CN108635443A - A kind of navel paster for treating abdominal distention - Google Patents
A kind of navel paster for treating abdominal distention Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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Abstract
The present invention relates to a kind of navel paster for treating abdominal distention, the ointment of the navel paster is made of active ingredient and medically acceptable auxiliary material, which is characterized in that the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Green peel 11~15%, corydalis tuber 11~15%, Cortex Magnoliae Officinalis 11~15%, the root of three-nerved spicebush 11~15%, Radix Paeoniae Alba 7~10%, Fructus meliae toosendan 4~6%, Rhizoma Atractylodis Macrocephalae 7~10%, the dried immature fruit of citron orange 11~15%, Semen Raphani 11~15%.According to clinical verification, the navel paster significant effect for the treatment of abdominal distention of the present invention, total effective rate reach 88.5%, and without there is any clinical adverse.
Description
Invention field
The present invention relates to medicinal preparations, and in particular to containing in the treatment abdominal distention from the not determining structure of plant
Medicine preparation.
Technical background
Abdominal distention causes dyspepsia stagnation, mechanism of qi to be obstructed, digestive disorder causes, patient mostly because eating and drinking without temperance or feelings will are hindered
Diet is bad, digestive disorder, frequent abdominal distension, have dyspepsia stagnate and abdominal pain sense, when be intended to dislike and vomit, be the main disease of Patients with Chronic Gastritis
Shape, abdominal distention patient account for about the 40~50% of Patients with Chronic Gastritis.Abdominal distention clinical manifestation is big belly and lower abdomen is not swollen,
Belch is then alleviated；Lower abdominal distension and upper abdomen is not swollen, fart alleviate；Notably obstructed, abdominal fullness and distention, dysphoria seriously affect up and down
Normal study, work and the life of people.Doctor trained in Western medicine mostly uses digestive tract power reinforcing medicine Mosapride, and drug effect is very fast, but normal companion
There are an adverse reactions such as dry, dizziness, slight abdominal pain, adverse reaction rate is up to 15% or so.Chinese medicine abdominal distention is gone through
History is long, there is certain advantage.The drug for treating the disease at present is mainly oral medicine.Chinese medicine thinks that the cause of disease of abdominal distention is main
It is that liver-stomach disharmony, weakness of the spleen and the stomach, stagnation of liver qi loses in catharsis, and perverse and unreasonable manner violates stomach and makees epigastric pain, and the dysfunction of the spleen in transport is stomach Qi rising, in
Burnt mechanism of qi blocks and gives birth to feeling of fullness, and the key for the treatment of is inverse, the strengthening the spleen and stomach of soothing the liver drop, the ruffian that disappears analgesic.Traditional Chinese medicine has poison is secondary to make
With small advantage, adverse reaction can be effectively reduced, therefore, seek it is a kind of treat abdominal distention it is significant in efficacy Chinese medicine preparation tool
There is important realistic meaning.
Invention content
Technical problem to be solved by the invention is to provide a kind of navel paster for treating abdominal distention, the navel paster curative effect is aobvious
It writes.
The scheme that the present invention solves above-mentioned technical problem is as follows：
A kind of navel paster for treating abdominal distention, the ointment of the navel paster is by active ingredient and medically acceptable auxiliary material
Composition, which is characterized in that the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Green peel 11~15%, prolongs
Hu rope 11~15%, Cortex Magnoliae Officinalis 11~15%, the root of three-nerved spicebush 11~15%, Radix Paeoniae Alba 7~10%, Fructus meliae toosendan 4~6%, Rhizoma Atractylodis Macrocephalae 7~10%,
The dried immature fruit of citron orange 11~15%, Semen Raphani 11~15%.
In above-mentioned navel paster, the optimum weight percentage of the prepared slices of Chinese crude drugs is：Green peel 12%, corydalis tuber 13% are thick
Piao 13%, the root of three-nerved spicebush 13%, Radix Paeoniae Alba 9%, Fructus meliae toosendan 5%, Rhizoma Atractylodis Macrocephalae 9%, the dried immature fruit of citron orange 13%, Semen Raphani 13%.
