CN107441369A - A kind of medicine for being used to treat enterogastric diseases - Google Patents
A kind of medicine for being used to treat enterogastric diseases Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The present invention relates to a kind of medicine, is a kind of medicine for being used to treat enterogastric diseases.It is made up of the raw material of following parts by weight：The bletilla striata 25 ~ 40；Rhizoma imperatae 30 ~ 50；The Chinese bulbul 20 ~ 30；The banksia rose 60 ~ 90；Cloves 10 ~ 20；Cassia bark 10 ~ 20；Radish 30 ~ 50；Garden burnet 50 ~ 80.Preparation method includes 1）Prescription drug is extracted with ethanol；2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction；3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；4）Organic matter flavoring and anti-corrosion are carried out, medicine of the present invention is made.The present invention has the advantages of curative for effect, quick, therapeutic domain is wide, has no toxic side effect compared with the medicine for having treated stomach trouble.Spirituosity, suitable most of stomach and intestine patients do not use this product, and because formula is pure Chinese medicine, wherein the overwhelming majority is medicine edible variety, safe to use.
Description
Technical field
The present invention relates to a kind of medicine, is a kind of medicine for being used to treat enterogastric diseases.
Background technology
Modern allegro life causes many people to have ignored health, and especially living and diet does not have rule, causes
Stomach is impaired serious, and various stomach trouble are of common occurrence.
The classical documents of traditional Chinese medicine are always attached great importance to taste,《Ling Shu Miraculous Pivot or Divine Axis, beautiful version》Say " stomach person, sea of QI and blood from water and grain
"；《Element really hides opinion to, beautiful machine》Say and " the five internal organs person, all report gas in stomach；Stomach person, the source of vital essence of five ZANG-organs "；This explanation stomach is particularly significant
Organ, all kinds of diseases and ailments all decline and given birth to by taste.The epigastric pain of traditional Chinese medical science demonstration, contains the peptic ulcer on western medicine, acute and chronic
Gastritis, a series of enterogastric diseases such as gastrospasm and stomach functional disease, this is global frequently-occurring disease, common disease, only gastric ulcer
The incidence of disease just accounts for the 10%-20% of total world population, and recurrence rate is high.It has had a strong impact on the health of people, therefore
How to prevent stomach trouble is the problem that the whole world is concerned about.
Current existing stomach medicine is divided into two kinds of Western medicine and Chinese medicine, and Western medicine has kind more than 100, and Chinese medicine also has nearly hundred kinds.Western medicine exists
Some aspects are quick but cure the symptoms, not the disease, and toxic side effect is big.And existing Chinese patent drug works the slower course for the treatment of relatively mostly
Long, equally there is also certain toxic side effect.The deficiencies of existing stomach medicine also generally existing uncertain therapeutic efficacy simultaneously is determined, and indication is narrower
Part.
The content of the invention
The purpose of the present invention is to provide a kind of medicine for being used to treat enterogastric diseases for above-mentioned weak point, is a kind of
It is quick, therapeutic domain is wide, the medicine having no toxic side effect.
The present invention takes following technical scheme to realize：
A kind of medicine for being used to treat enterogastric diseases is made up of the raw material of following parts by weight：
The bletilla striata 25 ~ 40
Rhizoma imperatae 30 ~ 50
The Chinese bulbul 20 ~ 30
The banksia rose 60 ~ 90
Cloves 10 ~ 20
Cassia bark 10 ~ 20
Radish 30 ~ 50
Garden burnet 50 ~ 80.
Further, the preferable parts by weight of the raw material are：
The bletilla striata 30 ~ 35
Rhizoma imperatae 35 ~ 40
The Chinese bulbul 25 ~ 30
The banksia rose 70 ~ 80
Cloves 15 ~ 20
Cassia bark 15 ~ 20
Radish 35 ~ 45
Garden burnet 60 ~ 80.
