CN104857168A - Application of agilawood - Google Patents
Application of agilawood Download PDFInfo
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- CN104857168A CN104857168A CN201510342740.8A CN201510342740A CN104857168A CN 104857168 A CN104857168 A CN 104857168A CN 201510342740 A CN201510342740 A CN 201510342740A CN 104857168 A CN104857168 A CN 104857168A
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- lignum aquilariae
- aquilariae resinatum
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Abstract
The invention relates to the technical field of traditional Chinese medicines, particularly to application of agilawood. Experiments show that the agilawood is an effective medicine for treating tinea manuum and tinea pedis, is convenient, fast in effect and low in cost, has no side effect in treatment, and is safe medication and stable in curative effect, wherein the curative effect reaches up to 98.0%.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly the application of Lignum Aquilariae Resinatum.
Background technology
The tinea manuum and tinea pedis are extremely common fungal infection dermatoses, and in being mainly in, adolescence, male is generally more than women, and in adult, the people of 70-80% has tinea pedis, just weight different and oneself.Be everlasting and increase the weight of summer, winter alleviates, and also has people not heal all the year round.Cure slowly and infectivity, cardinal symptom is vesicle desquamation, floods, thickens with to crack, is characterized in grabbing and more itching, itches and more grab, as treated not in time, but other position sometimes, as caused the tinea manuum and tinea unguium etc., is scratched because itch sometimes, secondary bacterial infection, also can cause time serious fester, infect, inflammation, serious complication can be caused, make troubles social, in life to patient.
The medicine of current treatment beriberi has multiple poultice and powdered drug, but less effective, if particularly use powdered drug solution foot bath to be coated with its affected part with cream drug more for many years, not only can not cure beriberi, often make the both sides of foot generate thick hard cocoon, thus increase the difficulty of curing.
Lignum Aquilariae Resinatum is the core that thymelaeceae Lignum Aquilariae Resinatum belongs to Aquilaria plant and contains resin, is a kind of traditional rare medicinal herbs and natural perfume material.The main component of Lignum Aquilariae Resinatum is sesquiterpenoids, chromone class and some volatile ingredients.Lignum Aquilariae Resinatum acrid in the mouth, hardship, slightly warm in nature, has promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, effect of helping inspiration to relieve asthma, is used for the treatment of the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration etc.But the treatment that Lignum Aquilariae Resinatum is used for the tinea pedis tinea manuum have not been reported.
Summary of the invention
In view of this, the invention provides the application of Lignum Aquilariae Resinatum.Experiment shows, Lignum Aquilariae Resinatum is the active drug of the treatment tinea manuum, tinea pedis, convenient, instant effect, and cost is low, and acomia what side effect incumbent in the treatment, drug safety, stable curative effect, curative effect is up to 98.0%.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides Lignum Aquilariae Resinatum and prepare the application prevented and/or treated in the medicine of fungal infection associated diseases.
In specific embodiments more of the present invention, described fungus is superficial mycosis.
In specific embodiments more of the present invention, described fungus is permitted at least one in blue achorion (Trichophytonschoenleinii ATCC 6950), trichophyton concentricum (Trichophyton concentricum ATCC 4568), acrothesium floccosum (Epidermophyton floccosum ATCC38826), Microsporum ferrugineum (Microsporum ferrugineum ATCC 42560) or trichophyton (Trichophyton rubrumATCC 28188).
In specific embodiments more of the present invention, described disease is that moss is sick.
In specific embodiments more of the present invention, described disease is hands moss or foot moss.
In specific embodiments more of the present invention, the pharmaceutical dosage form of described Lignum Aquilariae Resinatum is linaloe oil.
In specific embodiments more of the present invention, the preparation method of described linaloe oil mixes with water for getting after Lignum Aquilariae Resinatum is pulverized, and heating and refluxing extraction, after oil-water separation, collects oil.
In specific embodiments more of the present invention, the mass ratio of described Lignum Aquilariae Resinatum and described water is 1:(5 ~ 15).
Concrete, in the preparation method of linaloe oil, the extraction time of heating and refluxing extraction is 2 times, each 2 ~ 4h.
