CN104857203A - Method for preparing compound anti-cold softgel preparation by using ultrasonic extraction - Google Patents
Method for preparing compound anti-cold softgel preparation by using ultrasonic extraction Download PDFInfo
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- CN104857203A CN104857203A CN201510055120.6A CN201510055120A CN104857203A CN 104857203 A CN104857203 A CN 104857203A CN 201510055120 A CN201510055120 A CN 201510055120A CN 104857203 A CN104857203 A CN 104857203A
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Abstract
The invention provides a method for preparing a compound anti-cold softgel preparation by using ultrasonic extraction. The method adopting Radix Platycodonis, cassia twig, Incised Notopterygium, Herbal Ephedrae, Radix Scutellariae, Radix Puerariae, bitter apricot kernel, dahurian angelica root, Chinese angelica, Divaricate Saposhnikovia Root, dahurian angelica root, Ligusticum wallichii, Acorus gramineus and mint as raw medicines comprises the following steps: drying, crushing, carrying out ultrasonic extraction, carrying out concentration drying to obtain a dry paste, and processing the dry paste to prepare the softgel preparation. Compared with routine solvent extraction methods, the method provided by the invention has the advantages of simple process steps, high extraction rate, short extraction time, energy saving, low production cost, and increase of economic and social benefits; and the softgel preparation prepared in the invention has the advantages of stable quality and good curative effect.
Description
Technical field
What the present invention relates to is the ultrasonic extraction preparation method of compounded anti-cold soft capsule preparation, belongs to technical field of Chinese medicines.
Technical background
Flu, although be a kind of commonly encountered diseases, bring serious impact to the live and work of people, easily causes a lot of complication simultaneously, bring threat to life.Flu cardinal symptom is headache, fever, nasal obstruction, watery nasal discharge etc.
GANMAO RUANJIAONANG is included in " the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation " the 6th, be made up of 14 taste Chinese medicines such as Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Scutellariae, Semen Armeniacae Amarum, Rhizoma Et Radix Notopterygii, Rhizoma Chuanxiong, Radix Saposhnikoviaes, there is obvious diaphoresis, antipyretic, calm, antitussive, eliminate the phlegm, relieving asthma, the multiple effect such as antiinflammatory, antiviral, what cause for affection of exogenous wind-cold has a headache and fever, nasal obstruction watery nasal discharge, the diseases such as aversion to cold is lossless, and joint is ached, laryngopharynx swelling and pain.Not containing any one western medicine composition inside GANMAO RUANJIAONANG composition, safety is good, is the good recipe for the treatment of anemofrigid cold,
In prior art, not yet there is GANMAO RUANJIAONANG extracting the report adopting ultrasonic extraction in preparation, generally adopt organic solvent extraction, but whole technique having the shortcomings such as length consuming time, complex operation, extraction ratio are not high.In recent years, using ultrasonic technology demonstrates certain advantage in extraction Effective Component of Chinese Medicine.This technology utilizes ultrasound wave to produce " mechanical vibration ", the characteristic such as " cavitation phenomenon " and " heat effect ", solid sample is disperseed, increase the contact area between sample and Extraction solvent, improve object and transfer to the transfer rate of liquid phase from solid phase, thus shorten extraction time, reduce energy consumption, extraction ratio improves.
