CN104826029A - Traditional Chinese medicine composition for treating breast cancer and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating breast cancer and application of traditional Chinese medicine composition Download PDFInfo
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- CN104826029A CN104826029A CN201510276465.4A CN201510276465A CN104826029A CN 104826029 A CN104826029 A CN 104826029A CN 201510276465 A CN201510276465 A CN 201510276465A CN 104826029 A CN104826029 A CN 104826029A
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Abstract
The invention discloses traditional Chinese medicine composition for treating breast cancer, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition comprises 20-60 parts of codonopsis pilosula, 10-40 parts of safflowers, 10-30 parts of myrrh, 10-30 parts of radix cyathulae, 5-15 parts of indigowoad roots, 10-30 parts of artemisa capillaris, 10-30 parts of evening primrose, 5-15 parts of concha arcae, 5-15 parts of plantain herbs, 5-20 parts of fructus aurantii, 10-30 parts of bulbus fritillariae cirrhosae, 10-30 parts of curcuma aromatica, 20-40 parts of cowherb seeds, 10-30 parts of herba epimedii and 10-30 parts of cyclocarya paliurus leaves. The traditional Chinese medicine composition has the advantages that synergistic effects can be realized by various medicaments in the traditional Chinese medicine composition, obvious breast cancer treating effects can be realized, the total effective rate can reach 88%, the cure rate can reach 76%, and the breast cancer is difficult to relapse after being cured.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of breast carcinoma and uses thereof, it belongs to the field of Chinese medicines.
Background technology
Breast carcinoma is one of modal malignant tumor of women, and sickness rate accounts for the 7-10% of the various malignant tumor of whole body, is that one has a strong impact on the even life-threatening disease of women's physical and mental health.The cause of disease of breast carcinoma is also completely not clear and definite so far, but the factor such as bearing status, oral contraceptive, inherited genetic factors, ionizing radiation, unsound dietary habit has been identified with breast cancer related.The factors such as especially long-term dietary structure, living habit cause the excessive acidify of body constitution, the function of human body integral declines, cause liver of suffering from a deficiency of the kidney also empty, and then cause part of the body cavity above the diaphragm housing the heart and lungs metabolic cycles slack-off, easily cause thyroid disease and endocrine disturbance, immunologic function degression, thus develop into mammary gland tissue paraplasm, whole carcinogenesis.Breast carcinoma performance the earliest suffers from breast to occur single-shot, form relatively circular, oval or difform little lump, and quality is comparatively hard, indefinite border generally; A few patients can have distending pain, dull pain.The morbidity of breast carcinoma is normal relevant with heredity, and 40-60 year between, women's sickness rate before and after menopause is higher.
Current Therapeutic Method mainly contains operative treatment, chemotherapy and Drug therapy, but therapeutic effect is all undesirable, cures the symptoms, not the disease, and also can recur after healing, and large to patient body wound, easily causes complication, and medical expense is expensive.Chemotherapy is one of common method of breast carcinoma non-operative treatment, but it also exists, and cancerous cell is killed together with normal cell, effective dose and toxic dose closely, the wretched insufficiency such as toxic and side effects, wherein and hemopoietic function of bone marrow impaired with digestive function is suppressed waits reaction the most obvious, often makes patient with breast cancer be difficult to accept chemotherapy because reacting serious and maybe can not adhere to the whole course for the treatment of.
Primary disease, in tcm clinical practice, belongs to the category such as " breast carcinoma ", " mammary calculus carbuncle " more, thinks that breast carcinoma is due to disorder of emotion, depression of liver-QI or because of Chong and Ren channel disorder, and QI-blood circulation is smooth, qi stagnation hemagglutination, and meridians block, and ties stagnant caused by the Ruzhong.Chinese medicine is the exclusive medical advantages of China, in treatment breast carcinoma, not only can promote physical recovery, strengthen immunologic function, and can play antitumaous effect, prevents recurrence and transfer, improves survival rate.In this context, the present inventor is groped and creative work by a large amount of experiments, obtains a kind of Chinese medicine composition for the treatment of breast carcinoma, and its pharmacodynamics and clinical experiment effect are very remarkable, serve positive impetus to the hygiene medical treatment cause of China.
