CN104824508A - Nisin oral refreshing and tasting chips and preparation method therefor - Google Patents
Nisin oral refreshing and tasting chips and preparation method therefor Download PDFInfo
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- CN104824508A CN104824508A CN201510191569.5A CN201510191569A CN104824508A CN 104824508 A CN104824508 A CN 104824508A CN 201510191569 A CN201510191569 A CN 201510191569A CN 104824508 A CN104824508 A CN 104824508A
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- nisin
- film
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- refreshing
- refreshing tablets
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- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 title claims abstract description 54
- 108010053775 Nisin Proteins 0.000 title claims abstract description 54
- 239000004309 nisin Substances 0.000 title claims abstract description 54
- 235000010297 nisin Nutrition 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000003756 stirring Methods 0.000 claims abstract description 21
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000013736 caramel Nutrition 0.000 claims abstract description 11
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940041616 menthol Drugs 0.000 claims abstract description 10
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- 150000004676 glycans Chemical class 0.000 claims description 29
- 229920001282 polysaccharide Polymers 0.000 claims description 29
- 239000005017 polysaccharide Substances 0.000 claims description 29
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 14
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 14
- 239000003086 colorant Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 108010011485 Aspartame Proteins 0.000 claims description 6
- 241000206575 Chondrus crispus Species 0.000 claims description 6
- 239000000605 aspartame Substances 0.000 claims description 6
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 6
- 235000010357 aspartame Nutrition 0.000 claims description 6
- 229960003438 aspartame Drugs 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 5
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 5
- 229960004998 acesulfame potassium Drugs 0.000 claims description 5
- 239000000619 acesulfame-K Substances 0.000 claims description 5
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229920000161 Locust bean gum Polymers 0.000 claims description 3
- 239000000711 locust bean gum Substances 0.000 claims description 3
- 235000010420 locust bean gum Nutrition 0.000 claims description 3
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 2
- AHRFRRASJMTTQU-UHFFFAOYSA-N 6-methyl-2,2-dioxooxathiazin-4-one;potassium Chemical compound [K].CC1=CC(=O)NS(=O)(=O)O1 AHRFRRASJMTTQU-UHFFFAOYSA-N 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 235000019482 Palm oil Nutrition 0.000 claims description 2
- 239000004376 Sucralose Substances 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 claims description 2
- 238000013019 agitation Methods 0.000 claims description 2
- 229930182478 glucoside Natural products 0.000 claims description 2
- 150000008131 glucosides Chemical class 0.000 claims description 2
- 239000004519 grease Substances 0.000 claims description 2
- 239000002540 palm oil Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229940083542 sodium Drugs 0.000 claims description 2
- 235000015424 sodium Nutrition 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- -1 sucrose fatty ester Chemical class 0.000 claims description 2
- 229920001285 xanthan gum Polymers 0.000 claims description 2
- 230000001055 chewing effect Effects 0.000 abstract description 10
- 210000000214 mouth Anatomy 0.000 abstract description 8
- 241000894006 Bacteria Species 0.000 abstract description 6
- 235000013305 food Nutrition 0.000 abstract description 5
- 241000194019 Streptococcus mutans Species 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 230000007774 longterm Effects 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000002925 dental caries Diseases 0.000 abstract 2
- 239000003292 glue Substances 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000049 pigment Substances 0.000 abstract 2
- 206010006326 Breath odour Diseases 0.000 abstract 1
- 241000186660 Lactobacillus Species 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 229940039696 lactobacillus Drugs 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 241000194035 Lactococcus lactis Species 0.000 description 5
- 235000014897 Streptococcus lactis Nutrition 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 229920001218 Pullulan Polymers 0.000 description 4
- 239000004373 Pullulan Substances 0.000 description 4
- 235000015111 chews Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 235000019423 pullulan Nutrition 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 230000000675 anti-caries Effects 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 241000192125 Firmicutes Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 229910000645 Hg alloy Inorganic materials 0.000 description 1
- 206010020674 Hypermetabolism Diseases 0.000 description 1
