CN104814996A - Composition containing eurycoma longifolia jack extract - Google Patents
Composition containing eurycoma longifolia jack extract Download PDFInfo
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- CN104814996A CN104814996A CN201510269226.6A CN201510269226A CN104814996A CN 104814996 A CN104814996 A CN 104814996A CN 201510269226 A CN201510269226 A CN 201510269226A CN 104814996 A CN104814996 A CN 104814996A
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Abstract
The invention discloses a composition containing a eurycoma longifolia jack extract. The composition is prepared by mixing an eurycoma longifolia jack extract, a termitomyces albuminosus extract, a gynostemma pentaphyllum extract, a milkvetch root extract and glycyrrhizic acid which are taken as raw materials. The composition containing the eurycoma longifolia jack extract, disclosed by the invention, has the effects of enhancing the body immunity, inhibiting the tumor growth and repairing body immune function damages caused by medicines, especially has relatively good treatment and health protection effects on patients suffering prostate cancer and uterus cancer, can be directly brewed with water for drinking, or can be further used for preparing auxiliary medicines or health products for treating cancer.
Description
Technical field
The invention belongs to Medicines and Health Product technical field, be specifically related to a kind of compositions containing Eurycoma longifolia extract product.
Background technology
At present, cancer has become one of the principal disease having a strong impact on human health, threaten human life, and World Health Organization (WHO) and hygiene department of national governments are all classified as capture cancer as a vital task.The current treatment for cancer mainly adopts radiotherapy or chemotherapy, or to adopt after excision pathological tissues combination with radiotherapeutic or chemotherapy again, to kill and to suppress growth of cancer cells in body.But not only medical expense is high, the misery that can increase patient to adopt excision, and the large damage of patient's Post operation vigour, and radiotherapy or chemotherapeutic treatment, while killing cancerous cell, also make immune cell sustain damage, patient's immunity is reduced.
Eurycoma longifolia, also known as Nan Yang Radix Ginseng, is the special product in the high hill ridge of Malaysia, with tinware, Nidus collocaliae be called Malaysian three essentials-essence.Eurycoma longifolia bitter in the mouth, cool in nature, have effect of clearing away heat-damp and promoting diuresis, tonifying YANG, modern medicine study further proves, the extract of Eurycoma longifolia also has effects such as promoting muscle power, lessen fatigue, sterilize, be anticancer.The present invention take Eurycoma longifolia extract product as primary raw material, coordinates and has the termitomyces extract of antitumaous effect, Herb Gynostemmae Pentaphylli extract, Radix Astragali extract and glycyrrhizic acid, prepare a kind ofly contribute to giving protection against cancer, anticancer compositions.
Summary of the invention
The object of the present invention is to provide a kind of compositions containing Eurycoma longifolia extract product, it has the effects such as enhancing human body immunity power, Tumor suppression growth, the body's immunity damage that causes of repair medicine, all has better effects to cancer early prevention and treatment, post-operative recovery.
For achieving the above object, the present invention adopts following technical scheme:
Containing a compositions for Eurycoma longifolia extract product, its raw material composition comprises by weight: Eurycoma longifolia extract product 5-10 part, termitomyces extract 5-8 part, Herb Gynostemmae Pentaphylli extract 3-5 part, Radix Astragali extract 3-5 part, glycyrrhizic acid 1-3 part.
In described Eurycoma longifolia extract product, the content of eurycomanone is not less than 0.2%.
The preparation method of described Eurycoma longifolia extract product is: the root of Eurycoma longifolia is cleaned, dries, pulverized, and add raw material weight 3-5 water doubly, heating extraction 1 ~ 2h at 60 ~ 80 DEG C, filter, filtrate reduced in volume is to thick paste shape; Then add the extraction into ethyl acetate 2 times of concentrated solution volume 3-5 times amount, extract 0.5 ~ 1h at every turn, after stratification, collect ethyl acetate solution, then by ethyl acetate solution at 40 ~ 50 DEG C concentrating under reduced pressure recycling design to dry; Gained solid matter is added the dissolve with ethanol solution that mass concentration is 80% ~ 90%, is evaporated to dry at 40 ~ 50 DEG C through activated carbon decolorizing, sucking filtration, filtrate, then through vacuum lyophilization, micronizing, excessively 200 ~ 300 mesh sieves.
