CN104837560B - 用于制备生物样品的盒和装置 - Google Patents

用于制备生物样品的盒和装置 Download PDF

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Publication number
CN104837560B
CN104837560B CN201380065195.1A CN201380065195A CN104837560B CN 104837560 B CN104837560 B CN 104837560B CN 201380065195 A CN201380065195 A CN 201380065195A CN 104837560 B CN104837560 B CN 104837560B
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CN
China
Prior art keywords
fluid
substrate
reaction chamber
cartridge
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380065195.1A
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English (en)
Chinese (zh)
Other versions
CN104837560A (zh
Inventor
R.维姆伯格-弗里伊德
F.范赫梅特
A.范德斯托佩
M.W.J.普林斯
J.A.范托伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
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Publication of CN104837560A publication Critical patent/CN104837560A/zh
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/082—Active control of flow resistance, e.g. flow controllers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201380065195.1A 2012-12-13 2013-09-24 用于制备生物样品的盒和装置 Active CN104837560B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261736697P 2012-12-13 2012-12-13
US61/736697 2012-12-13
PCT/IB2013/058789 WO2014091321A1 (en) 2012-12-13 2013-09-24 Cartridge and apparatus for preparing a biological sample

Publications (2)

Publication Number Publication Date
CN104837560A CN104837560A (zh) 2015-08-12
CN104837560B true CN104837560B (zh) 2017-03-22

Family

ID=49766135

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380065195.1A Active CN104837560B (zh) 2012-12-13 2013-09-24 用于制备生物样品的盒和装置

Country Status (7)

Country Link
US (1) US10393634B2 (enExample)
EP (1) EP2931426B1 (enExample)
JP (1) JP6180542B2 (enExample)
CN (1) CN104837560B (enExample)
BR (1) BR112015013512A2 (enExample)
RU (1) RU2679226C2 (enExample)
WO (1) WO2014091321A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10976334B2 (en) 2015-08-24 2021-04-13 Illumina, Inc. In-line pressure accumulator and flow-control system for biological or chemical assays
US20170158999A1 (en) * 2015-12-03 2017-06-08 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Modular bioreactor for culture of biopaper based tissues
US11460383B2 (en) 2016-06-16 2022-10-04 Nanocytomics, LLC Automated staining system
EP3523622B1 (en) * 2016-10-06 2025-04-30 Ventana Medical Systems, Inc. System, method and kit for sample preparation
KR101852719B1 (ko) * 2017-04-06 2018-04-27 인제대학교 산학협력단 박막을 이용하여 분리 가능한 구조를 갖는 미세 유체 유속 측정장치
CN107389391B (zh) * 2017-05-11 2024-02-27 武汉康录生物技术股份有限公司 一种自动脱蜡抗原修复系统
EP3401665A1 (en) * 2017-05-12 2018-11-14 University College Dublin National University Of Ireland, Dublin A system and device for analysis of specific matter in liquid samples by optical microscopy
CN107202879B (zh) * 2017-05-18 2018-12-25 杭州依美洛克医学科技有限公司 一种生化实验用加样系统
EP3534139A1 (en) * 2018-03-01 2019-09-04 Koninklijke Philips N.V. Device and method for controlling the volume of a micro chamber arrangement
WO2020106556A1 (en) 2018-11-20 2020-05-28 Xatek, Inc. Dielectric spectroscopy sensing apparaus and method of use
US20250130143A1 (en) * 2020-03-11 2025-04-24 Jin V. WU Devices and components for automated tissue processing and staining and uses thereof
WO2021259497A1 (en) 2020-06-26 2021-12-30 Swissmeca Sa Microfluidic chip and pumping device
TR202016236A2 (tr) * 2020-10-12 2022-04-21 Aselsan Elektroni̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Bi̇r mi̇kro-akişkan kartuş
WO2022102748A1 (ja) * 2020-11-12 2022-05-19 株式会社GramEye 顕微鏡検査支援装置、顕微鏡検査支援方法、自動染色装置、自動染色物質推定システム、プログラム、及び記録媒体
WO2025193084A1 (es) * 2024-03-13 2025-09-18 Beltran Ramirez Jesus Raul Aparato para teñir y montar cubreobjetos en laminillas