The ointment of navel paster of the present invention is prepared by following methods：The prepared slices of Chinese crude drugs are taken, are ground into thin
Vaseline and lanolin, mixing is added in powder.
Chinese medicine thinks that navel is congenital umbilical cord, and the Qishe of the day after tomorrow, for the remittance sea through gas, the vital organs of the human body are originally.Institute of the present invention
The active ingredient for the navel paster stated is by green peel, corydalis tuber, Cortex Magnoliae Officinalis, the root of three-nerved spicebush, Radix Paeoniae Alba, Fructus meliae toosendan, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, Semen Raphani composition.
Fang Zhong, green peel is soothing the liver relieving stagnant Qi, disperse accumulationization are stagnant, are altogether monarch drug in a prescription during gas is wide under Cortex Magnoliae Officinalis, stomach strengthening and digestion promoting；Dried immature fruit of citron orange relieving stagnant Qi disperse accumulation, resolving sputum dissipate
Ruffian, Semen Raphani help digestion and eliminate flatulence, lowering the adverse-rising QI to resolve phlegm, root of three-nerved spicebush promoting qi circulation and relieving pain, open chest solution strongly fragrant, Radix Paeoniae Alba nourishing blood and liver, analgesic in delaying, corydalis tuber
Promoting qi circulation and relieving pain, promoting blood circulation to remove blood stasis, Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis, Fructus meliae toosendan is soothing the liver to expel the heat-evil, promoting qi circulation and relieving pain, it
Can promoting the circulation of qi soft liver analgesic principal drug assistance treat abdominal distention, while can also strengthening the spleen and replenishing qi, release gastral cavity abdomen caused by the spleen deficiency stagnation of the circulation of vital energy
The symptom of distending pain is altogether ministerial drug；Rhizoma Atractylodis Macrocephalae can also restrict green peel, Cortex Magnoliae Officinalis, the dried immature fruit of citron orange, Semen Raphani, corydalis tuber promoting the circulation of qi and the effect of gas consumption,
And it is adjutant.The effect of full side is total to long memorial liver and drops inverse, strengthening the spleen and stomach, and the ruffian that disappears relieves pain, achievees the purpose that treat abdominal distention.
In order to better understand the present invention, technique effect possessed by the present invention will be proved by clinical trial below.
One, clinical data
By 44 abdominal distention patients, two groups are randomly divided into, treatment group is 26 (average ages 21 years old), control group 18
Example (average age 21 years old).Two groups of cases are at age, gender, the course of disease etc. through statistical analysis there was no significant difference (P ＞
0.05) it, is comparable.
Two, diagnostic criteria
Doctor trained in Western medicine：It is chronic gastritis through gastroscope.Chinese medicine：Meet《New Chinese medicine guideline of clinical investigations (tentative)》It is right
The CM syndrome differentiation criterion of syndrome of incoordination between liver and stomach and weakness of the spleen and stomach feeling of fullness.Liver-stomach disharmony：Gastral cavilty turgor, sighing frequently uncomfortable in chest, often because feelings will because
Element and aggravates, attack to alter and have a pain, connect two sides of body bitterly, nausea, belch, stool it is not well, tongue it is thin in vain, veins string；Weakness of the spleen and stomach：Gastral cavity abdomen ruffian
It is full, postemphasis, loss of appetite are eaten, fatigue and weak, nausea is intended to spit, and loose watery stool, tongue nature is light, tongue is white, deep thready pulse, while abdomen occurs
Bitterly, the patient of abdominal distension, belch symptom.
Three, exclusion criteria
1. merging peptic ulcer, polyp of stomach person；2. merging the systems serious disease persons such as the heart, liver, brain, lung, kidney；It is disliked 3. suffering from
Property tumour person；4. gestation or women breast-feeding their children；5. psychiatric patient；6. there is the patient of thoracic and abdominal operation history.
Four, therapy
Treatment group：Navel paster described in Example 1, is attached on SHENQUE acupoint, daily 1 patch, continuous treatment 7 days.
Control group：Oral Domperidone Tablets (Chinese medicines quasi-word H20033864), 1 tablet once, 3 times a day, 15~30 points before meals
Clock is taken, and continuously takes 7 days.