The preparation method of described termitomyces extract is: by termitomyces clean, section after, dry at 50 ~ 60 DEG C, pulverize, cross 60 ~ 100 mesh sieves, then the water of termitomyces weight 3 ~ 5 times is added, supersound extraction 2 times at 50 ~ 70 DEG C, each 20 ~ 40min, filters, merging filtrate, after filtrate reduced in volume to original volume 1/5, spend the night through precipitate with ethanol, Sevag method deproteination, then through vacuum lyophilization, micronizing, cross 200 ~ 300 mesh sieves.
The described compositions containing Eurycoma longifolia extract product, directly soakedly can drink, or is further used for the paramedicines or the health product that are prepared into treatment of cancer.
Principle active component in Eurycoma longifolia extract product is eurycomanone (Eurycomanone), report is had to point out, the Eurycoma longifolia extract product being rich in eurycomanone can by P53 path cancer cell specific induction of apoptosis, also have research display, eurycomanone reaches anticancer effect by suppressing correlative protein expression.The present invention is primary raw material with Eurycoma longifolia extract product, and limits the content of wherein eurycomanone, can ensure product with stable quality, guarantee the performance of its effect.In termitomyces, polyoses content is higher, and polysaccharide has the effect of antitumor, antioxidation and enhancing human body immunity power, meanwhile, research display is had, termitomyces polysaccharide can antagonism cyclophosphamide to the inhibitory action of body's immunity, can improve and recover the immunity of organisms function damage that chemotherapeutics causes.In Herb Gynostemmae Pentaphylli extract, the content of gypenoside is higher, and gypenoside all has obvious inhibitory action for the propagation of the cancerous cell such as hepatocarcinoma, pulmonary carcinoma, uterus carcinoma, and has the functions such as nourishing, sleeping, raising immunity of organisms to human body.The Radix Astragali has spleen reinforcing lung qi, ascending up spleen-Qi and Yang, benefit defend the effects such as consolidating superficial resistance, the compositions such as the astragaloside contained in Radix Astragali extract, astragalus polysaccharides not only have the effects such as resisting fatigue, antitumor, analgesia, also have completeness Immunonormalizing action to the infringement of tumor patient lymphocyte function.Glycyrrhizic acid is also known as glycyrrhizin, it is topmost active component in Radix Glycyrrhizae, it has certain inhibitory action to the growth of sarcoma, cancerous cell, and can immune function of human body be strengthened, simultaneously, glycyrrhizic acid sugariness is high, heat is low, is joined by glycyrrhizic acid in the present composition and can improve compositions mouthfeel, the mild property of medicine.
The present invention take Eurycoma longifolia extract product as primary raw material, and coordinate with termitomyces extract, Herb Gynostemmae Pentaphylli extract, Radix Astragali extract and glycyrrhizic acid, there is the effect of Synergistic, can the body's immunity damage that causes of enhancing human body immunity power, Tumor suppression growth, repair medicine, especially there are preferably treatment and health-care effect for carcinoma of prostate and uterus carcinoma patient.Soakedly to drink daily for the present composition, through the routine case of clinical observation 100, obviously can reduce patient's cancer return rate, effective percentage reaches more than 80%, there is no obvious adverse reaction, illustrates that the present composition is safe and effective, has good market prospect.
Detailed description of the invention
More being convenient to make content of the present invention understand, below in conjunction with detailed description of the invention, technical solutions according to the invention are described further, but the present invention being not limited only to this.
Embodiment 1
Containing a compositions for Eurycoma longifolia extract product, its raw material composition comprises by weight: Eurycoma longifolia extract product 5g, termitomyces extract 5g, Herb Gynostemmae Pentaphylli extract 3g, Radix Astragali extract 3g, glycyrrhizic acid 1g.