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101334419A (zh) * 2007-06-29 2008-12-31 株式会社东芝 微化学分析装置及其测定方法、以及被检试样提取器具
CN101896275A (zh) * 2007-12-17 2010-11-24 龚海庆 微流控器件
CN102740976A (zh) * 2010-01-29 2012-10-17 精密公司 取样-应答微流体盒

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673620B1 (en) * 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
BR0207095A (pt) * 2001-02-12 2004-01-20 Immunivest Corp Método para vedar uma câmara para evitar aprisionamento de ar em um lìquido de teste, sistema de vedação para vedar uma câmara de teste para evitar aprisionamento de ar em lìquido inserido para o interior da câmara, e, cartucho que contém uma câmara de teste para utilização em aparelho para realizar análise óptica de espécimes de lìquido por meio de observação óptica
DE60333715D1 (de) * 2002-10-30 2010-09-23 Hitachi Ltd Verfahren zur Herstellung funktioneller Substrate, die kolumnare Mikrosäulen aufweisen
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7141386B2 (en) * 2002-10-31 2006-11-28 Hewlett-Packard Development Company, L.P. Cell culture device
US7854897B2 (en) 2003-05-12 2010-12-21 Yokogawa Electric Corporation Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system
JP2005037368A (ja) * 2003-05-12 2005-02-10 Yokogawa Electric Corp 化学反応用カートリッジおよびその作製方法および化学反応用カートリッジ駆動システム
US7695676B2 (en) * 2004-08-11 2010-04-13 Hans Kloepfer Methods and apparatus for analyzing an analysis fluid
JP4721414B2 (ja) * 2005-08-15 2011-07-13 キヤノン株式会社 反応カートリッジ、反応装置および反応カートリッジの溶液の移動方法
JP4997571B2 (ja) 2006-12-19 2012-08-08 有限会社フルイド マイクロ流体デバイスおよびそれを用いた分析装置
JP2008196943A (ja) 2007-02-13 2008-08-28 Matsushita Electric Ind Co Ltd 生物学的特異的反応物質の測定チップ、測定システムおよび測定方法
RU2386970C2 (ru) 2007-06-25 2010-04-20 Закрытое акционерное общество "Молекулярно-медицинские технологии" Биочип с многофункциональной системой идентификации (варианты)
US9329170B2 (en) 2009-01-20 2016-05-03 The Board Of Trustees Of The Leland Stanford Junior University Single cell gene expression for diagnosis, prognosis and identification of drug targets
US8867803B2 (en) 2010-04-20 2014-10-21 Eric J. Seibel Optical projection tomography microscopy (OPTM) for large specimen sizes
ES2549752T3 (es) 2010-07-19 2015-11-02 The Board Of Trustees Of The Leland Stanford Junior University Métodos y sistemas para el análisis de células individuales
US9522344B2 (en) 2010-11-18 2016-12-20 The Regents Of The University Of California Method and device for high-throughput solution exchange for cell and particle suspension
US9295988B2 (en) 2011-03-08 2016-03-29 Colorado State University Research Foundation Microfluidic cytochemical staining system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101334419A (zh) * 2007-06-29 2008-12-31 株式会社东芝 微化学分析装置及其测定方法、以及被检试样提取器具
CN101896275A (zh) * 2007-12-17 2010-11-24 龚海庆 微流控器件
CN102740976A (zh) * 2010-01-29 2012-10-17 精密公司 取样-应答微流体盒

Also Published As

Publication number Publication date
BR112015013512A2 (pt) 2017-07-11
WO2014091321A1 (en) 2014-06-19
JP2015537229A (ja) 2015-12-24
EP2931426A1 (en) 2015-10-21
US20150316454A1 (en) 2015-11-05
US10393634B2 (en) 2019-08-27
CN104837560A (zh) 2015-08-12
RU2015128059A (ru) 2017-01-16
EP2931426B1 (en) 2016-11-23
JP6180542B2 (ja) 2017-08-16
RU2679226C2 (ru) 2019-02-06

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