CN104857079A - Traditional Chinese medicine preparation for curing vascular cognitive impairment no dementia - Google Patents
Traditional Chinese medicine preparation for curing vascular cognitive impairment no dementia Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for curing vascular cognitive impairment no dementia. The vascular cognitive impairment no dementia belongs to the category of traditional Chinese medicine dementia and amnesia. The disease is mostly caused by the deficiency of qi and blood caused by agedness and weakness, internal injury of seven emotions and aeipathia wear, kidney essence loss, brain marrow deprived of nourishment, or depression, phlegm stagnation and blood stasis in brain. The traditional Chinese medicine preparation is prepared from the following Chinese medicinal herbs: schisandra lancifolia, many-nerved bauhinia root, root of wallich swallowwort, herb of stickyhair pearleverlasting, doellingeria scaber nees, corallina officinalis, platycarya strobilacea, ipomoea cairica and uraria crinita, and the Chinese medicinal herbs are decocted into decoction with water. Clinical experiments show that the total effective rate is 88.0 percent, and the curative effect is remarkable.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of non-dementia type vascular cognitive impairment.
Background technology
Non-dementia type vascular cognitive impairment (vascular cognitiveimpairment no dementia, VCIND) be vascular factor cause extremely in early days, extremely slight Cognitive function damage, the degree of its Cognitive function damage does not also reach dull-witted standard, between normal and dementia, onset is comparatively hidden, As time goes on the development of the state of an illness, most of VCIND develops into the senile dementia based on angiogenic gradually.Research and practice for many years proves developing into dull-witted patient, in, though western medical treatment has certain curative effect, but can not control or reverse its natural history increased the weight of gradually, but early stage in Cognitive function damage, namely VCIND is before even Cognitive function damage occurs, and carries out All-round intervention, treatment can delay even to reverse dull-witted progress.Therefore, the EARLY RECOGNITION of VCIND patient and pai n nursing, to its progress of prevention, improve patients ' life quality and be significant.Treatment at present to VCIND; there is no clear and definite specific medicament; some cholinesterase inhibitor (CHEI), the agent of brain cell metabolic activation, the nerve cell-protective agents etc. of using improves cognitive function more clinically; delay the state of an illness; extending life; but there is uncertain therapeutic efficacy to cut, the shortcomings such as expensive and side effect is large.In the past few years, applicant utilizes treatment by Chinese herbs clinically, and this is sick, achieves good curative effect, and little in side effect, and treatment cost is low.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of non-dementia type vascular cognitive impairment.There is no the name of disease of non-dementia type vascular cognitive impairment in traditional Chinese medical science ancient documents, according to its clinical manifestation, it should belong to the sick category such as the traditional Chinese medical science " dementia ", " forgetful ".Primary disease many genus deficiency in origin and excess in superficiality, the card of simulataneous insufficiency and excessive.How causing insufficiency of vital energy and blood, kidney essense loss by body deficiency due to old age, internal injury caused by excess of seven emotions, prolonged illness consume etc., brains lose supports, or the stagnation of QI, stagnation of phlegm, blood stasis form in brain.Marrow of suffering from a deficiency of the kidney subtracts, and insufficiency of vital energy and blood is the basis of causing cognitive dysfunction, and obstruction of collaterals by blood stasis, turbid phlegm blocking the clear orifices are the key pathological mechanism causing cognitive dysfunction, between deficiency and excess can mutually each other because of, influence each other.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment non-dementia type vascular cognitive impairment is made up of the Chinese medicine of following weight portion: Fructus Schisandrae lancifoliae 6-9 part, Radix Bauhiniae pemervosae 10-20 part, Radix cynanchi wallichii 20-40 part, Herba Clematidis Meyenianae 8-10 part, Radix Doellingeriae 10-15 part, Flos Spatholirionis longifolii 8-12 part, Fructus Platycaryae strobilaceac 10-14 part, Herba Stellariae paniculigerae 6-10 part, Radix Urariae crinitae 8-12 part.
Preferably, Fructus Schisandrae lancifoliae 7 parts, Radix Bauhiniae pemervosae 15 parts, Radix cynanchi wallichii 30 parts, Herba Clematidis Meyenianae 9 parts, Radix Doellingeriae 12 parts, Flos Spatholirionis longifolii 10 parts, Fructus Platycaryae strobilaceac 12 parts, Herba Stellariae paniculigerae 8 parts, Radix Urariae crinitae 10 parts.
Preparation method decocting makes decoction.
Fang Zhong: Fructus Schisandrae lancifoliae benefit essence is reinforced the kidney; Radix Bauhiniae pemervosae the kidney invigorating gas, cough-relieving, hemostasis; Radix cynanchi wallichii Bu Shen Zhuang waist, bone and muscle strengthening; Herba Clematidis Meyenianae promoting the circulation of QI to relieve pain, stomach invigorating antiinflammatory; Radix Doellingeriae promoting the circulation of QI to relieve pain, promoting blood circulation by removing wind; Flos Spatholirionis longifolii QI and blood regulating, pain relieving; The pleasant pain relieving of Fructus Platycaryae strobilaceac, reduce phlegm, parasite killing, dispel the wind, subside a swelling; Herba Stellariae paniculigerae regulating QI to expel dampness, removing food stagnancy, promoting blood circulation and hemostasis; Radix Urariae crinitae is regulated the flow of vital energy, reduce phlegm, kidney tonifying.