Summary of the invention
In view of the defect that existing Therapeutic Method exists, the invention provides a kind of Chinese medicine composition for the treatment of breast carcinoma and uses thereof, the Be very effective of this traditional Chinese medicine composition for treating breast carcinoma and having no side effect, there is very high patient compliance.
For solving technical problem of the present invention, have employed following technical scheme:
Treat a Chinese medicine composition for breast carcinoma, it is characterized in that: be prepared from by the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 20-60 part, Flos Carthami 10-40 part, Myrrha 10-30 part, Radix Cyathulae 10-30 part, Radix Isatidis 5-15 part, Herba Artemisiae Scopariae 10-30 part, Radix Oenotherae erythrosepalae 10-30 part, Concha Arcae 5-15 part, Herba Plantaginis 5-15 part, Fructus Aurantii 5-20 part, Bulbus Fritillariae Cirrhosae 10-30 part, Radix Curcumae 10-30 part, Semen Vaccariae 20-40 part, Herba Epimedii 10-30 part, leaf of Cyclocarya paliurus Iljinskaja 10-30 part.
In a preferred embodiment, described Chinese medicine composition is preferably prepared from by the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 60 parts, 40 parts, Flos Carthami, Myrrha 30 parts, Radix Cyathulae 30 parts, Radix Isatidis 15 parts, Herba Artemisiae Scopariae 30 parts, Radix Oenotherae erythrosepalae 30 parts, Concha Arcae 15 parts, Herba Plantaginis 15 parts, Fructus Aurantii 20 parts, Bulbus Fritillariae Cirrhosae 30 parts, Radix Curcumae 30 parts, Semen Vaccariae 40 parts, Herba Epimedii 30 parts, leaf of Cyclocarya paliurus Iljinskaja 30 parts.
In another preferred embodiment, described Chinese medicine composition is preferably prepared from by the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 20 parts, 10 parts, Flos Carthami, Myrrha 10 parts, Radix Cyathulae 10 parts, Radix Isatidis 5 parts, Herba Artemisiae Scopariae 10 parts, Radix Oenotherae erythrosepalae 10 parts, Concha Arcae 5 parts, Herba Plantaginis 5 parts, Fructus Aurantii 5 parts, Bulbus Fritillariae Cirrhosae 10 parts, Radix Curcumae 10 parts, Semen Vaccariae 20 parts, Herba Epimedii 10 parts, leaf of Cyclocarya paliurus Iljinskaja 10 parts.
In a further preferred embodiment, described Chinese medicine composition is preferably prepared from by the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 40 parts, 25 parts, Flos Carthami, Myrrha 20 parts, Radix Cyathulae 20 parts, Radix Isatidis 10 parts, Herba Artemisiae Scopariae 20 parts, Radix Oenotherae erythrosepalae 20 parts, Concha Arcae 10 parts, Herba Plantaginis 10 parts, Fructus Aurantii 12 parts, Bulbus Fritillariae Cirrhosae 20 parts, Radix Curcumae 20 parts, Semen Vaccariae 30 parts, Herba Epimedii 20 parts, leaf of Cyclocarya paliurus Iljinskaja 20 parts.
Another object of the present invention there is provided the preparation method of described Chinese medicine composition, and concrete steps are as follows:
1) each raw material of Chinese medicine medicine is taken according to the weight portion of described Chinese medicine composition, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have mixture 4-8cm, soak after 20-40 minute, boil with high heat, then use slow fire boiling 30-50 minute, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 2-6cm, boil with high heat, then use slow fire boiling 20-40 minute, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
In the present invention's preferred embodiment, the preparation method of described Chinese medicine composition comprises following step
Rapid:
1) each raw material of Chinese medicine medicine is taken according to the weight portion of described Chinese medicine composition, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have mixture 6cm, soak after 30 minutes, boil with high heat, then use slow fire boiling 40 minutes, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 4cm, boil with high heat, then use slow fire boiling 30 minutes, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
In a preferred embodiment, according to the preparation method of this area routine, by adding appropriate adjuvant, Chinese medicine composition of the present invention can be made suitable pharmaceutical preparation.