In specific embodiments more of the present invention, the preparation method of described linaloe oil mixes with organic solvent for getting after Lignum Aquilariae Resinatum is pulverized, and supersound extraction, removes described organic solvent.
In specific embodiments more of the present invention, described organic solvent is ether, and the volumetric concentration of ether is 100%, and the mass ratio of described Lignum Aquilariae Resinatum and described ether is 1:(5 ~ 15).
Concrete, in the preparation method of linaloe oil, the extraction time of supersound extraction is 2 times, each 0.5 ~ 2h.
Lignum Aquilariae Resinatum is the active drug of the treatment tinea manuum, tinea pedis, convenient, instant effect, and cost is low, and acomia what side effect incumbent in the treatment, drug safety, stable curative effect, curative effect, up to 98.0%, has great clinical meaning.
Detailed description of the invention
The invention discloses the application of Lignum Aquilariae Resinatum, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination, realize and apply the technology of the present invention.
In the application of Lignum Aquilariae Resinatum provided by the invention, raw materials used and reagent all can be buied by market.Wherein, described fungus is for being permitted blue achorion (Trichophyton schoenleinii ATCC 6950), trichophyton concentricum (Trichophyton concentricum ATCC 4568), acrothesium floccosum (Epidermophytonfloccosum ATCC38826), Microsporum ferrugineum (Microsporum ferrugineum ATCC42560), trichophyton (Trichophyton rubrum ATCC 28188).
Below in conjunction with embodiment, set forth the present invention further:
Embodiment 1
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add the ether merceration supersound extraction 2 times that 2.5L volumetric concentration is 100%, each 2h, except after desolventizing linaloe oil.
Embodiment 2
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add the ether supersound extraction 2 times that 5L volumetric concentration is 100%, each 30min, except after desolventizing linaloe oil.
Embodiment 3
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add the ether supersound extraction 2 times that 7.5L volumetric concentration is 100%, each 1h, except after desolventizing linaloe oil.
Embodiment 4
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add 2.5L water heating and refluxing extraction 2 times, each 4h, after oil, water are separated, obtain linaloe oil.
Embodiment 5
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add 5L water heating and refluxing extraction 2 times, each 2h, after oil, water are separated, obtain linaloe oil.
Embodiment 6
Get Lignum Aquilariae Resinatum medical material, clean, decontamination, after pulverizing, take 500g, add 7.5L water heating and refluxing extraction 2 times, each 3h, after oil, water are separated, obtain linaloe oil.
Embodiment 7
Strain: provide following five kinds of funguses by China Microbiological preservation committee fungus center of preserving: permitted blue achorion, trichophyton concentricum, acrothesium floccosum, rust little armful of daughter bacteria and trichophyton.
Wherein, described fungus is for being permitted blue achorion (Trichophyton schoenleinii ATCC 6950), trichophyton concentricum (Trichophyton concentricum ATCC 4568), acrothesium floccosum (Epidermophyton floccosum ATCC38826), Microsporum ferrugineum (Microsporumferrugineum ATCC 42560), trichophyton (Trichophyton rubrum ATCC 28188).
Linaloe oil is prepared according to embodiment 1,2,3,4,5 and 6.
Method adopts sabouraud culture medium in vitro medicine base method.Culture medium is through 121 DEG C of autoclaving 15min, be cooled to 50 DEG C, respectively embodiment 1, 2, 3, 4, linaloe oil and the clotrimazole powder of 5 and 6 preparations add in each test-tube culture medium, mix homogeneously, making it containing linaloe oil concentration (g/L) is 10.0, 5.0, 2.5, 1.25, 1.0, 0.5, 0.25, 0.0 (blank), concentration (mg/L) containing clotrimazole powder is 500.0, 200.0, 100.0, 50.0, 25.0, 12.5, 6.25, 0.0 (blank), these 5 kinds of funguses are inoculated on the pharmaceutical culture medium of two groups of respective variable concentrations respectively later, put into incubator, observe 2 weeks, repeat experiment 3 times.
The fungus inhibitory action of the linaloe oil of 6 embodiment gained is identical, and it the results are shown in Table 1.
The fungus inhibitory action of clotrimazole powder is in table 2.
