CN104824783A - A preparing method of a sea cucumber protein effervescent tablet - Google Patents
A preparing method of a sea cucumber protein effervescent tablet Download PDFInfo
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- CN104824783A CN104824783A CN201510131219.XA CN201510131219A CN104824783A CN 104824783 A CN104824783 A CN 104824783A CN 201510131219 A CN201510131219 A CN 201510131219A CN 104824783 A CN104824783 A CN 104824783A
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- sea cucumber
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Abstract
The invention relates to a preparing method of an effervescent tablet adopting sea cucumber enzymolytic protein as a main raw material. Components of the effervescent tablet comprise the sea cucumber enzymolytic protein, an inclusion agent, an excipient, a lubricant, a flavoring agent, a sweetener and an effervescing agent. The effervescent tablet comprises 5% of the sea cucumber enzymolytic protein, 10% of the inclusion agent, 27% of an acid agent in the effervescing agent, 35% of an alkali agent in the effervescing agent, 20% of lactose, 1% of the lubricant, 1.5% of the sweetener and 0.5% of the flavoring agent. The method adopts enzyme-membrane coupling, freeze-drying, and other techniques to prepare a sea cucumber protein enzymolysis product, and a plurality of auxiliary materials are added to prepare particles and prepare the effervescent tablet. Solubility tests show that the effervescent tablet prepared by the method can fully effervesce and be dissolved into a uniform solution in one minute. The effervescent tablet has characteristics of taking convenience, high bioavailability, good taste, novel sense, capability of being easily acceptable by various people groups, and the like.
Description
Technical field
The present invention relates to a kind of preparation method of the effervescent tablet containing sea cucumber protein hydrolysate
Technical background
Sea cucumber (Apostichopus japonicus) for Stichopodidae imitate stichopus japonicus belong to animal, popular name stichopus japonicus.Be distributed in district of North Pacific, comprise Russia, the ground such as Liaoning, Hebei, Shandong, Jiangsu of the littoral and China's Mainland in Japan, the Korea peninsula, be common in wave current quiet steady, sea grass is in great numbers and in the bay injected without fresh water and substrate be cay or the hard end.Sea cucumber, as a kind of living resources of medicine-food two-purpose, has long use history in China.Sea cucumber is warm in nature, and taste is salty, enters the heart, kidney, spleen, stomach warp, has the merit of tonifying Qi benefit the moon, the effect of tonifying kidney and benefiting sperm.Beche-de-mer products common at present mainly contains oral liquid and soft capsule, and effervescent tablet is more rare.
Effervescent tablet can produce rapidly bubble (i.e. effervesce) after one puts into water and make the rapid disintegration of tablet, for solid pharmaceutical preparation that is for oral administration or external application, its maximum feature is disintegrant is meet the sour inorganic salts (alkaline agent) that can produce carbon dioxide with one or several organic acids (sour agent) and one or several jointly to form, and it is met water generation acid-base neutralization reaction releasing carbon dioxide and makes disintegration of tablet.Effervescent tablet, as a kind of new formulation, has following characteristics:
(1) it is produced, transport, storage be solid form, have dosage of solid formulations accurately, steady quality, production automation degree is high, cost is low, the feature such as portable.
(2) effervescent tablet is taken being made into liquid before use, therefore has again that liquid preparation is easy to swallow, bioavilability is high, to features such as gastrointestinal irritation are little.
(3) its disintegrant is made up of sour agent and alkaline agent, therefore calving disaggregation is powerful, and the rapid disintegration of medicine can be made to become fine particle and dissolve rapidly.
(4) effervescent tablet is met aquatic products anger bubble and is seethed up and down, interesting, meets the curious psychology of people, especially applicable children taking.
(5) liquid is refrigerant good to eat, can as cold drink, and mouthfeel is good, and patient is easy to accept.
Summary of the invention
The object of this invention is to provide one and carry taking convenience, the preparation method of a kind of effervescent tablet that mouthfeel is good.
A kind of sea cucumber albumen effervescent tablet, is characterized in that: described sea cucumber albumen effervescent tablet composition comprises sea cucumber enzymolysis protein, inclusion agents, excipient, lubricant, sweetener, aromatic and effervescent agent.
