CN106234909A - A kind of Intestinum Stichopi japonici effervescent tablet - Google Patents
A kind of Intestinum Stichopi japonici effervescent tablet Download PDFInfo
- Publication number
- CN106234909A CN106234909A CN201610646141.XA CN201610646141A CN106234909A CN 106234909 A CN106234909 A CN 106234909A CN 201610646141 A CN201610646141 A CN 201610646141A CN 106234909 A CN106234909 A CN 106234909A
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- China
- Prior art keywords
- parts
- stichopus japonicus
- intestinum stichopi
- stichopi japonici
- effervescent tablet
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- A—HUMAN NECESSITIES
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of Intestinum Stichopi japonici effervescent tablet, be made up of the component of following weight portion: Stichopus japonicus rice noodle roll 10～30 parts, vitamin C 5～10 parts, acid compound 10～50 parts, alkali compounds 10～30 parts, filler 4～10 parts, lubricant 0.5～5 parts, binding agent 1～4 parts.The Intestinum Stichopi japonici effervescent tablet of the present invention, the comprehensive utilization for Intestinum Stichopi japonici provides a method that, is of high nutritive value, it is possible to give full play to its health-care effect.The Intestinum Stichopi japonici effervescent tablet of the present invention, is to be processed on the basis of Stichopus japonicus purifies and tells after sand, it is to avoid the silt in Intestinum Stichopi japonici, humus is on post-production and the impact of nutritive value.Stichopus japonicus is as traditional tonic, and price is high, and most of common people can not consume.Use Stichopus japonicus rice noodle roll price than Stichopus japonicus cheap a lot, greatly reduce the financial burden of patient.And the effervescent tablet prepared gets final product rapid disintegrate in cold water, bioactive ingredients availability is high, is easy to carry again simultaneously, instant-drink, also has longer storage period, the solid effervescent beverage prepared, good health-care effect can be played with enhancing human body immunity function.
Description
Technical field
The present invention relates to a kind of Intestinum Stichopi japonici effervescent tablet and preparation method thereof, belong to health-care solid beverage technical field.
Background technology
In today that health promoting beverage makes rapid progress, wholefood and extract thereof have obtained people and have more paid close attention to.At present
Solid beverage mostly be after fruit is dried or pulverizes, be used alone or as a mixture.Seldom see use animality nourishing food
Thing produces the product of solid beverage.
Stichopus japonicus belongs to one of precious seafood, and traditional habit is considered as nourishing food Stichopus japonicus.In scientific validation, Stichopus japonicus body
Containing more than the 50 kinds of nutritional labelings useful to human physiological activity, it can continue human senility, tonify Qi of the kidney, essence-replenishing and marrow-strengthening,
The ability of allaying tiredness, has more anticoagulation, antitumor, antibacterial, antiviral and improves the effects such as immunity.Intestinum Stichopi japonici i.e. Stichopus japonicus
Casing and Stichopus japonicus ovum, find according to the study, and nutritional labeling contained in Intestinum Stichopi japonici, no less than body wall.It is reported, Intestinum Stichopi japonici has
Antioxidation, slow down aging, the normal carbohydrate metabolism of maintenance, stimulate the hemopoietic function of body, promote the hematopoietic potential of skeleton, anti-
Tumor, radioprotective, antifungal, cholinolytic effect, also the most effective in cure to gastric ulcer and duodenal ulcer.But, sea at present
The ginseng general waste treatment of intestinal, utilization rate is the lowest, not only wastes resource but also pollute environment.Have not seen use Intestinum Stichopi japonici at present
The report of processing effervescent tablet.
Summary of the invention
The present invention relates to a kind of Intestinum Stichopi japonici effervescent tablet, with the problem solving to propose in technical background.
The technical solution used in the present invention is: the parts by weight of its supplementary material are: Stichopus japonicus rice noodle roll 10～30 parts, vitamin
C5～10 parts, acid compound 10～50 parts, alkali compounds 10～30 parts, filler 4～10 parts, lubricant 0.5～5
Part, binding agent 1～4 parts.
Described filler is selected from any one in starch, Icing Sugar, mannitol, maltodextrin, sucrose or the most several groups
Close.
Described acid compound is selected from any one in citric acid, tartaric acid, malic acid or the most several combinations.
Described alkali compounds is selected from sodium bicarbonate or sodium carbonate.
Described lubricant is selected from polyethylene glycol 6000.
Described binding agent is selected from dehydrated alcohol.
Described Intestinum Stichopi japonici effervescent tablet is to prepare through Stichopus japonicus rice noodle roll, and effervescent tablet the step such as is prepared and prepared.