Summary of the invention
The compounded anti-cold soft capsule preparation utilizing ultrasonic extraction to prepare, is characterized in that, the weight proportion of described crude drug is composed as follows:
Rhizoma Et Radix Notopterygii 30g
Radix Angelicae Dahuricae 30g
Semen Armeniacae Amarum 60g
Herba Ephedrae 60g
Ramulus Cinnamomi 45g
Herba Schizonepetae 45g
Radix Saposhnikoviae 30g
Rhizoma Chuanxiong 30g
Rhizoma Acori Graminei 15g
Radix Puerariae 45g
Herba Menthae 15g
Radix Angelicae Sinensis 30g
Radix Scutellariae 60g
Radix Platycodonis 30g
The ultrasonic extraction that utilizes of the present invention prepares compounded anti-cold soft capsule preparation, it is characterized in that being made up of following steps:
(1) band drier is adopted to carry out dried to medical material and pulverize;
(2) Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot, add 4 ~ 5 times to the drinking water of medical material total amount, extract 2 ~ 3 hours, open simultaneously and collect volatile oil device, extract volatile oil with steam distillation;
(3) dropped in ultrasonic extraction tank by remaining for recipe quantity 12 taste medical materials, add 80% ethanol of medical material 4 ~ 5 times amount, supersound extraction 20 ~ 40 minutes, collect extracting solution and put into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract, for subsequent use;
(4) the dry cream pulverizer that step (3) is obtained is pulverized, add the volatile oil that step (2) is obtained, and add adjuvant, mixing;
(5) by step (4) gained drug particles, soft capsule preparation is made.
In one embodiment, step (3) is improved to: dropped in ultrasonic extraction tank by all the other 12 taste medical materials of remaining medicinal residues and recipe quantity in step (2).
In one embodiment, in step (2), extraction conditions seethes with excitement for being heated to.
In one embodiment, in step (3), hyperacoustic power is 150 ~ 250W, ultrasonic temperature 40 ~ 50 DEG C.
In one embodiment, described adjuvant can be one or more in surfactant, antiseptic, suspending agent, antioxidant.
Described surfactant is one or more in polyethylene glycols, tween, propylene glycol, water, vegetable oil; Suspending agent is one or more in xanthan gum, oily wax, Cera Flava, hydroxypropyl emthylcellulose; Antioxidant is one or more in ascorbic acid, malic acid, succinic acid, ethylenediaminetetraacetic acid; Antiseptic is one or more in glycerol, benzoic acid, sorbic acid, benzyl alcohol, butyl p-hydroxybenzoate.
The present invention adopts ultrasonic extraction to extract the effective ingredient in 14 kinds of medical materials, processing step is simple, extraction ratio is high, extraction time is short, energy savings, production cost are low, improve economic benefit and social benefit, obtained soft capsule preparation steady quality, good effect.
Detailed description of the invention
For the ease of understanding the present invention, especially exemplified by following examples.Its effect is understood to be explaination of the present invention but not to any type of restriction of the present invention.
embodiment 1
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 2 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 250W, ultrasonic temperature 50 DEG C, 30 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 2
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 3 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 150W, ultrasonic temperature 40 DEG C, 20 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 3
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 3 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 250W, ultrasonic temperature 60 DEG C, 40 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 4
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 3 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 200W, ultrasonic temperature 50 DEG C, 30 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 5
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 3 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 200W, ultrasonic temperature 60 DEG C, 20 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 6
Band drier is adopted to carry out dried to medical material and pulverize.The Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot and add 4 times to the drinking water of medical material total amount, extracts 3 hours (boiling starts timing), open simultaneously and collect volatile oil device, extract volatile oil with steam distillation.Remaining for recipe quantity 12 taste medical materials are dropped in ultrasonic extraction tank, adds 80% ethanol of medical material 5 times amount, ultrasonic power 150W, ultrasonic temperature 40 DEG C, 40 minutes extraction times, collects extracting solution and puts into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract.Pulverized by dry cream pulverizer, disintegrator sieving net 100 order, add volatile oil and corresponding adjuvant, mixing, make soft capsule preparation, every fills 0.425 gram.
embodiment 7
The present embodiment is the antiinflammatory action research of the soft capsule (embodiment 1) of compound cold-treating medicine:
Laboratory animal, adopts SD rat, body weight 180 ~ 220g, raise 12h daytime/night alternate cycles environment under, temperature 20 ± 1 DEG C, humidity 55 ± 10%, rate of ventilation 20 ± 2 times/time, the pellet of feeding standard, freely ingests and drinks water.The 3 groups: 1st group is divided into be model group at random by body weight; 1st group is soft capsule group of the present invention (4g crude drug kg
-1); 3rd group is positive controls, gives commercially available soft capsule group (4g crude drug kg
-1).
