2-6 part, Herba Agerati Conyzoidis 3-7 part, procaine 0.1-0.4 part, Flos Lonicerae 1-5 part, Herba Menthae 2-6 part, gelatin 60-80 part.
2. the medicinal sponge for the injured hemostasis in open air according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 4-6 part, cirsii japonici,radix 5-7 part, Herba Senecionis Chrysanthemoidis 3-5 part, Herba Agerati Conyzoidis 4-6 part, procaine 0.2-0.3 part, Flos Lonicerae 2-4 part, Herba Menthae 3-5 part, gelatin 65-75 part.
3. the medicinal sponge for the injured hemostasis in open air according to claim 1, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Cortex Hibisci 5 parts, cirsii japonici,radix 6 parts, Herba Senecionis Chrysanthemoidis 4 parts, Herba Agerati Conyzoidis 5 parts, procaine 0.25 part, Flos Lonicerae 3 parts, Herba Menthae 4 parts, 70 parts, gelatin.
4., according to the preparation method of the arbitrary described medicinal sponge for the injured hemostasis in open air of claim 1-3, it is characterized in that: step is as follows:
(1) Cortex Hibisci, cirsii japonici,radix, Herba Senecionis Chrysanthemoidis and Herba Agerati Conyzoidis are together placed in crock, add the Chinese liquor of 30-40 DEG C, 1-3 days is soaked in sealing, and take out on the iron plate that is put in and burns heat, little fire dries 10-20 minute slowly, dries in the air coolly to grind to form smalls to cross 60-80 mesh sieve stand-by;
(2) be placed in marmite by Flos Lonicerae and Herba Menthae, little fire decocts 50-70 minute slowly, and filter, filtering residue is exposed to the sun 1-5 day under being placed in daylight, and become smalls stand-by with mortar grinder, filtrate is for subsequent use;
(3) procaine is added in step (2) gained filtrate, after melting completely, add the gelatin processed, put in water-bath and heat, stir in the process of heating and add gained smalls in step (1) and (2), after its mix homogeneously, be placed in yarn box, standing and drying 18-25 hour, obtain sponge, in 120-150 DEG C of dry heat sterilization 3-7 minute, obturage with paper wrapper, be sealed in plastic bag, obtain final product.
5. preparation method according to claim 4, is characterized in that: step (1) adds the Chinese liquor (preferred, to add the Chinese liquor of 35 DEG C) of 33-38 DEG C.
6. preparation method according to claim 4, is characterized in that: step (1) smalls crosses 65-75 mesh sieve (preferred, smalls crosses 70 mesh sieves).
7. preparation method according to claim 4, is characterized in that: step (2) little fire is decocted 55-65 minute (preferred, little fire decocts 60 minutes slowly) slowly.
8. preparation method according to claim 4, is characterized in that: be exposed to the sun 2-4 day under step (2) filtering residue is placed in daylight (preferred, filtering residue is exposed to the sun under being placed in daylight 3).
9. preparation method according to claim 4, is characterized in that: step (3) standing and drying 20-23 hour (preferred, standing and drying 21 hours).
10. preparation method according to claim 4, is characterized in that: step (3) was in 130-140 DEG C of dry heat sterilization 4-6 minute (preferred, in 135 DEG C of dry heat sterilizations 5 minutes).
CN201410604193.1A 2014-10-31 2014-10-31 Medicinal sponge for emergency hemostasis for outdoor injuries and preparation method thereof Pending CN104435097A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1835723A (en) * 2003-06-16 2006-09-20 洛马林达大学医学中心 Deployable multifunctional hemostatic agent
CN103110774A (en) * 2013-01-31 2013-05-22 李浩成 Chinese herbal preparation for treating epistaxis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1835723A (en) * 2003-06-16 2006-09-20 洛马林达大学医学中心 Deployable multifunctional hemostatic agent
CN103110774A (en) * 2013-01-31 2013-05-22 李浩成 Chinese herbal preparation for treating epistaxis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陕西省中医药研究院药剂科: "《中药制剂》", 31 July 1982, 技术陕西科学出版社 *

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