- 102000001621 Mucoproteins Human genes 0.000 description 1
- 108010093825 Mucoproteins Proteins 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000011797 cavity material Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides nisin oral refreshing and tasting chips and a preparation method therefor, belonging to the technical field of leisure foods. The oral refreshing and tasting chips are prepared from the following raw materials: food-grade pulullan, an auxiliary member agent, a high sweetening agent, an emulsifier, nisin, menthol, caramel pigment and citric acid. The preparation method comprises: firstly, food-grade pulullan and the auxiliary member agent are slowly added into water at 60-70 DEG C to get dissolved and swelled, and the solution is stirred at the same time; the PH is adjusted with a moderate amount of citric acid, afterwards, the solution is allowed to stand to obtain a glue solution; nisin, the edible pigment and menthol are added into glue solution which is stirred evenly prior to standing; the emulsifier is added with stirring, the solution is cooled down to room temperature, so that bubbles in a membrane solution are removed; and an organic glass sheet is coated with the membrane solution, then the member gets dry and gets stripped, thereby obtaining the oral refreshing and tasting chips. The oral refreshing and tasting chips provided by the invention can effectively restrain the growth of streptococcus mutans and lactobacillus in the process of occurrence of dental caries; the product can effectively prevent dental caries caused by bacteria breeding, and without long-term chewing, also eliminate bad breath and keep oral cavity fresh and sanitary.
Description
Technical field
The invention belongs to application leisure food technical field, be specifically related to a kind of non-masticatory pattern pulullan polysaccharide nisin refreshing tablets containing nisin and preparation method thereof.
Background technology
Carious tooth occurs and in evolution, bacterium plays leading role, and cariogenic bacterial species is a lot, most importantly some streptococcus mutans and Bacillus acidi lactici.Mucoprotein in these bacteriums and saliva and food scraps mix, and stick in dental surface and nest ditch securely, form bacterial plaque or bacterial plaque (dentalplaque).A large amount of Production by Bacteria acid in bacterial plaque, cause the enamel surfaces decalcification below bacterial plaque, dissolving.At present, the chewing gum for preventing decayed tooth containing xylitol is favored by consumers in general deeply, but the potential harm that chews gum for a long time is ignored by people.Long-time chew gum, allows oral cavity be in hypermetabolism state for a long time, can a large amount of hydrochloric acid in gastric juice of reflectivity ground secretion, digestive ferment is increased, causes nausea, the symptom such as sour regurgitation water, easily damages stomach; Often do masticatory movement in large quantities, masseter can be made more flourishing, cause facial deformations; A research of Switzerland scientist finds, often chew gum the material that can damage for dental filling in oral cavity, and mercury alloy is wherein discharged, and causes the mercury content in blood, urine to exceed standard, thus work the mischief to brain, nervous centralis and kidney.In addition, children's self-control is poor, and all day is contained in chewing gum in the mouth, likely eats or is strayed into tracheae, threat to life.
Pulullan polysaccharide (Pullulan) Chinese is also translated into pullulan, pullulan, pullulan or pulullan, a kind of soluble in water, safety non-toxic evil, edible, low-calorie natural polysaccharide, its plasticity, good film-forming property, film gas barrier properties are good, have been widely used at field tools such as medicine, food, cosmetics, environmental protection.Streptococcus lactis peptide (Nisin) is also known as nisin, newborn chain, it be some streptococcus lactis (now claiming Lactococcus lactis) by fermentation, the little peptide of biosynthetic amino acid composition, the complete structure that Gross equals to illustrate for 1971 streptococcus lactis peptide molecule is made up of 34 amino acid.Breast chain is to gram-positive bacteria, and comprising germs such as causing the streptococcus mutans of carious tooth and Bacillus acidi lactici has stronger Growth and reproduction inhibitory action.Chen Xifu equals within 2011, to propose streptococcus lactis peptide and has certain effect to preventing carious tooth.Being that the refreshing tablets of substrate material is more and more subject to focusing on food health and safe occurrences in human life with pulullan polysaccharide, is especially all the favor of white collar, its have entrance dissolution velocity soon, the plurality of advantages of the not easily moisture absorption, instant and environmental protection.Pfizer Inc. just took the lead in being proposed refreshing chewing gum chips as far back as calendar year 2001.At present, the report of anti-caries refreshing tablets Related product and technology is not also had.