Described pharmaceutical preparation is preferably oral formulations.
Described oral formulations is preferably the preparations such as granule, tablet, capsule, soft extract, pill, medicinal tea, powder, drop pill.
Described adjuvant comprises the general conventional adjuvant of various medical standards.
Another object of the present invention is to provide the purposes of described Chinese medicine composition in the medicine of preparation treatment breast carcinoma.In said composition, each medicine synergism, has the effects such as depressed liver-energy dispersing and QI regulating, blood circulation promoting and dispersing pathogen accumulation, anti-inflammatory analgetic, has obvious therapeutical effect to breast carcinoma, its total effective rate can reach 88%, and cure rate can reach 76%, has no side effect, not easily recur after healing, and cheap, taking convenience.The instructions of taking of Chinese medicine composition of the present invention: be decocted in water for oral dose, every day 1 dose, a point morning and evening takes for twice, and serveing on 30 days is a course for the treatment of.
Detailed description of the invention
Technical scheme of the present invention is further described by following embodiment.It is pointed out that following explanation is only illustrating the technical scheme that application claims is protected, any restriction not to these technical schemes.The content that protection scope of the present invention is recorded with appended claims is as the criterion.
embodiment 1
Prescription forms: Radix Codonopsis 40g, Flos Carthami 25g, Myrrha 20g, Radix Cyathulae 20g, Radix Isatidis 10g, Herba Artemisiae Scopariae 20g, Radix Oenotherae erythrosepalae 20g, Concha Arcae 10g, Herba Plantaginis 10g, Fructus Aurantii 12g, Bulbus Fritillariae Cirrhosae 20g, Radix Curcumae 20g, Semen Vaccariae 30g, Herba Epimedii 20g, leaf of Cyclocarya paliurus Iljinskaja 20g.
Preparation method:
1) each raw material of Chinese medicine medicine is taken according to above-described embodiment 1 prescription, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have medicinal residues face 6cm, soak after 30 minutes, intense fire boils, slow fire boiling 40 minutes, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 4cm, intense fire boils, slow fire boiling 30 minutes, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
embodiment 2
Prescription forms: Radix Codonopsis 60g, Flos Carthami 40g, Myrrha 30g, Radix Cyathulae 30g, Radix Isatidis 15g, Herba Artemisiae Scopariae 30g, Radix Oenotherae erythrosepalae 30g, Concha Arcae 15g, Herba Plantaginis 15g, Fructus Aurantii 20g, Bulbus Fritillariae Cirrhosae 30g, Radix Curcumae 30g, Semen Vaccariae 40g, Herba Epimedii 30g, leaf of Cyclocarya paliurus Iljinskaja 30g.
Preparation method:
1) each raw material of Chinese medicine medicine is taken according to above-described embodiment 2 prescription, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have medicinal residues face 8cm, soak after 40 minutes, intense fire boils, slow fire boiling 50 minutes, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 6cm, intense fire boils, slow fire boiling 40 minutes, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
embodiment 3
Prescription forms: Radix Codonopsis 20g, Flos Carthami 10g, Myrrha 10g, Radix Cyathulae 10g, Radix Isatidis 5g, Herba Artemisiae Scopariae 10g, Radix Oenotherae erythrosepalae 10g, Concha Arcae 5g, Herba Plantaginis 5g, Fructus Aurantii 5g, Bulbus Fritillariae Cirrhosae 10g, Radix Curcumae 10g, Semen Vaccariae 20g, Herba Epimedii 10g, leaf of Cyclocarya paliurus Iljinskaja 10g.
Preparation method:
1) each raw material of Chinese medicine medicine is taken according to above-described embodiment 3 prescription, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have medicinal residues face 4cm, soak after 20 minutes, intense fire boils, slow fire boiling 30 minutes, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 3cm, intense fire boils, slow fire boiling 20 minutes, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
the Clinical observation of embodiment 4 Chinese medicine composition of the present invention
1. case selection:
Select inpatient's totally 50 examples with complete data, the age be 35-55 year, 45 years old mean age.
2. diagnostic criteria:
Touch lump in breast, matter is hard, air spots, pathology or cytolgical examination have found cancerous cell, are diagnosed as breast carcinoma.