Described Stichopus japonicus rice noodle roll is to use the preparation of one of following two mode:
(1) Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, every part clean after Intestinum Stichopi japonici add 0.2-3 times cleaning
Water, adds alkaline protease and the flavor protease of 0.1%-0.5% of the 0.1%-0.5% of Intestinum Stichopi japonici weight, at 50 DEG C-60 DEG C
At a temperature of carry out enzymolysis, enzymolysis 0.5-4 was as a child warmed up to 80-100 degree enzyme denaturing 10-30 minute, through filter, be spray-dried prepare
Stichopus japonicus rice noodle roll；
(2) Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, then Intestinum Stichopi japonici is cleaned carry out after draining freezing dry
Dry, dried Intestinum Stichopi japonici obtains powder through micronizing 200-400 mesh again.
The preparation method of described Intestinum Stichopi japonici effervescent tablet, the steps include: to take Stichopus japonicus rice noodle roll, vitamin C and alkali compounds,
It is dry mixed；After being dry mixed, add the lubricant wet mixing of the total consumption of lubricant 1/2, and alkaline grain of pelletizing to obtain；Take acid compound
And filler, it is dry mixed；After being dry mixed, add remaining lubricant wet mixing, and acid grain of pelletizing to obtain；Granule is 45 DEG C of air blast
It is dried；Acid grain, alkalescence grain add binding agent, mixing, tabletting, to obtain final product.
Stichopus japonicus belongs to one of precious seafood, and traditional habit is considered as nourishing food Stichopus japonicus.In scientific validation, Stichopus japonicus body
Containing more than the 50 kinds of nutritional labelings useful to human physiological activity, it can continue human senility, tonify Qi of the kidney, and essence-replenishing and marrow-strengthening disappears
Except tired ability, have more anticoagulation, antitumor, antibacterial, antiviral and improve the effects such as immunity.Intestinum Stichopi japonici (digestive tract)
I.e. Stichopus japonicus casing and Stichopus japonicus ovum, find according to the study, and nutritional labeling contained in Intestinum Stichopi japonici, no less than body wall.
The amino acid classes contained in Intestinum Stichopi japonici is complete, comprises 8 kinds of aminoacid of needed by human.Wherein, free amino acid
In leucic content higher, it is disorderly that leucine can correct the aminoacid caused due to liver failure；In conjunction with aminoacid two-story valley
The content of propylhomoserin is higher.In Intestinum Stichopi japonici, essential amino acids content accounts for the 36.68% of total amino acid content respectively, higher than Stichopus japonicus wall
(31.02%), it is 0.59 with the ratio of non essential amino acid amount, higher than Stichopus japonicus wall (0.45).Lysine is as the first restricted ammonia
Base acid content in 8 kinds of essential amino acids is the highest, and higher than body wall.Aminoacid composition and WHO (the world health group of Intestinum Stichopi japonici
Knit) and E (essential amino acids)/T (total amino acids) of proposing of FAO (Food and Agricultural Organization of the United Nations) should be
0.4, E/N (non essential amino acid) should be 0.6 protein reference pattern close, but also containing accounting for total amino acid content
The drug effect aminoacid of 46. 86%.Additionally, the taurine not having possibly together with body wall in Stichopus japonicus intestinal wall, its content is higher than Carnis ostreae, horse
The content of taurine in martensii meat, taurine is a kind of with sulfonic special conditionally essential amino acid, and it is with trip
From state rich in intracellular in irritated tissue (neural, muscle), neuropathy, insulin resistant and the heart to diabetic
Vascular complication has notable preventive and therapeutic effect.This explanation Intestinum Stichopi japonici has the highest researching value in medical science and threpsology, tool
There are the potentiality developing into health product or medicament.
In Intestinum Stichopi japonici, fat content ratio is relatively low, but content of fatty acid is higher, and fatty acid is 0.43 with the ratio of crude fat,
Higher than wall of sea cucumber Stichopus japonicus (0.42).This is likely to be exactly one of Stichopus japonicus reason of having the highest nutrition and medical value.
In Intestinum Stichopi japonici, fatty acid has 21 kinds, and unsaturated fatty acid accounts for 70%, hence it is evident that higher than unsaturated fatty acid in body wall
Content (54.2%), Antarctic krill (47.98%) that higher than content of polyunsaturated fatty acid is higher, yellowfin Fugu ocellatus (37.91%
), salmon fish, Chlamys farreri etc..Wherein docosatetratenoic acid (C22: 4) and DHA (C22:6) are not had in wall of sea cucumber Stichopus japonicus
Having, total amount is 5.782 mg/g (weight in wet bases).Unsaturated fatty acid 17 kinds, total amount 4.798 mg/g (weight in wet base).Saturated fat
The kind of acid is identical with wall of sea cucumber Stichopus japonicus.In polyunsaturated fatty acid, EPA content is the highest, accounts for the 17.36% of all fatty acids,
Contain DHA simultaneously.EPA and DHA is the omega-3 polyunsaturated fatty acids of needed by human, has physiologically active widely, can compete
Property ground suppress hematoblastic gathering, reduce thrombosis formation, prevent cardiovascular and cerebrovascularinfarction.Therefore from composition and the content of fatty acid
For, the nutritive value of Intestinum Stichopi japonici is higher than wall of sea cucumber Stichopus japonicus.