Summary of the invention
The object of the invention is to utilize that the antibiotic property of nisin, pulullan polysaccharide are water-soluble, the feature of safety non-toxic, good film-forming property, develop a kind of containing nisin, just can rapid solution in the oral cavity without the need to chewing, the non-masticatory pattern pulullan polysaccharide anti-caries refreshing tablets of instant, provides its preparation method simultaneously.
Technical scheme of the present invention is:
A kind of nisin refreshing tablets, is characterized in that, adds water make by the raw material of following percentage by weight:
65 ~ 80% food-grade pulullan polysaccharides, 0 ~ 2% auxiliary film, 0.5 ~ 1.5% high sweetener, 0.5% emulsifying agent, 5% ~ 18% nisin, 2.5 ~ 5% menthols, 0.5 ~ 1% caramel colorant, 0.5 ~ 1.5% citric acid; Above component is dry weight.
Further, be made up of the raw material of following percentage by weight:
13% ~ 16% food-grade pulullan polysaccharide, 0 ~ 0.4% auxiliary film, 0.1% ~ 0.3% high sweetener, 0.1% emulsifying agent, 1% ~ 3.6% nisin, 0.5 ~ 1% menthol, 0.1 ~ 0.2% caramel colorant, 0.1 ~ 0.3% citric acid, 75 ~ 85% water.
Further, the viscosity of described food-grade pulullan polysaccharide is 50-170
2/ s.
Further, described auxiliary film is at least one in carragheen, locust bean gum, xanthans, carboxylic third methylcellulose, cyclodextrin.
Further, described high sweetener is selected from least one in glucosides sodium, Aspartame, acesulfame potassium, Sucralose, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt.
Further, described emulsifying agent is the one in Tween-80, sucrose fatty ester, polyglycereol palm oil grease.
Present invention also offers a kind of preparation method of nisin refreshing tablets, it is characterized in that, comprise the following steps:
Take raw material:
Raw material is taken according to above-mentioned percentage by weight;
Preparation:
A. the above-mentioned food-grade pulullan polysaccharide that takes and auxiliary film are mixed, under agitation, slowly join in the water of 60 ~ 70 DEG C, with the speed stirring and dissolving of 30r/min;
B. the pH value of solution obtained with citric acid regulating step a is to 5.5-6.5;
C. nisin is added in the solution that step b obtains, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 20 ~ 40min;
D. the mixture that step c obtains is cooled to room temperature;
E. high sweetener, menthol, caramel colorant are dissolved in the solution that steps d obtains, and stir 5min with the speed of 30r/min;
F. emulsifying agent is added in the mixture of step e, with the speed stirring and dissolving of 30r/min, until evenly;
G. ultrasonic 15min, then leaves standstill 60 ~ 120min, the bubble in the solution obtained in removing step f;
H. film liquid step g prepared carries out film on poly (methyl methacrylate) plate;
I. the poly (methyl methacrylate) plate of film is dried;
J. refreshing tablets is obtained after taking off film.
Further,
Described step I is: the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dries 15 ~ 25min for 50 ~ 60 DEG C,
In described step j, after taking off film, with paper knife, film is cut into the small pieces of 20 × 25mm.
The invention has the beneficial effects as follows:
(1) pulullan polysaccharide has good plasticity, film forming and dissolubility, can support the edible film that transparency is high and density is high, therefore can reduce the use amount of thickener in process.
(2) nisin is to gram-positive bacteria, and comprising germs such as causing the streptococcus mutans of carious tooth and Bacillus acidi lactici has stronger Growth and reproduction inhibitory action.