The preparation method of described Eurycoma longifolia extract product is: the root of Eurycoma longifolia is cleaned, dries, pulverized, and adds the water of raw material weight 3 times, heating extraction 2h at 60 DEG C, and filter, filtrate reduced in volume is to thick paste shape; Then add the extraction into ethyl acetate 2 times of concentrated solution volume 3 times amount, extract 1h at every turn, after stratification, collect ethyl acetate solution, then by ethyl acetate solution at 40 DEG C concentrating under reduced pressure recycling design to dry; Gained solid matter is added the dissolve with ethanol solution that mass concentration is 80%, is evaporated to dry at 40 DEG C through activated carbon decolorizing, sucking filtration, filtrate, then through vacuum lyophilization, micronizing, excessively 200 mesh sieves; In gained Eurycoma longifolia extract product, the content of eurycomanone is 0.20%.
The preparation method of described termitomyces extract is: by termitomyces clean, section after, dry at 50 DEG C, pulverize, cross 60 mesh sieves, then the water of termitomyces weight 3 times is added, supersound extraction 2 times at 50 DEG C, each 40min, filters, merging filtrate, after filtrate reduced in volume to original volume 1/5, spend the night through precipitate with ethanol, Sevag method deproteination, then through vacuum lyophilization, micronizing, cross 200 mesh sieves.
Embodiment 2
Containing a compositions for Eurycoma longifolia extract product, its raw material composition comprises by weight: Eurycoma longifolia extract product 8g, termitomyces extract 6g, Herb Gynostemmae Pentaphylli extract 4g, Radix Astragali extract 4g, glycyrrhizic acid 2g.
The preparation method of described Eurycoma longifolia extract product is: the root of Eurycoma longifolia is cleaned, dries, pulverized, and adds the water of raw material weight 4 times, heating extraction 1.5h at 70 DEG C, and filter, filtrate reduced in volume is to thick paste shape; Then add the extraction into ethyl acetate 2 times of concentrated solution volume 4 times amount, extract 0.5h at every turn, after stratification, collect ethyl acetate solution, then by ethyl acetate solution at 45 DEG C concentrating under reduced pressure recycling design to dry; Gained solid matter is added the dissolve with ethanol solution that mass concentration is 85%, is evaporated to dry at 45 DEG C through activated carbon decolorizing, sucking filtration, filtrate, then through vacuum lyophilization, micronizing, excessively 200 mesh sieves; In gained Eurycoma longifolia extract product, the content of eurycomanone is 0.24%.
The preparation method of described termitomyces extract is: by termitomyces clean, section after, dry at 55 DEG C, pulverize, cross 80 mesh sieves, then the water of termitomyces weight 4 times is added, supersound extraction 2 times at 60 DEG C, each 30min, filters, merging filtrate, after filtrate reduced in volume to original volume 1/5, spend the night through precipitate with ethanol, Sevag method deproteination, then through vacuum lyophilization, micronizing, cross 200 mesh sieves.
Embodiment 3
Containing a compositions for Eurycoma longifolia extract product, its raw material composition comprises by weight: Eurycoma longifolia extract product 10g, termitomyces extract 8g, Herb Gynostemmae Pentaphylli extract 5g, Radix Astragali extract 5g, glycyrrhizic acid 3g.
The preparation method of described Eurycoma longifolia extract product is: the root of Eurycoma longifolia is cleaned, dries, pulverized, and adds the water of raw material weight 5 times, heating extraction 1h at 80 DEG C, and filter, filtrate reduced in volume is to thick paste shape; Then add the extraction into ethyl acetate 2 times of concentrated solution volume 5 times amount, extract 0.5h at every turn, after stratification, collect ethyl acetate solution, then by ethyl acetate solution at 50 DEG C concentrating under reduced pressure recycling design to dry; Gained solid matter is added the dissolve with ethanol solution that mass concentration is 90%, is evaporated to dry at 50 DEG C through activated carbon decolorizing, sucking filtration, filtrate, then through vacuum lyophilization, micronizing, excessively 300 mesh sieves; In gained Eurycoma longifolia extract product, the content of eurycomanone is 0.32%.