The fungus inhibitory action of table 1 linaloe oil
(-) antibacterial (+) growth MIC 1.25-2.5g/L
The fungus inhibitory action of table 2 clotrimazole powder
(-) antibacterial (+) growth MIC 50-100mg/L
Linaloe oil to permitted blue achorion, trichophyton concentricum, acrothesium floccosum, rust little armful of daughter bacteria and trichophyton minimal inhibitory concentration (MIC) be 1.25-2.5g/L, the MIC of clotrimazole powder is 50-100mg/L, prove that its anti-mycotic efficiency is reliable, can be used as the Therapeutic Method of tinea pedis and the tinea manuum.
The clinical trial of embodiment 8 linaloe oil
Tinea pedis diagnostic criteria:
1. water scar type tinea pedis, be apt to occur in the 2nd, 3, between 4 toes, the palm hesitates, refers to side and sufficient lateral margin, shows as gregariousness heavy wall water scar, can in the form of a ring or arcuation arrangement, play is itched, flowing water after ulceration, and secondary infection can form fester, is mainly seen in summer;
2. macerative erosive tinea pedis, be apt to occur in the 3rd, 4 or 4, between 5 toes, show as between toe and toe is bent side moist skin, is turned white, softening, in beancurd sheet shape, be easy to peel off, expose scarlet rotten to the corn face, companion's stench and tumor are itched, normal secondary infection causes erysipelas, lymphangitis, and summer is common, also has send out patient autumn and winter;
3. squama keratinization type tinea pedis, comparatively common, be apt to occur in autumn and winter season, mainly hesitate at the palm, refer to, between toe and veutro, also can spread to hands, instep and heel, show as annular little squama, small pieces squama or dark red patch, constantly come off, easily repeatedly occur, xerosis cutis is coarse, and dermatoglyph obviously accompanies desquamation skin shame to split, border is more clear, tumor can be had to itch, have pain when shame is split, the summer in Chang Yushui scar type winter alternately occurs.
The diagnostic criteria of the tinea manuum:
1, vesicle squama type: onset many between the centre of the palm and thumb, forefinger position, onset is anxious, based on vesicle, troops or is dispersed in.Its infringement starts from the centre of the palm or ringed finger root place, normal one-sided hands morbidity, show as local skin itch, rubescent, on have pinhead-sized vesicle, wall thickness, shinny and not easily ulceration, many clusterings, subcutaneous in Semen setariae shape, after a couple of days, bleb liquid absorbs desquamation, and squama is neckline shape, and skin lesion spreads diffusion more towards periphery.Acute pruritus, if scratch skin lesion, easily forms erosion.Do not scratch person, treat that vesicle is dry and can occur cracking, decortication, often adhering in edge has squama, and skin lesion can expand to surrounding gradually, ringwise or polycyclic.
2, keratinization incrassation type: can betide one hand, also can betide both hands, shows as the annular desquamation speckle without obvious vesicle.In the course of time, can occur that the full palm or large portion fill the air rubescent, palm skin thickens, coarse, dermatoglyph intensification etc., Ru Ezhang.Winter due to pachylosis plump, also there will be chap, hemorrhage and pain.Often turn out trichophyton and acrothesium floccosum.Fingers and palms are easily caused to stretch limited.
Therapeutic scheme:
With linaloe oil of the present invention, patient is treated, linaloe oil of the present invention is smeared affected part, once a day, within 2-3 days, effectively, within general 7 days, can cure, after 7 days, add up curative effect, check after 2 years.
Efficacy assessment standard:
Cure: symptom disappears completely, and without recurrence in 2 years;
Effective: symptom disappears substantially, or symptom is obviously improved, and still needs continual cure;
Invalid: symptom is not improved, other drug treatment need be used instead.
Statistical procedures:
Treat 1100 people with linaloe oil prepared by the embodiment of the present invention 1 to 6, the lighter smears affected part every day once, and severe one is respectively smeared once every day sooner or later, as follows to treatment patient census's structure of 3-7 days: male 550 people, female 550 people, age 7-80 year, wherein 7-16 year 185 people, 17-60 year 815 people, more than 60 years old 100 people, cure 890 people, account for 80.9% of sum, effective 196 people, account for 17.8% of sum, invalid 22 people, account for 2.0% of sum, total effective rate reaches 98.0%.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. Lignum Aquilariae Resinatum is preparing the application prevented and/or treated in the medicine of fungal infection associated diseases.