(3) pulullan polysaccharide in refreshing tablets of the present invention, auxiliary film have the feature low with hygroscopicity, even if the refreshing tablets prepared also not easily moisture absorption adhesion under high humidity environment.
(4) refreshing tablets of the present invention have without the need to chewing, the feature of instant, avoid the harm because long-term chew gum brings.
Detailed description of the invention
In order to understand the present invention better, illustrate content of the present invention further below in conjunction with embodiment, but content of the present invention is not only confined to the following examples, embodiment should not regard as limiting the scope of the present invention.
Embodiment 1
A kind of containing nisin, without the need to chewing, rapid solution non-masticatory pattern pulullan polysaccharide nisin refreshing tablets, comprise the composition of following weight percentage:
Said components material is made non-masticatory pattern pulullan polysaccharide nisin refreshing tablets by following preparation method:
1. food-grade pulullan polysaccharide, carragheen and locust bean gum are mixed, slowly join in the water of 60 ~ 70 DEG C, stirring and dissolving, regulate PH to 6.0 with appropriate citric acid, nisin is added in solution, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 40min, Aspartame, menthol, caramel colorant are added in solution, stir 5min, add emulsifier for mixing until evenly, ultrasonic 15min, then leaves standstill 60min, removing bubble;
2. the film liquid of preparation is carried out film on poly (methyl methacrylate) plate;
3. the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dry 15min for 50 ~ 60 DEG C;
4. obtain refreshing tablets after taking off film, with paper knife film cut into and do not have small pieces 20 × 25mm.
Embodiment 2
A kind of containing nisin, without the need to chewing, rapid solution non-masticatory pattern pulullan polysaccharide nisin refreshing tablets, comprise the composition of following weight percentage:
Said components material is made non-masticatory pattern pulullan polysaccharide nisin refreshing tablets by following preparation method:
1. food-grade pulullan polysaccharide, carragheen are mixed, slowly join in the water of 60 ~ 70 DEG C, stirring and dissolving, regulate PH to 6.0 with appropriate citric acid, nisin is added in solution, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 40min, Aspartame, acesulfame potassium, menthol, caramel colorant are added in solution, stir 5min, add emulsifier for mixing until evenly, ultrasonic 15min, then leaves standstill 60min, removing bubble;
2. the film liquid of preparation is carried out film on poly (methyl methacrylate) plate;
3. the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dry 15min for 50 ~ 60 DEG C;
4. obtain refreshing tablets after taking off film, with paper knife film cut into and do not have small pieces 20 × 25mm.
Embodiment 3
A kind of containing nisin, without the need to chewing, rapid solution non-masticatory pattern pulullan polysaccharide nisin refreshing tablets, comprise the composition of following weight percentage:
Said components material is made non-masticatory pattern pulullan polysaccharide nisin refreshing tablets by following preparation method:
1. food-grade pulullan polysaccharide, carragheen, carboxylic third methylcellulose are mixed, slowly join in the water of 60 ~ 70 DEG C, stirring and dissolving, regulate PH to 6.0 with appropriate citric acid, nisin is added in solution, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 40min, Aspartame, acesulfame potassium, menthol, caramel colorant are added in solution, stir 5min, add emulsifier for mixing until evenly, ultrasonic 15min, then leaves standstill 60min, removing bubble;
2. the film liquid of preparation is carried out film on poly (methyl methacrylate) plate;
3. the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dry 15min for 50 ~ 60 DEG C;
4. obtain refreshing tablets after taking off film, with paper knife film cut into and do not have small pieces 20 × 25mm.
