CN102335449A - Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing - Google Patents
Nanometer composite gel dressing containing baicalin and soapstone and preparation method for nanometer composite gel dressing Download PDFInfo
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- CN102335449A CN102335449A CN2011103053717A CN201110305371A CN102335449A CN 102335449 A CN102335449 A CN 102335449A CN 2011103053717 A CN2011103053717 A CN 2011103053717A CN 201110305371 A CN201110305371 A CN 201110305371A CN 102335449 A CN102335449 A CN 102335449A
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Abstract
The invention relates to a nanometer composite gel dressing containing baicalin and soapstone and a preparation method for the nanometer composite gel dressing. The nanometer composite gel dressing containing the baicalin and the soapstone comprises the following ingredients of: alkyl acrylamide monomers, inorganic nanometer soapstone grains, an initiator, a catalyst, the baicalin, deionized water and absolute ethanol. The preparation method comprises the following steps of: (1) dispersing the inorganic nanometer soapstone grains; (2) preparing a gel dressing; (3) purifying the gel dressing; and (4) adsorbing the baicalin by the gel dressing. The preparation method has the core that the nanometer composite gel dressing crosslinkd with the soapstone is soaked in absolute ethanol solution of the baicalin. The nanometer composite gel dressing is high in biocompatibility and antibacterial performance, and can be used for skin trauma, ulcers, burn, scald and other skin diseases. The nanometer composite gel dressing and the preparation method have the advantages that a preparation process is simple, the condition is mild, the transparency and toughness of the dressing are high, and the absorption and release of the baicalin are controllable.
Description
Technical field
The present invention relates to pharmaceutical preparation, inorganic nano material, biomaterial and intelligent macromolecule material field, be specifically related to nano-composite gel dressing that contains baicalin and saponite and preparation method thereof.
Background technology
Hydrogel (hydrogels) is a kind of hydrophilic but water-fast high molecular polymer; In water, a balance volume be can be swelling to rapidly and its shape and three-dimensional space network structure still can be kept; And the deswelling of dewatering under certain conditions, be a class set suction, water conservation, slow release is in one and develop functional high molecule material rapidly.Intelligent aqueous gel capable (intelligent or smart hydrogels) is one type to stimulate as physical stimulation such as heat, gas, electricity, magnetic, mechanics energy and pH value, salinity, chemical substance etc. to external world, can produce the hydrogel that sensitivity responds.Nano-composite gel is that the particles of inorganic material with nano-scale is dispersed in the composite that forms in the hydrogel.Because it has not only kept the functional character of nano material itself, but also rigidity, dimensional stability and the heat stability of nano material merged with the soft wet performance of hydrogel mutually, can obviously improve physical and mechanical properties, the heat stability of hydrogel.
Poly-N-isopropyl acrylic acid amides (PNIPAM) Nanometer composite hydrogel is to study one type of temperature-sensitive hydrogel the most widely; Its temperature-responsive is by hydrophilic amide groups in the molecular structure and the coefficient result of hydrophobicity isopropyl; And owing to added inorganic nano-particle such as hectorite, the gained gel has excellent swelling and mechanical property.Utilize the temperature response performance of thermosensitive hydrogel can realize the automatic perception of ANOMALOUS VARIATIONS such as perilesional temperature, chemical environment are discharged the medicine of aequum automatically.In medical dressing field; The peculiar softness of hydrogel can impel it more effectively to contact with wound; For wound provides a good moist environment; Can be widely used in skin trauma, skin ulcer (decubital ulcer, tuberculosis, mycete, fungal infection etc.), burn, scald and other dermatosis, thereby play the purpose of effective treatment.Prepare the certain medicine of adding in the process at Nanometer composite hydrogel, can reach the local antibacterial function at the wound local sustained release during use.