The preparation method of described termitomyces extract is: by termitomyces clean, section after, dry at 60 DEG C, pulverize, cross 100 mesh sieves, then the water of termitomyces weight 5 times is added, supersound extraction 2 times at 70 DEG C, each 20min, filters, merging filtrate, after filtrate reduced in volume to original volume 1/5, spend the night through precipitate with ethanol, Sevag method deproteination, then through vacuum lyophilization, micronizing, cross 300 mesh sieves.
tumor suppression is tested
Ganoderma has been proved has good inhibitory action to tumor, the present invention carries out contrast experiment with 5mg/mL Eurycoma longifolia extract product and 5mg/mL embodiment 1 compositions, and with 5mg/mL Ganoderma water extract be positive control, with the JEG-3 without drug treating for negative control, adopt mtt assay to measure the suppression ratio of each experimental group to human hepatoma cell strain HepG-2, Prostatic cancer cell lines DU-145, MCF-7 cell strainHJ2mm, human stomach cancer cell line MKN-45, the results are shown in Table 1.The computing formula of tumor control rate is:
Suppression ratio (%)=(matched group optical density value-experimental group optical density value)/matched group optical density value × 100%.
Table 1 tumor suppression result of the test
From table 1 result, when dosage is consistent, embodiment 1 compositions is obviously better than Eurycoma longifolia extract product and Ganoderma water extract to the inhibition of tumor cell, especially remarkable to the inhibition of prostate gland cancer cell and breast cancer cell; Meanwhile, and be used alone compared with Eurycoma longifolia extract product, the tumor inhibitory effect of embodiment 1 compositions is better, illustrates that the suppression of each composition to tumor cell in said composition has good synergistic function.
The foregoing is only preferred embodiment of the present invention, all equalizations done according to the present patent application the scope of the claims change and modify, and all should belong to covering scope of the present invention.
Claims (5)
1. containing a compositions for Eurycoma longifolia extract product, it is characterized in that: the raw material composition of described compositions comprises by weight: Eurycoma longifolia extract product 5-10 part, termitomyces extract 5-8 part, Herb Gynostemmae Pentaphylli extract 3-5 part, Radix Astragali extract 3-5 part, glycyrrhizic acid 1-3 part.
2., according to claim 1 containing the compositions of Eurycoma longifolia extract product, it is characterized in that: in described Eurycoma longifolia extract product, the content of eurycomanone is not less than 0.2%.
3. according to claim 1 containing the compositions of Eurycoma longifolia extract product, it is characterized in that: the preparation method of described Eurycoma longifolia extract product is: the root of Eurycoma longifolia is cleaned, dries, pulverized, add raw material weight 3-5 water doubly, heating extraction 1 ~ 2h at 60 ~ 80 DEG C, filter, filtrate reduced in volume is to thick paste shape; Then add the extraction into ethyl acetate 2 times of concentrated solution volume 3-5 times amount, extract 0.5 ~ 1h at every turn, after stratification, collect ethyl acetate solution, then by ethyl acetate solution at 40 ~ 50 DEG C concentrating under reduced pressure recycling design to dry; Gained solid matter is added the dissolve with ethanol solution that mass concentration is 80% ~ 90%, is evaporated to dry at 40 ~ 50 DEG C through activated carbon decolorizing, sucking filtration, filtrate, then through vacuum lyophilization, micronizing, excessively 200 ~ 300 mesh sieves.