Clinical data
1, physical data originally studies 60 routine cases all from January, 2013 my Out-patient Department and inpatient of in December ,-2013.By meet inclusive criteria 60 routine patients by being divided into treatment group and each 30 examples of matched group at random with regard to computer distributor.Treatment group male 17 example, women 13 example, the age be 55-75 year, the mean age be (64.28 ± 8.09) year, average schooling (6.36 ± 2.78) year; Matched group male 19 example, women 11 example, the age be 54-76 year, the mean age be (64.42 ± 7.96) year, average schooling (6.31 ± 2.74) year.Through statistical procedures, two groups of sexes, age, the course of disease there are no significant difference (P > 0.05).Come off during research 9 routine patients altogether, and wherein treatment group comes off 5 people, and matched group comes off 4 people.Falling-away cause is mainly inpatient and requires suddenly to leave hospital and therapy discontinued, or outpatient's telephone contact is reluctant to accept the rear inspection for the treatment of etc.That finally complete whole clinical research is matched group 26 people, treatment group 25 people, comparing difference not statistically significant (p > 0.05) in 2 groups of patient's Hachinski scorings before sex, age, schooling, treatment, MoCA scoring, P300 wave amplitude, incubation period, ADL scoring, SDSVD scorings etc., has comparability.
2, subtract card about the marrow of suffering from a deficiency of the kidney in the TCM syndrome diagnostic criteria of senile dementia in " new Chinese medicine guideline of clinical investigations (the trying) " of diagnostic criteria with reference to Ministry of Public Health promulgation in 2002, formulate in conjunction with clinical experience.Primary symptom: hypophrenia, Yao Xi Acid is soft, and asthenia is thought sleeping.Secondary disease: witless expression, bradyphrenia, susceptible to fright and fear, vertigo and tinnitus, has heavy feet, and walks difficult, lusterless complexion, urinary incontinence, and stool is from losing, and the thin color of tongue is light, white and thin fur, and deep pulse is thin and delicate.Judge: primary symptom possesses 2 (hypophrenia is indispensable), and secondary disease at least possesses more than 2 persons and can make a definite diagnosis.
3, treatment and care method matched group: give nimodipine tablet (Beijing Beyer Co., Ltd produces, lot number: the accurate word H20003010 of traditional Chinese medicines), 30mg/ sheet, every day 3 times, each 1.Treatment group takes Chinese medicine preparation of the present invention, takes Fructus Schisandrae lancifoliae 7g, Radix Bauhiniae pemervosae 15g, Radix cynanchi wallichii 30g, Herba Clematidis Meyenianae 9g, Radix Doellingeriae 12g, Flos Spatholirionis longifolii 10g, Fructus Platycaryae strobilaceac 12g, Herba Stellariae paniculigerae 8g, Radix Urariae crinitae 10g.Decocting makes decoction, within 4 weeks, is 1 course for the treatment of, treats 6 courses for the treatment of altogether.
Treatments period two groups of patients all give antiplatelet aggregation treatment for vascular risk factors, if the disease such as complicated hypertension, diabetes, hyperlipidemia, infection, all give the treatments such as blood pressure lowering, blood sugar lowering, blood fat reducing, infection, but can not use other have expand blood vessel, regulate neurotransmitter and psychosis etc. effect in, western drug.
Care method: live regular.Keep good hours, strike a proper balance between work and rest, ensure sufficient sleep; Diet is suitable.Enough nutrition should be ensured, limit some again to the disadvantageous food of old people.Suitably participate in sports activites.But do what one is capable of, incremental, do the physical training meeting I and health status a bit at age; Emotion is wanted steadily.Do not watch excitatory very large TV programme, film and participation gambling.Participating in recreational activities (as playing card) also should be suitable, and not night and day, impact is had a rest.
4, criterion of therapeutical effect judges about efficacy assessment standard with reference in Ministry of Public Health " guideline of clinical investigations that new Chinese medicine treatment is dull-witted ", is divided into clinical recovery, effective, effective, invalid level Four.1. clinical recovery: cardinal symptom recovers normal substantially, directed sound, can correctly answer a question, life can be taken care of oneself, and recovers mass society activity; 2. effective: cardinal symptom major part recovers normal, and orientation is substantially sound, answers a question and is in the main true, and life can be taken care of oneself, and reaction is general; 3. effective: main spirits symptom alleviates or partial disappearance to some extent, and daily life is taken care of oneself substantially, answers a question and is in the main true, but reaction is still blunt, and intelligence and personality still have obstacle; 4. invalid: cardinal symptom, without improvement, even continues development.