Radix Scutellariae is the dry root of Labiatae Scutellaria herbaceos perennial Radix Scutellariae, has another name called Radix Scutellariae, mashed heart grass, Chimonanthus salicifolius S.Y.Hu., sub-a kind of reed mentioned in ancient books, bar a kind of reed mentioned in ancient books, Radix Scutellariae etc., is one of China's large medical material commonly used.Its cold in nature, bitter in the mouth has that heat clearing and damp drying, removing heat from blood are antiabortive, effects such as hemostasis and eliminating fire and detoxication, is used for diseases such as treatment heating excessive thirst, cough due to lung-heat, dysentery pyretic stranguria, jaundice due to damp-heat, frequent fetal movement and carbuncle sore tumefacting virus.Modern pharmacology research shows that Radix Scutellariae has antiinflammatory, antibiotic, antiviral, antiallergic, antioxidation, removing free radical, antitumor, neuroprotective unit cell, suppresses aldose reductase activity, stops effects such as calcium channel and apoptosis.The material base of Radix Scutellariae performance pharmacologically active is flavone and flavones ingredient, has separated at present to obtain flavone and flavonols chemical compound kind more than 40, is mainly four kinds of baicalin, aglycon baicalin, wogonoside and aglycon wogonins, all has the antiphlogistic antibacterial effect.Baicalin (baicalin) another name baicalin has anticancer, antibiotic, antiviral, removing oxygen-derived free radicals and antioxidation, analgesic, arrhythmia, blood pressure lowering and calmness, adjusting immunologic function, suppresses effects such as vascular smooth muscle cell proliferation, blood lipid regulation, atherosclerosis.Baicalin is absorbed thereby generate the aglycon baicalin through intestinal flora hydrolysis mostly with the oral way administration.
Chinese patent CN101933996A discloses a kind of pharmaceutical composition and method for preparing and detection method with clearing away heat-fire Detoxication.The pharmaceutical composition crude drug is made up of Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Scutellariae, has fine clearing away heat-fire Detoxication.Chinese patent CN1813781 discloses the application of a kind of heavy dose of baicalin in preparation antiviral or antibacterial-anti-inflammatory drug.Research shows, advantage such as said preparation has antiviral and the anti-inflammation effect is remarkable, and good stability is quality controllable, and toxic and side effects is little.Chinese patent CN1552449 discloses a kind of baicalin cyclodextrin clathrate, preparation and method for preparing; Baicalin and cyclodextrin or derivatives thereof (like beta-schardinger dextrin-, HP-etc.) are processed the baicalin cyclodextrin clathrate; Solved the water solublity problem of baicalin, avoided the toxicity of tween 80, can be prepared into various preparations body; Like various oral formulations, suppository, spray, injection etc., and have that good water solubility, stability are strong, good effect, the little advantage of side effect.
No matter baicalin oral administration or drug administration by injection; Though have taking convenience or absorb advantages such as rapid; But all there is short, shortcoming such as blood drug level descends rapidly, blood drug level rises and falls excessive and bioavailability is low of half-life; Baicalin is introduced in the intelligent gel, can be realized intelligent administration on the one hand, have the effect of antiphlogistic antibacterial on the other hand.
Chinese patent CN101732237A discloses a kind of baicalin thermosensitive gelatin and method for preparing and purposes; This baicalin thermosensitive gelatin mainly is made up of baicalin, poloxamer, solvent, viscosity modifier and antiseptic, when being placed to free flowable translucent solution for 4 ℃, is baicalin thermosensitive gelatin behind the mixing.Liquid in a flowable under the room temperature and receives the phase transformation of temperature influence generation reversibility after mucosa or body fluid contact, and medicine and mucosal tissue are fitted tightly, and is difficult for leaking.After in body fluid, taking place to change mutually, adjustable drug releasing rate.This patent core is to have adopted macromolecule non-ionic surface active agent poloxamer, and promptly the polyoxyethylene poly-oxygen propylene aether block copolymer can be used as emulsifying agent, stabilizing agent, solubilizing agent, absorption enhancer, slow releasing agent and solid dispersion.But because of the baicalin thermosensitive gelatin of being reported is liquid at normal temperatures, bump, be easy to break, thereby ooze out if receive the knife-edge stamp.
The present invention has taken all factors into consideration the temperature sensitivity of nano-composite gel dressing, the physical crosslinking of inorganic nano saponite and the antiphlogistic antibacterial function of baicalin; Near utilize the dressing of alkyl acrylamide class nano-composite gel volume phase transition temperature (VPTT), to stretch or shrink fast conformation change; Nano-composite gel dressing is soaked in the alcoholic solution of baicalin; Through changing temperature, realize controllable release to baicalin, reach the purpose of antiphlogistic antibacterial.
Summary of the invention
A kind of nano-composite gel dressing that contains baicalin and saponite that the objective of the invention is to overcome the deficiency of existing aerogel dressing toughness and antiphlogistic antibacterial property and provide and preparation method thereof; So that pliability is easy to pull well in this gel dressing use; The transparency height is easy to observe; The high hemostasis of swellbility is fast, the antiphlogistic antibacterial performance is good, and regulating and controlling temperature can be realized the automatic release of baicalin medicine.