3. Therapeutic Method:
Take the Chinese medicine composition of the embodiment of the present invention 1, potion, divided and sooner or later took for twice, take two months continuously every day.
4. efficacy assessment standard:
1. disappear (CR) entirely: all cancer seen of looking into disappear completely, and osteolytic lesion is complete on x-ray
Portion's calcification;
2. partial disappearance (PR): pathological changes can be measured and reduce 50% (products of 2 maximum perpendicular diameters of axle),
Occur without new focus simultaneously;
3. stable without becoming (S): tumor regression < 50%, or increase < 25%.
4. worsen (PD): some focus reduces < 50%, some focus increases > 25% simultaneously, or all focuses increase, or has new focus to occur.
5. therapeutic outcome: (CR) group that entirely disappears in 50 cases is 38 people, and partial disappearance (PR) group is 6 people, stable is 4 people without becoming (S) group, and worsening (PD) group is 2 people.Total effective rate is 88%, and cure rate is 76%.
the clinical model case of embodiment 5 traditional Chinese medicine composition for treating of the present invention breast carcinoma
Grandson, female, 46 years old, in June, 2012 health check-up found lump in breast, and quality is hard, and mobility is poor.Be breast carcinoma through hospital diagnosis, disease sees premenstrual distending pain of the breast, and lump in breast is hard, pale tongue, white and thin fur, stringy and thready pulse.Take 1 course for the treatment of (namely 30 days) after the Chinese medicine composition of the embodiment of the present invention 1, the premenstrual distending pain of the breast of patient alleviates to some extent.1 course for the treatment of of Chinese medicine composition of the following the service embodiment of the present invention 1, the premenstrual distending pain of the breast of patient disappears, and lump in breast obviously reduces.1 course for the treatment of of Chinese medicine composition of the following the service embodiment of the present invention 1, lump in breast disappears completely, through examination in hospital without difference.Recurrence of following up a case by regular visits to that so far there are no.
Zhang, female, 38 years old, in December, 2011 was breast carcinoma through hospital diagnosis.Disease sees arm pain, and random thoughts are numb, tired mind, insomnia and dreamful sleep, thin and greasy fur.Take 1 course for the treatment of of Chinese medicine composition of the embodiment of the present invention 1, the above-mentioned symptom of patient is eased, and sleep quality makes moderate progress.Following the service Chinese medicine composition of the present invention 2 courses for the treatment of, patient's chest mass reduction, arm distending pain and numb transference cure.1 course for the treatment of of following the service Chinese medicine composition of the present invention, after treatment, through examination in hospital without difference.Recurrence of following up a case by regular visits to that so far there are no.
Lee, female, 55 years old, in October, 2012 determines to suffer from breast carcinoma through examination in hospital, and breast has lump, and matter is hard, pain, inappetence, weak, poor sleeping quality, takes the Chinese medicine composition of the embodiment of the present invention 1, after 1 course for the treatment of, above-mentioned various symptom is alleviated all to some extent, and wherein appetite obviously takes a turn for the better, and sleep therapy is improved.Continue to take 2 courses for the treatment of, lump in breast obviously diminishes, and pain also significantly alleviates.Continue to take 1 course for the treatment of, lump in breast disappears, and health is strong, finds that the index of tumor is all normal through examination in hospital.Recurrence of following up a case by regular visits to that so far there are no.
Content of the present invention merely illustrates some claimed specific embodiments; one of them or more described technical characteristic can be combined with arbitrary one or more technical scheme in technical scheme; these technical schemes obtained through combination also in the application's protection domain, just as these technical schemes obtained through combination in the disclosure of invention concrete record.
Claims (7)
1. treat the Chinese medicine composition of breast carcinoma for one kind, it is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 20-60 part, Flos Carthami 10-40 part, Myrrha 10-30 part, Radix Cyathulae 10-30 part, Radix Isatidis 5-15 part, Herba Artemisiae Scopariae 10-30 part, Radix Oenotherae erythrosepalae 10-30 part, Concha Arcae 5-15 part, Herba Plantaginis 5-15 part, Fructus Aurantii 5-20 part, Bulbus Fritillariae Cirrhosae 10-30 part, Radix Curcumae 10-30 part, Semen Vaccariae 20-40 part, Herba Epimedii 10-30 part, leaf of Cyclocarya paliurus Iljinskaja 10-30 part.