5, after therapeutic outcome two groups of patient treatments, clinical total effects comparing difference significantly (p < 0.05), shows that treatment by Chinese herbs group clinical efficacy is remarkable.
Table 2 liang group patient clinical comparitive study
Note: p < 0.05.
After treatment, treatment group does not all have significant difference (p > 0.05) in every safety indexes such as three large routine, hepatic and renal function, electrolyte and electrocardiograms with matched group compared with before treatment, illustrate that two medicines have no adverse effects to the every safety index of patient, it is all safe for taking two kinds of medicines.But there is the untoward reaction such as blood pressure slightly declines, skin irritation, gastrointestinal hemorrhage, accidental transient dizziness, headache, flushed face in the afternoon, vomiting, gastrointestinal upset in matched group, after drug withdrawal, symptom alleviates until disappear after the treatment.
Detailed description of the invention
Embodiment one: take Fructus Schisandrae lancifoliae 7g, Radix Bauhiniae pemervosae 15g, Radix cynanchi wallichii 30g, Herba Clematidis Meyenianae 9g, Radix Doellingeriae 12g, Flos Spatholirionis longifolii 10g, Fructus Platycaryae strobilaceac 12g, Herba Stellariae paniculigerae 8g, Radix Urariae crinitae 10g, decocting makes decoction.
Embodiment two: take Fructus Schisandrae lancifoliae 9g, Radix Bauhiniae pemervosae 10g, Radix cynanchi wallichii 40g, Herba Clematidis Meyenianae 8g, Radix Doellingeriae 15g, Flos Spatholirionis longifolii 8g, Fructus Platycaryae strobilaceac 14g, Herba Stellariae paniculigerae 6g, Radix Urariae crinitae 12g, decocting makes decoction.
Embodiment three: take Fructus Schisandrae lancifoliae 6g, Radix Bauhiniae pemervosae 20g, Radix cynanchi wallichii 20g, Herba Clematidis Meyenianae 10g, Radix Doellingeriae 10g, Flos Spatholirionis longifolii 12g, Fructus Platycaryae strobilaceac 10g, Herba Stellariae paniculigerae 10g, Radix Urariae crinitae 8g, decocting makes decoction.
Claims (2)
1. treat a Chinese medicine preparation for non-dementia type vascular cognitive impairment, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Fructus Schisandrae lancifoliae 6-9 part, Radix Bauhiniae pemervosae 10-20 part, Radix cynanchi wallichii 20-40 part, Herba Clematidis Meyenianae 8-10 part, Radix Doellingeriae 10-15 part, Flos Spatholirionis longifolii 8-12 part, Fructus Platycaryae strobilaceac 10-14 part, Herba Stellariae paniculigerae 6-10 part, Radix Urariae crinitae 8-12 part.
2. a kind of Chinese medicine preparation for the treatment of non-dementia type vascular cognitive impairment as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Fructus Schisandrae lancifoliae 7 parts, Radix Bauhiniae pemervosae 15 parts, Radix cynanchi wallichii 30 parts, Herba Clematidis Meyenianae 9 parts, Radix Doellingeriae 12 parts, Flos Spatholirionis longifolii 10 parts, Fructus Platycaryae strobilaceac 12 parts, Herba Stellariae paniculigerae 8 parts, Radix Urariae crinitae 10 parts.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105664030A (en) * | 2016-02-22 | 2016-06-15 | 霍清萍 | Traditional Chinese medicine composition for improving cerebral small vessel disease cognition impairment and preparation method and application thereof |
WO2017079455A1 (en) * | 2015-11-05 | 2017-05-11 | Academia Sinica | Bauhinia extract and uses thereof |
KR102009966B1 (en) * | 2018-06-29 | 2019-08-12 | 나천수 | Composition comprising the extract of platycarya strobilacea as and effective component for treatment, improvement or prevention of stroke |
-
2015
- 2015-05-27 CN CN201510297932.1A patent/CN104857079A/en active Pending
Non-Patent Citations (1)
Title |
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肖姝云等: "调心补肾方治疗非痴呆型血管性认知功能障碍临床研究", 《辽宁中医杂志》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017079455A1 (en) * | 2015-11-05 | 2017-05-11 | Academia Sinica | Bauhinia extract and uses thereof |
CN108778303A (en) * | 2015-11-05 | 2018-11-09 | 中央研究院 | Bauhinia extract and application thereof |
US10610557B2 (en) | 2015-11-05 | 2020-04-07 | Academia Sinica | Bauhinia extract and uses thereof |
US11311592B2 (en) | 2015-11-05 | 2022-04-26 | Academia Sinica | Bauhinia extract and uses thereof |
CN105664030A (en) * | 2016-02-22 | 2016-06-15 | 霍清萍 | Traditional Chinese medicine composition for improving cerebral small vessel disease cognition impairment and preparation method and application thereof |
KR102009966B1 (en) * | 2018-06-29 | 2019-08-12 | 나천수 | Composition comprising the extract of platycarya strobilacea as and effective component for treatment, improvement or prevention of stroke |
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Application publication date: 20150826 |