Formal test respectively to be organized rat urethane intraperitoneal injection of anesthesia layback position the same day and is fixed, abdominal part and two groin shave hair, abdominal part minimal incision * is made after routine disinfection, subcutaneous tissue is expanded with vascular forceps, sterilizing cotton balls (weight is 50 ± 1mg) is implanted both sides groin subcutaneous, then sew up wound.Postoperative next day, each test group started gastric infusion, administration group every day at upper and lower noon each administration 1 time by setting dosage.After last administration, animal is put to death in dislocation in 1 hour, strip out cotton balls granulation tissue, reject fatty tissue, weigh after 1 hour in 70 DEG C of oven dryings, after drying, cotton balls weight deducts cotton balls net weight, be granuloma weight, statistics and between more each test group granulomatous weight to evaluate the effect of medicine to inflammation proliferative phase.
Each group of table 1 on rat granuloma swell formed impact (x ± s, n=10)
| Group | Granuloma weight (mg/100g) | Suppression ratio (%) |
| Model group | 33.1±8.9 | - |
| This product soft capsule group | 19.6±5.3** | 40.79 |
| Commercially available soft capsule group | 24.2±7.2* | 26.88 |
Compared with model group, * P<0.05, * * P<0.01; N=10
Compared with model group, soft capsule group of the present invention significantly can alleviate the mice auricle swelling (P<0.05) caused by dimethylbenzene, and antiinflammatory action is obvious.Soft capsule group of the present invention is compared with commercially available soft capsule group, and under dosage same case, the former antiphlogistic effects is better.This experiment shows, compared with commercially available soft capsule group, in this product soft capsule, active constituent content is higher.
embodiment 8
The present embodiment is the refrigeration function research of the soft capsule (embodiment 1) of compound cold-treating medicine:
Laboratory animal, adopts rabbit in 4 week age, body weight 20 ± 2g, raise 12h daytime/night alternate cycles environment under, temperature 20 ± 1 DEG C, humidity 55 ± 10%, rate of ventilation 20 ± 2 times/time, the pellet of feeding standard, freely ingests and drinks water.By 24 rabbit, at room temperature 18 DEG C measure anus temperature, measure 1 time every 1h, survey 5 times altogether.The rabbit that 5 average body temperature difference are no more than 0.5 DEG C is qualified rabbit.Qualified rabbit is divided into 3 groups at random, often organizes 10.3 groups are respectively negative control group (normal saline 10mLkg
-1), the commercially available soft capsule of positive controls (4g crude drug kg
-1), soft capsule group of the present invention (4g crude drug kg
-1).Every rabbit injection typhoid fever first and second triple vaccine 10mLkg
-1after, carry out administration by above-mentioned administering mode immediately.Result shows, and in vaccinate 1 ~ 6h, administration group compares with saline control group, and antipyretic response is remarkable, and wherein the antipyretic speed of soft capsule group of the present invention is faster than commercially available soft capsule group.This experiment shows, compared with commercially available soft capsule group, in this product soft capsule, active constituent content is higher.
Claims (8)
1. a compounded anti-cold soft capsule preparation, is characterized in that, crude drug comprises following Chinese medicine ingredients: Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae, Semen Armeniacae Amarum, Herba Ephedrae, Ramulus Cinnamomi, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Radix Puerariae, Herba Menthae, Radix Angelicae Sinensis, Radix Scutellariae, Radix Platycodonis.