Effervescent agent is wherein made up of sour agent and alkaline agent, and sour agent is tartaric acid, and alkaline agent is sodium acid carbonate; Inclusion agents is beta-schardinger dextrin-; Excipient is lactose; Lubricant is dolomol or Macrogol 6000; Sweetener is acesulfame potassium; Aromatic is acesulfame potassium and orange flavor.
By the proportioning mass ratio of each component be: sea cucumber enzymolysis protein 5%, beta-schardinger dextrin-10%, lactose 20%, dolomol 1% or Macrogol 6000 1%, acesulfame potassium 1.5%, orange flavor 0.5%, tartaric acid 27%, sodium acid carbonate 35%.
Concrete operation step comprises:
(1) the sea cucumber albumen Benexate Hydrochloride sealing obtained through super-dry saves backup; By sour agent, alkaline agent respectively at 95-105 DEG C of dry 2-4 hour, pulverized 80-100 mesh sieve, sealing saves backup; Excipient was pulverized 80-100 mesh sieve and was saved backup; 80-100 mesh sieve pulverized by sweetener and aromatic; 80-100 mesh sieve pulverized by lubricant, saved backup in normal temperature dryer; The temperature and humidity that controls environment in preparation process is respectively at 15-25 DEG C and 25-35%.
(2) by sea cucumber albumen Benexate Hydrochloride, excipient and sweetener are divided into two parts, particle is prepared respectively with sour agent and alkaline agent, with 95% ethanol for particle prepared by adhesive, after preparing particle, reduced pressure at room temperature 0.08-0.1Mpa, drying time is 12-24h, and drying terminates rear further whole grain.
(3), before compressing tablet, after soda acid uniform particles being mixed, 1% lubricant is added and 2.0% aromatic mixes.
(4) by the granulation of fully mixing in (3), sea cucumber albumen effervescent tablet is obtained.
1) sea cucumber is cleaned removing impurity, after adding 3 times of water gaging making beating, add water to 5 times amount volumes again and carry out enzymolysis, add the compound protease Protomax (in protein content) of 20000U/g, temperature 50 C, pH is 7.0, enzymolysis 3h while stirring, 100 DEG C of heating 10min go out after enzyme, and 4000 revs/min of centrifugal 15min, get supernatant;
2) molecular cut off is adopted to be that enzymolysis liquid filters by the milipore filter of 3000Da, collect the part that ultrafiltration molecular weight is less than 3000Da, adopt again molecular cut off be 150 NF membrane, carry out nanofiltration process desalination, nanofiltration condition: molecular weight is 150 mwco membranes, enter film pressure 1.1MPa, go out film pressure 1.1MPa, finally protein hydrolysate is carried out freeze drying;
3) by 2) the sea cucumber enzymolysis protein product that obtains, add the beta-schardinger dextrin-(in sea cucumber enzymolysis protein product) of 2 times amount, add 5 times of water gagings (in beta-schardinger dextrin-) again, after grinding 30min, 60 DEG C of dry 12h, dry thing was pulverized 100 mesh sieves and was obtained sea cucumber albumen Benexate Hydrochloride.
Described step 2) in freeze drying condition be: temperature controlled condition: 0-30min, 0 DEG C rises to 30 DEG C; 30-360min, 30 DEG C; 360-480min, 30 DEG C rise to 40 DEG C; 489-720min, 40 DEG C; 720-840min, is down to 20 DEG C for 40 DEG C; Vacuum is 40Mpa, and temperature-30 DEG C finally obtains sea cucumber protein hydrolysate.
The effervesce effect of sea cucumber albumen effervescent tablet of the present invention:
Dropped into by prepared effervescent tablet 2 in 150ml warm water, at the bottom of it suspends or to fall within bottle, and release a large amount of bubble immediately, tablet dissolves rapidly thereupon, in 1 minute, form light yellow transparent solution, and good mouthfeel is novel.
Sea cucumber albumen effervescent tablet involved in the present invention for raw material with sea cucumber enzymolysis protein, is equipped with the auxiliary material such as tartaric acid, sodium bicarbonate and is prepared from.Sea cucumber is after enzymolysis, obtain the biological peptide of molecular weight, in preparation process, the biological peptide position that molecular cut off is less than 3000, large quantity research has proved that the biological peptide that molecular weight is less than 2000 has good physiologically active, simultaneously through freeze drying, maintain the activity of peptide to greatest extent.This one dosage type low temperature of effervescent tablet have be convenient to take, bioavilability is high, mouthfeel good, effervesce sense organ novel, all kinds of crowd is easy to the features such as acceptance.The food form of current sea cucumber protide is also few, and this product has filled up the market vacancy, has expanded the approach of sea cucumber deep processing, has inspiration meaning to the deep processing of precious marine product albumen.