4. according to claim 1 containing the compositions of Eurycoma longifolia extract product, it is characterized in that: the preparation method of described termitomyces extract is: by termitomyces clean, section after, dry at 50 ~ 60 DEG C, pulverize, cross 60 ~ 100 mesh sieves, then the water of termitomyces weight 3 ~ 5 times is added, supersound extraction 2 times at 50 ~ 70 DEG C, each 20 ~ 40min, filter, merging filtrate, after filtrate reduced in volume to original volume 1/5, spend the night through precipitate with ethanol, Sevag method deproteination, then through vacuum lyophilization, micronizing, cross 200 ~ 300 mesh sieves.
5., according to claim 1 containing the compositions of Eurycoma longifolia extract product, it is characterized in that: described compositions is directly soaked drinks, or is further used for the paramedicines or the health product that are prepared into treatment of cancer.
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Cited By (8)
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| CN106109528A (en) * | 2016-07-14 | 2016-11-16 | 上海新肌生物科技有限公司 | Nanoscale Eurycoma longifolia and Maca extraction process |
| CN106366092A (en) * | 2016-08-29 | 2017-02-01 | 湖南华诚生物资源股份有限公司 | Industrial preparation method for separating high-purity eurycomanone from eurycoma longifolia |
| CN106474167A (en) * | 2015-08-25 | 2017-03-08 | 沈阳药科大学 | Eurycoma longifolia extract product, eurycomanone and its preparation method and application |
| CN106562469A (en) * | 2015-10-07 | 2017-04-19 | 惠州市吉瑞科技有限公司 | Electronic cigarette tobacco liquid |
| CN106689569A (en) * | 2015-11-17 | 2017-05-24 | 济南健康人药品有限公司 | Eurycoma longifolia anti-fatigue health tea |
| CN106810564A (en) * | 2016-12-05 | 2017-06-09 | 陕西嘉禾药业有限公司 | The method for separating eurycomanone is extracted in a kind of root from Tongkat Ali |
| CN107033159A (en) * | 2017-04-11 | 2017-08-11 | 刘寒毅 | A kind of technique that eurycomanone is rapidly and efficiently extracted from Tongkat Ali |
| CN117257891A (en) * | 2023-01-13 | 2023-12-22 | 再造再生健康科技(杭州)有限公司 | Plant extract pharmaceutical composition for improving secretion of endogenous insulin-like growth factor 1 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474167A (en) * | 2015-08-25 | 2017-03-08 | 沈阳药科大学 | Eurycoma longifolia extract product, eurycomanone and its preparation method and application |
| CN106562469A (en) * | 2015-10-07 | 2017-04-19 | 惠州市吉瑞科技有限公司 | Electronic cigarette tobacco liquid |
| CN106689569A (en) * | 2015-11-17 | 2017-05-24 | 济南健康人药品有限公司 | Eurycoma longifolia anti-fatigue health tea |
| CN106109528A (en) * | 2016-07-14 | 2016-11-16 | 上海新肌生物科技有限公司 | Nanoscale Eurycoma longifolia and Maca extraction process |
| CN106366092A (en) * | 2016-08-29 | 2017-02-01 | 湖南华诚生物资源股份有限公司 | Industrial preparation method for separating high-purity eurycomanone from eurycoma longifolia |
| CN106366092B (en) * | 2016-08-29 | 2018-09-04 | 湖南华诚生物资源股份有限公司 | A kind of industrial production process detaching eurycomanone from Tongkat Ali |
| CN106810564A (en) * | 2016-12-05 | 2017-06-09 | 陕西嘉禾药业有限公司 | The method for separating eurycomanone is extracted in a kind of root from Tongkat Ali |
| CN107033159A (en) * | 2017-04-11 | 2017-08-11 | 刘寒毅 | A kind of technique that eurycomanone is rapidly and efficiently extracted from Tongkat Ali |
| CN107033159B (en) * | 2017-04-11 | 2018-03-09 | 刘寒毅 | A kind of technique that eurycomanone is extracted from Tongkat Ali |
| CN117257891A (en) * | 2023-01-13 | 2023-12-22 | 再造再生健康科技(杭州)有限公司 | Plant extract pharmaceutical composition for improving secretion of endogenous insulin-like growth factor 1 |
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Application publication date: 20150805 |