Five, efficacy assessment standard
1, the standard of curative effect evaluation：Tcm syndrome criterion of therapeutical effect, recovery from illness：Symptom, sign disappear or mostly disappear, syndrome integral
Reduce >=95%；It is effective：Symptom, sign are obviously improved, and 70%≤syndrome integral reduces ＜ 95%；Effectively：Symptom, sign have
It improves, 30%≤syndrome integral reduces ＜ 70%；In vain：Symptom, sign are not improved, even aggravating, syndrome integral subtracts
Less less than 30%.
2, symptom integral evaluation criterion：Respectively to (0 point of abdominal distension number：Without this symptom, 1 point：Often abdominal distension 1 time daily, 2
Point：Often daily abdominal distension 2 times, 3 points：Often daily abdominal distension 2 times, 4 points：Frequent daily abdominal distension)；(0 point of abdominal distension degree：Without this disease
Shape, 1 point：Slight abdominal distension, 2 points：Apparent abdominal distension, but can endure, 3 points：Apparent abdominal distension, and feel fidgety, 4 points：Abdominal distension pain is strong
It is strong, can not endure, seriously affect life)；(0 point of belch number：Without this symptom, 1 point：Often daily belch 1 time, 2 points：Through
Often daily belch 2 times, 3 points：Often daily belch 3 times, 4 points：Often belch 4 times or more daily)；(0 point of sour regurgitation：Without this symptom,
1 point：Often daily sour regurgitation 1 time, 2 points：Often sour regurgitation 2 is owed daily, 3 points：Often daily sour regurgitation 3 times, 4 points：Often daily sour regurgitation 4
More than secondary)；(0 point of nausea：Without this symptom, 1 point：It is often 1 time, 2 points nauseous after food daily：Often nausea 2 times after food daily, 3
Point：It is often 3 times, 4 points nauseous after food daily：It is often 4 times nauseous or more after food daily)；(0 point of loss of appetite：Without this symptom, 1
Point：Often daily 1 meal loss of appetite, 2 points：Often daily 2 meal loss of appetite, 3 points：Often daily 3 meal loss of appetite, 4 points：Through
Often loss of appetite, feeling of repletion are strong), (0 point of fatigue and weak：Without this symptom, 1 point：Weakness of limbs once in a while, 2 points：Frequent weakness of limbs,
3 points：The aching and limp inability of whole body, spirit is not good, 4 points：The aching and limp inability of daily whole body, it is listless, influence normal life)..
Six, treatment results
Total data is for statistical analysis using 17.0 statistics softwares of SPSS.Enumeration data, withIt indicates, compares
It is examined using t, ranked data are indicated with number of cases, are compared using rank sum test.P<0.05 indicates that difference has statistical significance.
Statistical result is shown in Table 1~2.
1 two groups for the treatment of abdominal distention effects of table compare
Note：※ indicates treatment group P ＜ 0.05 compared with the control group.
2 two groups for the treatment of average integrals of table compare
Note：※ indicates treatment group P ＜ 0.05 compared with the control group after treatment；# indicates to compare P ＜ before and after treatment with group
0.05。
Can be seen that treatment group from the data in table, total effective rate is higher than control group compared with the control group, and difference has system
Meter learns meaning (P ＜ 0.05), the significant effect of navel paster treatment abdominal distention of the present invention, and total effective rate is up to 92.30%.Two groups
Symptom integral compares before treatment, and difference does not have statistical significance, after treatment, with organizing before and after treatment relatively, integrates significant difference
Symptom integral compares after (P ＜ 0.05) two groups of treatments, and treatment group is less than control group, and difference has statistical significance (P ＜ 0.05).
Clinical study results show that the present invention treats the navel paster of abdominal distention, can be effectively improved abdominal distention symptom, alleviate not
It is suitable, it is significant in efficacy, and without there is any clinical adverse.
Specific implementation mode
Green peel in following embodiments, corydalis tuber, Cortex Magnoliae Officinalis, the root of three-nerved spicebush, Radix Paeoniae Alba, Fructus meliae toosendan, Rhizoma Atractylodis Macrocephalae, the dried immature fruit of citron orange, Semen Raphani are
Medicine materical crude slice.Navel paster described in following embodiments, often the dosage of adhesive plaster is 0.6 gram by crude drug gauge.