Detailed description of the invention
1. the preparation of sea cucumber protein hydrolysate
(1) sea cucumber is cleaned removing impurity, add suitable quantity of water making beating, then add water to 5 times amount, add the compound protease Protomax (in protein content) of 20000U/g, temperature 50 C, pH is 7.0, while stirring enzymolysis 3h.100 DEG C of heating 10min go out after enzyme, and 4000 revs/min of centrifugal 15min, get supernatant;
(2) adopt molecular weight to be that enzymolysis liquid filters by the milipore filter of 3000Da, collect the part that ultrafiltration molecular weight is less than 3000D, then adopt molecular weight be 150 NF membrane, carry out nanofiltration process desalination, nanofiltration condition: molecular weight is 150 mwco membranes, enters film pressure 11MPa, goes out film pressure 11MPa.Finally protein hydrolysate is carried out freeze drying, freeze drying condition: temperature controlled condition: 0-30min, 0 DEG C rises to 30 DEG C; 30-360min, 30 DEG C; 360-480min, 30 DEG C rise to 40 DEG C; 489-720min, 40 DEG C; 720-840min, is down to 20 DEG C for 40 DEG C; Vacuum is 40pa, and temperature-30 DEG C finally obtains sea cucumber protein hydrolysate.
(3) (2) are obtained sea cucumber protein hydrolysate, add 2 times amount beta-schardinger dextrin-s, then add 5 times of water gagings, after grinding 30min, 60 DEG C of dry 12h, dry thing was pulverized 100 mesh sieves and was obtained sea cucumber albumen Benexate Hydrochloride.
2. prepare sea cucumber albumen effervescent tablet
[prescription proportioning]
[preparation method] is according to said components proportioning
(1) the sea cucumber albumen Benexate Hydrochloride sealing obtained through super-dry saves backup; By tartaric acid and edible sodium bicarbonate, respectively at 105 DEG C of dryings 2 hours, pulverized 100 mesh sieves, sealing saved backup; 100 mesh sieves pulverized by lactose, and sealing saves backup; Acesulfame potassium and orange flavor, pulverized 100 mesh sieves; Dolomol pulverized 100 mesh sieves.Save backup in drier; The temperature budget that controls environment in preparation process humidity is respectively at 25 DEG C, 35%.
(2) by sea cucumber protein hydrolysate, lactose and acesulfame potassium are divided into two parts, prepare particle respectively, use 95% ethanol when preparing particle with tartaric acid and edible sodium bicarbonate.After preparing particle, reduced pressure at room temperature 12h, can not heat, and drying terminates rear whole grain.
(3), before compressing tablet, after soda acid uniform particles being mixed, dolomol is added and orange flavor mixes.
(4) by the granulation of fully mixing in (3), obtain sea cucumber albumen effervescent tablet, setting sheet is heavily 1g.The average sheet of gained sea cucumber proteolysis effervescent tablet is heavily 1.02 ± 0.04g, any surface finish, exquisiteness, yellow, a slice effervescent tablet is dropped in 40 DEG C of 150ml warm waters, at the bottom of effervescent tablet sinks to glass very soon, and release a large amount of bubble immediately, tablet dissolves rapidly thereupon, in 1 minute, form light yellow transparent solution, and good mouthfeel.
Claims (6)
1. a sea cucumber albumen effervescent tablet, is characterized in that: described sea cucumber albumen effervescent tablet composition comprises sea cucumber enzymolysis protein, inclusion agents, excipient, lubricant, sweetener, aromatic and effervescent agent.
2. according to sea cucumber albumen effervescent tablet according to claim 1, it is characterized in that: effervescent agent is wherein made up of sour agent and alkaline agent, sour agent is tartaric acid, and alkaline agent is sodium acid carbonate; Inclusion agents is beta-schardinger dextrin-; Excipient is lactose; Lubricant is dolomol or Macrogol 6000; Sweetener is acesulfame potassium; Aromatic is acesulfame potassium and orange flavor.