For realizing above-mentioned purpose, the invention provides a kind of method for preparing that contains the nano-composite gel dressing of baicalin and saponite, comprise the steps:
1) inorganic nano saponite dispersion of nano-particles: under 20～25 ℃, inorganic nano saponite particle is added in the deionized water, stir 10～30min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier alkyl acrylamide class monomer is added in the above-mentioned clear solution reuse ice block cooling to 0～5 ℃; Add initiator, behind stirring 5～25min, the plastic injection quality percent concentration is 0.1～2% aqueous catalyst solution 60～120 μ L; Behind 10～30min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 20～25 ℃, stopped reaction behind 20～50h;
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described saponite.
4) gel dressing is to the absorption of baicalin: under 25 ℃; Baicalin is dissolved in the dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that saponite is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
The mass percent of each component is in step 1 of the present invention～2:
Alkyl acrylamide class monomer: 5-15%
Inorganic nano saponite particle: 0.15-5%
Initiator: 0.05-0.1%
Deionized water: 94.8-79.9%
The mass percent of each component is in the step 4 of the present invention:
Baicalin: 0.001-0.1%
Dehydrated alcohol: 99.9-99.999%
Described alkyl acrylamide class monomer has temperature sensitivity, a kind of for N-Isopropylacrylamide or isopropyl methyl acrylamide.
Described inorganic nano saponite particle is any one in magnesium hectorite, hectorite, magnesium soap stone or the sauconite; Contain metal ions such as silica group and magnesium, lithium, zinc, outward appearance is the white solid powder, but in water after stirring homodisperse; Be clear solution, concrete as:
Lithium magnesium soap stone Na
0.33(Mg
2.67Li
0.33) [Si
4O
10] (OH)
2NH
2O,
Hectorite Na
0.66(Mg
5.34Li
0.66) [Si
8O
20] (OH)
2NH
2O,
Magnesium soap stone Na
0.33Mg
3[Si
3.67Al
0.33O
10] (OH)
2NH
2O,
Sauconite (Na, Li)
x{ (Zn
3-2xLi
x) [Si
4O
10] (OH)
2NH
2O.
Described initiator is Ammonium persulfate. or potassium peroxydisulfate, and described catalyst is any one in tetramethylethylenediamine, 4-methyl-diaminopropane or the sodium sulfite.
Described baicalin is a light yellow crystalline powder, and being dissolved in the mixed solution that obtains in the dehydrated alcohol has a very strong ultraviolet and visible absorption peak at the 278nm place.
The crosslinked nano-composite gel dressing of described saponite is the water white transparency shape, and the nano-composite gel dressing that contains baicalin and saponite is for yellow.
The described nano-composite gel dressing that contains baicalin and saponite is that crosslinked nano-composite gel dressing is soaked in the ethanol solution of baicalin and makes with saponite in the time of 25 ℃.
The described nano-composite gel dressing that contains baicalin and saponite takes place to change mutually when 37 ℃ of human body temperature, and the baicalin micromolecule is discharged from dressing.
Replaceable a kind of in Rhizoma Coptidis and the Radix Isatidis of baicalin in the described nano-composite gel dressing that contains baicalin and saponite.
Compare with other conventional gel dressing and preparation method thereof, the present invention has following advantage:
1. simple, the simple operation of method for preparing, mild condition are lower with the temperature conditions requirement to concentration;
2. inorganic nano saponite particle homodisperse in reaction system plays the physical crosslinking effect in gel preparation course, and the crosslinked nano-composite gel dressing of gained saponite has good transmittance and toughness;
3. because baicalin is a hydrophobic monomer, the present invention adopts the cosolvent of dehydrated alcohol as the crosslinked nano-composite gel of baicalin and saponite, makes baicalin and nano-composite gel dressing combine the shortcoming of having avoided both to be separated;
4. gel dressing composition of the present invention is simple; Biocompatibility and anti-microbial property are good, and convenient in application is quick, and it is big inadequately to overcome the normal gauze dressing liquid absorption that uses clinically at present; Need thick wrapping and often replacing; And after imbibition, be prone to dryly, and stick together with wound and cause the shortcoming of secondary wound and biological dressing (cadaver skin, amniotic membrane): be difficult for obtaining and also the holding time short; Can not use on a large scale, exist spread germs, fungus and the danger of viral disease and the shortcoming of immunological rejection;
5. the anti-inflammation characteristic that contains the nano-composite gel dressing of baicalin and saponite of the present invention can be by baicalin consumption and thermoregulation.
Description of drawings
Fig. 1 is the structural formula of baicalin.