Containing abundant Stichopus japonicus polysaccharide in Intestinum Stichopi japonici.Stichopus japonicus polysaccharide has multiple pharmacotoxicological effect, such as antioxidation: measuring
Finding when polysaccharide and esterificated polysaccharide scavenging hydroxyl and ultra-oxygen anion free radical ability in Intestinum Stichopi japonici, intestinal wall polysaccharide shows
Certain oxidation resistance, the ability of its scavenging hydroxyl ability and ultra-oxygen anion free radical is more than body wall polysaccharide；
Antitumor: Apostichopus japonicus intestinal polysaccharide has the inhibitory action of dose dependent, and high dose group (400mg/kg/d) to H22 tumor
Tumor inhibitory effect is best；Blood fat reducing: the eyeball of mouse having fed five weeks intestinal wall polysaccharide is taken blood, measures glycerol three in its serum
Ester, low-density lipoprotein cholesterol, total cholesterol, the content of HDL-C, result shows high, normal, basic dosage
All the energy triglyceride of significant reduction hyperlipemia in mice, low-density lipoprotein cholesterol, the level of T-CHOL, improves
Atherogenic index and HDL-C value, display Intestinum Stichopi japonici polysaccharide has effect for reducing blood fat.
Selenka, also known as holothurin, is the main secondary metabolite of Stichopus japonicus, and in intestinal wall, saponin content is about its weight in wet base
1.03%, hence it is evident that higher than body wall saponin (0.37%).Saponin is respectively provided with haematolysis ability.
Intestinum Stichopi japonici is possibly together with pigment and the compositions such as vanadium, nucleic acid such as abundant beta-carotene, astaxanthin, echinenones.According to
Report, Intestinum Stichopi japonici has antioxidation, slow down aging, the normal carbohydrate metabolism of maintenance, stimulates the hemopoietic function of body, promotion bone
The hematopoietic potential of bone, antitumor, radioprotective, antifungal, cholinolytic effect, the most also have treatment to gastric ulcer and duodenal ulcer
Effect.
But, the general waste treatment of current Intestinum Stichopi japonici, utilization rate is the lowest, not only wastes resource but also pollute environment.
Compared with prior art, the invention has the beneficial effects as follows: the Intestinum Stichopi japonici effervescent tablet of the present invention, comprehensive for Intestinum Stichopi japonici
Utilization provides a method that, is of high nutritive value, it is possible to give full play to its health-care effect.The Intestinum Stichopi japonici effervescent tablet of the present invention, be
It is processed on the basis of Stichopus japonicus purifies and tells after sand, gives full play to the nutritive value of Intestinum Stichopi japonici, it is to avoid the mud in Intestinum Stichopi japonici
Sand, humus is on post-production and the impact of nutritive value.Stichopus japonicus is as traditional tonic, and price is high, and most of old hundred
Surname can not consumed.Use Stichopus japonicus rice noodle roll price than Stichopus japonicus cheap a lot, greatly reduce the financial burden of patient.And prepare
Effervescent tablet in cold water can rapid disintegrate, bioactive ingredients availability is high, is easy to carry again simultaneously, instant-drink, also
There is longer storage period, the solid effervescent beverage prepared, can play good health care make with enhancing human body immunity function
With.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all
Belong to the scope of protection of the invention.
Embodiment 1:
Intestinum Stichopi japonici effervescent tablet parts by weight form: Stichopus japonicus rice noodle roll 10 parts, vitamin C 8 parts, maltodextrin 6 parts, citric acid 15 parts,
Sodium bicarbonate 20 parts, polyethylene glycol 6000 2 parts, dehydrated alcohol 4 parts.
Preparation method: prepared by (1) Stichopus japonicus rice noodle roll: Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, and every part clear
Intestinum Stichopi japonici after washing adds 0.5 times of clean water, the alkaline protease of the 0.2 of addition Intestinum Stichopi japonici weight and the local flavor albumen of 0.1%
Enzyme, carries out enzymolysis at a temperature of 55 DEG C-58 DEG C, and enzymolysis 3 was as a child warmed up to 90 degree of enzyme denaturing 20 minutes, through filtration, spray dried
Dry prepared Stichopus japonicus rice noodle roll.