Embodiment 4
A kind of containing nisin, without the need to chewing, rapid solution non-masticatory pattern pulullan polysaccharide nisin refreshing tablets, comprise the composition of following weight percentage:
Said components material is made non-masticatory pattern pulullan polysaccharide nisin refreshing tablets by following preparation method:
1. food-grade pulullan polysaccharide, carragheen, carboxylic third methylcellulose are mixed, slowly join in the water of 60 ~ 70 DEG C, stirring and dissolving, regulate PH to 6.0 with appropriate citric acid, nisin is added in solution, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 40min, Aspartame, acesulfame potassium, menthol, caramel colorant are added in solution, stir 5min, add emulsifier for mixing until evenly, ultrasonic 15min, then leaves standstill 60min, removing bubble;
2. the film liquid of preparation is carried out film on poly (methyl methacrylate) plate;
3. the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dry 15min for 50 ~ 60 DEG C;
4. obtain refreshing tablets after taking off film, with paper knife film cut into and do not have small pieces 20 × 25mm.
Pulullan polysaccharide used is food-grade above.
Embodiment 5
The external moisture absorption experiment of nisin refreshing tablets
Experimental technique: the nisin refreshing tablets cut is loaded commercially available refreshing tablets packing box, 24, every box, is placed on that temperature is 37 DEG C, humidity is under 80% experimental situation respectively, and weighed every 2 days, every example is three Duplicate Samples.
Table 1 contains the external moisture absorption experimental result of nisin and xylo-oligosaccharide anti-caries refreshing tablets
| Time (d) | Example 1 (g) | Example 2 (g) | Example 3 (g) | Example 4 (g) | Example 5 (g) |
| 0 | 23.45±0.03 | 24.17±0.05 | 23.96±0.02 | 24.06±0.01 | 24.28±0.04 |
| 2 | 24.44±0.02 | 24.17±0.02 | 23.98±0.06 | 24.06±0.03 | 24.31±0.03 |
| 4 | 24.46±0.03 | 24.16±0.04 | 24.96±0.05 | 24.07±0.02 | 24.30±0.01 |
| 6 | 24.47±0.04 | 24.17±0.03 | 24.97±0.01 | 24.06±0.01 | 24.30±0.03 |
| 8 | 24.45±0.02 | 2.148±0.02 | 24.99±0.03 | 24.08±0.03 | 24.31±0.02 |
| 10 | 24.47±0.03 | 24.18±0.01 | 24.98±0.04 | 24.08±0.01 | 24.30±0.01 |
| 12 | 24.49±0.03 | 24.19±0.03 | 24.99±0.02 | 24.08±0.02 | 24.31±0.04 |
Table 1 experimental result shows, and before carrying out moisture absorption experiment, does not have significant difference with between group.Place 12d under high humidity environment after, statistical significance (p > 0.05) is not had with the refreshing tablets weight differential between group, nisin refreshing tablets tool not easily moisture absorption prepared by this method is described, even if under hot and humid environment, still effectively adhesion can be prevented.
Embodiment 6
The oral bacteriostasis experiment of nisin refreshing tablets
Research method: random selecting 18 volunteers, 9 women, 9 male sex, the age was 22 ~ 35 one full year of life, volunteer was divided at random 3 groups (A, B, C), often organized 3 women, 3 male sex.Volunteer normally takes food 2h after unified lunch, to dip in volunteer oral cavity material inside frist premolar gently with disinfecting cotton swab, and in superclean bench, be diluted to 10000 times in sterilized water rapidly, coat total plate count and detect on culture medium, after 37 DEG C of cultivation 48h, counting.
Then, A group chews the nisin refreshing tablets 1 of preparation, and B group chews the nisin refreshing tablets 2 of preparation, and C group chews the nisin refreshing tablets 3 of preparation.After 2h, according to above-mentioned experimental technique, measure total plate count in oral cavity.
Total number of bacteria (× 10 inside table 2 frist premolar
3individual):
| Before chewing | After chewing | |
| A group | 526±23 | 11.79±0.44 |
| B group | 601±37 | 14.55±0.34 |
| C group | 622±39 | 14.60±0.47 |
Table 2 experimental result shows, and after chewing nisin refreshing tablets, the total number of bacteria in oral cavity has obvious reduction, and the amplitude reduced reaches more than 44 times, and as can be seen here, nisin refreshing tablets of the present invention has obvious fungistatic effect.