Fig. 2 is the outward appearance that contains the nano-composite gel dressing of baicalin and saponite.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
1) inorganic nano saponite dispersion of nano-particles: under 22 ℃, 0.2g lithium magnesium soap stone is added in the 10mL deionized water, stir 20min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier the 1.0g Isopropylacrylamide is added in the above-mentioned clear solution reuse ice block cooling to 3 ℃; Add the 0.01g Ammonium persulfate., behind the stirring 20min, the plastic injection quality percent concentration is 2% tetramethylethylenediamine aqueous solution 80 μ L; Behind the 15min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 22 ℃, stopped reaction behind the 36h;
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described lithium magnesium soap stone.
4) gel dressing is to the absorption of baicalin: under 25 ℃; The 0.02g baicalin is dissolved in the 1000mL dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that lithium magnesium soap stone is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
Employing ultraviolet-uisible spectrophotometer test, the crosslinked nano-composite gel dressing of 25 ℃ of following gained lithium magnesium soap stone when 60min to the adsorbance of baicalin be 6mg/g, 37 ℃ of interior baicalin burst sizes of following 10min are 72% of maximal absorptive capacity.
Embodiment 2
1) inorganic nano saponite dispersion of nano-particles: under 20 ℃, the 0.1g hectorite is added in the 10mL deionized water, stir 15min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier 1.1g isopropyl methyl acrylamide is added in the above-mentioned clear solution reuse ice block cooling to 2 ℃; Add the 0.01g potassium peroxydisulfate, behind the stirring 15min, the plastic injection quality percent concentration is 1% sodium sulfite aqueous solution 100 μ L; Behind the 20min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 23 ℃, stopped reaction behind the 40h;
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described hectorite.
4) gel dressing is to the absorption of baicalin: under 25 ℃; The 0.05g baicalin is dissolved in the 1000mL dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that hectorite is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
Employing ultraviolet-uisible spectrophotometer test, the crosslinked nano-composite gel dressing of 25 ℃ of following gained hectorites when 60min to the adsorbance of baicalin be 33mg/g, 37 ℃ of interior baicalin burst sizes of following 10min are 81% of maximal absorptive capacity.
Embodiment 3
1) inorganic nano saponite dispersion of nano-particles: under 25 ℃, 0.3g magnesium soap stone is added in the 15mL deionized water, stir 25min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier the 1.5g Isopropylacrylamide is added in the above-mentioned clear solution reuse ice block cooling to 1 ℃; Add the 0.015g Ammonium persulfate., behind the stirring 20min, the plastic injection quality percent concentration is 0.5% 4-methyl-diaminopropane aqueous solution 120 μ L; Behind the 15min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 24 ℃, stopped reaction behind the 48h;
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described magnesium soap stone.
4) gel dressing is to the absorption of baicalin: under 25 ℃; The 0.04g baicalin is dissolved in the 1000mL dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that magnesium soap stone is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
Employing ultraviolet-uisible spectrophotometer test, the crosslinked nano-composite gel dressing of 25 ℃ of following gained magnesium soap stone when 60min to the adsorbance of baicalin be 18mg/g, 37 ℃ of interior baicalin burst sizes of following 10min are 63% of maximal absorptive capacity.
Embodiment 4
1) inorganic nano saponite dispersion of nano-particles: under 20 ℃, the 0.05g sauconite is added in the 11mL deionized water, stir 10min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier 1.1g isopropyl methyl acrylamide is added in the above-mentioned clear solution reuse ice block cooling to 3 ℃; Add 0.011 potassium peroxydisulfate, behind the stirring 20min, the plastic injection quality percent concentration is 2% tetramethylethylenediamine aqueous solution 80 μ L; Behind the 15min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 22 ℃, stopped reaction behind the 36h;
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described sauconite.
4) gel dressing is to the absorption of baicalin: under 25 ℃; The 0.06g baicalin is dissolved in the 1000mL dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that sauconite is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
Employing ultraviolet-uisible spectrophotometer test, the crosslinked nano-composite gel dressing of 25 ℃ of following gained sauconites when 60min to the adsorbance of baicalin be 39mg/g, 37 ℃ of interior baicalin burst sizes of following 10min are 87% of maximal absorptive capacity.
