CN104837560B - 用于制备生物样品的盒和装置 - Google Patents

用于制备生物样品的盒和装置 Download PDF

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Publication number
CN104837560B
CN104837560B CN201380065195.1A CN201380065195A CN104837560B CN 104837560 B CN104837560 B CN 104837560B CN 201380065195 A CN201380065195 A CN 201380065195A CN 104837560 B CN104837560 B CN 104837560B
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CN
China
Prior art keywords
fluid
substrate
reaction chamber
cartridge
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380065195.1A
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English (en)
Chinese (zh)
Other versions
CN104837560A (zh
Inventor
R.维姆伯格-弗里伊德
F.范赫梅特
A.范德斯托佩
M.W.J.普林斯
J.A.范托伦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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Publication of CN104837560A publication Critical patent/CN104837560A/zh
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/082—Active control of flow resistance, e.g. flow controllers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201380065195.1A 2012-12-13 2013-09-24 用于制备生物样品的盒和装置 Active CN104837560B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261736697P 2012-12-13 2012-12-13
US61/736697 2012-12-13
PCT/IB2013/058789 WO2014091321A1 (en) 2012-12-13 2013-09-24 Cartridge and apparatus for preparing a biological sample

Publications (2)

Publication Number Publication Date
CN104837560A CN104837560A (zh) 2015-08-12
CN104837560B true CN104837560B (zh) 2017-03-22

Family

ID=49766135

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380065195.1A Active CN104837560B (zh) 2012-12-13 2013-09-24 用于制备生物样品的盒和装置

Country Status (7)

Country Link
US (1) US10393634B2 (cg-RX-API-DMAC7.html)
EP (1) EP2931426B1 (cg-RX-API-DMAC7.html)
JP (1) JP6180542B2 (cg-RX-API-DMAC7.html)
CN (1) CN104837560B (cg-RX-API-DMAC7.html)
BR (1) BR112015013512A2 (cg-RX-API-DMAC7.html)
RU (1) RU2679226C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014091321A1 (cg-RX-API-DMAC7.html)

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CN116338219A (zh) 2015-08-24 2023-06-27 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制系统
WO2017096207A1 (en) * 2015-12-03 2017-06-08 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Modular bioreactor for culture of biopaper based tissues
WO2017218882A1 (en) 2016-06-16 2017-12-21 Nanocytomics, LLC Automated staining system
EP3523622B1 (en) * 2016-10-06 2025-04-30 Ventana Medical Systems, Inc. System, method and kit for sample preparation
KR101852719B1 (ko) * 2017-04-06 2018-04-27 인제대학교 산학협력단 박막을 이용하여 분리 가능한 구조를 갖는 미세 유체 유속 측정장치
CN107389391B (zh) * 2017-05-11 2024-02-27 武汉康录生物技术股份有限公司 一种自动脱蜡抗原修复系统
EP3401665A1 (en) * 2017-05-12 2018-11-14 University College Dublin National University Of Ireland, Dublin A system and device for analysis of specific matter in liquid samples by optical microscopy
CN107202879B (zh) * 2017-05-18 2018-12-25 杭州依美洛克医学科技有限公司 一种生化实验用加样系统
EP3534139A1 (en) * 2018-03-01 2019-09-04 Koninklijke Philips N.V. Device and method for controlling the volume of a micro chamber arrangement
US12007345B2 (en) 2018-11-20 2024-06-11 Xatek, Inc. Dielectric spectroscopy sensing apparatus and method of use
US20250130143A1 (en) * 2020-03-11 2025-04-24 Jin V. WU Devices and components for automated tissue processing and staining and uses thereof
EP4171813A1 (en) 2020-06-26 2023-05-03 Swissmeca SA Microfluidic chip and pumping device
TR202016236A2 (tr) * 2020-10-12 2022-04-21 Aselsan Elektroni̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Bi̇r mi̇kro-akişkan kartuş
JP7723425B2 (ja) * 2020-11-12 2025-08-14 株式会社GramEye 自動染色物質推定システム
WO2025193084A1 (es) * 2024-03-13 2025-09-18 Beltran Ramirez Jesus Raul Aparato para teñir y montar cubreobjetos en laminillas

Citations (3)

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CN101334419A (zh) * 2007-06-29 2008-12-31 株式会社东芝 微化学分析装置及其测定方法、以及被检试样提取器具
CN101896275A (zh) * 2007-12-17 2010-11-24 龚海庆 微流控器件
CN102740976A (zh) * 2010-01-29 2012-10-17 精密公司 取样-应答微流体盒

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DE60333715D1 (de) * 2002-10-30 2010-09-23 Hitachi Ltd Verfahren zur Herstellung funktioneller Substrate, die kolumnare Mikrosäulen aufweisen
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
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CN101896275A (zh) * 2007-12-17 2010-11-24 龚海庆 微流控器件
CN102740976A (zh) * 2010-01-29 2012-10-17 精密公司 取样-应答微流体盒

Also Published As

Publication number Publication date
JP2015537229A (ja) 2015-12-24
RU2679226C2 (ru) 2019-02-06
EP2931426A1 (en) 2015-10-21
BR112015013512A2 (pt) 2017-07-11
CN104837560A (zh) 2015-08-12
RU2015128059A (ru) 2017-01-16
EP2931426B1 (en) 2016-11-23
JP6180542B2 (ja) 2017-08-16
US20150316454A1 (en) 2015-11-05
US10393634B2 (en) 2019-08-27
WO2014091321A1 (en) 2014-06-19

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