The present invention is used for the medicine for treating enterogastric diseases, and its preparation method comprises the following steps：
1）Prescription drug is extracted with ethanol；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；
4）Organic matter flavoring and anti-corrosion are carried out, medicine of the present invention is made.
Step 1）Used in the parts by weight of ethanol be 2.5 ~ 3.5 times, preferably 3 times of medicine material parts by weight.
In step 1）In employ infusion process medicine extracted.
Step 2）In employ distilled water and carry out water extraction, the parts by weight of the distilled water are medicine material parts by weight
2.5 ~ 3.5 times, preferably 3 times.
Step 3）In heating-up temperature be 50~85 °.
Step 4）It is middle that the medicine anti-corrosion level for meeting national standard is used as flavouring, anti-corrosion using syrup.
Medicine of the present invention is herb mixture, and the herb mixture is oral liquid.
The theory and the characteristic of raw material that medicine of the present invention is cured the disease for the traditional Chinese medical science, to be prepared, the traditional Chinese medical science is cured the disease is first
" dialectical ", i.e., analyzed according to illness and distinguish etiology and pathogenesis, characteristic of disease disease position etc., be dialectical clear by controlling then " opinion is controlled "
On the basis of, appropriate therapy is determined to the disease.
The garden burnet that raw material of the present invention use, cooling blood and hemostasis, heat-clearing sore, and broad-spectrum antiseptic；Bletilla striata cooling blood and hemostasis, convergence
Myogenic；Rhizoma imperatae cooling blood and hemostasis, tonifying middle-Jiao and Qi, clearing stomach are promoted the production of body fluid；The Chinese bulbul is clearing heat and detoxicating, removes heat from the blood and relieve diarrhea；The banksia rose uses Aplotaxis auriculata,
Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion；Inverse, dispelling cold warm stomach, and coronary circulation-promoting pain-relieving drop in cloves and cassia bark middle benefit gas；Radish seed removes completely with, helps digestion
Lead stagnant, these raw material are shared, and good effect is played to treating a variety of gastrointestinal diseases.
《Sheng Nong's herbal classic》In it is on the books " bitter, put down.The main pain malignant sore that swells loses subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach, harmful wind ghost
Hit, miliaria is slow not to be received.",《Traditional Chinese medical science various schools of thinkers medicine opinion is assembled》Say that " pharmacological research shows that the bletilla striata has hemostasis, protects ulcer, suppresses knot
Core bacillus etc. acts on.”；King's medicine rain exists《Practical Chinese medicinal》Described in " be used for lung hemoptysis, gastrorrhagia do not recover for a long time or it is repeatedly multiple
Originator has good effect "；Liang Songming exists《Science of prescription》" bletilla striata can not only stop blooding, and have and promote healing of focus for middle record
Effect.... also there is preferable ponding to Gastroduodenal perforation.”；Zunyi Medical College《Conventional herbal medicine is newly organized》Then use
Case is described that " bletilla striata powder, often takes 3-6 grams, day controls digestive ulcerative bleeding 69 3-4 times, average to the effect of bletilla striata
Stool turns Huang within 5.17 days.Supplying cuttlefish bone meal and aluminium hydroxide gel control peptic ulcer perforation 31, fully recover 29, and cure rate is
93.5%.”；《On dictionary of medicinal plant》With《Modern Chinese herbal medicine clinic handbook》Anastalsis and antibacterial action Zuo Liao sections all to the bletilla striata
Identification is learned, the bletilla striata is had also been proposed to and contains a kind of broad-spectrum anti-tumor composition, repair vascular defects, perforated ulcer etc. is blocked and makees
With；Li Xiaorui exists《Modern Chinese herbal medicine clinic handbook》It is middle to say that " this product bitter drop, sweet to mend, and puckery can receive of property can hold back, and work(specially stops blooding
Expelling pus and promoting granulation, therefore to treat mass formed by blood stasis, the panacea of sore.”