Embodiment 1
1, prescription：Green peel 24g, corydalis tuber 26g, Cortex Magnoliae Officinalis 26g, root of three-nerved spicebush 26g, Radix Paeoniae Alba 18g, Fructus meliae toosendan 10g, Rhizoma Atractylodis Macrocephalae 18g, trifoliate orange
Real 26g, Semen Raphani 26g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 160g, lanolin 40g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 2
1, prescription：Green peel 23g, corydalis tuber 27g, Cortex Magnoliae Officinalis 27g, root of three-nerved spicebush 29g, Radix Paeoniae Alba 20g, Fructus meliae toosendan 10g, Rhizoma Atractylodis Macrocephalae 18g, trifoliate orange
Real 23g, Semen Raphani 23g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 140g, lanolin 60g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 3
1, prescription：Green peel 26g, corydalis tuber 23g, Cortex Magnoliae Officinalis 27g, root of three-nerved spicebush 29g, Radix Paeoniae Alba 20g, Fructus meliae toosendan 10g, Rhizoma Atractylodis Macrocephalae 19g, trifoliate orange
Real 23g, Semen Raphani 23g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 170g, lanolin 30g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 4
1, prescription：Green peel 28g, corydalis tuber 26g, Cortex Magnoliae Officinalis 23g, root of three-nerved spicebush 22g, Radix Paeoniae Alba 15g, Fructus meliae toosendan 10g, Rhizoma Atractylodis Macrocephalae 18g, trifoliate orange
Real 28g, Semen Raphani 30g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 180g, lanolin 20g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 5
1, prescription：Green peel 29g, corydalis tuber 27g, Cortex Magnoliae Officinalis 29g, root of three-nerved spicebush 27g, Radix Paeoniae Alba 15g, Fructus meliae toosendan 8g, Rhizoma Atractylodis Macrocephalae 15g, trifoliate orange
Real 23g, Semen Raphani 27g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 160g, lanolin 40g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Claims (3)
1. a kind of navel paster for treating abdominal distention, the ointment of the navel paster is by active ingredient and medically acceptable auxiliary material group
At, which is characterized in that the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Green peel 11~15% prolongs recklessly
Rope 11~15%, Cortex Magnoliae Officinalis 11~15%, the root of three-nerved spicebush 11~15%, Radix Paeoniae Alba 7~10%, Fructus meliae toosendan 4~6%, Rhizoma Atractylodis Macrocephalae 7~10%, trifoliate orange
Real 11~15%, Semen Raphani 11~15%.
2. a kind of navel paster for treating abdominal distention according to claim 1, which is characterized in that the prepared slices of Chinese crude drugs
Weight percent is：Green peel 12%, corydalis tuber 13%, Cortex Magnoliae Officinalis 13%, the root of three-nerved spicebush 13%, Radix Paeoniae Alba 9%, Fructus meliae toosendan 5%, Rhizoma Atractylodis Macrocephalae 9%,
The dried immature fruit of citron orange 13%, Semen Raphani 13%.
3. a kind of navel paster for treating abdominal distention according to claim 1 or 2, which is characterized in that the medicine of the navel paster
Cream is made by following methods：The prepared slices of Chinese crude drugs are taken, fine powder is ground into, vaseline and lanolin, mixing is added.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512867A (en) * | 2018-11-30 | 2019-03-26 | 贵州新融医药科技有限公司 | The Chinese medicine composition for treating abdominal pain |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244248A (en) * | 2008-02-02 | 2008-08-20 | 孟德芹 | Method of preparing traditional Chinese medicine for treating chronic superficial gastritis |
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2018
- 2018-07-28 CN CN201810848732.4A patent/CN108635443A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244248A (en) * | 2008-02-02 | 2008-08-20 | 孟德芹 | Method of preparing traditional Chinese medicine for treating chronic superficial gastritis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512867A (en) * | 2018-11-30 | 2019-03-26 | 贵州新融医药科技有限公司 | The Chinese medicine composition for treating abdominal pain |
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Application publication date: 20181012 |