(2) effervescent tablet is prepared: take Stichopus japonicus rice noodle roll, vitamin C and alkali compounds, be dry mixed；After being dry mixed, add
The lubricant wet mixing of the total consumption of lubricant 1/2, and alkaline grain of pelletizing to obtain；Take acid compound and filler, be dry mixed；Dry
After Hun, add remaining lubricant wet mixing, and acid grain of pelletizing to obtain；Granule is 45 DEG C of forced air dryings；Acid grain, alkalescence grain add
Binding agent, mixing, tabletting, to obtain final product.
Embodiment 2:
Intestinum Stichopi japonici effervescent tablet parts by weight form: Stichopus japonicus rice noodle roll 12 parts, vitamin C 6 parts, sucrose 2 parts, maltodextrin 4 parts,
10 parts of tartaric acid, sodium carbonate 15 parts, polyethylene glycol 6000 2 parts, dehydrated alcohol 4 parts.
Preparation method: prepared by (1) Stichopus japonicus rice noodle roll: Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, then will
Intestinum Stichopi japonici cleans after draining and carries out lyophilization, and dried Intestinum Stichopi japonici obtains powder through micronizing 300 mesh again.
(2) effervescent tablet is prepared: take Stichopus japonicus rice noodle roll, vitamin C and alkali compounds, be dry mixed；After being dry mixed, add
The lubricant wet mixing of the total consumption of lubricant 1/2, and alkaline grain of pelletizing to obtain；Take acid compound and filler, be dry mixed；Dry
After Hun, add remaining lubricant wet mixing, and acid grain of pelletizing to obtain；Granule is 45 DEG C of forced air dryings；Acid grain, alkalescence grain add
Binding agent, mixing, tabletting, to obtain final product.
Claims (3)
1. an Intestinum Stichopi japonici effervescent tablet, it is characterised in that: it is made up of the component of following weight portion: Stichopus japonicus rice noodle roll 10～30
Part, vitamin C 5～10 parts, acid compound 10～50 parts, alkali compounds 10～30 parts, filler 4～10 parts, lubrication
Agent 0.5～5 parts, binding agent 1～4 parts；
Described filler is selected from any one in starch, Icing Sugar, mannitol, maltodextrin, sucrose or the most several combinations；
Described acid compound is selected from any one in citric acid, tartaric acid, malic acid or the most several combinations；
Described alkali compounds is selected from sodium bicarbonate or sodium carbonate；
Described lubricant is selected from polyethylene glycol 6000；
Described binding agent is selected from dehydrated alcohol；
Described Intestinum Stichopi japonici effervescent tablet is to prepare through Stichopus japonicus rice noodle roll, and effervescent tablet preparation process prepares.
2. the preparation method of the Intestinum Stichopi japonici effervescent tablet described in claim 1, it is characterised in that: described Stichopus japonicus rice noodle roll is to use
Prepared by one of following two mode:
(1) Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, every part clean after Intestinum Stichopi japonici add 0.2-3 times cleaning
Water, adds alkaline protease and the flavor protease of 0.1%-0.5% of the 0.1%-0.5% of Intestinum Stichopi japonici weight, at 50 DEG C-60 DEG C
At a temperature of carry out enzymolysis, enzymolysis 0.5-4 was as a child warmed up to 80-100 degree enzyme denaturing 10-30 minute, through filter, be spray-dried prepare
Stichopus japonicus rice noodle roll；
(2) Stichopus japonicus takes intestinal by fishing for after telling husky purification in clarifier-tank, then Intestinum Stichopi japonici is cleaned carry out after draining freezing dry
Dry, dried Intestinum Stichopi japonici obtains powder through micronizing 200-400 mesh again.
3. the preparation method of the Intestinum Stichopi japonici effervescent tablet described in claim 1, it is characterised in that: take Stichopus japonicus rice noodle roll, vitamin C
And alkali compounds, it is dry mixed；After being dry mixed, add the lubricant wet mixing of the total consumption of lubricant 1/2, and alkaline grain of pelletizing to obtain；
Take acid compound and filler, be dry mixed；After being dry mixed, add remaining lubricant wet mixing, and acid grain of pelletizing to obtain；Granule
45 DEG C of forced air dryings；Acid grain, alkalescence grain add binding agent, mixing, tabletting, to obtain final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109757595A (en) * | 2019-03-02 | 2019-05-17 | 大连棒棰岛海产股份有限公司 | Sea cucumber intestine extract pressed candy and its preparation method |
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