《National Chinese herbal medicine compilation, the first volume》The pharmacological action of the Chinese bulbul is described, Chinese bulbul decoction can suppress Amoeba
Growth, the minimum effective concentration that can kill Trichomonas vaginalis is 2 mg/mls；Found in bacteriostatic test, Chinese bulbul decoction pair
Staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli have inhibitory action；The Chinese bulbul
It is known as calm, analgesia and anti-spasm effect.It is mainly used in damp and hot or heat toxin rush down dysentery heating, stomachache, tenesmus, purulent and bloody stool
Deng.
《Compendium of Materia Medica》Point out " banksia rose, to be the medicine of three burnt qi leels, all gas can be lifted.... middle gas is not transported, and comes under spleen,
Therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance.”；《Japan hanako materia medica》Say that the banksia rose " controls all gas of trusted subordinate, antidiarrheal, cholera, dysentery
Disease, antiabortive, reinforcing spleen to promote digestion, thin bad, bladder crymodynia is treated, it is vomiting and regurgitation.”；Modern research suggests that " banksia rose is to dredge antalgesic.With
In internal organs contraction hernia and all functionality pain, inflatable, there is the effect of spasmolysis and analgesia, especially more notable to digester system "（King's medicine rain
《Practical traditional Chinese medicine》）；Feng Ruoshui exists《Basic Theories of Chinese Medicine knowledge》It is middle that the function of the banksia rose is summarised as to " warm stomach, warm spleen, lets out three
It is burnt ".
《Modern Chinese herbal medicine clinic handbook》Identification of the modern science and technology to radish seed is summarized, is said in pharmacology and application
" radish seed water extract has obvious inhibitory action to staphylococcus, Escherichia coli.... still there is anti-inflammatory and antalgic, removing toxic substances etc. to make
With.", capillary effect army in the note of the chapters and sections conclusion for " this product work(arrogates to oneself promoting digestion and removing indigestion, and de-swelling row is stagnant, is most suitable for accumulation of food in the stomach and intes tine due to indigestion, in
Burnt stagnation of the circulation of vital energy person.”
Among these raw material, using garden burnet as main ingredient（That is major ingredient）,《Book on Chinese herbal medicine is looked for the truth》Point out that " cloud garden burnet can be clear in one book
Drop, and can inducing astrigency, then it is clear do not consider it and cross let out, puckery also not consider that it is excessively stagnant, actually antipyretic hemostatic ",《Herbal justice》In mention
" garden burnet bitter cold, it is special agent ... ... the blood-head fire victory of cool blood, then dislikes meat bitterly more.”；《Modern Chinese herbal medicine clinic handbook》In point out
" this product hardship can drop, and acid can be received, and trembling with fear can be clear, and work(arrogates to oneself blood-stanching and blood-cooling, to control the key medicine that intestines wind, hemorrhoid, ulcer are had blood in stool ", the book is quoted
Zhu's step first writes《Zhu Liang spring medication experiences》Say " Zhu Liangchun think this product not only can heat-clearing, cool blood, astringing to arrest bleeding, and to ulcer
The alcove of disease has the work(that cuticula treats sore, takes during non-only bleeding, is still used as canker conventional treatment drug.... face card and find to be somebody's turn to do
Medicine life anastalsis relatively fries carbon to be excellent, and opinion is without exception raw to be used, it is not necessary to fries carbon；On dosage, break through it is conventional, largely with to 30-
60 grams, have no adverse reaction, and the You Jie that makes contributions.... residence is puckery during this product is logical, eliminating evil and without the disadvantage of consumption the moon that is impairment of the kidney, it is sincere it is non-other its
He can compare at the light product for oozing clear profit ".