Claims (10)
1. a method for preparing that contains the nano-composite gel dressing of baicalin and saponite comprises the steps:
1) inorganic nano saponite dispersion of nano-particles: under 20～25 ℃, inorganic nano saponite particle is added in the deionized water, stir 10～30min, until disperseing to form clear solution fully;
2) preparation of gel dressing: under nitrogen protection and the magnetic agitation, earlier alkyl acrylamide class monomer is added in the above-mentioned clear solution reuse ice block cooling to 0～5 ℃; Add initiator, behind stirring 5～25min, the plastic injection quality percent concentration is 0.1～2% aqueous catalyst solution 60～120 μ L; Behind 10～30min solution is slowly poured in the glass drying oven that thickness is 2mm; Carry out the original position Raolical polymerizable after the sealing, control reaction temperature is at 20～25 ℃, stopped reaction behind 20～50h:
3) purification of gel dressing: the thin slice that reacted product is cut into about diameter 10mm; Be soaked in each 1 week in deionized water and the dehydrated alcohol respectively; Every interval was changed deionized water and dehydrated alcohol in 8 hours; To remove unreacted monomer, cross-linking agent and various impurity, obtain the crosslinked nano-composite gel dressing of described saponite.
4) gel dressing is to the absorption of baicalin: under 25 ℃; Baicalin is dissolved in the dehydrated alcohol; Be mixed with the ethanol solution of baicalin; The nano-composite gel dressing that saponite is crosslinked is soaked in the ethanol solution of baicalin, promptly obtains the described nano-composite gel dressing that contains baicalin and saponite.
2. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that; The mass percent of each component is in step 1 of the present invention～2: alkyl acrylamide class monomer: 5-15%; Inorganic nano saponite particle: 0.15-5%, initiator: 0.05-0.1%, deionized water: 94.8-79.9%; The mass percent of each component is in the step 4 of the present invention: baicalin: 0.001-0.1%, dehydrated alcohol: 99.9-99.999%.
3. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: described alkyl acrylamide class monomer has temperature sensitivity, a kind of for N-Isopropylacrylamide or isopropyl methyl acrylamide.
4. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: described inorganic nano saponite particle is any one in magnesium hectorite, hectorite, magnesium soap stone or the sauconite; Contain metal ions such as silica group and magnesium, lithium, zinc, outward appearance is the white solid powder, but in water after stirring homodisperse; Be clear solution, concrete as:
Lithium magnesium soap stone Na
0.33(Mg
2.67Li
0.33) [Si
4O
10] (OH)
2NH
2O,
Hectorite Na
0.66(Mg
5.34Li
0.66) [Si
8O
20] (OH)
2NH
2O,
Magnesium soap stone Na
0.33Mg
3[Si
3.67Al
0.33O
10] (OH)
2NH
2O,
Sauconite (Na, Li)
x{ (Zn
3-2xLi
x) [Si
4O
10] (OH)
2NH
2O.
5. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: described initiator is Ammonium persulfate. or potassium peroxydisulfate, and described catalyst is any one in tetramethylethylenediamine, 4-methyl-diaminopropane or the sodium sulfite.
6. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: described baicalin is a light yellow crystalline powder, and being dissolved in the mixed solution that obtains in the dehydrated alcohol has a very strong ultraviolet and visible absorption peak at the 278nm place.
7. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: the crosslinked nano-composite gel dressing of described saponite is the water white transparency shape, and the nano-composite gel dressing that contains baicalin and saponite is for yellow.
8. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1 is characterized in that: the described nano-composite gel dressing that contains baicalin and saponite is that crosslinked nano-composite gel dressing is soaked in the ethanol solution of baicalin and makes with saponite in the time of 25 ℃.
9. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1; It is characterized in that: the described nano-composite gel dressing that contains baicalin and saponite takes place to change mutually when 37 ℃ of human body temperature, and the baicalin micromolecule is discharged from dressing.
10. the method for preparing that contains the nano-composite gel dressing of baicalin and saponite according to claim 1 is characterized in that: replaceable a kind of in Rhizoma Coptidis and the Radix Isatidis of baicalin in the described nano-composite gel dressing that contains baicalin and saponite.
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| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
| CN104189947A (en) * | 2014-08-19 | 2014-12-10 | 张秀华 | Sponge preparation for traumatic hemostasis and preparation method of sponge preparation |
| CN105879046A (en) * | 2016-04-18 | 2016-08-24 | 天津工业大学 | Preparation method of beta-cyclodextrin modified organic hectorite based antibacterial agent |
| CN113521089A (en) * | 2021-07-21 | 2021-10-22 | 河南中医药大学 | Baicalin hydrogel and preparation method thereof |
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| WO2011028579A2 (en) * | 2009-08-26 | 2011-03-10 | The Regents Of The University Of California | Aligning cells on wrinkled surface |
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