3. according to sea cucumber albumen effervescent tablet according to claim 2, it is characterized in that: by the proportioning mass ratio of each component be: sea cucumber enzymolysis protein 5%, beta-schardinger dextrin-10%, lactose 20%, dolomol 1% or Macrogol 6000 1%, acesulfame potassium 1.5%, orange flavor 0.5%, tartaric acid 27%, sodium acid carbonate 35%.
4. a preparation method for sea cucumber albumen effervescent tablet, is characterized in that:
Concrete operation step comprises:
(1) the sea cucumber albumen Benexate Hydrochloride sealing obtained through super-dry saves backup; By sour agent, alkaline agent respectively at 95-105 DEG C of dry 2-4 hour, pulverized 80-100 mesh sieve, sealing saves backup; Excipient was pulverized 80-100 mesh sieve and was saved backup; 80-100 mesh sieve pulverized by sweetener and aromatic; 80-100 mesh sieve pulverized by lubricant, saved backup in normal temperature dryer; The temperature and humidity that controls environment in preparation process is respectively at 15-25 DEG C and 25-35%.
(2) by sea cucumber albumen Benexate Hydrochloride, excipient and sweetener are divided into two parts, particle is prepared respectively with sour agent and alkaline agent, with 95% ethanol for particle prepared by adhesive, after preparing particle, reduced pressure at room temperature 0.08-0.1Mpa, drying time is 12-24h, and drying terminates rear further whole grain.
(3), before compressing tablet, after soda acid uniform particles being mixed, 1% lubricant is added and 2.0% aromatic mixes.
(4) by the granulation of fully mixing in (3), sea cucumber albumen effervescent tablet is obtained.
5. according to the preparation method of sea cucumber albumen effervescent tablet according to claim 4, it is characterized in that: the preparation method of described sea cucumber albumen Benexate Hydrochloride is:
1) sea cucumber is cleaned removing impurity, after adding 3 times of water gaging making beating, add water to 5 times amount volumes again and carry out enzymolysis, add the compound protease Protomax (in protein content) of 20000U/g, temperature 50 C, pH is 7.0, enzymolysis 3h while stirring, 100 DEG C of heating 10min go out after enzyme, and 4000 revs/min of centrifugal 15min, get supernatant;
2) molecular cut off is adopted to be that enzymolysis liquid filters by the milipore filter of 3000Da, collect the part that ultrafiltration molecular weight is less than 3000Da, adopt again molecular cut off be 150 NF membrane, carry out nanofiltration process desalination, nanofiltration condition: molecular weight is 150 mwco membranes, enter film pressure 1.1MPa, go out film pressure 1.1MPa, finally protein hydrolysate is carried out freeze drying;
3) by step 2) the sea cucumber enzymolysis protein product that obtains, add the beta-schardinger dextrin-(in sea cucumber enzymolysis protein product) of 2 times amount, add 5 times of water gagings (in beta-schardinger dextrin-) again, after grinding 30min, 60 DEG C of dry 12h, dry thing was pulverized 100 mesh sieves and was obtained sea cucumber albumen Benexate Hydrochloride.
6., according to the preparation method of sea cucumber albumen effervescent tablet according to claim 5, it is characterized in that: described step 2) in freeze drying condition be: temperature controlled condition: 0-30min, 0 DEG C rises to 30 DEG C; 30-360min, 30 DEG C; 360-480min, 30 DEG C rise to 40 DEG C; 489-720min, 40 DEG C; 720-840min, is down to 20 DEG C for 40 DEG C; Vacuum is 40Mpa, and temperature-30 DEG C finally obtains sea cucumber protein hydrolysate.
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Cited By (3)
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| CN106234909A (en) * | 2016-08-09 | 2016-12-21 | 渤海大学 | A kind of Intestinum Stichopi japonici effervescent tablet |
| CN106473156A (en) * | 2016-09-30 | 2017-03-08 | 彝良山益宝生物科技有限公司 | A kind of Rhizoma Gastrodiae protein peptide effervescent tablet and preparation method thereof |
| CN107125533A (en) * | 2017-06-09 | 2017-09-05 | 合肥工业大学 | A kind of preparation method of Xuancheng's pawpaw effervescent tablet |
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| CN107125533A (en) * | 2017-06-09 | 2017-09-05 | 合肥工业大学 | A kind of preparation method of Xuancheng's pawpaw effervescent tablet |
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