Liang Songming is edited《Science of prescription》In addition to approval document above and modern each view, also say that experiment proves " this
Product have broad-spectrum antibacterial action ", another portion is edited by Wang Huiwu《Traditional Chinese medical science various schools of thinkers medicine opinion is assembled》" pharmacological research is said in note
Show, garden burnet has the effects such as stop blooding, town is told, be antibacterial.The clinical preparation based on garden burnet, for ileotyphus, tumor of bladder, bacterium
Dysentery, UGB, cervical erosion etc. have good therapeutic effect ".《On dictionary of medicinal plant》Record《Kunming common drug among the people》
There is " treating for stomachache, gastrointestinal bleeding " under garden burnet bar, describe clinical report again：50 grams of garden burnet matches somebody with somebody 25 grams of decoctings of oldenlandia diffusa, day 2
To 3 times, 57 ileotyphus of 4-14 year children are treated, cure rate 86%, are brought down a fever average 7.3 days, most short 2 days, experiment proved 1:
5 or 1:10 Sanguisorbae Decoction has bacteriostasis, and no side effects occurs in treatment.Therefore, the present invention regard garden burnet as this medicine
Main ingredient, other raw material are as adjuvant.
Advantage of the present invention：Clearing away heat pathogen is intended to, mechanism of qi is dredged and eliminates carbuncle swells, hemostasia and promoting granulation, calm down inflammation so as to reach,
Ulcer is made up, and spleen and stomach function recovers normal purpose；As a result of cold Wen Tongyong, the therapy that only row develops simultaneously, no matter therefore real heat
It can all be proved effective with the cold of insufficiency type, and analgesic therapy hemostasis is very rapid.Compared with the medicine for having treated stomach trouble, have it is curative for effect, take effect
It hurry up, therapeutic domain is wide, the advantages of having no toxic side effect.This product not spirituosity, be adapted to most of stomach and intestine patients to use, due to
Side is pure Chinese medicine, and wherein the overwhelming majority is medicine edible variety, safe to use.
Embodiment
Below with reference to specific embodiment, the invention will be further described.
Embodiment 1：
Following raw material are taken,
Bletilla striata 25g
Rhizoma imperatae 30g
Chinese bulbul 20g
Banksia rose 60g
Cloves 10g
Cassia bark 10g
The sub- 30g of radish
Garden burnet 50g,
1）Infusion process extraction is carried out to prescription drug with the ethanol of 2.5 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 2.5 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 50 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 2：
Bletilla striata 30g
Rhizoma imperatae 35g
Chinese bulbul 25g
Banksia rose 65g
Cloves 15g
Cassia bark 15g
The sub- 35g of radish
Garden burnet 55g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 2.8 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 2.8 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 55 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 3：
Bletilla striata 35g
Rhizoma imperatae 40g
Chinese bulbul 28g
Banksia rose 70g
Cloves 18g
Cassia bark 18g
The sub- 40g of radish
Garden burnet 60g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 58 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 4：
Bletilla striata 35g
Rhizoma imperatae 45g
Chinese bulbul 30g
Banksia rose 75g
Cloves 20g
Cassia bark 20g
The sub- 45g of radish
Garden burnet 65g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.2 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.2 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 60 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 5：
Bletilla striata 40g
Rhizoma imperatae 50g
Chinese bulbul 30g
Banksia rose 80g
Cloves 20g
Cassia bark 20g
The sub- 45g of radish
Garden burnet 70g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.5 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.5 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 65 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 6：
Bletilla striata 40g
Rhizoma imperatae 50g
Chinese bulbul 30g
Banksia rose 90g
Cloves 20g
Cassia bark 20g
The sub- 50g of radish
Garden burnet 75g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.5 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.5 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 70 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 7：
Bletilla striata 40g
Rhizoma imperatae 50g
Chinese bulbul 30g
Banksia rose 90g
Cloves 20g
Cassia bark 20g
The sub- 50g of radish
Garden burnet 80g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 75 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 8：
Bletilla striata 30g
Rhizoma imperatae 35g
Chinese bulbul 25g
Banksia rose 70g
Cloves 15g
Cassia bark 15g
The sub- 35g of radish
Garden burnet 60g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.3 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.3 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 80 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 9：
Bletilla striata 32g
Rhizoma imperatae 37g
Chinese bulbul 28g
Banksia rose 75g
Cloves 18g
Cassia bark 18g
The sub- 40g of radish
Garden burnet 70g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.3 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.3 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 80 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Embodiment 10：
Bletilla striata 35g
Rhizoma imperatae 40g
Chinese bulbul 30g
Banksia rose 80g
Cloves 20g
Cassia bark 20g
The sub- 45g of radish
Garden burnet 80g；
1）Infusion process extraction is carried out to prescription drug with the ethanol of 3.5 times of mass parts of raw material；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction, the distilled water used is 3.5 times of mass parts of raw material；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；Heating-up temperature
For 85 °；
4）Organic matter flavoring and anti-corrosion are carried out, is made.