2. compounded anti-cold soft capsule preparation according to claim 1, is characterized in that, the weight proportion of described crude drug is composed as follows:
Rhizoma Et Radix Notopterygii 30g
Radix Angelicae Dahuricae 30g
Semen Armeniacae Amarum 60g
Herba Ephedrae 60g
Ramulus Cinnamomi 45g
Herba Schizonepetae 45g
Radix Saposhnikoviae 30g
Rhizoma Chuanxiong 30g
Rhizoma Acori Graminei 15g
Radix Puerariae 45g
Herba Menthae 15g
Radix Angelicae Sinensis 30g
Radix Scutellariae 60g
Radix Platycodonis 30g.
3. the ultrasonic extraction preparation method of compounded anti-cold soft capsule preparation as described in any one of claim 1-2, it is characterized in that, the method comprises the following steps:
(1) band drier is adopted to carry out dried to medical material and pulverize;
(2) Herba Schizonepetae of recipe quantity, Herba Menthae are dropped in extraction pot, add 4 ~ 5 times to the drinking water of medical material total amount, extract 2 ~ 3 hours, open simultaneously and collect volatile oil device, extract volatile oil with steam distillation;
(3) dropped in ultrasonic extraction tank by remaining for recipe quantity 12 taste medical materials, add 80% ethanol of medical material 4 ~ 5 times amount, supersound extraction 20 ~ 40 minutes, collect extracting solution and put into concentrator, decompression recycling ethanol is also concentrated, and vacuum drying gets dry extract, for subsequent use;
(4) the dry cream pulverizer that step (3) is obtained is pulverized, add the volatile oil that step (2) is obtained, and add adjuvant, mixing;
(5) by step (4) gained drug particles, soft capsule preparation is made.
4. ultrasonic extraction preparation method according to claim 3, is characterized in that, step (3) is improved to, and is dropped in ultrasonic extraction tank by all the other 12 taste medical materials of remaining medicinal residues and recipe quantity in step (2).
5. ultrasonic extraction preparation method according to claim 3, is characterized in that, in step (2), extraction conditions is for being heated to boiling.
6. ultrasonic extraction preparation method according to claim 3, is characterized in that, in step (3), hyperacoustic power is 150 ~ 250W, ultrasonic temperature 40 ~ 50 DEG C.
7. ultrasonic extraction preparation method according to claim 3, is characterized in that, described adjuvant can be one or more in surfactant, antiseptic, suspending agent, antioxidant.
8. ultrasonic extraction preparation method according to claim 7, is characterized in that, described surfactant is one or more in polyethylene glycols, tween, propylene glycol, water, vegetable oil; Suspending agent is one or more in xanthan gum, oily wax, Cera Flava, hydroxypropyl emthylcellulose; Antioxidant is one or more in ascorbic acid, malic acid, succinic acid, ethylenediaminetetraacetic acid; Antiseptic is one or more in glycerol, benzoic acid, sorbic acid, benzyl alcohol, butyl p-hydroxybenzoate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158178A (en) * | 2017-06-27 | 2017-09-15 | 洛阳君山制药有限公司 | A kind of preparation technology of soft capsule for treating common cold |
| CN112587601A (en) * | 2020-12-26 | 2021-04-02 | 贵州健兴药业有限公司 | Improved cold medicine composition and its prepn |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259197A (en) * | 2007-03-09 | 2008-09-10 | 广州王老吉药业股份有限公司 | Medicinal composition for treating cold and preparation thereof |
-
2015
- 2015-02-03 CN CN201510055120.6A patent/CN104857203A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259197A (en) * | 2007-03-09 | 2008-09-10 | 广州王老吉药业股份有限公司 | Medicinal composition for treating cold and preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编: "《卫生部药品标准中药成方制剂》", 31 December 1992 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158178A (en) * | 2017-06-27 | 2017-09-15 | 洛阳君山制药有限公司 | A kind of preparation technology of soft capsule for treating common cold |
| CN112587601A (en) * | 2020-12-26 | 2021-04-02 | 贵州健兴药业有限公司 | Improved cold medicine composition and its prepn |
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Application publication date: 20150826 |