2. application according to claim 1, is characterized in that, described fungus is superficial mycosis.
3. application according to claim 1 and 2, is characterized in that, described fungus is permitted at least one in blue achorion, trichophyton concentricum, acrothesium floccosum, rust little armful of daughter bacteria or trichophyton.
4. application according to any one of claim 1 to 3, is characterized in that, described disease is that moss is sick.
5. application according to any one of claim 1 to 4, is characterized in that, described disease is hands moss or foot moss.
6. application according to any one of claim 1 to 5, is characterized in that, the pharmaceutical dosage form of described Lignum Aquilariae Resinatum is linaloe oil.
7. application according to claim 6, is characterized in that, the preparation method of described linaloe oil mixes with water for getting after Lignum Aquilariae Resinatum is pulverized, and heating and refluxing extraction, after oil-water separation, collects oil.
8. application according to claim 7, is characterized in that, the mass ratio of described Lignum Aquilariae Resinatum and described water is 1:(5 ~ 15).
9. application according to claim 6, is characterized in that, the preparation method of described linaloe oil mixes with organic solvent for getting after Lignum Aquilariae Resinatum is pulverized, and supersound extraction, removes described organic solvent.
10. application according to claim 9, is characterized in that, described organic solvent is ether, and the volumetric concentration of ether is 100%, and the mass ratio of described Lignum Aquilariae Resinatum and described ether is 1:(5 ~ 15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510342740.8A CN104857168B (en) | 2015-06-19 | 2015-06-19 | The application of agalloch eaglewood |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510342740.8A CN104857168B (en) | 2015-06-19 | 2015-06-19 | The application of agalloch eaglewood |
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| CN104857168A true CN104857168A (en) | 2015-08-26 |
| CN104857168B CN104857168B (en) | 2019-04-12 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999013A (en) * | 2016-07-28 | 2016-10-12 | 杨锦玲 | Aquilariae lignum resinatum collateral activating oil and preparation method thereof |
| CN106075251A (en) * | 2016-08-23 | 2016-11-09 | 杨锦玲 | Chinese medicine composition, its preparation and preparation method |
| WO2022147702A1 (en) * | 2021-01-07 | 2022-07-14 | 启动生物科技股份有限公司 | Antibacterial use of agarwood extract and composition thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690642A (en) * | 2013-12-10 | 2014-04-02 | 曾瑞光 | Herbal footbath powder for treating beriberi |
| CN104001148A (en) * | 2014-06-24 | 2014-08-27 | 李文职 | Traditional Chinese medicine preparation for treating dermatophytosis |
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2015
- 2015-06-19 CN CN201510342740.8A patent/CN104857168B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690642A (en) * | 2013-12-10 | 2014-04-02 | 曾瑞光 | Herbal footbath powder for treating beriberi |
| CN104001148A (en) * | 2014-06-24 | 2014-08-27 | 李文职 | Traditional Chinese medicine preparation for treating dermatophytosis |
Non-Patent Citations (2)
| Title |
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| 李广勋主编: "《中药药理毒理与临床》", 31 December 1992, 天津科技翻译出版公司 * |
| 王纪保等主编: "《临床实用药物概要》", 31 March 1993, 陕西科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999013A (en) * | 2016-07-28 | 2016-10-12 | 杨锦玲 | Aquilariae lignum resinatum collateral activating oil and preparation method thereof |
| CN105999013B (en) * | 2016-07-28 | 2020-02-07 | 海南娜古芳沉香科技有限公司 | Agilawood collateral-activating oil and preparation method thereof |
| CN106075251A (en) * | 2016-08-23 | 2016-11-09 | 杨锦玲 | Chinese medicine composition, its preparation and preparation method |
| WO2022147702A1 (en) * | 2021-01-07 | 2022-07-14 | 启动生物科技股份有限公司 | Antibacterial use of agarwood extract and composition thereof |
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| Publication number | Publication date |
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| CN104857168B (en) | 2019-04-12 |
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