Medicine of the present invention has carried out clinical test in the attached institute's department of traditional Chinese medicine of Guizhou Province People's Hospital department of traditional Chinese medicine and Guizhou medical college,
60 observation, treatment patients, Clinical results show that total effective rate is 95%, obtain the effect of fine altogether for experiment.
Wherein in oral liquid treatment group 60, male 25, women 35, the age, average age was between 18 ~ 65
43.93 years old, the course of disease was most short 1 month, most long 20 years, TCM Syndrome Type：Syndrome of deficiency of spleen qi 45, syndrome of dampness-heat stagnating in spleen 15.
Treatment method is：Oral formulations, a 30ml, two times a day, surrounding are a course for the treatment of, disable other during treatment and control
Treatment and tonic class Chinese medicine nostrum.
Model case：
Case 1, old * *, man, 53 years old
First visit：Patient before 5 years diet raw food and arrive and suffer from diarrhoea, suffer from diarrhoea and take a turn for the better after medication, but do not adhere to treating, in the future frequent big loose stool
OK, daily 2-3 times, and stomach receives reduction, abdominal distention after meal, tastelessness and no thirst, spiritlessness and sparing of words, fatigue and asthenia, face is discouraged Huang, pale tongue tongue
In vain, arteries and veins is thin and delicate.Card system deficiency-weakness of spleen-QI diarrhea.
Therapy：Strengthening the spleen and replenishing qi antidiarrheal.Invention formulation is taken, each 30ml, two times a day, is treated two weeks, spiritlessness and weakness
The tired lazy speech of body has improvement, and stomach, which is received, slightly to be increased, and times of defecation is reduced.Medication surrounding, stool is normal, and abdominal distention after meal disappears, spiritlessness and weakness
It is clearly better, continues to fully recover after treating according to the method described above.
Case 2, Lee * *, man, 21 years old
Body weight fatigue and asthenia, diet reduce half a year, and often thirsty drinking-water is few, two just no abnormality seens, red tongue body, middle root yellow greasy
Tongue, slippery slightly count.Doctor trained in Western medicine is diagnosed as chronic gastritis, and Chinese medical discrimination damp-heat retention in spleen is thirsty to disappear after taking invention formulation four weeks
Lose, diet is normal, and the tired basic disappearance of body weight body, red tongue with yellowish and greasy fur mitigates.
Case 3, Wang * *, female, 32 years old, normal lassitude, fatigue and asthenia over 2 years, it is reluctant activity, appetite is poor, nothing in mouth
Taste, often there is after food abdominal distension uncomfortable, through B ultrasound, fibergastroscopy no abnormality seen, lustreless complexion, light red tongne is partially fat, print with teeth,
Tongue fur is white slightly greasy, and arteries and veins is thin and delicate, receives invention formulation oral medication, a 30ml, two times a day, after taking January, has in mouth
Taste, diet increase, abdominal distention after meal disappears substantially, and spirit is clearly better, and tongue nature changes without obvious, tongue fur in vain slightly it is greasy switch to it is thin white
Tongue, it is judged as effective.