Claims (8)
1. a nisin refreshing tablets, is characterized in that, adds water make by the raw material of following percentage by weight:
65 ~ 80% food-grade pulullan polysaccharides, 0 ~ 2% auxiliary film, 0.5 ~ 1.5% high sweetener, 0.5% emulsifying agent, 5% ~ 18% nisin, 2.5 ~ 5% menthols, 0.5 ~ 1% caramel colorant, 0.5 ~ 1.5% citric acid; Above component is dry weight.
2. nisin refreshing tablets according to claim 1, is characterized in that, is made up of the raw material of following percentage by weight:
Food-grade pulullan polysaccharide, 0 ~ 0.4% auxiliary film, 0.1% ~ 0.3% high sweetener, 0.1% emulsifying agent, 1% ~ 3.6% nisin, 0.5 ~ 1% menthol, 0.1 ~ 0.2% caramel colorant, 0.1 ~ 0.3% citric acid, 75 ~ 85% water of 13% ~ 16%.
3. nisin refreshing tablets according to claim 1, is characterized in that, the viscosity of described food-grade pulullan polysaccharide is 50-1702/s.
4. nisin refreshing tablets according to claim 1, is characterized in that, described auxiliary film is at least one in carragheen, locust bean gum, xanthans, carboxylic third methylcellulose, cyclodextrin.
5. nisin refreshing tablets according to claim 1, is characterized in that, described high sweetener is selected from least one in glucosides sodium, Aspartame, acesulfame potassium, Sucralose, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt.
6. nisin refreshing tablets according to claim 1, is characterized in that, described emulsifying agent is the one in Tween-80, sucrose fatty ester, polyglycereol palm oil grease.
7. a preparation method for the nisin refreshing tablets according to claim 1-6, is characterized in that, comprise the following steps:
Take raw material:
Raw material is taken according to the arbitrary described percentage by weight of claim 1-6;
Preparation:
A. the above-mentioned food-grade pulullan polysaccharide that takes and auxiliary film are mixed, under agitation, slowly join in the water of 60 ~ 70 DEG C, with the speed stirring and dissolving of 30r/min;
B. the pH value of solution obtained with citric acid regulating step a is to 5.5-6.5;
C. nisin is added in the solution that step b obtains, with the speed stirring and dissolving of 30r/min, until evenly, leave standstill 20 ~ 40min;
D. the mixture that step c obtains is cooled to room temperature;
E. high sweetener, menthol, caramel colorant are dissolved in the solution that steps d obtains, and stir 5min with the speed of 30r/min;
F. emulsifying agent is added in the mixture of step e, with the speed stirring and dissolving of 30r/min, until evenly;
G. ultrasonic 15min, then leaves standstill 60 ~ 120min;
H. film liquid step g prepared carries out film on poly (methyl methacrylate) plate;
I. the poly (methyl methacrylate) plate of film is dried;
J. refreshing tablets is obtained after taking off film.
8. the preparation method of nisin refreshing tablets according to claim 7, is characterized in that,
Described step I is: the poly (methyl methacrylate) plate of film is put into constant temperature oven dry, dries 15 ~ 25min, in described step j, with paper knife, film is cut into the small pieces of 20 × 25mm after taking off film for 50 ~ 60 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
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| CN1602716A (en) * | 2004-11-16 | 2005-04-06 | 江南大学 | Tasty tablet production method directly using liquid Pullulan |
| CN1706269A (en) * | 2005-05-17 | 2005-12-14 | 汕头市富味制果厂有限公司 | Instant tasty and refreshing tablet and its making process |
| CN104256258A (en) * | 2014-10-16 | 2015-01-07 | 北京中科邦尼国际科技有限责任公司 | Composition for compound functional sugar, tasty tablets and preparation method of tasty tablets |
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| CN1602716A (en) * | 2004-11-16 | 2005-04-06 | 江南大学 | Tasty tablet production method directly using liquid Pullulan |
| CN1706269A (en) * | 2005-05-17 | 2005-12-14 | 汕头市富味制果厂有限公司 | Instant tasty and refreshing tablet and its making process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
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