2. a kind of Chinese medicine composition for the treatment of breast carcinoma according to claim 1, it is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 60 parts, 40 parts, Flos Carthami, Myrrha 30 parts, Radix Cyathulae 30 parts, Radix Isatidis 15 parts, Herba Artemisiae Scopariae 30 parts, Radix Oenotherae erythrosepalae 30 parts, Concha Arcae 15 parts, Herba Plantaginis 15 parts, Fructus Aurantii 20 parts, Bulbus Fritillariae Cirrhosae 30 parts, Radix Curcumae 30 parts, Semen Vaccariae 40 parts, Herba Epimedii 30 parts, leaf of Cyclocarya paliurus Iljinskaja 30 parts.
3. a kind of Chinese medicine composition for the treatment of breast carcinoma according to claim 1, it is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 20 parts, 10 parts, Flos Carthami, Myrrha 10 parts, Radix Cyathulae 10 parts, Radix Isatidis 5 parts, Herba Artemisiae Scopariae 10 parts, Radix Oenotherae erythrosepalae 10 parts, Concha Arcae 5 parts, Herba Plantaginis 5 parts, Fructus Aurantii 5 parts, Bulbus Fritillariae Cirrhosae 10 parts, Radix Curcumae 10 parts, Semen Vaccariae 20 parts, Herba Epimedii 10 parts, leaf of Cyclocarya paliurus Iljinskaja 10 parts.
4. a kind of Chinese medicine composition for the treatment of breast carcinoma according to claim 1, it is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion: Radix Codonopsis 40 parts, 25 parts, Flos Carthami, Myrrha 20 parts, Radix Cyathulae 20 parts, Radix Isatidis 10 parts, Herba Artemisiae Scopariae 20 parts, Radix Oenotherae erythrosepalae 20 parts, Concha Arcae 10 parts, Herba Plantaginis 10 parts, Fructus Aurantii 12 parts, Bulbus Fritillariae Cirrhosae 20 parts, Radix Curcumae 20 parts, Semen Vaccariae 30 parts, Herba Epimedii 20 parts, leaf of Cyclocarya paliurus Iljinskaja 20 parts.
5. a preparation method for the Chinese medicine composition for the treatment of breast carcinoma according to claim 1, is characterized in that, comprise the steps:
1) each raw material of Chinese medicine medicine is taken according to the weight portion of described Chinese medicine composition, dry, pulverizing, mixing for standby use;
2) by step 1) in crude drug mixture be soaked in water, add water and do not have mixture 4-8cm, soak after 20-40 minute, boil with high heat, then use slow fire boiling 30-50 minute, cooling, filter after obtain filtrate and medicinal residues;
3) by step 2) in the medicinal residues that obtain decoct with water, add water and do not have medicinal residues face 2-6cm, intense fire boils, slow fire boiling 20-40 minute, cooling, filter after obtain filtrate and filtering residue,
4) Chinese medicine composition that namely twice filtrate obtain described treatment breast carcinoma is merged.
6. a kind of preparation method for the treatment of the Chinese medicine composition of breast carcinoma according to claim 5, it is characterized in that: described step 2) amount that adds water was not for there to be mixture 6cm, described step 2) time of soaking is 30 minutes, described step 2) time of slow fire boiling is 40 minutes; Described step 3) amount that adds water for not have medicinal residues face 4cm, described step 3) time of slow fire boiling is 30 minutes.
7. treat a Chinese medicine composition for breast carcinoma, it is characterized in that in the medicine for the preparation for the treatment of breast carcinoma.
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| CN109568385A (en) * | 2018-11-30 | 2019-04-05 | 丽水学院 | A kind of blue or green money willow extract is preparing the application in breast cancer medicines or health care product |
| CN110269916A (en) * | 2019-05-05 | 2019-09-24 | 张永德 | A kind of Chinese medicine composition of anti-breast cancer |
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