Above-mentioned case explanation, for the present invention to the fatigue and asthenia caused by insufficiency of the spleen, damp-heat retention in spleen, stomach receives reductions, and body weighs the tired disease of body
There is therapeutic action, during Ureteral Calculus, have no adverse reaction and toxic side effect, illustrate that it is safe to be taken by prescribed dose.
In order to meet medicine safety, toxicity test is also carried out, experiment shows, the maximum tolerance determination of this medicine is more than
40g/kg, this dosage is 178 times of the clinical consumption per day of adult, therefore, safe to use.To rat medication 10 weeks, heavy dose of group
12g/kg.d, equivalent to 55 times, small dose group 3g/kg.d of a clinical consumption per day, equivalent to 14 times of quantity, testing
Period animal behavior is active, and hair is smooth, and stool and urine is normal, in body weight increase, hematology, blood biochemical analysis, and internal organs weight/power ratio,
Naked eyes and pathology testing result no significant difference compared with control group, this medicine of surface can long-term use of safety.
The present invention has carried out pharmacodynamics test by Guiyang Medical College pharmacology teaching and research room, using by Traditional Chinese Medicine Research Institute, Sichuan Province
The Kunming mouse of offer and rat participate in experiment, and the content of experiment includes effect of this medicine to gastric ulcer model, this medicine
Analgesic activity, the influence to smooth muscle, anastalsis and antiinflammatory action.Experiment shows, this medicine can substantially suppress mouse, big
Ulcer caused by mouse stress ulcer and suppression rat indocin, acetic acid, moreover it is possible to suppress rat gastric secretion, reduce hydrochloric acid in gastric juice and stomach egg
The discharge rate of white enzyme；With obvious analgesia and spasmolysis；Mouse bleeding time, reduced clotting time can substantially be made；Have
Obvious antiinflammatory action.
Table 1 represents influence of the medicine of the present invention to mouse stress ulcer
Note：Ulcer index is as follows, and rubescent contrafluxion is 1 point, and petechial hemorrhage or erosion are respectively 1 point, and rotten to the corn 1 of wire is 3 points,
Index is used as after total, carries out statistical analysis.
As a result show, administration each group can substantially suppress the ulcer index that mouse stress be caused, with control group comparing difference
Significantly.
Table 2 represents influence of the medicine of the present invention to rat stress ulcer
As a result show, 2 groups of 1 group of the present invention and the present invention, ulcer index significantly reduces, and there were significant differences compared with control group.
Table 3 represents influence of the medicine of the present invention to indocin type ulcer
As a result show：Ulcer index caused by administration each group can reduce indocin is notable with control group comparing difference.
Table 4 represents effect of the medicine of the present invention to rat acetic acid method chronic ulcer
As a result show：The present invention 1 group, the present invention 2 groups and the present invention 3 groups can reduce ulcer area and increase ulcer healing rate with
Control group comparing difference is notable.
Table 5 represents influence of the medicine of the present invention to rat gastric secretion
As a result show, 2 groups of 1 group of the present invention and the present invention suppress gastric secretion with obvious, reduce hydrochloric acid in gastric juice and pepsin discharge
Amount is notable with control group comparing difference.
Table 6 represents analgesic activity of the medicine of the present invention to mouse（Writhing method）
As a result show, administration each group has obvious analgesic activity, notable with control group comparing difference.
Table 7 represents analgesic activity of the medicine of the present invention to mouse（Hot plate method）
As a result show, 1 group of the present invention is notable with control group comparing difference.
Table 8 represents influence of the medicine of the present invention to Constipation
As a result show：The present invention causes enterocinesia is hyperfunction to have antagonism neostigmine group.
Table 9 represents influence of the medicine of the present invention to mouse anastalsis
As a result show：2 groups of 1 group of the present invention and the present invention can substantially shorten the clotting time, notable with control group comparing difference.
Claims (10)
1. a kind of medicine for being used to treat enterogastric diseases, it is characterised in that be made up of the raw material of following parts by weight：
The bletilla striata 25 ~ 40
Rhizoma imperatae 30 ~ 50
The Chinese bulbul 20 ~ 30
The banksia rose 60 ~ 90
Cloves 10 ~ 20
Cassia bark 10 ~ 20
Radish 30 ~ 50
Garden burnet 50 ~ 80.
2. the medicine according to claim 1 for being used to treat enterogastric diseases, it is characterised in that the weight of the raw material
Part it is：
The bletilla striata 30 ~ 35
Rhizoma imperatae 35 ~ 40
The Chinese bulbul 25 ~ 30
The banksia rose 70 ~ 80
Cloves 15 ~ 20
Cassia bark 15 ~ 20
Radish 35 ~ 45
Garden burnet 60 ~ 80.
3. the preparation method for being used to treat the medicine of enterogastric diseases described in claim 1, it is characterised in that including following step
Suddenly：
1）Prescription drug is extracted with ethanol；
2）By step 1）Extract the remaining dregs of a decoction and carry out water extraction；
3）By step 1）With step 2）Described in two kinds of extract solutions heating carry out concentration mixing after extract supernatant；
4）Organic matter flavoring and anti-corrosion are carried out, medicine of the present invention is made.
4. the preparation method according to claim 3 for being used to treat the medicine of enterogastric diseases, it is characterised in that step 1）
Used in the parts by weight of ethanol be 2.5 ~ 3.5 times of medicine material parts by weight.
5. the preparation method according to claim 4 for being used to treat the medicine of enterogastric diseases, it is characterised in that step 1）
Used in the parts by weight of ethanol be 3 times of medicine material parts by weight.
6. the preparation method according to claim 3 for being used to treat the medicine of enterogastric diseases, it is characterised in that in step
1）In employ infusion process medicine extracted.
7. the preparation method according to claim 3 for being used to treat the medicine of enterogastric diseases, it is characterised in that step 2）
In employ distilled water and carry out water extraction, the parts by weight of the distilled water are 2.5 ~ 3.5 times of medicine material parts by weight.
8. the preparation method according to claim 7 for being used to treat the medicine of enterogastric diseases, it is characterised in that the steaming
The parts by weight of distilled water are 3 times of medicine material parts by weight.
9. the preparation method according to claim 3 for being used to treat the medicine of enterogastric diseases, it is characterised in that step 3）
In heating-up temperature be 50~85 °.
10. being used for described in claim 1 treats the medicines of enterogastric diseases, it is characterised in that the medicine is herb mixture, institute
It is oral liquid to state herb mixture.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150912A (en) * | 1996-09-18 | 1997-06-04 | 罗启伦 | Health-care medicinal liquor for treatment of stomach disease and its technology |
| CN1557437A (en) * | 2004-02-12 | 2004-12-29 | 张中强 | Mixture of aucklandia root and garden burnet for easing stomach and its preparation |
| CN100998652A (en) * | 2006-12-28 | 2007-07-18 | 江蕾 | Umbilicus dressing medicine for treating infantile anorexia |
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2017
- 2017-07-24 CN CN201710607490.5A patent/CN107441369A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150912A (en) * | 1996-09-18 | 1997-06-04 | 罗启伦 | Health-care medicinal liquor for treatment of stomach disease and its technology |
| CN1557437A (en) * | 2004-02-12 | 2004-12-29 | 张中强 | Mixture of aucklandia root and garden burnet for easing stomach and its preparation |
| CN100998652A (en) * | 2006-12-28 | 2007-07-18 | 江蕾 | Umbilicus dressing medicine for treating infantile anorexia |
Non-Patent Citations (1)
| Title |
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| 欧阳荣等: "《常用非处方药物速查手册》", 30 April 2015, 湖南科学技术出版社 * |
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Application publication date: 20171208 |